LOCUS       NM_021082               5447 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens solute carrier family 15 member 2 (SLC15A2),
            transcript variant 1, mRNA.
ACCESSION   NM_021082
VERSION     NM_021082.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5447)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 5447)
  AUTHORS   Kudo,M., Kobayashi-Nakamura,K., Kitajima,N. and Tsuji-Naito,K.
  TITLE     Alternate expression of PEPT1 and PEPT2 in epidermal
            differentiation is required for NOD2 immune responses by
            bacteria-derived muramyl dipeptide
  JOURNAL   Biochem Biophys Res Commun 522 (1), 151-156 (2020)
   PUBMED   31757425
  REMARK    GeneRIF: Alternate expression of PEPT1 and PEPT2 in epidermal
            differentiation is required for NOD2 immune responses by
            bacteria-derived muramyl dipeptide.
REFERENCE   3  (bases 1 to 5447)
  AUTHORS   Oppermann,H., Heinrich,M., Birkemeyer,C., Meixensberger,J. and
            Gaunitz,F.
  TITLE     The proton-coupled oligopeptide transporters PEPT2, PHT1 and PHT2
            mediate the uptake of carnosine in glioblastoma cells
  JOURNAL   Amino Acids 51 (7), 999-1008 (2019)
   PUBMED   31073693
  REMARK    GeneRIF: The transporters PEPT2, PHT1, and PHT2 are responsible for
            the uptake of carnosine into glioblastoma cells and full function
            of all three transporters is required for maximum uptake.
REFERENCE   4  (bases 1 to 5447)
  AUTHORS   Sweeney,M.D., Zhao,Z., Montagne,A., Nelson,A.R. and Zlokovic,B.V.
  TITLE     Blood-Brain Barrier: From Physiology to Disease and Back
  JOURNAL   Physiol Rev 99 (1), 21-78 (2019)
   PUBMED   30280653
  REMARK    Review article
REFERENCE   5  (bases 1 to 5447)
  AUTHORS   Cai,L.L., Huang,W.Q., Su,Z.Y., Ye,H.M., Wang,L.S., Wu,Y.,
            Zhang,Z.Y., Zhang,W. and Tzeng,C.M.
  TITLE     Identification of two novel genes SLC15A2 and SLCO1B3 associated
            with maintenance dose variability of warfarin in a Chinese
            population
  JOURNAL   Sci Rep 7 (1), 17379 (2017)
   PUBMED   29234073
  REMARK    GeneRIF: Two novel genes, SLC15A2 (rs1143671 and rs1143672) and
            SLCO1B3 (rs4149117 and rs7311358), are associated with the warfarin
            maintenance dose in a Chinese population.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5447)
  AUTHORS   Daniel,H. and Kottra,G.
  TITLE     The proton oligopeptide cotransporter family SLC15 in physiology
            and pharmacology
  JOURNAL   Pflugers Arch 447 (5), 610-618 (2004)
   PUBMED   12905028
  REMARK    Review article
REFERENCE   7  (bases 1 to 5447)
  AUTHORS   Groneberg,D.A.
  TITLE     [Expression, localization and functional aspects of the peptide
            transporter PEPT2 in the normal respiratory tract and in cystic
            fibrosis]
  JOURNAL   Pneumologie 57 (2), 104-105 (2003)
   PUBMED   12579467
  REMARK    GeneRIF: expression, localization and functional aspects of this
            protein in the normal respiratory tract and in cystic fibrosis
REFERENCE   8  (bases 1 to 5447)
  AUTHORS   Alcorn,J., Lu,X., Moscow,J.A. and McNamara,P.J.
  TITLE     Transporter gene expression in lactating and nonlactating human
            mammary epithelial cells using real-time reverse
            transcription-polymerase chain reaction
  JOURNAL   J Pharmacol Exp Ther 303 (2), 487-496 (2002)
   PUBMED   12388627
REFERENCE   9  (bases 1 to 5447)
  AUTHORS   Doring,F., Martini,C., Walter,J. and Daniel,H.
  TITLE     Importance of a small N-terminal region in mammalian peptide
            transporters for substrate affinity and function
  JOURNAL   J Membr Biol 186 (2), 55-62 (2002)
   PUBMED   11944083
  REMARK    GeneRIF: the two identified aminoterminal regions in mammalian
            peptide carriers play an important role in determining the
            substrate affinity and also other characteristic features of the
            two transporter subtypes.
