LOCUS       NM_022829               4041 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens solute carrier family 13 member 3 (SLC13A3),
            transcript variant 1, mRNA.
ACCESSION   NM_022829
VERSION     NM_022829.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4041)
  AUTHORS   Zhao,W., Wang,X., Han,L., Zhang,C., Wang,C., Kong,D., Zhang,M.,
            Xu,T., Li,G., Hu,G., Luo,J., Yee,S.W., Yang,J., Stahl,A., Chen,X.
            and Zhang,Y.
  TITLE     SLC13A3 is a major effector downstream of activated beta-catenin in
            liver cancer pathogenesis
  JOURNAL   Nat Commun 15 (1), 7522 (2024)
   PUBMED   39215042
  REMARK    GeneRIF: SLC13A3 is a major effector downstream of activated
            beta-catenin in liver cancer pathogenesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4041)
  AUTHORS   Hussain,S.I., Muhammad,N., Shah,S.U.D., Fardous,F., Khan,S.A.,
            Khan,N., Rehman,A.U., Siddique,M., Wasan,S.A., Niaz,R., Ullah,H.,
            Khan,N., Muhammad,N., Mirza,M.U., Wasif,N. and Khan,S.
  TITLE     Structural and functional implications of SLC13A3 and SLC9A6
            mutations: an in silico approach to understanding intellectual
            disability
  JOURNAL   BMC Neurol 23 (1), 353 (2023)
   PUBMED   37794328
  REMARK    GeneRIF: Structural and functional implications of SLC13A3 and
            SLC9A6 mutations: an in silico approach to understanding
            intellectual disability.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4041)
  AUTHORS   Kumari,R., Tiwari,S., Atlani,M., Anirudhan,A., Goel,S.K. and
            Kumar,A.
  TITLE     Association of Single Nucleotide Polymorphisms in KCNA10 and
            SLC13A3 Genes with the Susceptibility to Chronic Kidney Disease of
            Unknown Etiology in Central Indian Patients
  JOURNAL   Biochem Genet 61 (4), 1548-1566 (2023)
   PUBMED   36696070
  REMARK    GeneRIF: Association of Single Nucleotide Polymorphisms in KCNA10
            and SLC13A3 Genes with the Susceptibility to Chronic Kidney Disease
            of Unknown Etiology in Central Indian Patients.
REFERENCE   4  (bases 1 to 4041)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 4041)
  AUTHORS   Dewulf,J.P., Wiame,E., Dorboz,I., Elmaleh-Berges,M., Imbard,A.,
            Dumitriu,D., Rak,M., Bourillon,A., Helaers,R., Malla,A.,
            Renaldo,F., Boespflug-Tanguy,O., Vincent,M.F., Benoist,J.F.,
            Wevers,R.A., Schlessinger,A., Van Schaftingen,E., Nassogne,M.C. and
            Schiff,M.
  TITLE     SLC13A3 variants cause acute reversible leukoencephalopathy and
            alpha-ketoglutarate accumulation
  JOURNAL   Ann Neurol 85 (3), 385-395 (2019)
   PUBMED   30635937
REFERENCE   6  (bases 1 to 4041)
  AUTHORS   Burckhardt,B.C., Lorenz,J., Kobbe,C. and Burckhardt,G.
  TITLE     Substrate specificity of the human renal sodium dicarboxylate
            cotransporter, hNaDC-3, under voltage-clamp conditions
  JOURNAL   Am J Physiol Renal Physiol 288 (4), F792-F799 (2005)
   PUBMED   15561973
  REMARK    GeneRIF: The narrow substrate specificity prevents interaction of
            drugs with dicarboxylate-like structure with hNaDC-3 and ensures
            sufficient support of the proximal tubule cells with
            alpha-ketoglutarate for anion secretion via organic anion
            transporter 1 or 3.
REFERENCE   7  (bases 1 to 4041)
  AUTHORS   Markovich,D. and Murer,H.
  TITLE     The SLC13 gene family of sodium sulphate/carboxylate cotransporters
  JOURNAL   Pflugers Arch 447 (5), 594-602 (2004)
   PUBMED   12915942
  REMARK    Review article
            Erratum:[Pflugers Arch. 2004 Feb;447(5):816-7]
REFERENCE   8  (bases 1 to 4041)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   9  (bases 1 to 4041)
  AUTHORS   Huang,W., Wang,H., Kekuda,R., Fei,Y.J., Friedrich,A., Wang,J.,
            Conway,S.J., Cameron,R.S., Leibach,F.H. and Ganapathy,V.
