LOCUS       NM_015865               3917 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens solute carrier family 14 member 1 (Kidd blood group)
            (SLC14A1), transcript variant 2, mRNA.
ACCESSION   NM_015865
VERSION     NM_015865.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3917)
  AUTHORS   Zhang,Y., Yang,Y., Qi,X., Cui,P., Kang,Y., Liu,H., Wei,Z. and
            Wang,H.
  TITLE     SLC14A1 and TGF-beta signaling: a feedback loop driving EMT and
            colorectal cancer metachronous liver metastasis
  JOURNAL   J Exp Clin Cancer Res 43 (1), 208 (2024)
   PUBMED   39061061
  REMARK    GeneRIF: SLC14A1 and TGF-beta signaling: a feedback loop driving
            EMT and colorectal cancer metachronous liver metastasis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3917)
  AUTHORS   Ma,J., Xue,K., Jiang,Y., Wang,X., He,D. and Guo,P.
  TITLE     Down-regulation of SLC14A1 in prostate cancer activates CDK1/CCNB1
            and mTOR pathways and promotes tumor progression
  JOURNAL   Sci Rep 14 (1), 14914 (2024)
   PUBMED   38942821
  REMARK    GeneRIF: Down-regulation of SLC14A1 in prostate cancer activates
            CDK1/CCNB1 and mTOR pathways and promotes tumor progression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3917)
  AUTHORS   Wan,Z., Wang,Y., Li,C. and Zheng,D.
  TITLE     SLC14A1 is a new biomarker in renal cancer
  JOURNAL   Clin Transl Oncol 25 (8), 2607-2623 (2023)
   PUBMED   37004669
  REMARK    GeneRIF: SLC14A1 is a new biomarker in renal cancer.
REFERENCE   4  (bases 1 to 3917)
  AUTHORS   Ye,B., Ding,K., Li,K. and Zhu,Q.
  TITLE     Study on the role of SLC14A1 gene in biochemical recurrence of
            prostate cancer
  JOURNAL   Sci Rep 12 (1), 17064 (2022)
   PUBMED   36257969
  REMARK    GeneRIF: Study on the role of SLC14A1 gene in biochemical
            recurrence of prostate cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3917)
  AUTHORS   Zwiech,R., Bruzda-Zwiech,A., Balcerczak,E., Szczepanska,J.,
            Krygier,A., Malachowska,B., Michalek,D. and Szmajda-Krygier,D.
  TITLE     A potential link between AQP3 and SLC14A1 gene expression level and
            clinical parameters of maintenance hemodialysis patients
  JOURNAL   BMC Nephrol 23 (1), 297 (2022)
   PUBMED   36038817
  REMARK    GeneRIF: A potential link between AQP3 and SLC14A1 gene expression
            level and clinical parameters of maintenance hemodialysis patients.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3917)
  AUTHORS   Olives,B., Martial,S., Mattei,M.G., Matassi,G., Rousselet,G.,
            Ripoche,P., Cartron,J.P. and Bailly,P.
  TITLE     Molecular characterization of a new urea transporter in the human
            kidney
  JOURNAL   FEBS Lett 386 (2-3), 156-160 (1996)
   PUBMED   8647271
REFERENCE   7  (bases 1 to 3917)
  AUTHORS   Davey,S. and Beach,D.
  TITLE     RACH2, a novel human gene that complements a fission yeast cell
            cycle checkpoint mutation
  JOURNAL   Mol Biol Cell 6 (10), 1411-1421 (1995)
   PUBMED   8573795
REFERENCE   8  (bases 1 to 3917)
  AUTHORS   Olives,B., Mattei,M.G., Huet,M., Neau,P., Martial,S., Cartron,J.P.
            and Bailly,P.
