LOCUS       NM_001318192            2906 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens solute carrier family 13 member 4 (SLC13A4),
            transcript variant 1, mRNA.
ACCESSION   NM_001318192 XM_005250261
VERSION     NM_001318192.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2906)
  AUTHORS   Yang,M.L., Zhang,J.H., Li,S., Zhu,R. and Wang,L.
  TITLE     SLC13A4 Might Serve as a Prognostic Biomarker and be Correlated
            with Immune Infiltration into Head and Neck Squamous Cell Carcinoma
  JOURNAL   Pathol Oncol Res 27, 1609967 (2021)
   PUBMED   34840533
  REMARK    GeneRIF: SLC13A4 Might Serve as a Prognostic Biomarker and be
            Correlated with Immune Infiltration into Head and Neck Squamous
            Cell Carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2906)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2906)
  AUTHORS   Zhang,Z., Aung,Z.T., Simmons,D.G. and Dawson,P.A.
  TITLE     Molecular analysis of sequence and splice variants of the human
            SLC13A4 sulfate transporter
  JOURNAL   Mol Genet Metab 121 (1), 35-42 (2017)
   PUBMED   28385533
  REMARK    GeneRIF: Study found that despite differential expression of the
            two SLC13A4 transcripts, no detectable functional difference in the
            cellular sorting or sulfate transporting was found. However, some
            variants can influence both mechanism in specific cell membranes.
            This is like to have clinical implications based on the
            consequences of impaired sulfate transport during pregnancy in
            rodent models.
REFERENCE   4  (bases 1 to 2906)
  AUTHORS   Simmons,D.G., Rakoczy,J., Jefferis,J., Lourie,R., McIntyre,H.D. and
            Dawson,P.A.
  TITLE     Human placental sulfate transporter mRNA profiling from term
            pregnancies identifies abundant SLC13A4 in syncytiotrophoblasts and
            SLC26A2 in cytotrophoblasts
  JOURNAL   Placenta 34 (4), 381-384 (2013)
   PUBMED   23453247
  REMARK    GeneRIF: SLC13A4 and SLC26A2 were the most abundant sulfate
            transporter mRNAs, which localized to syncytiotrophoblast and
            cytotrophoblast cells, respectively.
REFERENCE   5  (bases 1 to 2906)
  AUTHORS   Jefferis,J., Rakoczy,J., Simmons,D.G. and Dawson,P.A.
  TITLE     Molecular analysis of the human SLC13A4 sulfate transporter gene
            promoter
  JOURNAL   Biochem Biophys Res Commun 433 (1), 79-83 (2013)
   PUBMED   23485456
  REMARK    GeneRIF: To investigate the regulation of SLC13A4 gene expression,
            we analysed the transcriptional activity of the SLC13A4 5'-flanking
            region in the JEG-3 placental cell line using luciferase reporter
            assays.
REFERENCE   6  (bases 1 to 2906)
  AUTHORS   Pajor,A.M.
  TITLE     Molecular properties of the SLC13 family of dicarboxylate and
            sulfate transporters
  JOURNAL   Pflugers Arch 451 (5), 597-605 (2006)
   PUBMED   16211368
  REMARK    Review article
REFERENCE   7  (bases 1 to 2906)
  AUTHORS   Markovich,D., Regeer,R.R., Kunzelmann,K. and Dawson,P.A.
  TITLE     Functional characterization and genomic organization of the human
            Na(+)-sulfate cotransporter hNaS2 gene (SLC13A4)
  JOURNAL   Biochem Biophys Res Commun 326 (4), 729-734 (2005)
   PUBMED   15607730
  REMARK    GeneRIF: Here, we characterized the functional properties of the
            human Na(+)-sulfate cotransporter (hNaS2), determined its tissue
            distribution, and identified its gene (SLC13A4) structure.
REFERENCE   8  (bases 1 to 2906)
  AUTHORS   Girard,J.P., Baekkevold,E.S., Feliu,J., Brandtzaeg,P. and
            Amalric,F.
  TITLE     Molecular cloning and functional analysis of SUT-1, a sulfate
            transporter from human high endothelial venules
  JOURNAL   Proc Natl Acad Sci U S A 96 (22), 12772-12777 (1999)
   PUBMED   10535998
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB208809.1, AF169301.1, BC030689.2 and AC091736.2.
