LOCUS       NM_007163               4073 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens solute carrier family 14 member 2 (SLC14A2),
            transcript variant 1, mRNA.
ACCESSION   NM_007163
VERSION     NM_007163.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4073)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4073)
  AUTHORS   Xie,L., Jin,L., Feng,J. and Lv,J.
  TITLE     The Expression of AQP5 and UTs in the Sweat Glands of Uremic
            Patients
  JOURNAL   Biomed Res Int 2017, 8629783 (2017)
   PUBMED   29279852
  REMARK    GeneRIF: The urea transporter subtypes, UT-A1 and UT-B1, were
            expressed in the skin basal cell layer and exocrine sweat glands.
            The abundance of UT-A1 and UT-B1 in uremic sweat glands was
            significantly increased in UP, while the expression of AQP5 was
            decreased.
REFERENCE   3  (bases 1 to 4073)
  AUTHORS   Lee,D., Wang,Y.H., Kalaitzidis,D., Ramachandran,J., Eda,H.,
            Sykes,D.B., Raje,N. and Scadden,D.T.
  TITLE     Endogenous transmembrane protein UT2 inhibits pSTAT3 and suppresses
            hematological malignancy
  JOURNAL   J Clin Invest 126 (4), 1300-1310 (2016)
   PUBMED   26927669
  REMARK    GeneRIF: UT2 is a negative regulator shared across STAT3 and mTORC2
            signaling cascades, functioning as a tumor suppressor in
            hematologic malignancies driven by those pathways.
REFERENCE   4  (bases 1 to 4073)
  AUTHORS   Chen,G.
  TITLE     Biochemical properties of urea transporters
  JOURNAL   Subcell Biochem 73, 109-126 (2014)
   PUBMED   25298341
  REMARK    GeneRIF: Studies indicate that the cell signaling pathway for
            vasopressin-mediated urea transporters phosphorylation and activity
            involves two cAMP-dependent signaling pathways.
            Review article
REFERENCE   5  (bases 1 to 4073)
  AUTHORS   Klein,J.D.
  TITLE     Expression of urea transporters and their regulation
  JOURNAL   Subcell Biochem 73, 79-107 (2014)
   PUBMED   25298340
  REMARK    GeneRIF: Studies indicate that osmotic diuresis, where urea
            concentrations are low, can prompt an increase in urea transporter
            abundance.
            Review article
REFERENCE   6  (bases 1 to 4073)
  AUTHORS   Bagnasco,S.M., Peng,T., Janech,M.G., Karakashian,A. and Sands,J.M.
  TITLE     Cloning and characterization of the human urea transporter UT-A1
            and mapping of the human Slc14a2 gene
  JOURNAL   Am J Physiol Renal Physiol 281 (3), F400-F406 (2001)
   PUBMED   11502588
REFERENCE   7  (bases 1 to 4073)
  AUTHORS   Bradford,A.D., Terris,J.M., Ecelbarger,C.A., Klein,J.D.,
            Sands,J.M., Chou,C.L. and Knepper,M.A.
  TITLE     97- and 117-kDa forms of collecting duct urea transporter UT-A1 are
            due to different states of glycosylation
  JOURNAL   Am J Physiol Renal Physiol 281 (1), F133-F143 (2001)
   PUBMED   11399654
REFERENCE   8  (bases 1 to 4073)
  AUTHORS   Martial,S., Olives,B., Abrami,L., Couriaud,C., Bailly,P., You,G.,
            Hediger,M.A., Cartron,J.P., Ripoche,P. and Rousselet,G.
  TITLE     Functional differentiation of the human red blood cell and kidney
            urea transporters
  JOURNAL   Am J Physiol 271 (6 Pt 2), F1264-F1268 (1996)
   PUBMED   8997401
REFERENCE   9  (bases 1 to 4073)
  AUTHORS   Olives,B., Martial,S., Mattei,M.G., Matassi,G., Rousselet,G.,
            Ripoche,P., Cartron,J.P. and Bailly,P.
