LOCUS       NM_006598               5300 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens solute carrier family 12 member 7 (SLC12A7), mRNA.
ACCESSION   NM_006598
VERSION     NM_006598.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5300)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 5300)
  AUTHORS   Jin,S.C., Furey,C.G., Zeng,X., Allocco,A., Nelson-Williams,C.,
            Dong,W., Karimy,J.K., Wang,K., Ma,S., Delpire,E. and Kahle,K.T.
  TITLE     SLC12A ion transporter mutations in sporadic and familial human
            congenital hydrocephalus
  JOURNAL   Mol Genet Genomic Med 7 (9), e892 (2019)
   PUBMED   31393094
  REMARK    GeneRIF: SLC12A ion transporter mutations in sporadic and familial
            human congenital hydrocephalus.
REFERENCE   3  (bases 1 to 5300)
  AUTHORS   Brown,T.C., Nicolson,N.G., Stenman,A., Juhlin,C.C., Gibson,C.E.,
            Callender,G.G., Korah,R. and Carling,T.
  TITLE     Insulin-Like Growth Factor and SLC12A7 Dysregulation: A Novel
            Signaling Hallmark of Non-Functional Adrenocortical Carcinoma
  JOURNAL   J Am Coll Surg 229 (3), 305-315 (2019)
   PUBMED   31034883
  REMARK    GeneRIF: The IGF1 gene was amplified in 9 of 19 ACC samples,
            similar to findings in The Cancer Genome Atlas database. The IGF1
            overexpression was observed in 5 samples and was associated with
            SLC12A7 overexpression and non-functional, early-stage tumors (p <
            0.05). endogenous overexpression and silencing of SLC12A7
            significantly altered IGF1 and IGF1R expression without impacting
            other IGFs.
REFERENCE   4  (bases 1 to 5300)
  AUTHORS   Brown,T.C., Murtha,T.D., Rubinstein,J.C., Korah,R. and Carling,T.
  TITLE     SLC12A7 alters adrenocortical carcinoma cell adhesion properties to
            promote an aggressive invasive behavior
  JOURNAL   Cell Commun Signal 16 (1), 27 (2018)
   PUBMED   29884238
  REMARK    GeneRIF: SLC12A7 alters adrenocortical carcinoma cell adhesion
            properties to promote an aggressive invasive behavior
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5300)
  AUTHORS   Fu,B., Wang,L., Li,S. and Dorf,M.E.
  TITLE     ZMPSTE24 defends against influenza and other pathogenic viruses
  JOURNAL   J Exp Med 214 (4), 919-929 (2017)
   PUBMED   28246125
REFERENCE   6  (bases 1 to 5300)
  AUTHORS   Brauer,M., Frei,E., Claes,L., Grissmer,S. and Jager,H.
  TITLE     Influence of K-Cl cotransporter activity on activation of
            volume-sensitive Cl- channels in human osteoblasts
  JOURNAL   Am J Physiol Cell Physiol 285 (1), C22-C30 (2003)
   PUBMED   12637262
  REMARK    GeneRIF: human osteoblasts express functional K-Cl cotransporters
            in their cell membrane that seem to be able to induce the indirect
            activation of volume-sensitive Cl- channels by KCl through an
            increase in the intracellular ions, water influx and cell swelling.
REFERENCE   7  (bases 1 to 5300)
  AUTHORS   Boettger,T., Hubner,C.A., Maier,H., Rust,M.B., Beck,F.X. and
            Jentsch,T.J.
  TITLE     Deafness and renal tubular acidosis in mice lacking the K-Cl
            co-transporter Kcc4
  JOURNAL   Nature 416 (6883), 874-878 (2002)
   PUBMED   11976689
  REMARK    GeneRIF: Mice lacking SLC12A7 function suffer from deafness and
            renal metabolic acidosis. The phenotype suggests a function in
            inner ear potassium recycling. A function in the proton secreting
            alpha-intercalating cells of the kidney is shown.
REFERENCE   8  (bases 1 to 5300)
  AUTHORS   Hattori,A., Okumura,K., Nagase,T., Kikuno,R., Hirosawa,M. and
            Ohara,O.
  TITLE     Characterization of long cDNA clones from human adult spleen
  JOURNAL   DNA Res 7 (6), 357-366 (2000)
   PUBMED   11214971
REFERENCE   9  (bases 1 to 5300)
  AUTHORS   Mercado,A., Song,L., Vazquez,N., Mount,D.B. and Gamba,G.