            
            On Jun 2, 2019 this sequence version replaced NM_001318192.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF169301.1, SRR1660807.25384.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968189,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682651.1/ ENSP00000508027.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AB208809.1         19-30
            13-366              AF169301.1         1-354
            367-1283            BC030689.2         367-1283
            1284-2307           AF169301.1         1272-2295
            2308-2900           BC030689.2         2305-2897
            2901-2906           AC091736.2         16608-16613         c
FEATURES             Location/Qualifiers
     source          1..2906
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q33"
     gene            1..2906
                     /gene="SLC13A4"
                     /gene_synonym="NAS2; SUT-1; SUT1"
                     /note="solute carrier family 13 member 4"
                     /db_xref="GeneID:26266"
                     /db_xref="HGNC:HGNC:15827"
                     /db_xref="MIM:604309"
     exon            1..789
                     /gene="SLC13A4"
                     /gene_synonym="NAS2; SUT-1; SUT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             691..2574
                     /gene="SLC13A4"
                     /gene_synonym="NAS2; SUT-1; SUT1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sulphate transporter 1; solute carrier family 13
                     (sodium/sulfate symporters), member 4; solute carrier
                     family 13 (sodium/sulphate symporters), member 4; solute
                     carrier family 13 (sodium/sulfate symporter), member 4;
                     Na(+)/sulfate cotransporter SUT-1"
                     /codon_start=1
                     /product="solute carrier family 13 member 4 isoform 1"
                     /protein_id="NP_001305121.1"
                     /db_xref="CCDS:CCDS94210.1"
                     /db_xref="GeneID:26266"
                     /db_xref="HGNC:HGNC:15827"
                     /db_xref="MIM:604309"
                     /translation="MGLLQGLLRVRKLLLVVCVPLLLLPLPVLHPSSEASCAYVLIVT
                     AVYWVSEAVPLGAAALVPAFLYPFFGVLRSNEVAAEYFKNTTLLLVGVICVAAAVEKW
                     NLHKRIALRMVLMAGAKPGMLLLCFMCCTTLLSMWLSNTSTTAMVMPIVEAVLQELVS
                     AEDEQLVAGNSNTEEAEPISLDVKNSQPSLELIFVNEDRSNADLTTLMHNENLNGVPS
                     ITNPIKTANQHQGKKQHPSQEKPQVLTPSPRKQKLNRKYRSHHDQMICKCLSLSISYS
                     ATIGGLTTIIGTSTSLIFLEHFNNQYPAAEVVNFGTWFLFSFPISLIMLVVSWFWMHW
                     LFLGCNFKETCSLSKKKKTKREQLSEKRIQEEYEKLGDISYPEMVTGFFFILMTVLWF
                     TREPGFVPGWDSFFEKKGYRTDATVSVFLGFLLFLIPAKKPCFGKKNDGENQEHSLGT
                     EPIITWKDFQKTMPWEIVILVGGGYALASGSKSSGLSTWIGNQMLSLSSLPPWAVTLL
                     ACILVSIVTEFVSNPATITIFLPILCSLSETLHINPLYTLIPVTMCISFAVMLPVGNP
                     PNAIVFSYGHCQIKDMVKAGLGVNVIGLVIVMVAINTWGVSLFHLDTYPAWARVSNIT
                     DQA"
     exon            790..918
                     /gene="SLC13A4"
                     /gene_synonym="NAS2; SUT-1; SUT1"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1055
                     /gene="SLC13A4"
                     /gene_synonym="NAS2; SUT-1; SUT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1228
                     /gene="SLC13A4"
                     /gene_synonym="NAS2; SUT-1; SUT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1283
                     /gene="SLC13A4"
                     /gene_synonym="NAS2; SUT-1; SUT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1323
                     /gene="SLC13A4"
                     /gene_synonym="NAS2; SUT-1; SUT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1404
                     /gene="SLC13A4"
                     /gene_synonym="NAS2; SUT-1; SUT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1589
                     /gene="SLC13A4"
                     /gene_synonym="NAS2; SUT-1; SUT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1709
                     /gene="SLC13A4"
                     /gene_synonym="NAS2; SUT-1; SUT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1811
                     /gene="SLC13A4"
                     /gene_synonym="NAS2; SUT-1; SUT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1913
                     /gene="SLC13A4"
                     /gene_synonym="NAS2; SUT-1; SUT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2011
                     /gene="SLC13A4"
                     /gene_synonym="NAS2; SUT-1; SUT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2136