  TITLE     Molecular characterization of a new urea transporter in the human
            kidney
  JOURNAL   FEBS Lett 386 (2-3), 156-160 (1996)
   PUBMED   8647271
REFERENCE   10 (bases 1 to 4073)
  AUTHORS   Olives,B., Neau,P., Bailly,P., Hediger,M.A., Rousselet,G.,
            Cartron,J.P. and Ripoche,P.
  TITLE     Cloning and functional expression of a urea transporter from human
            bone marrow cells
  JOURNAL   J Biol Chem 269 (50), 31649-31652 (1994)
   PUBMED   7989337
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF349446.1, DR002593.1, BC110446.1, BC110445.1, X96969.1 and
            AC023421.7.
            
            On Jul 9, 2019 this sequence version replaced NM_007163.3.
            
            Summary: The protein encoded by this gene belongs to the urea
            transporter family. In mammalian cells, urea is the chief end
            product of nitrogen catabolism, and plays an important role in the
            urinary concentration mechanism. This protein is expressed in the
            inner medulla of the kidney, and mediates rapid transepithelial
            urea transport across the inner medullary collecting duct.
            Alternatively spliced transcript variants have been found for this
            gene. [provided by RefSeq, Sep 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF349446.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000255226.11/ ENSP00000255226.5
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               AF349446.1         676-875
            201-615             DR002593.1         137-551
            616-1669            BC110446.1         499-1552
            1670-1799           BC110445.1         1553-1682
            1800-2279           X96969.1           363-842
            2280-3165           BC110445.1         2163-3048
            3166-3464           AC023421.7         88043-88341
            3465-3492           AF349446.1         4139-4166
            3493-4073           AC023421.7         88370-88950
FEATURES             Location/Qualifiers
     source          1..4073
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q12.3"
     gene            1..4073
                     /gene="SLC14A2"
                     /gene_synonym="hUT-A6; HUT2; UT-A2; UT2; UTA; UTR"
                     /note="solute carrier family 14 member 2"
                     /db_xref="GeneID:8170"
                     /db_xref="HGNC:HGNC:10919"
                     /db_xref="MIM:601611"
     exon            1..107
                     /gene="SLC14A2"
                     /gene_synonym="hUT-A6; HUT2; UT-A2; UT2; UTA; UTR"
                     /inference="alignment:Splign:2.1.0"
     exon            108..291
                     /gene="SLC14A2"
                     /gene_synonym="hUT-A6; HUT2; UT-A2; UT2; UTA; UTR"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..2904
                     /gene="SLC14A2"
                     /gene_synonym="hUT-A6; HUT2; UT-A2; UT2; UTA; UTR"
                     /note="urea transporter, kidney; solute carrier family 14
                     (urea transporter), member 2"
                     /codon_start=1
                     /product="urea transporter 2"
                     /protein_id="NP_009094.3"
                     /db_xref="CCDS:CCDS11924.1"
                     /db_xref="GeneID:8170"
                     /db_xref="HGNC:HGNC:10919"
