LOCUS       NM_145648               2751 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens solute carrier family 15 member 4 (SLC15A4), mRNA.
ACCESSION   NM_145648
VERSION     NM_145648.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2751)
  AUTHORS   Dong,M., Li,P., Luo,J., Chen,B. and Jiang,H.
  TITLE     Oligopeptide/Histidine Transporter PHT1 and PHT2 - Function,
            Regulation, and Pathophysiological Implications Specifically in
            Immunoregulation
  JOURNAL   Pharm Res 40 (11), 2585-2596 (2023)
   PUBMED   37610621
  REMARK    GeneRIF: Oligopeptide/Histidine Transporter PHT1 and PHT2 -
            Function, Regulation, and Pathophysiological Implications
            Specifically in Immunoregulation.
            Review article
REFERENCE   2  (bases 1 to 2751)
  AUTHORS   Chen,X., Xie,M., Zhang,S., Monguio-Tortajada,M., Yin,J., Liu,C.,
            Zhang,Y., Delacretaz,M., Song,M., Wang,Y., Dong,L., Ding,Q.,
            Zhou,B., Tian,X., Deng,H., Xu,L., Liu,X., Yang,Z., Chang,Q., Na,J.,
            Zeng,W., Superti-Furga,G., Rebsamen,M. and Yang,M.
  TITLE     Structural basis for recruitment of TASL by SLC15A4 in human
            endolysosomal TLR signaling
  JOURNAL   Nat Commun 14 (1), 6627 (2023)
   PUBMED   37863913
  REMARK    GeneRIF: Structural basis for recruitment of TASL by SLC15A4 in
            human endolysosomal TLR signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2751)
  AUTHORS   Boeszoermenyi,A., Bernaleau,L., Chen,X., Kartnig,F., Xie,M.,
            Zhang,H., Zhang,S., Delacretaz,M., Koren,A., Hopp,A.K., Dvorak,V.,
            Kubicek,S., Aletaha,D., Yang,M., Rebsamen,M., Heinz,L.X. and
            Superti-Furga,G.
  TITLE     A conformation-locking inhibitor of SLC15A4 with TASL proteostatic
            anti-inflammatory activity
  JOURNAL   Nat Commun 14 (1), 6626 (2023)
   PUBMED   37863876
  REMARK    GeneRIF: A conformation-locking inhibitor of SLC15A4 with TASL
            proteostatic anti-inflammatory activity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2751)
  AUTHORS   Mazzei,A., Serino,G., Romano,A., Piccinno,E., Scalavino,V.,
            Valentini,A.M., Armentano,R., Schiavone,R., Giannelli,G., Verri,T.
            and Barca,A.
  TITLE     Identification of SLC15A4/PHT1 Gene Products Upregulation Marking
            the Intestinal Epithelial Monolayer of Ulcerative Colitis Patients
  JOURNAL   Int J Mol Sci 23 (21), 13170 (2022)
   PUBMED   36361959
  REMARK    GeneRIF: Identification of SLC15A4/PHT1 Gene Products Upregulation
            Marking the Intestinal Epithelial Monolayer of Ulcerative Colitis
            Patients.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2751)
  AUTHORS   Skopelitou,D., Srivastava,A., Miao,B., Kumar,A., Dymerska,D.,
            Paramasivam,N., Schlesner,M., Lubinski,J., Hemminki,K., Forsti,A.
            and Reddy Bandapalli,O.
  TITLE     Whole exome sequencing identifies novel germline variants of
            SLC15A4 gene as potentially cancer predisposing in familial
            colorectal cancer
  JOURNAL   Mol Genet Genomics 297 (4), 965-979 (2022)
   PUBMED   35562597
  REMARK    GeneRIF: Whole exome sequencing identifies novel germline variants
            of SLC15A4 gene as potentially cancer predisposing in familial
            colorectal cancer.