                     /gene="SLC13A4"
                     /gene_synonym="NAS2; SUT-1; SUT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2298
                     /gene="SLC13A4"
                     /gene_synonym="NAS2; SUT-1; SUT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2299..2436
                     /gene="SLC13A4"
                     /gene_synonym="NAS2; SUT-1; SUT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2906
                     /gene="SLC13A4"
                     /gene_synonym="NAS2; SUT-1; SUT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2875..2880
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC13A4"
                     /gene_synonym="NAS2; SUT-1; SUT1"
                     /note="hexamer: ATTAAA"
     polyA_site      2906
                     /gene="SLC13A4"
                     /gene_synonym="NAS2; SUT-1; SUT1"
                     /note="major polyA site"
ORIGIN      
        1 ctgctttgca ggcccaggct caaggcaaat tataagtagg gaaccaattt gagggaaaga
       61 catgtgaaca gagttaaggt accacgtcct gggagcgacc agcagcccca cctgaagtcc
      121 gcatgcaact ctgacaagct caggtgcttg ttttaaggaa aggggctact agagtcttac
      181 caacagcgag cccaggtggg agatgaaaca ggtactcccc aaaataggtc atccgaggga
      241 ggaaaactga tggagagcac aatgtgctct gagcgttttt aatgttttta agcttttaaa
      301 tgatttcttc aaggccgagc agcagcagca aaggtgtggc ttaaaggatt aagggggttt
      361 ctgctgacac ctagaatgaa gttactctat tactaatcaa gccgagagga ggcccactat
      421 gcccccgttt atcatccttt cccagttcct ttttgctggt cacaaaacga tgctcatcaa
      481 tcccacctaa agcaggaggc caggagccca gcctcttgta gaaacagcga gggtataact
      541 gccctcccgt tctgccccca agacgaagga ggactctcgg aagccaagaa aggtttaaga
      601 agtctttctg gatagagagc agtgcccagg caggaagcct ttcgccggca gagcggggtc
      661 caaggacgag ctggagagga cagaggcgcg atgggcctgc tgcagggcct gctccgagtc
      721 cggaagctgc tgctggtcgt ctgcgtcccg ctcctgctgc tgcctctgcc cgtcctccac
      781 cccagcagcg aggcctcgtg tgcttacgtg ctgatcgtga ctgctgtgta ctgggtgtcg
      841 gaggcagtgc ctctgggagc tgcagccctg gtgccggcct tcctttaccc gttcttcgga
      901 gtcctccggt ccaatgaggt ggcggcggag tacttcaaga acaccacgct gctgctggtg
      961 ggggtcatct gcgtggcggc tgccgtggag aagtggaacc tgcataagcg cattgctctg
     1021 cgcatggtct tgatggccgg agccaagccg ggcatgctgc tgctctgctt catgtgctgt
     1081 accacgttgc tgtccatgtg gctgtccaac acctccacca ccgccatggt gatgcccatc
     1141 gtggaggccg tgctgcagga gctggtcagt gctgaggacg agcagctcgt ggcgggcaac
     1201 tccaacaccg aagaggccga acccatcagt ctggatgtaa agaacagcca accttctctg
     1261 gaactcatct ttgtcaatga agacaggtcc aacgcagacc tcaccactct gatgcacaac
     1321 gagaacctga atggtgtgcc ctcgatcacc aaccccatca aaactgcaaa ccaacaccag
     1381 ggcaagaagc aacacccatc ccaggaaaag ccacaagtcc tgacccccag ccccaggaag
     1441 cagaagctga acagaaagta caggtcccac catgaccaga tgatctgcaa gtgcctctcc
     1501 ctgagcatat cctactccgc taccattggc ggcctgacca ccatcatcgg cacctccacc
     1561 agcctcatct tcctggaaca cttcaacaac cagtatccag ccgcagaggt ggtgaacttt
     1621 ggcacctggt tcctcttcag cttccccata tccctcatca tgctggtggt cagctggttc
     1681 tggatgcact ggctgttcct gggctgcaat tttaaagaga cctgctctct gagcaagaag
     1741 aagaagacca aaagggaaca gttgtcagag aagaggatcc aagaagaata tgaaaaactg
     1801 ggagacatta gctacccaga aatggtgact ggatttttct tcatcctgat gaccgtactg
     1861 tggtttaccc gggagcctgg ctttgtccct ggctgggatt ctttctttga aaagaaaggc
     1921 taccgtactg atgccacagt ctctgtcttc cttggcttcc tcctcttcct cattccagcg
     1981 aagaagccct gctttgggaa aaagaatgat ggagagaacc aggagcactc actggggacc
     2041 gagcccatca tcacgtggaa ggacttccag aagaccatgc cctgggagat tgtcattctg
     2101 gttgggggag gctatgctct ggcttctggt agcaagagct ctggcctctc tacatggatt
     2161 gggaaccaga tgttgtccct gagcagcctc ccaccgtggg ctgtcaccct gctggcatgc
     2221 atcctcgtgt ccattgtcac tgagtttgtg agcaacccag caaccatcac catcttcctg
     2281 cccatcctgt gcagcctgtc tgaaacgctg cacattaacc ccctctacac cctgatccca
     2341 gtcaccatgt gcatctcctt tgcagtgatg ctgcctgtgg gcaatccccc taatgccatc
     2401 gtcttcagct atgggcactg ccagatcaaa gatatggtga aagctggcct gggagtcaac
     2461 gttattggac tggtgatagt aatggtggcc atcaacacct ggggagttag cctcttccac
     2521 ctggacactt acccagcatg ggcgagggtc agcaacatca ctgatcaagc ctaacgccaa
     2581 gtgtacaaac tggcccaacc acaggagctg ccagtatcca gcagtatctg gaccacaggc
     2641 aaagaaaacc actaggacca ccaggagcac acaaccccag acccacgccg gagggcatcc
     2701 ctccaccaga agattccgcc acctcaagtg aactgcagga atcctccaac aaccacaaac
     2761 acatgcttcg ctgttagtgt cttcttcctg ccctcagcac cacagctcaa gaaaacctaa
     2821 agtttcaata caagccatag gctcacagaa aaagaaaaag aaaataaaaa ttaaattaaa
     2881 aaaaaagaag acaaagaaaa cctaaa
//
