LOCUS       NM_016582               2506 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens solute carrier family 15 member 3 (SLC15A3),
            transcript variant 1, mRNA.
ACCESSION   NM_016582
VERSION     NM_016582.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2506)
  AUTHORS   Dong,M., Li,P., Luo,J., Chen,B. and Jiang,H.
  TITLE     Oligopeptide/Histidine Transporter PHT1 and PHT2 - Function,
            Regulation, and Pathophysiological Implications Specifically in
            Immunoregulation
  JOURNAL   Pharm Res 40 (11), 2585-2596 (2023)
   PUBMED   37610621
  REMARK    GeneRIF: Oligopeptide/Histidine Transporter PHT1 and PHT2 -
            Function, Regulation, and Pathophysiological Implications
            Specifically in Immunoregulation.
            Review article
REFERENCE   2  (bases 1 to 2506)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2506)
  AUTHORS   Wang,Y., Li,P., Song,F., Yang,X., Weng,Y., Ma,Z., Wang,L. and
            Jiang,H.
  TITLE     Substrate Transport Properties of the Human Peptide/Histidine
            Transporter PHT2 in Transfected MDCK Cells
  JOURNAL   J Pharm Sci 108 (10), 3416-3424 (2019)
   PUBMED   31254495
  REMARK    GeneRIF: Substrate Transport Properties of the Human
            Peptide/Histidine Transporter PHT2 in Transfected MDCK Cells.
REFERENCE   4  (bases 1 to 2506)
  AUTHORS   Oppermann,H., Heinrich,M., Birkemeyer,C., Meixensberger,J. and
            Gaunitz,F.
  TITLE     The proton-coupled oligopeptide transporters PEPT2, PHT1 and PHT2
            mediate the uptake of carnosine in glioblastoma cells
  JOURNAL   Amino Acids 51 (7), 999-1008 (2019)
   PUBMED   31073693
  REMARK    GeneRIF: The transporters PEPT2, PHT1, and PHT2 are responsible for
            the uptake of carnosine into glioblastoma cells and full function
            of all three transporters is required for maximum uptake.
REFERENCE   5  (bases 1 to 2506)
  AUTHORS   He,L., Wang,B., Li,Y., Zhu,L., Li,P., Zou,F. and Bin,L.
  TITLE     The Solute Carrier Transporter SLC15A3 Participates in Antiviral
            Innate Immune Responses against Herpes Simplex Virus-1
  JOURNAL   J Immunol Res 2018, 5214187 (2018)
   PUBMED   30069489
  REMARK    GeneRIF: Our results demonstrate that SLC15A3 is induced by viral
            infection to participate in intracellular RNA and DNA
            receptor-mediated interferon production
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2506)
  AUTHORS   Agu,R., Cowley,E., Shao,D., Macdonald,C., Kirkpatrick,D., Renton,K.
            and Massoud,E.
  TITLE     Proton-coupled oligopeptide transporter (POT) family expression in
            human nasal epithelium and their drug transport potential
  JOURNAL   Mol Pharm 8 (3), 664-672 (2011)
   PUBMED   21366347
  REMARK    GeneRIF: PEPT1,PEPT2, PHT1, and PHT2 are expressed in human nasal
            epithelium.
REFERENCE   7  (bases 1 to 2506)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   8  (bases 1 to 2506)
  AUTHORS   Daniel,H. and Kottra,G.
  TITLE     The proton oligopeptide cotransporter family SLC15 in physiology
            and pharmacology
  JOURNAL   Pflugers Arch 447 (5), 610-618 (2004)
   PUBMED   12905028
  REMARK    Review article
REFERENCE   9  (bases 1 to 2506)
  AUTHORS   Sakata,K., Yamashita,T., Maeda,M., Moriyama,Y., Shimada,S. and
            Tohyama,M.
  TITLE     Cloning of a lymphatic peptide/histidine transporter
  JOURNAL   Biochem J 356 (Pt 1), 53-60 (2001)
   PUBMED   11336635
REFERENCE   10 (bases 1 to 2506)
  AUTHORS   Botka,C.W., Wittig,T.W., Graul,R.C., Nielsen,C.U., Higaka,K.,
            Amidon,G.L. and Sadee,W.