REFERENCE   6  (bases 1 to 2751)
  AUTHORS   Han,J.W., Zheng,H.F., Cui,Y., Sun,L.D., Ye,D.Q., Hu,Z., Xu,J.H.,
            Cai,Z.M., Huang,W., Zhao,G.P., Xie,H.F., Fang,H., Lu,Q.J., Xu,J.H.,
            Li,X.P., Pan,Y.F., Deng,D.Q., Zeng,F.Q., Ye,Z.Z., Zhang,X.Y.,
            Wang,Q.W., Hao,F., Ma,L., Zuo,X.B., Zhou,F.S., Du,W.H., Cheng,Y.L.,
            Yang,J.Q., Shen,S.K., Li,J., Sheng,Y.J., Zuo,X.X., Zhu,W.F.,
            Gao,F., Zhang,P.L., Guo,Q., Li,B., Gao,M., Xiao,F.L., Quan,C.,
            Zhang,C., Zhang,Z., Zhu,K.J., Li,Y., Hu,D.Y., Lu,W.S., Huang,J.L.,
            Liu,S.X., Li,H., Ren,Y.Q., Wang,Z.X., Yang,C.J., Wang,P.G.,
            Zhou,W.M., Lv,Y.M., Zhang,A.P., Zhang,S.Q., Lin,D., Li,Y.,
            Low,H.Q., Shen,M., Zhai,Z.F., Wang,Y., Zhang,F.Y., Yang,S.,
            Liu,J.J. and Zhang,X.J.
  TITLE     Genome-wide association study in a Chinese Han population
            identifies nine new susceptibility loci for systemic lupus
            erythematosus
  JOURNAL   Nat Genet 41 (11), 1234-1237 (2009)
   PUBMED   19838193
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   7  (bases 1 to 2751)
  AUTHORS   Takeuchi,F., Ochiai,Y., Serizawa,M., Yanai,K., Kuzuya,N., Kajio,H.,
            Honjo,S., Takeda,N., Kaburagi,Y., Yasuda,K., Shirasawa,S.,
            Sasazuki,T. and Kato,N.
  TITLE     Search for type 2 diabetes susceptibility genes on chromosomes 1q,
            3q and 12q
  JOURNAL   J Hum Genet 53 (4), 314-324 (2008)
   PUBMED   18259684
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 2751)
  AUTHORS   Bhardwaj,R.K., Herrera-Ruiz,D., Eltoukhy,N., Saad,M. and Knipp,G.T.
  TITLE     The functional evaluation of human peptide/histidine transporter 1
            (hPHT1) in transiently transfected COS-7 cells
  JOURNAL   Eur J Pharm Sci 27 (5), 533-542 (2006)
   PUBMED   16289537
REFERENCE   9  (bases 1 to 2751)
  AUTHORS   Daniel,H. and Kottra,G.
  TITLE     The proton oligopeptide cotransporter family SLC15 in physiology
            and pharmacology
  JOURNAL   Pflugers Arch 447 (5), 610-618 (2004)
   PUBMED   12905028
  REMARK    Review article
REFERENCE   10 (bases 1 to 2751)
  AUTHORS   Botka,C.W., Wittig,T.W., Graul,R.C., Nielsen,C.U., Higaka,K.,
            Amidon,G.L. and Sadee,W.
  TITLE     Human proton/oligopeptide transporter (POT) genes: identification
            of putative human genes using bioinformatics
  JOURNAL   AAPS PharmSci 2 (2), E16 (2000)
   PUBMED   11741232
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC108704.3.