  TITLE     Transport of N-acetylaspartate by the Na(+)-dependent high-affinity
            dicarboxylate transporter NaDC3 and its relevance to the expression
            of the transporter in the brain
  JOURNAL   J Pharmacol Exp Ther 295 (1), 392-403 (2000)
   PUBMED   10992006
REFERENCE   10 (bases 1 to 4041)
  AUTHORS   Wang,H., Fei,Y.J., Kekuda,R., Yang-Feng,T.L., Devoe,L.D.,
            Leibach,F.H., Prasad,P.D. and Ganapathy,V.
  TITLE     Structure, function, and genomic organization of human
            Na(+)-dependent high-affinity dicarboxylate transporter
  JOURNAL   Am J Physiol Cell Physiol 278 (5), C1019-C1030 (2000)
   PUBMED   10794676
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA636764.1, AY072810.3 and
            AL034424.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_022829.5.
            
            Summary: Mammalian sodium-dicarboxylate cotransporters transport
            succinate and other Krebs cycle intermediates. They fall into 2
            categories based on their substrate affinity: low affinity and high
            affinity. Both the low- and high-affinity transporters play an
            important role in the handling of citrate by the kidneys. The
            protein encoded by this gene represents the high-affinity form.
            Alternatively spliced transcript variants encoding different
            isoforms have been found for this gene, although the full-length
            nature of some of them have not been characterized yet. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.154856.1,
                                           SRR1803613.209759.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000279027.9/ ENSP00000279027.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                DA636764.1         3-21
            20-3316             AY072810.3         1-3297
            3317-4041           AL034424.9         46019-46743         c
FEATURES             Location/Qualifiers
     source          1..4041
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..4041
                     /gene="SLC13A3"
                     /gene_synonym="ARLIAK; NaC3; NADC3; SDCT2"
                     /note="solute carrier family 13 member 3"
                     /db_xref="GeneID:64849"
                     /db_xref="HGNC:HGNC:14430"
                     /db_xref="MIM:606411"
     exon            1..149
                     /gene="SLC13A3"
                     /gene_synonym="ARLIAK; NaC3; NADC3; SDCT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..1847
                     /gene="SLC13A3"
                     /gene_synonym="ARLIAK; NaC3; NADC3; SDCT2"
                     /note="isoform a is encoded by transcript variant 1;
                     sodium-dependent high affinity dicarboxylate transporter
                     3; Na(+)/dicarboxylate cotransporter 3; hNaDC3; naDC-3;
                     Na(+)-coupled carboxylate transporter 3"
                     /codon_start=1
                     /product="Na(+)/dicarboxylate cotransporter 3 isoform a"
                     /protein_id="NP_073740.2"
                     /db_xref="CCDS:CCDS13400.1"
                     /db_xref="GeneID:64849"
                     /db_xref="HGNC:HGNC:14430"
                     /db_xref="MIM:606411"
                     /translation="MAALAAAAKKVWSARRLLVLLFTPLALLPVVFALPPKEGRCLFV
                     ILLMAVYWCTEALPLSVTALLPIVLFPFMGILPSNKVCPQYFLDTNFLFLSGLIMASA
                     IEEWNLHRRIALKILMLVGVQPARLILGMMVTTSFLSMWLSNTASTAMMLPIANAILK
                     SLFGQKEVRKDPSQESEENTAAVRRNGLHTVPTEMQFLASTEAKDHPGETEVPLDLPA
                     DSRKEDEYRRNIWKGFLISIPYSASIGGTATLTGTAPNLILLGQLKSFFPQCDVVNFG
                     SWFIFAFPLMLLFLLAGWLWISFLYGGLSFRGWRKNKSEIRTNAEDRARAVIREEYQN
                     LGPIKFAEQAVFILFCMFAILLFTRDPKFIPGWASLFNPGFLSDAVTGVAIVTILFFF
                     PSQRPSLKWWFDFKAPNTETEPLLTWKKAQETVPWNIILLLGGGFAMAKGCEESGLSV
                     WIGGQLHPLENVPPALAVLLITVVIAFFTEFASNTATIIIFLPVLAELAIRLRVHPLY