                     /db_xref="MIM:601611"
                     /translation="MSDPHSSPLLPEPLSSRYKLYEAEFTSPSWPSTSPDTHPALPLL
                     EMPEEKDLRSSNEDSHIVKIEKLNERSKRKDDGVAHRDSAGQRCICLSKAVGYLTGDM
                     KEYRIWLKDKHLALQFIDWVLRGTAQVMFINNPLSGLIIFIGLLIQNPWWTITGGLGT
                     VVSTLTALALGQDRSAIASGLHGYNGMLVGLLMAVFSEKLDYYWWLLFPVTFTAMSCP
                     VLSSALNSIFSKWDLPVFTLPFNIAVTLYLAATGHYNLFFPTTLVEPVSSVPNITWTE
                     MEMPLLLQAIPVGVGQVYGCDNPWTGGVFLVALFISSPLICLHAAIGSIVGLLAALSV
                     ATPFETIYTGLWSYNCVLSCIAIGGMFYALTWQTHLLALICALFCAYMEAAISNIMSV
                     VGVPPGTWAFCLATIIFLLLTTNNPAIFRLPLSKVTYPEANRIYYLTVKSGEEEKAPS
                     GGGGEHPPTAGPKVEEGSEAVLSKHRSVFHIEWSSIRRRSKVFGKGEHQERQNKDPFP
                     YRYRKPTVELLDLDTMEESSEIKVETNISKTSWIRSSMAASGKRVSKALSYITGEMKE
                     CGEGLKDKSPVFQFFDWVLRGTSQVMFVNNPLSGILIILGLFIQNPWWAISGCLGTIM
                     STLTALILSQDKSAIAAGFHGYNGVLVGLLMAVFSDKGDYYWWLLLPVIIMSMSCPIL
                     SSALGTIFSKWDLPVFTLPFNITVTLYLAATGHYNLFFPTTLLQPASAMPNITWSEVQ
                     VPLLLRAIPVGIGQVYGCDNPWTGGIFLIALFISSPLICLHAAIGSTMGMLAALTIAT
                     PFDSIYFGLCGFNSTLACIAIGGMFYVITWQTHLLAIACALFAAYLGAALANMLSVFG
                     LPPCTWPFCLSALTFLLLTTNNPAIYKLPLSKVTYPEANRIYYLSQERNRRASIITKY
                     QAYDVS"
     exon            292..472
                     /gene="SLC14A2"
                     /gene_synonym="hUT-A6; HUT2; UT-A2; UT2; UTA; UTR"
                     /inference="alignment:Splign:2.1.0"
     exon            473..662
                     /gene="SLC14A2"
                     /gene_synonym="hUT-A6; HUT2; UT-A2; UT2; UTA; UTR"
                     /inference="alignment:Splign:2.1.0"
     exon            663..791
                     /gene="SLC14A2"
                     /gene_synonym="hUT-A6; HUT2; UT-A2; UT2; UTA; UTR"
                     /inference="alignment:Splign:2.1.0"
     exon            792..984
                     /gene="SLC14A2"
                     /gene_synonym="hUT-A6; HUT2; UT-A2; UT2; UTA; UTR"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1132
                     /gene="SLC14A2"
                     /gene_synonym="hUT-A6; HUT2; UT-A2; UT2; UTA; UTR"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1267
                     /gene="SLC14A2"
                     /gene_synonym="hUT-A6; HUT2; UT-A2; UT2; UTA; UTR"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1317
                     /gene="SLC14A2"
                     /gene_synonym="hUT-A6; HUT2; UT-A2; UT2; UTA; UTR"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1492
                     /gene="SLC14A2"
                     /gene_synonym="hUT-A6; HUT2; UT-A2; UT2; UTA; UTR"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1615
                     /gene="SLC14A2"
                     /gene_synonym="hUT-A6; HUT2; UT-A2; UT2; UTA; UTR"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1698
                     /gene="SLC14A2"
                     /gene_synonym="hUT-A6; HUT2; UT-A2; UT2; UTA; UTR"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1858
                     /gene="SLC14A2"
                     /gene_synonym="hUT-A6; HUT2; UT-A2; UT2; UTA; UTR"
                     /inference="alignment:Splign:2.1.0"
     exon            1859..2048
                     /gene="SLC14A2"