            
            On Nov 22, 2018 this sequence version replaced NM_145648.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC146803.1, AY038999.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000266771.10/ ENSP00000266771.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-561               AC108704.3         89043-89603         c
            562-857             AC108704.3         80420-80715         c
            858-1026            AC108704.3         75588-75756         c
            1027-1104           AC108704.3         75041-75118         c
            1105-1273           AC108704.3         74433-74601         c
            1274-1429           AC108704.3         66499-66654         c
            1430-1588           AC108704.3         64904-65062         c
            1589-2751           AC108704.3         58839-60001         c
FEATURES             Location/Qualifiers
     source          1..2751
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.33"
     gene            1..2751
                     /gene="SLC15A4"
                     /gene_synonym="FP12591; PHT1; PTR4"
                     /note="solute carrier family 15 member 4"
                     /db_xref="GeneID:121260"
                     /db_xref="HGNC:HGNC:23090"
                     /db_xref="MIM:615806"
     exon            1..561
                     /gene="SLC15A4"
                     /gene_synonym="FP12591; PHT1; PTR4"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1749
                     /gene="SLC15A4"
                     /gene_synonym="FP12591; PHT1; PTR4"
                     /note="peptide-histidine transporter 4; hPHT1; peptide
                     transporter 4; peptide/histidine transporter 1; solute
                     carrier family 15 (oligopeptide transporter), member 4"
                     /codon_start=1
                     /product="solute carrier family 15 member 4"
                     /protein_id="NP_663623.1"
                     /db_xref="CCDS:CCDS9264.1"
                     /db_xref="GeneID:121260"
                     /db_xref="HGNC:HGNC:23090"
                     /db_xref="MIM:615806"
                     /translation="MEGSGGGAGERAPLLGARRAAAAAAAAGAFAGRRAACGAVLLTE
                     LLERAAFYGITSNLVLFLNGAPFCWEGAQASEALLLFMGLTYLGSPFGGWLADARLGR
                     ARAILLSLALYLLGMLAFPLLAAPATRAALCGSARLLNCTAPGPDAAARCCSPATFAG
                     LVLVGLGVATVKANITPFGADQVKDRGPEATRRFFNWFYWSINLGAILSLGGIAYIQQ
                     NVSFVTGYAIPTVCVGLAFVVFLCGQSVFITKPPDGSAFTDMFKILTYSCCSQKRSGE
                     RQSNGEGIGVFQQSSKQSLFDSCKMSHGGPFTEEKVEDVKALVKIVPVFLALIPYWTV
                     YFQMQTTYVLQSLHLRIPEISNITTTPHTLPAAWLTMFDAVLILLLIPLKDKLVDPIL
                     RRHGLLPSSLKRIAVGMFFVMCSAFAAGILESKRLNLVKEKTINQTIGNVVYHAADLS
                     LWWQVPQYLLIGISEIFASIAGLEFAYSAAPKSMQSAIMGLFFFFSGVGSFVGSGLLA
                     LVSIKAIGWMSSHTDFGNINGCYLNYYFFLLAAIQGATLLLFLIISVKYDHHRDHQRS
                     RANGVPTSRRA"
     exon            562..857
                     /gene="SLC15A4"
                     /gene_synonym="FP12591; PHT1; PTR4"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1026
                     /gene="SLC15A4"
                     /gene_synonym="FP12591; PHT1; PTR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1104
                     /gene="SLC15A4"
                     /gene_synonym="FP12591; PHT1; PTR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1273
                     /gene="SLC15A4"
                     /gene_synonym="FP12591; PHT1; PTR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1429
                     /gene="SLC15A4"
                     /gene_synonym="FP12591; PHT1; PTR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1588
                     /gene="SLC15A4"
                     /gene_synonym="FP12591; PHT1; PTR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..2751
                     /gene="SLC15A4"