  TITLE     Functional comparison of the K+-Cl- cotransporters KCC1 and KCC4
  JOURNAL   J Biol Chem 275 (39), 30326-30334 (2000)
   PUBMED   10913127
REFERENCE   10 (bases 1 to 5300)
  AUTHORS   Mount,D.B., Mercado,A., Song,L., Xu,J., George,A.L. Jr., Delpire,E.
            and Gamba,G.
  TITLE     Cloning and characterization of KCC3 and KCC4, new members of the
            cation-chloride cotransporter gene family
  JOURNAL   J Biol Chem 274 (23), 16355-16362 (1999)
   PUBMED   10347194
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116351.2, DB451347.1, BC098390.1, AF105365.1, AK024497.1 and
            BU953746.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006598.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098390.1, SRR1803614.120186.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264930.10/ ENSP00000264930.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC116351.2         137986-137991       c
            7-28                DB451347.1         1-22
            29-1358             BC098390.1         1-1330
            1359-1636           AF105365.1         1291-1568
            1637-2771           BC098390.1         1609-2743
            2772-3438           AK024497.1         1616-2282
            3439-4111           BC098390.1         3411-4083
            4112-5299           AK024497.1         2956-4143
            5300-5300           BU953746.1         266-266
FEATURES             Location/Qualifiers
     source          1..5300
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p15.33"
     gene            1..5300
                     /gene="SLC12A7"
                     /gene_synonym="KCC4"
                     /note="solute carrier family 12 member 7"
                     /db_xref="GeneID:10723"
                     /db_xref="HGNC:HGNC:10915"
                     /db_xref="MIM:604879"
     exon            1..196
                     /gene="SLC12A7"
                     /gene_synonym="KCC4"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..3324
                     /gene="SLC12A7"
                     /gene_synonym="KCC4"
                     /note="potassium/chloride transporter KCC4; K-Cl
                     cotransporter 4; electroneutral potassium-chloride
                     cotransporter 4; solute carrier family 12
                     (potassium/chloride transporters), member 7; solute
                     carrier family 12 (potassium/chloride transporter), member
                     7; SUCO/SLC12A7 fusion"
                     /codon_start=1
                     /product="solute carrier family 12 member 7"
                     /protein_id="NP_006589.2"
                     /db_xref="CCDS:CCDS34129.1"
                     /db_xref="GeneID:10723"
                     /db_xref="HGNC:HGNC:10915"
                     /db_xref="MIM:604879"
                     /translation="MPTNFTVVPVEAHADGGGDETAERTEAPGTPEGPEPERPSPGDG
                     NPRENSPFLNNVEVEQESFFEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGVVEH
                     EEDEESRRREAKAPRMGTFIGVYLPCLQNILGVILFLRLTWIVGVAGVLESFLIVAMC
                     CTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYIL
                     GTIEIFLTYISPGAAIFQAEAAGGEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVNKL
                     ALVFLACVVLSILAIYAGVIKSAFDPPDIPVCLLGNRTLSRRSFDACVKAYGIHNNSA
                     TSALWGLFCNGSQPSAACDEYFIQNNVTEIQGIPGAASGVFLENLWSTYAHAGAFVEK
                     KGVPSVPVAEESRASALPYVLTDIAASFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKS
                     IPTGTILAIVTTSFIYLSCIVLFGACIEGVVLRDKFGEALQGNLVIGMLAWPSPWVIV
                     IGSFFSTCGAGLQSLTGAPRLLQAIARDGIVPFLQVFGHGKANGEPTWALLLTVLICE