  TITLE     Kidd blood group and urea transport function of human erythrocytes
            are carried by the same protein
  JOURNAL   J Biol Chem 270 (26), 15607-15610 (1995)
   PUBMED   7797558
REFERENCE   9  (bases 1 to 3917)
  AUTHORS   Olives,B., Neau,P., Bailly,P., Hediger,M.A., Rousselet,G.,
            Cartron,J.P. and Ripoche,P.
  TITLE     Cloning and functional expression of a urea transporter from human
            bone marrow cells
  JOURNAL   J Biol Chem 269 (50), 31649-31652 (1994)
   PUBMED   7989337
REFERENCE   10 (bases 1 to 3917)
  AUTHORS   Geitvik,G.A., Hoyheim,B., Gedde-Dahl,T., Grzeschik,K.H., Lothe,R.,
            Tomter,H. and Olaisen,B.
  TITLE     The Kidd (JK) blood group locus assigned to chromosome 18 by close
            linkage to a DNA-RFLP
  JOURNAL   Hum Genet 77 (3), 205-209 (1987)
   PUBMED   2890568
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA134800.1, Y19039.1,
            AV724913.1 and AC023421.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 6, 2018 this sequence version replaced NM_015865.6.
            
            Summary: The protein encoded by this gene is a membrane transporter
            that mediates urea transport in erythrocytes. This gene forms the
            basis for the Kidd blood group system. [provided by RefSeq, Mar
            2009].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            lacks an in-frame portion of the 5' coding sequence compared to
            variant 4. The resulting isoform (2) has a shorter N-terminus
            compared to isoform 1. Variants 2 and 3 both encode the same
            isoform (2).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.129470.1,
                                           SRR1803615.90532.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144335, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000321925.9/ ENSP00000318546.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-439               DA134800.1         55-493
            440-765             Y19039.1           283-608
            766-1174            AV724913.1         144-552
            1175-3917           AC023421.7         155040-157782
FEATURES             Location/Qualifiers
     source          1..3917
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q12.3"
     gene            1..3917
                     /gene="SLC14A1"
                     /gene_synonym="HsT1341; HUT11; HUT11A; JK; Jk(a); Jk(b);
                     RACH1; RACH2; UT-B1; UT1; UTE"
                     /note="solute carrier family 14 member 1 (Kidd blood
                     group)"
                     /db_xref="GeneID:6563"
                     /db_xref="HGNC:HGNC:10918"
                     /db_xref="MIM:613868"
     exon            1..93
                     /gene="SLC14A1"
                     /gene_synonym="HsT1341; HUT11; HUT11A; JK; Jk(a); Jk(b);
                     RACH1; RACH2; UT-B1; UT1; UTE"
                     /inference="alignment:Splign:2.1.0"
     exon            94..157
                     /gene="SLC14A1"
                     /gene_synonym="HsT1341; HUT11; HUT11A; JK; Jk(a); Jk(b);
                     RACH1; RACH2; UT-B1; UT1; UTE"
                     /inference="alignment:Splign:2.1.0"