  TITLE     Human proton/oligopeptide transporter (POT) genes: identification
            of putative human genes using bioinformatics
  JOURNAL   AAPS PharmSci 2 (2), E16 (2000)
   PUBMED   11741232
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP003721.3, AB020598.1 and BU731752.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016582.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and is protein-coding.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF135600.1, AB020598.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142670
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000227880.8/ ENSP00000227880.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-391               AP003721.3         58040-58430         c
            392-2502            AB020598.1         1-2111
            2503-2506           BU731752.1         20-23               c
FEATURES             Location/Qualifiers
     source          1..2506
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.2"
     gene            1..2506
                     /gene="SLC15A3"
                     /gene_synonym="hPHT2; OCTP; PHT2; PTR3"
                     /note="solute carrier family 15 member 3"
                     /db_xref="GeneID:51296"
                     /db_xref="HGNC:HGNC:18068"
                     /db_xref="MIM:610408"
     exon            1..1183
                     /gene="SLC15A3"
                     /gene_synonym="hPHT2; OCTP; PHT2; PTR3"
                     /inference="alignment:Splign:2.1.0"
     CDS             626..2371
                     /gene="SLC15A3"
                     /gene_synonym="hPHT2; OCTP; PHT2; PTR3"
                     /note="peptide transporter 3; osteoclast transporter;
                     peptide/histidine transporter 2; solute carrier family 15
                     (oligopeptide transporter), member 3"
                     /codon_start=1
                     /product="solute carrier family 15 member 3"
                     /protein_id="NP_057666.1"
                     /db_xref="CCDS:CCDS7998.1"
                     /db_xref="GeneID:51296"
                     /db_xref="HGNC:HGNC:18068"
                     /db_xref="MIM:610408"
                     /translation="MPAPRAREQPRVPGERQPLLPRGARGPRRWRRAAGAAVLLVEML
                     ERAAFFGVTANLVLYLNSTNFNWTGEQATRAALVFLGASYLLAPVGGWLADVYLGRYR
                     AVALSLLLYLAASGLLPATAFPDGRSSFCGEMPASPLGPACPSAGCPRSSPSPYCAPV
                     LYAGLLLLGLAASSVRSNLTSFGADQVMDLGRDATRRFFNWFYWSINLGAVLSLLVVA
                     FIQQNISFLLGYSIPVGCVGLAFFIFLFATPVFITKPPMGSQVSSMLKLALQNCCPQL
                     WQRHSARDRQCARVLADERSPQPGASPQEDIANFQVLVKILPVMVTLVPYWMVYFQMQ
                     STYVLQGLHLHIPNIFPANPANISVALRAQGSSYTIPEAWLLLANVVVVLILVPLKDR
                     LIDPLLLRCKLLPSALQKMALGMFFGFTSVIVAGVLEMERLHYIHHNETVSQQIGEVL
                     YNAAPLSIWWQIPQYLLIGISEIFASIPGLEFAYSEAPRSMQGAIMGIFFCLSGVGSL
                     LGSSLVALLSLPGGWLHCPKDFGNINNCRMDLYFFLLAGIQAVTALLFVWIAGRYERA
                     SQGPASHSRFSRDRG"
     exon            1184..1473
                     /gene="SLC15A3"
                     /gene_synonym="hPHT2; OCTP; PHT2; PTR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1621
                     /gene="SLC15A3"
                     /gene_synonym="hPHT2; OCTP; PHT2; PTR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1732
                     /gene="SLC15A3"
                     /gene_synonym="hPHT2; OCTP; PHT2; PTR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1901
                     /gene="SLC15A3"
                     /gene_synonym="hPHT2; OCTP; PHT2; PTR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2060
                     /gene="SLC15A3"
                     /gene_synonym="hPHT2; OCTP; PHT2; PTR3"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2216
                     /gene="SLC15A3"
                     /gene_synonym="hPHT2; OCTP; PHT2; PTR3"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2506