                     /gene_synonym="hUT-A6; HUT2; UT-A2; UT2; UTA; UTR"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2177
                     /gene="SLC14A2"
                     /gene_synonym="hUT-A6; HUT2; UT-A2; UT2; UTA; UTR"
                     /inference="alignment:Splign:2.1.0"
     exon            2178..2370
                     /gene="SLC14A2"
                     /gene_synonym="hUT-A6; HUT2; UT-A2; UT2; UTA; UTR"
                     /inference="alignment:Splign:2.1.0"
     exon            2371..2518
                     /gene="SLC14A2"
                     /gene_synonym="hUT-A6; HUT2; UT-A2; UT2; UTA; UTR"
                     /inference="alignment:Splign:2.1.0"
     exon            2519..2653
                     /gene="SLC14A2"
                     /gene_synonym="hUT-A6; HUT2; UT-A2; UT2; UTA; UTR"
                     /inference="alignment:Splign:2.1.0"
     exon            2654..2703
                     /gene="SLC14A2"
                     /gene_synonym="hUT-A6; HUT2; UT-A2; UT2; UTA; UTR"
                     /inference="alignment:Splign:2.1.0"
     exon            2704..4073
                     /gene="SLC14A2"
                     /gene_synonym="hUT-A6; HUT2; UT-A2; UT2; UTA; UTR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4052..4057
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC14A2"
                     /gene_synonym="hUT-A6; HUT2; UT-A2; UT2; UTA; UTR"
                     /note="hexamer: ATTAAA"
     polyA_site      4073
                     /gene="SLC14A2"
                     /gene_synonym="hUT-A6; HUT2; UT-A2; UT2; UTA; UTR"
                     /note="major polyA site"
ORIGIN      
        1 acaccatctc tctcttctgc cgccatttga gaaggtccaa gtttgcttcc ccttcgcctt
       61 ccaccatgac tgtaagtttc ctgaggcctc cccagcaatg tggaagttcc atcgatagaa
      121 gagtggctgt gacccgaagg aatgtctgac ccccacagca gtcctctcct gccagagcca
      181 ctttccagca gatacaaact ctacgaggca gagtttacca gcccgagctg gccctcgaca
      241 tccccggata ctcacccagc tctgcccctc ctggaaatgc ctgaagaaaa ggatctccgg
      301 tcttccaatg aagacagtca cattgtgaag atcgaaaagc tcaatgaaag gagtaaaagg
      361 aaagacgacg gggtggccca tcgggactca gcaggccaaa ggtgcatctg cctctccaaa
      421 gcagtgggct acctcacggg cgacatgaag gagtacagga tctggctgaa agacaagcac
      481 cttgccctcc agttcataga ctgggtcctg agagggaccg ctcaggtgat gttcatcaac
      541 aatcctctca gcggcctcat catcttcata gggctgctga tccagaatcc ctggtggaca
      601 atcactgggg gcctggggac agtggtctcg accttaacag ctctcgcctt gggccaagac
      661 aggtctgcca ttgcctcagg actccatggg tacaacggga tgctggtggg actgctgatg
      721 gccgtgttct cggagaagtt agactactac tggtggcttc tgtttcctgt gaccttcaca
      781 gccatgtcct gcccagttct ttctagtgcc ttgaattcca tcttcagcaa gtgggacctc
      841 ccggtcttca ctctgccctt caacattgca gtcaccttgt accttgcagc cacaggccac
      901 tacaacctct tcttccccac aacactggta gagcctgtgt cttcagtgcc caatatcacc
      961 tggacagaga tggaaatgcc cctgctgtta caagccatcc ctgttggggt cggccaggtg
     1021 tatggctgtg acaatccctg gacaggcggc gtgttcctgg tggctctgtt catctcctcg
     1081 ccactcatct gcttgcatgc agccattggc tcaatcgtgg ggctgctagc agccctgtca
     1141 gtggccacac ccttcgagac catctacaca ggcctctgga gctacaactg cgtcctctcc
     1201 tgcatcgcca tcggaggcat gttctatgcc ctcacctggc agactcacct gctggccctc
     1261 atctgtgccc tgttctgtgc atacatggaa gcagccatct ccaacatcat gtcagtggtg
     1321 ggcgtgccac caggcacctg ggccttctgc cttgccacca tcatcttcct gctcctgacg