REFERENCE   10 (bases 1 to 5447)
  AUTHORS   Liu,W., Liang,R., Ramamoorthy,S., Fei,Y.J., Ganapathy,M.E.,
            Hediger,M.A., Ganapathy,V. and Leibach,F.H.
  TITLE     Molecular cloning of PEPT 2, a new member of the H+/peptide
            cotransporter family, from human kidney
  JOURNAL   Biochim Biophys Acta 1235 (2), 461-466 (1995)
   PUBMED   7756356
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC072031.18.
            
            On Nov 23, 2018 this sequence version replaced NM_021082.3.
            
            Summary: The mammalian kidney expresses a proton-coupled peptide
            transporter that is responsible for the absorption of small
            peptides, as well as beta-lactam antibiotics and other peptide-like
            drugs, from the tubular filtrate. This transporter, SLC15A2,
            belongs to the same gene family as SLC15A1 (MIM 600544), the
            proton-coupled peptide transporter found in the small intestine
            (Liu et al, 1995 [PubMed 7756356]).[supplied by OMIM, Feb 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.250269.1,
                                           SRR1660803.238045.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000489711.6/ ENSP00000417085.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               AC072031.18        74312-74492         c
            182-269             AC072031.18        72400-72487         c
            270-411             AC072031.18        71364-71505         c
            412-504             AC072031.18        57227-57319         c
            505-604             AC072031.18        55773-55872         c
            605-695             AC072031.18        53576-53666         c
            696-773             AC072031.18        53200-53277         c
            774-856             AC072031.18        46591-46673         c
            857-943             AC072031.18        46032-46118         c
            944-1033            AC072031.18        45764-45853         c
            1034-1078           AC072031.18        45627-45671         c
            1079-1111           AC072031.18        44510-44542         c
            1112-1200           AC072031.18        43860-43948         c
            1201-1282           AC072031.18        41054-41135         c
            1283-1417           AC072031.18        40338-40472         c
            1418-1582           AC072031.18        39747-39911         c
            1583-1629           AC072031.18        39545-39591         c
            1630-1740           AC072031.18        37943-38053         c
            1741-1837           AC072031.18        37158-37254         c
            1838-1984           AC072031.18        29398-29544         c
            1985-2089           AC072031.18        28405-28509         c
            2090-5447           AC072031.18        24705-28062         c
FEATURES             Location/Qualifiers
     source          1..5447
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.33"
     gene            1..5447
                     /gene="SLC15A2"
                     /gene_synonym="PEPT2"
                     /note="solute carrier family 15 member 2"
                     /db_xref="GeneID:6565"
                     /db_xref="HGNC:HGNC:10921"
                     /db_xref="MIM:602339"
     exon            1..181
                     /gene="SLC15A2"
                     /gene_synonym="PEPT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..2266
                     /gene="SLC15A2"
                     /gene_synonym="PEPT2"
                     /note="isoform a is encoded by transcript variant 1;
                     kidney H(+)/peptide cotransporter; peptide transporter 2;
                     solute carrier family 15 (H+/peptide transporter), member
                     2; solute carrier family 15 (oligopeptide transporter),
                     member 2"
                     /codon_start=1