     exon            158..329
                     /gene="SLC14A1"
                     /gene_synonym="HsT1341; HUT11; HUT11A; JK; Jk(a); Jk(b);
                     RACH1; RACH2; UT-B1; UT1; UTE"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..1348
                     /gene="SLC14A1"
                     /gene_synonym="HsT1341; HUT11; HUT11A; JK; Jk(a); Jk(b);
                     RACH1; RACH2; UT-B1; UT1; UTE"
                     /note="isoform 2 is encoded by transcript variant 2; Kidd
                     blood group antigen; SLC14A1 JK; urea transporter JK
                     glycoprotein; urea transporter-B1; urea transporter,
                     erythrocyte; solute carrier family 14 (urea transporter),
                     member 1 (Kidd blood group); mutant KIDD blood group
                     antigen"
                     /codon_start=1
                     /product="urea transporter 1 isoform 2"
                     /protein_id="NP_056949.4"
                     /db_xref="CCDS:CCDS11925.1"
                     /db_xref="GeneID:6563"
                     /db_xref="HGNC:HGNC:10918"
                     /db_xref="MIM:613868"
                     /translation="MEDSPTMVRVDSPTMVRGENQVSPCQGRRCFPKALGYVTGDMKE
                     LANQLKDKPVVLQFIDWILRGISQVVFVNNPVSGILILVGLLVQNPWWALTGWLGTVV
                     STLMALLLSQDRSLIASGLYGYNATLVGVLMAVFSDKGDYFWWLLLPVCAMSMTCPIF
                     SSALNSMLSKWDLPVFTLPFNMALSMYLSATGHYNPFFPAKLVIPITTAPNISWSDLS
                     ALELLKSIPVGVGQIYGCDNPWTGGIFLGAILLSSPLMCLHAAIGSLLGIAAGLSLSA
                     PFEDIYFGLWGFNSSLACIAMGGMFMALTWQTHLLALGCALFTAYLGVGMANFMAEVG
                     LPACTWPFCLATLLFLIMTTKNSNIYKMPLSKVTYPEENRIFYLQAKKRMVESPL"
     exon            330..519
                     /gene="SLC14A1"
                     /gene_synonym="HsT1341; HUT11; HUT11A; JK; Jk(a); Jk(b);
                     RACH1; RACH2; UT-B1; UT1; UTE"
                     /inference="alignment:Splign:2.1.0"
     exon            520..648
                     /gene="SLC14A1"
                     /gene_synonym="HsT1341; HUT11; HUT11A; JK; Jk(a); Jk(b);
                     RACH1; RACH2; UT-B1; UT1; UTE"
                     /inference="alignment:Splign:2.1.0"
     exon            649..841
                     /gene="SLC14A1"
                     /gene_synonym="HsT1341; HUT11; HUT11A; JK; Jk(a); Jk(b);
                     RACH1; RACH2; UT-B1; UT1; UTE"
                     /inference="alignment:Splign:2.1.0"
     exon            842..989
                     /gene="SLC14A1"
                     /gene_synonym="HsT1341; HUT11; HUT11A; JK; Jk(a); Jk(b);
                     RACH1; RACH2; UT-B1; UT1; UTE"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1124
                     /gene="SLC14A1"
                     /gene_synonym="HsT1341; HUT11; HUT11A; JK; Jk(a); Jk(b);
                     RACH1; RACH2; UT-B1; UT1; UTE"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1174
                     /gene="SLC14A1"
                     /gene_synonym="HsT1341; HUT11; HUT11A; JK; Jk(a); Jk(b);
                     RACH1; RACH2; UT-B1; UT1; UTE"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..3917
                     /gene="SLC14A1"
                     /gene_synonym="HsT1341; HUT11; HUT11A; JK; Jk(a); Jk(b);