                     LMIPGTVGCSFAFMLPVSTPPNSIAFASGHLLVKDMVRTGLLMNLMGVLLLSLAMNTW
                     AQTIFQLGTFPDWADMYSVNVTALPPTLANDTFRTL"
     exon            150..415
                     /gene="SLC13A3"
                     /gene_synonym="ARLIAK; NaC3; NADC3; SDCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            416..579
                     /gene="SLC13A3"
                     /gene_synonym="ARLIAK; NaC3; NADC3; SDCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            580..646
                     /gene="SLC13A3"
                     /gene_synonym="ARLIAK; NaC3; NADC3; SDCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            647..832
                     /gene="SLC13A3"
                     /gene_synonym="ARLIAK; NaC3; NADC3; SDCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            833..958
                     /gene="SLC13A3"
                     /gene_synonym="ARLIAK; NaC3; NADC3; SDCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1054
                     /gene="SLC13A3"
                     /gene_synonym="ARLIAK; NaC3; NADC3; SDCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1159
                     /gene="SLC13A3"
                     /gene_synonym="ARLIAK; NaC3; NADC3; SDCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1257
                     /gene="SLC13A3"
                     /gene_synonym="ARLIAK; NaC3; NADC3; SDCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1370
                     /gene="SLC13A3"
                     /gene_synonym="ARLIAK; NaC3; NADC3; SDCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1532
                     /gene="SLC13A3"
                     /gene_synonym="ARLIAK; NaC3; NADC3; SDCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1670
                     /gene="SLC13A3"
                     /gene_synonym="ARLIAK; NaC3; NADC3; SDCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..4041
                     /gene="SLC13A3"
                     /gene_synonym="ARLIAK; NaC3; NADC3; SDCT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3424..3429
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC13A3"
                     /gene_synonym="ARLIAK; NaC3; NADC3; SDCT2"
                     /note="hexamer: AATAAA"
     polyA_site      3442
                     /gene="SLC13A3"
                     /gene_synonym="ARLIAK; NaC3; NADC3; SDCT2"
                     /note="major polyA site"
     regulatory      4023..4028
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC13A3"
                     /gene_synonym="ARLIAK; NaC3; NADC3; SDCT2"
                     /note="hexamer: AATAAA"
     polyA_site      4041
                     /gene="SLC13A3"
                     /gene_synonym="ARLIAK; NaC3; NADC3; SDCT2"
                     /note="major polyA site"
ORIGIN      
        1 agtcccgggc cggcccgtac cgccaggcga tcgcgctgat ggcggcgctg gcagcagcgg
       61 ccaagaaggt gtggagcgcg cggcggctgc tggtgctgct gttcacgccg ctcgcgctgc
      121 tgccggtggt cttcgccctc ccgcccaagg aaggccgctg cttgtttgtc atcctgctca
      181 tggcggtgta ctggtgcacg gaggccctgc cgctctcagt gacggcgctg ctgcccatcg
      241 tcctcttccc cttcatgggc atcttgccct ccaacaaggt ctgcccccag tacttcctcg
      301 acaccaactt cctcttcctc agtgggctga tcatggccag cgccattgag gagtggaacc
      361 tgcaccggcg aatcgccctc aagatcctga tgcttgttgg agtccagccg gccaggctca
      421 tcctggggat gatggtgacc acctcgttct tgtccatgtg gctgagcaac accgcctcca
      481 ctgccatgat gcttcccatt gccaatgcca tcctgaaaag tctctttggc cagaaggagg
      541 ttcgaaagga ccccagccag gagagtgaag agaacacagc tgctgtgcgg agaaacggcc
      601 tacacactgt gcccacggag atgcagtttc tcgccagcac agaagccaaa gaccaccctg
      661 gggagacaga ggttccactg gatctgccgg ctgactccag gaaggaggat gaatatcgtc
      721 ggaacatctg gaagggcttc ctcatctcca tcccctactc agccagtatt gggggcacag
      781 ccacactcac gggcacagcc cctaacctca tcctgcttgg ccagctcaag agtttctttc
      841 cgcagtgtga cgtggtgaat ttcggctcct ggttcatttt cgccttccct cttatgctgt