     1381 acaaacaacc cagccatctt cagactccca ctcagcaaag tcacctaccc cgaggccaac
     1441 cgcatctact acctgacagt gaaaagcggt gaagaagaga aggcccccag cggaggcggt
     1501 ggggagcatc cacccacagc aggcccaaag gtggaggagg gctcggaggc tgtgctctcc
     1561 aagcacagga gtgtatttca catcgagtgg tcatccattc ggaggaggag caaagtgttt
     1621 ggaaaaggcg aacaccagga aagacaaaac aaagacccat ttccctatcg ataccggaag
     1681 cccacagtcg agctgcttga tctggacacc atggaggaga gctctgagat aaaagtggaa
     1741 acaaacattt ccaagacatc ctggattcgg agttccatgg ctgccagtgg gaaaagggtc
     1801 agcaaagccc tcagctacat cacaggagag atgaaggagt gtggagaggg acttaaagac
     1861 aagtccccag tgttccagtt ctttgactgg gtcctccgag gcacatctca agtgatgttt
     1921 gtgaacaacc ccctcagcgg catcctcatc atcctcggcc tcttcatcca gaacccctgg
     1981 tgggcgatct caggctgcct gggtaccatc atgtccacct tgacagccct catcctgagt
     2041 caggacaagt cggccatcgc tgcaggattt cacggctaca atggggtgct ggtggggctg
     2101 ctgatggccg tgttctcaga caaaggtgac tactactggt ggctgttgct acccgtcatc
     2161 atcatgtcca tgtcttgccc catcctctcc agtgccctgg gtaccatctt cagcaagtgg
     2221 gacctcccag tcttcacact gcccttcaat atcactgtga ctttgtacct ggcagccacg
     2281 ggccactaca accttttctt ccccacaacg ctgctgcagc ctgcatccgc catgcccaac
     2341 atcacctggt cagaggtcca agtgcccttg cttttgagag ccatccccgt tggaattggc
     2401 caagtgtacg gctgtgataa cccctggact ggaggcatct tcctcatagc tctgttcata
     2461 tcctcacctc tcatttgctt gcatgcagca attggatcca ccatggggat gctagcagca
     2521 ctcactattg cgacgccctt tgactccatc tacttcggcc tgtgtggctt caacagcacc
     2581 ctcgcatgca tagcgatagg aggcatgttc tacgtcatca cctggcagac gcacctcctc
     2641 gccatcgcct gcgcactgtt tgctgcctac ctgggtgctg ccctggctaa catgttatct
     2701 gtgtttggat tgccgccctg cacttggccc ttctgtctct cagctctcac cttcctgctc
     2761 ctgacgacca ataaccccgc catctacaag ctcccgctca gcaaagtcac ctacccagag
     2821 gccaaccgca tctactacct gtcccaggag agaaacagaa gggcatcaat cataacaaag
     2881 tatcaggcct acgatgtctc ctaagtttcc ctgtctaaaa cacatcagtg taaattcagg
     2941 cttcagcacg ccgtccagat ccccaggata agagaccact tagccttccc tttggtctgt
     3001 tctgtgactc tctccccaaa cacaaagaag cgtgtatgta gtcaccattc cagaacctct
     3061 cttttctaag atgcacaaca cttatcaaag atatgtttag tttagacttt atacccttag
     3121 ctttcccata agagctccct ttgtggggaa cttgccctct tctgcgaaat aagcctcatc
     3181 cttaaagaga agtcaccggc cgggcacggt ggctcacgcc tgtaatccca gcactttggg
     3241 aggccgaggc gggtggatca cgaggtcagg agatcgagac catcctggcg aacatggtga
     3301 gaccccatct ctactaaaaa tacaaaaaat tagccaggca tggtggcggg cacctgtagt
     3361 cccagctact tgggaggctg aggcaggaga atggcgtgaa cccgggaggt ggagcttgca
     3421 gtgagccaag atcacgccac tgcactccag cctgggcaac ggagtgagac tctgtctcaa
     3481 aaaaaaaaaa aaggggaagt caccaagaaa gggatagagg tcagtgacat ggtcatcaca
     3541 caactcggtc atttaatatg gcaaaacaca ataccaagaa ctgtgcatta gcccggaagg
     3601 caagagggtt ggttctgccc cagctctgct gctaatgagc ccctaccagg ttgagcaagt
     3661 ctttccccac tctccacctc catttcttaa tcagtttcat gacagggaag gatttgaaag
     3721 tcctttccac ctcagaagtg ttgattattc tctctctcct ataatctgat gaaatcagca
     3781 tgacaacaag taatttaagt aaaggacaga agggttaccc aagaagaggc aggaaaatgt
     3841 taacgttcta taaagtttta ttcttgagtc ataggaaaat gctctccaga cgtggggtta
     3901 ggaacctaaa ttcactgaaa atgccaatgt gctttccttt acattacaga aatatttctg
     3961 gaagtgtcag atgaaaactg atctttatca acactcaaat catattataa acaaatgtgt
     4021 ttccctttgt aatattcata atcatactgt cattaaactg tttaagtttg caa
//