                     /product="solute carrier family 15 member 2 isoform a"
                     /protein_id="NP_066568.3"
                     /db_xref="CCDS:CCDS3007.1"
                     /db_xref="GeneID:6565"
                     /db_xref="HGNC:HGNC:10921"
                     /db_xref="MIM:602339"
                     /translation="MNPFQKNESKETLFSPVSIEEVPPRPPSPPKKPSPTICGSNYPL
                     SIAFIVVNEFCERFSYYGMKAVLILYFLYFLHWNEDTSTSIYHAFSSLCYFTPILGAA
                     IADSWLGKFKTIIYLSLVYVLGHVIKSLGALPILGGQVVHTVLSLIGLSLIALGTGGI
                     KPCVAAFGGDQFEEKHAEERTRYFSVFYLSINAGSLISTFITPMLRGDVQCFGEDCYA
                     LAFGVPGLLMVIALVVFAMGSKIYNKPPPEGNIVAQVFKCIWFAISNRFKNRSGDIPK
                     RQHWLDWAAEKYPKQLIMDVKALTRVLFLYIPLPMFWALLDQQGSRWTLQAIRMNRNL
                     GFFVLQPDQMQVLNPLLVLIFIPLFDFVIYRLVSKCGINFSSLRKMAVGMILACLAFA
                     VAAAVEIKINEMAPAQPGPQEVFLQVLNLADDEVKVTVVGNENNSLLIESIKSFQKTP
                     HYSKLHLKTKSQDFHFHLKYHNLSLYTEHSVQEKNWYSLVIREDGNSISSMMVKDTES
                     RTTNGMTTVRFVNTLHKDVNISLSTDTSLNVGEDYGVSAYRTVQRGEYPAVHCRTEDK
                     NFSLNLGLLDFGAAYLFVITNNTNQGLQAWKIEDIPANKMSIAWQLPQYALVTAGEVM
                     FSVTGLEFSYSQAPSSMKSVLQAAWLLTIAVGNIIVLVVAQFSGLVQWAEFILFSCLL
                     LVICLIFSIMGYYYVPVKTEDMRGPADKHIPHIQGNMIKLETKKTKL"
     exon            182..269
                     /gene="SLC15A2"
                     /gene_synonym="PEPT2"
                     /inference="alignment:Splign:2.1.0"
     exon            270..411
                     /gene="SLC15A2"
                     /gene_synonym="PEPT2"
                     /inference="alignment:Splign:2.1.0"
     exon            412..504
                     /gene="SLC15A2"
                     /gene_synonym="PEPT2"
                     /inference="alignment:Splign:2.1.0"
     exon            505..604
                     /gene="SLC15A2"
                     /gene_synonym="PEPT2"
                     /inference="alignment:Splign:2.1.0"
     exon            605..695
                     /gene="SLC15A2"
                     /gene_synonym="PEPT2"
                     /inference="alignment:Splign:2.1.0"
     exon            696..773
                     /gene="SLC15A2"
                     /gene_synonym="PEPT2"
                     /inference="alignment:Splign:2.1.0"
     exon            774..856
                     /gene="SLC15A2"
                     /gene_synonym="PEPT2"
                     /inference="alignment:Splign:2.1.0"
     exon            857..943
                     /gene="SLC15A2"
                     /gene_synonym="PEPT2"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1033
                     /gene="SLC15A2"
                     /gene_synonym="PEPT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1078
                     /gene="SLC15A2"
                     /gene_synonym="PEPT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1111
                     /gene="SLC15A2"
                     /gene_synonym="PEPT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1200
                     /gene="SLC15A2"
                     /gene_synonym="PEPT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1282
                     /gene="SLC15A2"
                     /gene_synonym="PEPT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1417
                     /gene="SLC15A2"
                     /gene_synonym="PEPT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1582
                     /gene="SLC15A2"
                     /gene_synonym="PEPT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1629
                     /gene="SLC15A2"
                     /gene_synonym="PEPT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1740
                     /gene="SLC15A2"
                     /gene_synonym="PEPT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1837
                     /gene="SLC15A2"
                     /gene_synonym="PEPT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..1984