                     TGILIASLDSVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKFYHWTLSFLGMS
                     LCLALMFICSWYYALSAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLRVEH
                     GPPHTKNWRPQVLVMLNLDAEQAVKHPRLLSFTSQLKAGKGLTIVGSVLEGTYLDKHM
                     EAQRAEENIRSLMSTEKTKGFCQLVVSSSLRDGMSHLIQSAGLGGLKHNTVLMAWPAS
                     WKQEDNPFSWKNFVDTVRDTTAAHQALLVAKNVDSFPQNQERFGGGHIDVWWIVHDGG
                     MLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNSIQMKKDLQMFLYHLRISAEVEVVEMV
                     ENDISAFTYERTLMMEQRSQMLKQMQLSKNEQEREAQLIHDRNTASHTAAAARTQAPP
                     TPDKVQMTWTREKLIAEKYRSRDTSLSGFKDLFSMKPDQSNVRRMHTAVKLNGVVLNK
                     SQDAQLVLLNMPGPPKNRQGDENYMEFLEVLTEGLNRVLLVRGGGREVITIYS"
     exon            197..291
                     /gene="SLC12A7"
                     /gene_synonym="KCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            292..414
                     /gene="SLC12A7"
                     /gene_synonym="KCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            415..561
                     /gene="SLC12A7"
                     /gene_synonym="KCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            562..616
                     /gene="SLC12A7"
                     /gene_synonym="KCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            617..747
                     /gene="SLC12A7"
                     /gene_synonym="KCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            748..989
                     /gene="SLC12A7"
                     /gene_synonym="KCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1201
                     /gene="SLC12A7"
                     /gene_synonym="KCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1369
                     /gene="SLC12A7"
                     /gene_synonym="KCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1468
                     /gene="SLC12A7"
                     /gene_synonym="KCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1526
                     /gene="SLC12A7"
                     /gene_synonym="KCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1701
                     /gene="SLC12A7"
                     /gene_synonym="KCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1820
                     /gene="SLC12A7"
                     /gene_synonym="KCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..1919
                     /gene="SLC12A7"
                     /gene_synonym="KCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..2039
                     /gene="SLC12A7"
                     /gene_synonym="KCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2144
                     /gene="SLC12A7"
                     /gene_synonym="KCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2313
                     /gene="SLC12A7"
                     /gene_synonym="KCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2509
                     /gene="SLC12A7"
                     /gene_synonym="KCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2510..2679
                     /gene="SLC12A7"
                     /gene_synonym="KCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2680..2811
                     /gene="SLC12A7"
                     /gene_synonym="KCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2812..2919
                     /gene="SLC12A7"
                     /gene_synonym="KCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2920..3098
                     /gene="SLC12A7"
                     /gene_synonym="KCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            3099..3232