                     /gene_synonym="FP12591; PHT1; PTR4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2723..2728
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC15A4"
                     /gene_synonym="FP12591; PHT1; PTR4"
                     /note="hexamer: TATAAA"
     polyA_site      2751
                     /gene="SLC15A4"
                     /gene_synonym="FP12591; PHT1; PTR4"
                     /note="major polyA site"
ORIGIN      
        1 agctggcggc gtcgcatgga gggctctggg ggcggtgcgg gcgagcgggc gccgctgctg
       61 ggcgcgcggc gggcggcggc ggccgcggcg gcggctgggg cgttcgcggg ccggcgcgcg
      121 gcgtgcgggg ccgtgctgct gacggagctg ctggagcgcg ccgctttcta cggcatcacg
      181 tccaacctgg tgctattcct gaacggggcg ccgttctgct gggagggcgc gcaggccagc
      241 gaggcgctgc tgctcttcat gggcctcacc tacctgggct cgccgttcgg aggctggctg
      301 gccgacgcgc ggctgggccg ggcgcgcgcc atcctgctga gcctggcgct ctacctgctg
      361 ggcatgctgg ccttcccgct gctggccgcg cccgccacgc gagccgcgct ctgcggttcc
      421 gcgcgcctgc tcaactgcac ggcgcctggt cccgacgccg ccgcccgctg ctgctcaccg
      481 gccaccttcg cggggctggt gctggtgggc ctgggcgtgg ccaccgtcaa ggccaacatc
      541 acgcccttcg gcgccgacca ggttaaagat cgaggtccgg aagccactag gagatttttt
      601 aattggtttt attggagcat taacctggga gcgatcctgt cgttaggtgg cattgcctat
      661 attcagcaga acgtcagctt tgtcactggt tatgcgatcc ccactgtctg cgtcggcctt
      721 gcttttgtgg tcttcctctg tggccagagc gttttcatca ccaagcctcc tgatggcagt
      781 gccttcaccg acatgttcaa gatactgacg tattcctgct gttcccagaa gcgaagtgga
      841 gagcgccaga gtaatggtga aggcattgga gtctttcagc aatcttctaa acaaagtctg
      901 tttgattcat gtaagatgtc tcatggtggg ccatttacag aagagaaagt ggaagatgtg
      961 aaagctctgg tcaagattgt ccctgttttc ttggctttga taccttactg gacagtgtat
     1021 ttccaaatgc agacaacata tgttttacag agtcttcatt tgaggattcc agaaatttca
     1081 aatattacaa ccactcctca cacgctccct gcagcctggc tgaccatgtt tgatgctgtg
     1141 ctcatcctcc tgctcatccc tctgaaggac aaactggtcg atcccatttt gagaagacat
     1201 ggcctgctcc catcctccct gaagaggatc gccgtgggca tgttctttgt catgtgctcg
     1261 gcctttgctg caggaatttt ggagagtaaa aggctgaacc ttgttaaaga gaaaaccatt
     1321 aatcagacca tcggcaacgt cgtctaccat gctgccgatc tgtcgctgtg gtggcaggtg
     1381 ccgcagtact tgctgattgg gatcagcgag atctttgcaa gtatcgcagg cctggaattt
     1441 gcatactcag ctgcccccaa gtccatgcag agtgccataa tgggcttgtt ctttttcttc
     1501 tctggcgtcg ggtcgttcgt gggttctgga ctgctggcac tggtgtctat caaagccatc
     1561 ggatggatga gcagtcacac agactttggt aatattaacg gctgctattt gaactattac
     1621 ttttttcttc tggctgctat tcaaggagct accctcctgc ttttcctcat tatttctgtg
     1681 aaatatgacc atcatcgaga ccatcagcga tcaagagcca atggcgtgcc caccagcagg
     1741 agggcctgac cttcctgagg ccatgtgcgg tttctgaggc tgacatgtca gtaactgact
     1801 ggggtgcact gagaacaggc aagactttaa attcccataa aatgtctgac ttcactgaaa
     1861 cttgcatgtt gcctggattg atttcttctt tccctctatc caaaggagct tggtaagtgc
     1921 cttactgcag cgtgtctcct ggcacgctgg gccctccggg aggagagctg cagatttcga
     1981 gtatgtcgct tgtcattcaa ggtctctgtg aatcctctag ctgggttccc ttttttacag
     2041 aaactcacaa atggagattg caaagtcttg gggaactcca cgtgttagtt ggcatcccag
     2101 tttcttaaac aaatagtatc acctgcttcc catagccata tctcactgta aaaaaaaaat
     2161 taataaactg ttacttatat ttaagaaagt gaggattttt ttttttttaa agataaaagc
     2221 atggtcagat gctgcaagga ttttacataa atgccatatt tatggtttcc ttcctgagaa
     2281 caatcttgct cttgccatgt tctttgattt aggctggtag taaacacatt tcatctgctg
     2341 cttcaaaaag tacttacttt ttaaaccatc aacattactt ttctttctta aggcaaggca
     2401 tgcataagag tcatttgaga ccatgtgtcc catctcaagc cacagagcaa ctcacggggt
     2461 acttcacacc ttacctagtc agagtgctta tatatagctt tattttggta cgattgagac
     2521 taaagactga tcatggttgt atgtaaggaa aacattcttt tgaacagaaa tagtgtaatt
     2581 aaaaataatt gaaagtgtta aatgtgaact tgagctgttt gaccagtcac atttttgtat
     2641 tgttactgta cgtgtatctg gggcttctcc gtttgttaat actttttctg tatttgttgc
     2701 tgtatttttg gcataacttt attataaaaa gcatctcaaa tgcgaaatcc a
//