                     RACH1; RACH2; UT-B1; UT1; UTE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1716..1721
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC14A1"
                     /gene_synonym="HsT1341; HUT11; HUT11A; JK; Jk(a); Jk(b);
                     RACH1; RACH2; UT-B1; UT1; UTE"
                     /note="hexamer: ATTAAA"
     polyA_site      1734
                     /gene="SLC14A1"
                     /gene_synonym="HsT1341; HUT11; HUT11A; JK; Jk(a); Jk(b);
                     RACH1; RACH2; UT-B1; UT1; UTE"
                     /note="major polyA site"
     regulatory      2302..2307
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC14A1"
                     /gene_synonym="HsT1341; HUT11; HUT11A; JK; Jk(a); Jk(b);
                     RACH1; RACH2; UT-B1; UT1; UTE"
                     /note="hexamer: TATAAA"
     polyA_site      2325
                     /gene="SLC14A1"
                     /gene_synonym="HsT1341; HUT11; HUT11A; JK; Jk(a); Jk(b);
                     RACH1; RACH2; UT-B1; UT1; UTE"
     regulatory      3896..3901
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC14A1"
                     /gene_synonym="HsT1341; HUT11; HUT11A; JK; Jk(a); Jk(b);
                     RACH1; RACH2; UT-B1; UT1; UTE"
                     /note="hexamer: AATAAA"
     polyA_site      3917
                     /gene="SLC14A1"
                     /gene_synonym="HsT1341; HUT11; HUT11A; JK; Jk(a); Jk(b);
                     RACH1; RACH2; UT-B1; UT1; UTE"
ORIGIN      
        1 accatctcct gagaagcact ctcccttgtc gtggaggtgg gcaaatcttt atcagccact
       61 gccttctgct gccaggaagc cagctagagt ggtctttaaa gaaaactggg catctcctgc
      121 tacttaaaat caaaaactac ctaaaataaa gattatagag ccagaggaag agatagccat
      181 ggaggacagc cccactatgg ttagagtgga cagccccact atggttaggg gtgaaaacca
      241 ggtttcgcca tgtcaaggga gaaggtgctt ccccaaagct cttggctatg tcaccggtga
      301 catgaaagaa cttgccaacc agcttaaaga caaacccgtg gtgctccagt tcattgactg
      361 gattctccgg ggcatatccc aagtggtgtt cgtcaacaac cccgtcagtg gaatcctgat
      421 tctggtagga cttcttgttc agaacccctg gtgggctctc actggctggc tgggaacagt
      481 ggtctccact ctgatggccc tcttgctcag ccaggacagg tcattaatag catctgggct
      541 ctatggctac aatgccaccc tggtgggagt actcatggct gtcttttcgg acaagggaga
      601 ctatttctgg tggctgttac tccctgtatg tgctatgtcc atgacttgcc caattttctc
      661 aagtgcattg aattccatgc tcagcaaatg ggacctcccc gtcttcaccc tccctttcaa
      721 catggcgttg tcaatgtacc tttcagccac aggacattac aatccattct ttccagccaa
      781 actggtcata cctataacta cagctccaaa tatctcctgg tctgacctca gtgccctgga
      841 gttgttgaaa tctataccag tgggagttgg tcagatctat ggctgtgata atccatggac
      901 agggggcatt ttcctgggag ccatcctact ctcctcccca ctcatgtgcc tgcatgctgc
      961 cataggatca ttgctgggca tagcagcggg actcagtctt tcagccccat ttgaggacat
     1021 ctactttgga ctctggggtt tcaacagctc tctggcctgc attgcaatgg gaggaatgtt
     1081 catggcgctc acctggcaaa cccacctcct ggctcttggc tgtgccctgt tcacggccta
     1141 tcttggagtc ggcatggcaa actttatggc tgaggttgga ttgccagctt gtacctggcc
     1201 cttctgtttg gccacgctat tgttcctcat catgaccaca aaaaattcca acatctacaa
     1261 gatgcccctc agtaaagtta cttatcctga agaaaaccgc atcttctacc tgcaagccaa
     1321 gaaaagaatg gtggaaagcc ctttgtgaga acaagcccca tttgcagcca tggtcacgag