                     /gene="SLC12A7"
                     /gene_synonym="KCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            3233..5300
                     /gene="SLC12A7"
                     /gene_synonym="KCC4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5279..5284
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC12A7"
                     /gene_synonym="KCC4"
                     /note="hexamer: AATAAA"
     polyA_site      5300
                     /gene="SLC12A7"
                     /gene_synonym="KCC4"
                     /note="major polyA site"
ORIGIN      
        1 agtcccgtgg cgtcggcggg agcggcgcag cgcgggccgg gccgggacgg ggactgtcgg
       61 ctgcaggcgg ccatgcccac caacttcacc gtggtgcccg tggaggctca cgccgacggc
      121 ggcggggacg agactgccga gcggacggag gctccgggca cccccgaggg ccccgagccc
      181 gagcgcccca gcccgggaga tggaaatcca agagaaaaca gcccattcct caacaatgtc
      241 gaggtggaac aagagagctt ctttgaaggg aagaacatgg cacttttcga ggaggagatg
      301 gacagtaacc ccatggtgtc ctcgctgctc aacaagctgg ccaactacac caacctgagc
      361 cagggcgtgg tggagcacga ggaggacgag gagagccggc ggcgggaggc caaggctccg
      421 cgcatgggca ccttcatcgg cgtctacctg ccgtgcctgc agaacatcct gggcgtcatc
      481 ctcttcctgc gcctgacgtg gatcgtgggg gtggctggtg tcctggagtc cttcctcatc
      541 gtggccatgt gctgcacatg tacaatgctg accgccattt ccatgagtgc gatcgctacc
      601 aacggtgtgg tcccagctgg cgggtcctac tacatgatat cgcgctcgct gggacccgag
      661 tttggaggcg ctgtcggcct ctgcttctac ctgggcacga cgtttgcagg ggccatgtat
      721 attttgggga ccatcgagat ttttctgacg tacatctccc cgggtgcggc catcttccag
      781 gcggaggctg caggtggcga ggcggccgcc atgctgcaca acatgcgtgt gtacggcacg
      841 tgcacgctcg tgctcatggc cctggtggtc ttcgtgggcg tcaagtatgt caacaagctg
      901 gcgctggtct tcctggcctg cgtcgtgctg tccatcctgg ccatctatgc cggcgtcatc
      961 aagtctgcct tcgacccccc ggacatcccg gtctgcctcc tggggaaccg cacgctgtca
     1021 cggcgcagct tcgatgcctg cgtcaaggcc tacggcatcc acaacaactc agccacctcc
     1081 gcgctctggg gcctcttctg caacggctcc cagcccagcg ccgcctgtga cgagtacttc
     1141 atccagaaca acgtcaccga aatccagggc atcccgggcg cggccagtgg tgtcttcctg
     1201 gagaacctgt ggagtacgta cgcgcacgcg ggggcgtttg tggagaagaa aggtgtgccc
     1261 tcggtgcccg tggcagagga gagccgtgcc agcgcactgc cctacgtgct caccgacatc
     1321 gcggcctcct tcaccctgct ggttggcatc tacttccctt ccgtgaccgg tatcatggcg
     1381 ggttcaaacc ggtccgggga cctcaaggat gcacagaagt ccatccccac ggggaccatc
     1441 ctggccatag tgacgacgtc tttcatctat ctctcctgca ttgtgctgtt tggggcctgc
     1501 attgaaggcg tggtcttacg agataagttc ggggaggccc tgcaggggaa cctggtcatc
     1561 ggcatgctgg cctggccctc cccctgggtc atcgtcatcg gctccttctt ctccacctgc
     1621 ggtgccggcc tgcagagcct cacgggggca ccgcgcctac tgcaggccat tgcccgtgac
     1681 ggcatcgtcc ccttcctgca ggtgtttggc cacgggaagg ccaacgggga gcccacgtgg
     1741 gcgctgctgc tgacagtcct catctgcgag actggcatcc tcatcgcctc tctggacagc
     1801 gtggccccga tcctctccat gttcttcctc atgtgctacc tgttcgtgaa cctggcctgc
     1861 gccgtgcaga ccctgctacg tacccccaac tggcgtccac gcttcaagtt ctaccactgg
     1921 accctgtcct ttctgggtat gagcctgtgc ctggcgctga tgttcatctg ctcctggtac
     1981 tacgcgctgt ccgccatgct catcgctggc tgcatctaca agtacatcga gtaccgcggg
     2041 gccgagaagg agtggggcga tggcatccgt ggcctatccc tgaacgccgc ccgctacgcc
     2101 ctgctgcgcg tggagcacgg tcccccccac accaagaact ggaggcccca ggtgctggtg
     2161 atgctgaacc tggacgcgga gcaggccgtg aagcaccccc gcctgctgtc cttcacgtcg
     2221 cagctgaagg ccggcaaggg cctgaccatc gtgggctcgg tgctggaggg gacgtacctg
     2281 gacaagcaca tggaggctca gcgggccgag gagaacatac ggtccctaat gagcacagag
     2341 aagaccaagg gcttctgcca gctggtggtc tcgtccagcc tgcgggatgg catgtcccac