                     /gene="SLC15A3"
                     /gene_synonym="hPHT2; OCTP; PHT2; PTR3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2461..2466
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC15A3"
                     /gene_synonym="hPHT2; OCTP; PHT2; PTR3"
                     /note="hexamer: AATGAA"
     regulatory      2479..2484
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC15A3"
                     /gene_synonym="hPHT2; OCTP; PHT2; PTR3"
                     /note="hexamer: AATAAG"
     polyA_site      2480
                     /gene="SLC15A3"
                     /gene_synonym="hPHT2; OCTP; PHT2; PTR3"
     polyA_site      2506
                     /gene="SLC15A3"
                     /gene_synonym="hPHT2; OCTP; PHT2; PTR3"
                     /note="major polyA site"
ORIGIN      
        1 agagtttctc aagaagccga gagagggaca gaggctgagc ctggggggag ggctgcaggg
       61 gactgagagg ggagtgtagg cagtgggggt gagggggaca gggaggaggt ggagaagacg
      121 gcaaggggca gcagggtgac tggggcagag ggagccccca ccccacgccc agggcaggcc
      181 aggagtcata aggagagggg acaacaggaa ggggcgacaa acggggaggg gaaagggagg
      241 cggaggggca gcgaagtgaa gcagggaggg tcgcagtgtg aacaagagtg cgaggaaggg
      301 tcaaggtgga gggaggagag gggagagtta gggagaaaca gctgcaggag aggcgcgggg
      361 aggaagcctt aggggtgggg gaagggagag gggagttgag aattagggag gaggtggtag
      421 agtccgggta gtgagcggag ggacaggaag ggtagggcaa gaaagggaga ggggacagga
      481 gggaagggtg ggccaaagcg gtgagaaagg agggccagcc agttgggtgg gggagagggc
      541 cgaggcccgg gggcaggagt gcagggctct gaggcgggga gaggagagga gagaagagcc
      601 gcggggggcc cagcccggag ccaggatgcc cgcgccgcgc gcccgggagc agccccgcgt
      661 gcccggggag cgccagccgc tgctgcctcg cggtgcgcgg ggccctcgac ggtggcggcg
      721 ggcggcgggc gcggccgtgc tgctggtgga gatgctggag cgcgccgcct tcttcggcgt
      781 caccgccaac ctcgtgctgt acctcaacag caccaacttc aactggaccg gcgagcaggc
      841 gacgcgcgcc gcgctggtat tcctgggcgc ctcctacctg ctggcgcccg tgggcggctg
      901 gctggccgac gtgtacctgg gccgctaccg cgcggtcgcg ctcagcctgc tgctctacct
      961 ggccgcctcg ggcctgctgc ccgccaccgc cttccccgac ggccgcagct ccttctgcgg
     1021 agagatgccc gcgtcgccgc tgggacctgc ctgcccctcg gccggctgcc cgcgctcctc
     1081 gcccagcccc tactgcgcgc ccgtcctcta cgcgggcctg ctgctactcg gcctggccgc
     1141 cagctccgtc cggagcaacc tcacctcctt cggtgccgac caggtgatgg atctcggccg
     1201 cgacgccacc cgccgcttct tcaactggtt ttactggagc atcaacctgg gtgctgtgct
     1261 gtcgctgctg gtggtggcgt ttattcagca gaacatcagc ttcctgctgg gctacagcat
     1321 ccctgtgggc tgtgtgggcc tggcattttt catcttcctc tttgccaccc ccgtcttcat
     1381 caccaagccc ccgatgggca gccaagtgtc ctctatgctt aagctcgctc tccaaaactg
     1441 ctgcccccag ctgtggcaac gacactcggc cagagaccgt caatgtgccc gcgtgctggc
     1501 cgacgagagg tctccccagc caggggcttc cccgcaagag gacatcgcca acttccaggt
     1561 gctggtgaag atcttgcccg tcatggtgac cctggtgccc tactggatgg tctacttcca
     1621 gatgcagtcc acctatgtcc tgcagggtct tcacctccac atcccaaaca ttttcccagc
     1681 caacccggcc aacatctctg tggccctgag agcccagggc agcagctaca cgatcccgga
     1741 agcctggctc ctcctggcca atgttgtggt ggtgctgatt ctggtccctc tgaaggaccg
     1801 cttgatcgac cctttactgc tgcggtgcaa gctgcttccc tctgctctgc agaagatggc
     1861 gctggggatg ttctttggtt ttacctccgt cattgtggca ggagtcctgg agatggagcg
     1921 cttacactac atccaccaca acgagaccgt gtcccagcag attggggagg tcctgtacaa
     1981 cgcggcacca ctgtccatct ggtggcagat ccctcagtac ctgctcattg ggatcagtga
     2041 gatctttgcc agcatcccag gcctggagtt tgcctactca gaggccccgc gctccatgca
     2101 gggcgccatc atgggcatct tcttctgcct gtcgggggtg ggctcactgt tgggctccag
     2161 cctagtggca ctgctgtcct tgcccggggg ctggctgcac tgccccaagg actttgggaa
     2221 catcaacaat tgccggatgg acctctactt cttcctgctg gctggcattc aggccgtcac
     2281 ggctctccta tttgtctgga tcgctggacg ctatgagagg gcgtcccagg gcccagcctc
     2341 ccacagccgt ttcagcaggg acaggggctg aacaggccct attccagccc ccttgcttca
     2401 ctctaccgga cagacggcag cagtcccagc tctggtttcc ttctcggttt attctgttag
     2461 aatgaaatgg ttcccataaa taaggggcat gagcccttcc tcacga
//