     1381 tcatttctgc ctgactgctc cagctaactt ccagggtctc agcaaactgc tgtttttcac
     1441 gagtatcaac tttcatactg acgcgtctgt aatctgttct tatgctcatt ttgtattttc
     1501 ctttcaactc caggaatatc cttgagcata tgagagtcac atccaggtga tgtgctctgg
     1561 tatggaattt gaaaccccaa tggggccttg gcactaagac tggaatgtat ataaagtcaa
     1621 agtgctccaa cagaaggagg aagtgaaaac aaactattag tatttattga tattcttggt
     1681 gtttagctgg ctcgatgatg ttaacagtat taaaaattaa accccataaa ccaactaagc
     1741 cttatggaat tcacagtcac aaaatcgaag ttaatccaga attctgtgat aagcagcttg
     1801 gctttttttt taaatcaatg caagttacac attatagcca gaatctgtat cacagaggtg
     1861 caagctgaca gcagagctca gtccccactt cctgcaaaca atggcctgca ccctatccct
     1921 tgtgtgtgtg acattctctc atgggacaat gttggggttt ttcagactga caggactgca
     1981 agagggagaa aggaattttg tcaatcaaaa ttattctgta ttgcaacttt tctcagagat
     2041 tgcaaaggat tttttaggta gagattattt ttccttatga aaaatgatct gttttaaatg
     2101 agataaaata ggagaagttc ctggcttaac ctgttcttac atattaaaga aaagttactt
     2161 actgtattta tgaaatactc agcttaggca tttttacttt aacccctaaa ttgattttgt
     2221 aaatgccaca aatgcataga attgttacca acctccaaag ggctctttaa aatcatattt
     2281 tttattcatt tgaggatgtc ttataaagac tgaaggcaaa ggtcagattg cttacgggtg
     2341 ttatttttat aagttgttga attccttaat ttaaaaaagc tcattatttt ttgcacactc
     2401 acaatattct ctctcagaaa tcaatggcat ttgaaccacc aaaaagaaat aaagggctga
     2461 gtgcggtggc tcacgcctgt aatcccagca ctttggggag cccaggcggg cagattgctt
     2521 gaacccagga gttcaagacc agcctgggca gcatggtgaa accctgtatc tacaaaaaat
     2581 acaaaaatta gccaggcatg gtggtgggtg cctgtagttc cagctacttg ggaggctgag
     2641 gtgggaaaat gacttgagcc caggaggagg aggctgcagt gagctaagat tgcaccactg
     2701 cactccaacc tgggcgacaa gagtgaaact gtgtctctca aaaaaaaaaa aaaacaaaca
     2761 aaaacaaaaa caaaacaaaa caaaacaaaa caaaacaggt aaggattccc ctgttttcct
     2821 ctctttaatt ttaaagttat cagttccgta aagtctctgt aaccaaacat actgaagaca
     2881 gcaacagaag tcacgttcag ggactggctc acacctgtaa tcccagcact ttgggagatg
     2941 gaggtaaaag gatctcttga gcccaggagt tcaagaccag cttgggcaac atagcaagac
     3001 tccatctctt aaaaaataaa aatagtaaca ttagccaggt gtagcagcac acatctgcag
     3061 cagctactca ggaggctgag gtggaaagat cgcttgtgca cagaagttcg aggctgcagt
     3121 gagctatatg atcatgtcac tgcactccag cctgtgtgac cgagcaagac cctatctcaa
     3181 aaaaattaat taattaatta attaattaat ttaaaaagga agtcatgttc atttactttc
     3241 cacttcagtg tgtatcgtgt agtattttgg aggttggaaa gtgaaacgta ggaatcctga
     3301 agattttttc cacttctagt ttgcagtgct cagtgcacaa tatacatttt gctgaatgaa
     3361 taaacagaaa tagggaagta aacctacaaa tattttaggg agaagctcac ttcttccttt
     3421 tctcaggaaa ccaagcaagc aaacatatcg ttccaatttt aaaacccagt gaccaaagcc
     3481 tttggaacta tgaatttgca actgtcatag gtttatggat attgctgtgg agaagctcaa
     3541 ttttcagtgt ttgaactgaa ccctttcttg ttagggaacg tgtgaaagaa gaattgtggg
     3601 gaaaaaaaag caagcataac caaagatcat cagcagtgaa gaatctaggc tgtggctgag
     3661 agaaccagag gcctctaaaa tggacccgag tcgatcttca gaacagggat ctaccatgca
     3721 ggagcttctt gtgctcacac aaatctgtaa atgggaacat tgtacattgt cgaatttaaa
     3781 tgatattaat tttctcaagc tatttttgtt actattttcc taaaattgaa tatttgcagg
     3841 gagcacttat actttttcct aatgtctgta taacaaattt ctatgcaagt acatgaataa
     3901 attatgctca cagctca
//