                     /gene="SLC15A2"
                     /gene_synonym="PEPT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2089
                     /gene="SLC15A2"
                     /gene_synonym="PEPT2"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..5447
                     /gene="SLC15A2"
                     /gene_synonym="PEPT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4054..4059
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC15A2"
                     /gene_synonym="PEPT2"
                     /note="hexamer: ATTAAA"
     polyA_site      4078
                     /gene="SLC15A2"
                     /gene_synonym="PEPT2"
                     /note="major polyA site"
     regulatory      5423..5428
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC15A2"
                     /gene_synonym="PEPT2"
                     /note="hexamer: ATTAAA"
     polyA_site      5447
                     /gene="SLC15A2"
                     /gene_synonym="PEPT2"
ORIGIN      
        1 agagtaggct ggcagctgtc ctaactgcct actaaagcca aatgcttgag gagagagaga
       61 gagtaaggag ccagccatga atcctttcca gaaaaatgag tccaaggaaa ctcttttttc
      121 acctgtctcc attgaagagg taccacctcg accacctagc cctccaaaga agccatctcc
      181 gacaatctgt ggctccaact atccactgag cattgccttc attgtggtga atgaattctg
      241 cgagcgcttt tcctattatg gaatgaaagc tgtgctgatc ctgtatttcc tgtatttcct
      301 gcactggaat gaagatacct ccacatctat ataccatgcc ttcagcagcc tctgttattt
      361 tactcccatc ctgggagcag ccattgctga ctcgtggttg ggaaaattca agacaatcat
      421 ctatctctcc ttggtgtatg tgcttggcca tgtgatcaag tccttgggtg ccttaccaat
      481 actgggagga caagtggtac acacagtcct atcattgatc ggcctgagtc taatagcttt
      541 ggggacagga ggcatcaaac cctgtgtggc agcttttggt ggagaccagt ttgaagaaaa
      601 acatgcagag gaacggacta gatacttctc agtcttctac ctgtccatca atgcagggag
      661 cttgatttct acatttatca cacccatgct gagaggagat gtgcaatgtt ttggagaaga
      721 ctgctatgca ttggcttttg gagttccagg actgctcatg gtaattgcac ttgttgtgtt
      781 tgcaatggga agcaaaatat acaataaacc accccctgaa ggaaacatag tggctcaagt
      841 tttcaaatgt atctggtttg ctatttccaa tcgtttcaag aaccgttctg gagacattcc
      901 aaagcgacag cactggctag actgggcggc tgagaaatat ccaaagcagc tcattatgga
      961 tgtaaaggca ctgaccaggg tactattcct ttatatccca ttgcccatgt tctgggctct
     1021 tttggatcag cagggttcac gatggacttt gcaagccatc aggatgaata ggaatttggg
     1081 gttttttgtg cttcagccgg accagatgca ggttctaaat ccccttctgg ttcttatctt
     1141 catcccgttg tttgactttg tcatttatcg tctggtctcc aagtgtggaa ttaacttctc
     1201 atcacttagg aaaatggctg ttggtatgat cctagcatgc ctggcatttg cagttgcggc
     1261 agctgtagag ataaaaataa atgaaatggc cccagcccag ccaggtcccc aggaggtttt
     1321 cctacaagtc ttgaatctgg cagatgatga ggtgaaggtg acagtggtgg gaaatgaaaa
     1381 caattctctg ttgatagagt ccatcaaatc ctttcagaaa acaccacact attccaaact
     1441 gcacctgaaa acaaaaagcc aggattttca cttccacctg aaatatcaca atttgtctct
     1501 ctacactgag cattctgtgc aggagaagaa ctggtacagt cttgtcattc gtgaagatgg
     1561 gaacagtatc tccagcatga tggtaaagga tacagaaagc agaacaacca atgggatgac
     1621 aaccgtgagg tttgttaaca ctttgcataa agatgtcaac atctccctga gtacagatac
     1681 ctctctcaat gttggtgaag actatggtgt gtctgcttat agaactgtgc aaagaggaga
     1741 ataccctgca gtgcactgta gaacagaaga taagaacttt tctctgaatt tgggtcttct
     1801 agactttggt gcagcatatc tgtttgttat tactaataac accaatcagg gtcttcaggc
     1861 ctggaagatt gaagacattc cagccaacaa aatgtccatt gcgtggcagc taccacaata
     1921 tgccctggtt acagctgggg aggtcatgtt ctctgtcaca ggtcttgagt tttcttattc
     1981 tcaggctccc tctagcatga aatctgtgct ccaggcagct tggctattga caattgcagt
     2041 tgggaatatc atcgtgcttg ttgtggcaca gttcagtggc ctggtacagt gggccgaatt
     2101 cattttgttt tcctgcctcc tgctggtgat ctgcctgatc ttctccatca tgggctacta
     2161 ctatgttcct gtaaagacag aggatatgcg gggtccagca gataagcaca ttcctcacat
     2221 ccaggggaac atgatcaaac tagagaccaa gaagacaaaa ctctgatgac tccctagatt
     2281 ctgtcctgac cccaattcct ggccctgtct tgaagcattt tttttcttct actggattag