      901 tgttcctgtt ggcaggctgg ctctggatct ccttcctgta cgggggactg agcttcaggg
      961 gctggaggaa gaataaatct gagataagaa ccaatgcaga agatagggct cgagctgtaa
     1021 ttcgggaaga ataccagaac ctggggccca tcaagtttgc cgaacaggct gttttcatcc
     1081 ttttctgcat gtttgccatc ctcctcttca cccgggaccc gaagttcatc cctggctggg
     1141 ccagcctctt caatcctggg tttctttctg atgctgtcac cggcgtggct attgtcacca
     1201 tcttgttctt cttcccgtcc caaaggccct ctctcaagtg gtggtttgac ttcaaagctc
     1261 ccaacacaga gacagagccc ttgctgacct ggaagaaggc ccaggagaca gtgccctgga
     1321 acatcatcct tctcctggga gggggcttcg ccatggccaa aggctgtgag gaatcggggc
     1381 tgtctgtatg gattggtggg cagctgcacc ccctggagaa tgtgcccccc gccctggctg
     1441 tgctgctcat cactgtggtc atcgccttct tcactgagtt tgccagcaac acggcgacca
     1501 tcatcatctt cctgccggtc ctggcagagc tggccatccg cctgagagtg caccccctgt
     1561 atctgatgat tccgggcaca gtcggctgct cctttgcctt catgctcccg gtctcaacgc
     1621 cccccaactc catcgccttc gcctctggac acttgctggt caaagacatg gtgcggacag
     1681 gcctcctgat gaacctgatg ggtgtcctgc tgctcagttt ggctatgaat acctgggcac
     1741 agaccatctt ccagctgggc accttcccgg actgggctga tatgtactcg gtcaatgtca
     1801 cagcattgcc acccaccttg gccaatgaca catttcggac cctctgagtc cccctggagg
     1861 actcccttga ggctgaaccc tctcaaaggg ctgtcaccat cacctgctgc taggacacta
     1921 caaaacaatc aaataattct tttctgtaat ccaatatgca gcaagcaagg gtgacctcca
     1981 gtggcccact caagtccatg agccattatc taggatactt tctctctctt tcatgcagtt
     2041 caaagcccag gtatctctca gatctgctgc ctgagaaata agctccttta tcagttagct
     2101 gttttatcat taggatacaa gacagcccag tgtcatcaac agtgagcaaa tctggcatgg
     2161 tgtttgtctc gtacagttgg gataggaggc cattcattcc catgggcaca gctaacatta
     2221 tcccccagtg attactttcg attacactga agagaccacc ttgtctttaa agatcacttt
     2281 cctgggctgc aatgttccaa cccagttgtt ccagctgttc acaaccagtg tgtgattttg
     2341 cttagttggt gcccattctg caccagttgt tttacccctg ccgataacca gcagtcagag
     2401 attctttttt aatccttgga gacagggaaa gggacagata gctttccaag gacatgagac
     2461 tgtgcaaagc ctctttgctg tttctctggg ctcctgagca taccagggga agttctagaa
     2521 accgcagctg acatctcgac ccaagagatt taggattctc ctgtttcatc tgggtcagtt
     2581 tggccataat tctggggtca ggccaggcct gggtcctgcc ctcccatggg gtgactcatg
     2641 acccctccag ccaggactct cctacatgtg gcccccatag gcctctgtgg ctgcaaggcg
     2701 gtcagttgct gcttgtccca gcaggtggcc ttgatctctc catgccccac cttaagtggt
     2761 aagcatgttt aattatcaaa ggccccattt gtcaggggtg agagaaaagt caaaagataa
     2821 attggggcct tgtaaaaggc cagggtaaaa tgtctcaggc aagcaaaaga ttgtcccctt
     2881 ctgcatatgg gtaaaactga gacgtccccg tgagcccgag gctggaagtg gtgtctgcct
     2941 tcaagggtta atccctcttt gttccaagca gaagcattct ggcatcccag tgaagagctc
     3001 aggccctcag gaagtgtctg ctgaatggaa tggcccagca ttagcccagt attggaaaag
     3061 acaccagccc aggggccctg actcgtcaca cttccctttc ctaagcctct gagggtggag
     3121 attcccctag gagcgcttgg ccagctggga aggcagcgcc cagctgcact tgttgttgat
     3181 acagcataag tgaatcatgg gcatttccct gagagcagtg ggagaggccc tctgagttgg
     3241 aagttgagct ccacctcctt tccaagtgag cactcagtgt tgaatcacag ttacaaccca
     3301 ctggggctgg tgggagatgc gttgtatggg actggaagca agaggttcat tcaaagagaa
     3361 actcatggga tttgtaacca gatgaatcat gatttctaag acttctgatc aaaaatactg
     3421 tgaaataaag aatgttaatc aactttggac ctggagatga tttgcctttc tgaacataag
     3481 agagcttcaa agccccaaat tcctgggctg gggattccac agagttgacc tctctgattt
     3541 tctactgctc ttccctcccc tctccagcta catactctgc ctcagggcct tcgcatgtgc
     3601 tgttccctct gcctagaaca ctctctccca agtatatgtc tggttccccg actcacttta
     3661 ttcaagtccc tgctcaggtg tcaccttccc tgagaggctt ccctgacctc ctgtctaaaa
     3721 tgtcaccctc attactctcc acccccttac tctgctataa tttctcctta ataggacact
     3781 gtataactta ttttcttatt atcttcttct ccctctagaa tataaattta tgaaaataca
     3841 aatgttattt tttttactgc tgtaactcca gttcctagaa caatttccag cacatagcaa
     3901 gtgttcagta aatatttgct gcttgaatct gctccagaat taacaagaaa gccatctctt
     3961 cctctgatct ggggtctgtt ttgttcatta ctttgttcac tccttcttcc atttattcat
     4021 tcaataaaca tttattggga a
//