     2401 ctgatccagt cggccggcct gggcggcctg aagcacaaca cggtgctcat ggcctggccc
     2461 gcatcctgga agcaggagga caaccccttc tcctggaaga actttgtgga caccgtccgc
     2521 gacaccaccg ccgcgcacca ggctctgctg gtggccaaga acgtcgactc gtttccgcaa
     2581 aaccaggagc gcttcggcgg gggccacatc gacgtgtggt ggatcgtgca cgacggcggc
     2641 atgctcatgc tgctgccctt cctgctgcgc cagcacaagg tgtggaggaa gtgccggatg
     2701 cgtatcttca ccgtggccca ggtggacgac aacagcatcc agatgaagaa ggacctgcag
     2761 atgttcttgt accacttgcg catcagcgcc gaggtggagg tggtggagat ggttgaaaac
     2821 gacatatctg ctttcaccta cgagaggaca ctaatgatgg agcagaggtc gcagatgctg
     2881 aagcagatgc agctgtccaa gaacgagcag gagcgagagg cccagctgat ccacgacagg
     2941 aacaccgcgt cccacaccgc ggcggcagcc aggacccaag cgccgcctac gccagacaag
     3001 gtgcagatga cctggaccag ggagaagctg atcgctgaga agtacaggag cagagacacc
     3061 agcctatctg gtttcaaaga cctcttcagc atgaagccgg accagtccaa cgtcaggcgg
     3121 atgcacacgg ctgtgaagct caatggcgtc gtcctcaaca agtcccagga tgcgcagctg
     3181 gtcctgctca acatgccagg tcctcccaaa aaccggcagg gagacgagaa ctacatggag
     3241 tttcttgaag tcctgaccga ggggctgaac agagtcctcc tggtcagggg tggcggccgg
     3301 gaggtgatca ccatctactc ctaatgccca acagcatcac ggcactctgg gacaggcacg
     3361 gaggacggcg tgggcagcct gggcctgggc ttggcccagg gaaacagacg gcagacacac
     3421 ctgtccccca gtgatgccgc ccaagctgcc catggggctt cctacggaag tttctaggcc
     3481 cgtcacctag ggctctcctg ttcagcctta acaggctcag caaatcaggg cgtggctgga
     3541 cgatttcctt gcatctgagg gcagacgctg ctaccggagt gacctggacg tggccagatc
     3601 ttctcgcagg tcacaagaag ccagtgagcc cttgccttgg tttctggaag ttcttttcct
     3661 tggctggatt tacccagtgg ttaggttgca tttctacccc atccagaaca ttcttggaag
     3721 agcacccgga gctgaagctg tccctgatga tgaaggtgaa acgtcagccc tggccatggc
     3781 tccgctcagg gccccggtca cctccgagtc actctgttcc ttgactgtct ttgtgtttct
     3841 gtacctcaag gcactgaagc tggaggactc tgtccatgcc cgtgtcaccc tcgtgtggga
     3901 gcctctgggc tcggcaggtc cacatttcat gagctgaggc gtgggccagg gccatctgga
     3961 aagggaactc ggcttttcca gaacgtggtg gatcatctgt cgggtgtgtg gtgaacacgt
     4021 tcagttcatc agggcctacg ctccgggaag gggcccccag ctgtggctct gccatgccgg
     4081 gctgtgtttg cagctgtccg agtctccatc cacctttaga aaaccagcca cttcttttca
     4141 taagcactga cagggcccag cccacagcca caggtgcgat cagtgcctca cgcaggcaaa
     4201 tgcactgaaa cccaggggca cacgcgcgca gagtgaacag tgagttcccc cgacagccca
     4261 cgacagccag gactgccctc cccaccccac cccaccccag gagcacggca cacagttcag
     4321 cctctgagct ggctcacacg tgccatcccc accccggtgc tccagggaag gaggacacgg
     4381 acccgacgtg ggaggtcctc aggcagcagt ggcgcctggt gtcaggtctg tctggctgag
     4441 tcccgggcgt cccctgccat ggcctgtgcc ttgcatggag gcggcggtgg cactgaagag
     4501 atagctttca agggcccaac actttgcact tcggctggct gtgagtttct gctttgtagg
     4561 ttgtggtcac atttgcaggc tgcgggcagt ggcaccgact tgggcctccc tttctatgtg
     4621 gcatatttat ttatttaaac accccaggga gttacgtggt aacaaggttg tccataaaga
     4681 ggttgcttct atatactaga ggccccagat ggccaggcct tgggctacgt ctggcttgca
     4741 tggtctccca agggaatcag ccccatcaac aaagttcaaa tcggggcaga ggctgcactt
     4801 gtgcccccag atgtttctga ggagccagac tagggctggc attgctgtag agtgacggct
     4861 gctgcccaga gcgtgtccca gacatcacag cggggctcag cagttcccac agcctctgcc
     4921 tgccttggct aagcatgagt taagcagcaa aacgctcctc catgtctgga tggggccggc
     4981 aggtcctgtg tcccctgcac ctggaggaga gcaggctaga ggcacagcgg ccacatggtg
     5041 ctggctctga acgttggttg gtggctggaa aacagccctg cttctgaggg ccgctcagtt
     5101 ctgcacacga aaccacctcc tgagggctca gctctgcccc cgccctgggc tgcagcctct
     5161 gcacgcaagc accaggcatc ctttgtgttg tcaactccgt gtaaccagta actacagcca
     5221 tttacaattg actccgtttc cttttgtagg tttccctgtc tgtctgtgtt agtagaaaaa
     5281 taaaatccta tgaaatctga
//