     2341 acaagagaga tagcagcata tcagagctga tctcctccac ctttctccaa tgacagaagt
     2401 tccaggactg gttttccagt acatctttaa acaaggcccc agagactcta tgtctgcccg
     2461 tccatcagtg aactcattaa aacttgtgca gtgttgctgg agctggcctg gtgtctccaa
     2521 atgaccatga aaatacacac gtataatgga gatcattctc tgtgggtatg caaagttatg
     2581 ggaattcctt tataggtaac tgccatttag gactgatggc cctaattttt gaggtgctga
     2641 tttagaggca aaattgcaga ataacaaaga aatggtattt caagtttttt tttttataag
     2701 caatgtaatt atgctattca caggggcctc aagaattggt atgtatgatg tgatctggtc
     2761 cagccagggc ctggcttgtc agctctctag gtttgatatg actttagtaa atttgtcaat
     2821 atagatggta ggaagcagaa tgccatttta ttaaaacaca ggagaagtta tatctctctg
     2881 attatgatag tattttattt acttatccaa accctccttt ctcagtatgg atagatcatg
     2941 gaaaccagat tagagatagt aagcattagt aaacattgtt ctggagaaca ggaacaggtg
     3001 taagttgtag aaatcctgaa gagccagtca ttcttttaca gagtacattc ttcttagcct
     3061 ctatggcgct ggtctatgcc cttcagtgaa cagttgtata aacaataatt ataatttgca
     3121 accttgtctt gtcaaccttg ctgatccagc tttttcttat tattacacct tgtcttgctt
     3181 attgcagcaa atattcaata acaacaatgt ttctataagt ccaacttcct ttattaatgt
     3241 ttccatttag cctcaaaaat atcaaagtag ttcctttttg atgttgtttt cctgatttac
     3301 ttttcccata agttttaaat accatttctg ccttgaagcc tagaaatttt ctttttattc
     3361 aaaaaaagtt acattaatgc tctaggtttg aggttctaaa atggaaatgt caatagagga
     3421 gcatggtcct atgtgaggtt cctatcaaaa tttgtgggag tagggatggt agagcatgag
     3481 ggttttgttt gtgtatgtgt atggtcatga aaaaaaattg agaaacatta cctcatacac
     3541 aatgaatgaa tcagaggaca gacacgggaa tggcacgact gtgcagtgtg ttactaggaa
     3601 aaaagttcag aatcactgtt ctagagagct tcatttccat tggttttaaa acattattct
     3661 catgtagaac agtgttgggt ctcatactgt taatgttaat acgtaacaat gttcatgtta
     3721 acaggcacct gttaatatta acagataatg ttactgttaa caggtaagag aaattgctct
     3781 aagtgcccaa actttatata cttcagtttt aatgacaagc atttcagaaa tataagagcg
     3841 gcagccagac caaccagttt ttccagatat cttgatgtga acctgaccct actcctttag
     3901 aagacagcct gttcattttt aaatagcttt aacccaaact gttctatgac cattgtttca
     3961 agagacatta acacagttct gtaaatagaa gtgtctatgg acaaataagt ttgggaaatg
     4021 tggcatactg tatccttttc ttaacatttg catattaaag actctgagat atcctgcagt
     4081 aaagacacaa gataccttgt ttaaattaac atgtacgctg cagaacattg gtttggaaaa
     4141 aactgttgag cagttcttcc ttgtaagtgc tgagcttcct ctctgaaacc tcctaccatt
     4201 gttttttttc ccctgtagct aacaagaata agtataacag ccggccaggc acagtggctc
     4261 atgcctgtaa tcccagcact ttgggaggct gagacaggtg gatcacctga ggtcaggagt
     4321 tcgagaccag cctggccaac atggtgaaac cgtgtctcta ctaaaagtac aaaaattagc
     4381 caggtgtgat ggcaggtgcc tgtaatccca gctactcggg aggctgaagc agaagaattg
     4441 cttgaacccg ggaggcagag gttgcaatga gccgagatca cgccatcaca ctctagcctg
     4501 ggggacaaga gtgagacttc atctaaaaaa aaaaagaaaa gaatatgtat accccctttt
     4561 tcatgtggca gatgtttagc tatttgggga gaactttcat ggctcttccc taatcatcaa
     4621 gtattcaagg taaagattct cggttcctgt aatggttcct caccaggcat aatttgtcct
     4681 tttaccatcc tactttctgt cttctgaaaa acattcttta tctgaaatac agcaattaat
     4741 attaagatat cttaatatga agtgcctgga gtcaaatata acattccaaa gtagtctgac
     4801 tggaagaact agcacctgcc tttcttcaaa caatgcactt ctgttaatgc agtgtaaggt
     4861 aacatgagtt gtttttggaa actacatcat aatgtgggct tacattctag cacttatcac
     4921 ttaatgacag ggatacattt gaggaatgca ttgttaggca attttgtcat tatgcaaaca
     4981 tcatagagtg tacttacaca aacctatggt atagcctact acacatctaa gttatatggt
     5041 atagactgtt tctccagcta tatggtgtag actgtttctc ctaggctaca aacctgcaca
     5101 gcatgttact gtattaaatg ctgtaggcaa ttgtaacaca atggtatttt tatacttaaa
     5161 catatctaaa catagaaacg gtacaaaaaa ctttacacat tatatagatg tatcaaatta
     5221 ttcatatgtg ctctgaaaat gtctatatct gttatgtatc aattttttaa aaagtgaatg
     5281 acataattca tttgaaaaaa tgtggacaca caaattggaa aagaggtata aatgcagtat
     5341 tataatctaa tgggaccacc atcacatatt tggtctgtca ttgactgaaa ctgcaatata
     5401 gagtttttct taacatttgc atattaaaga ctctgactat atatgga
//
