LOCUS       NM_005072               4708 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens solute carrier family 12 member 4 (SLC12A4),
            transcript variant 1, mRNA.
ACCESSION   NM_005072
VERSION     NM_005072.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4708)
  AUTHORS   Zhao,Y., Shen,J., Wang,Q., Ruiz Munevar,M.J., Vidossich,P., De
            Vivo,M., Zhou,M. and Cao,E.
  TITLE     Structure of the human cation-chloride cotransport KCC1 in an
            outward-open state
  JOURNAL   Proc Natl Acad Sci U S A 119 (27), e2109083119 (2022)
   PUBMED   35759661
  REMARK    GeneRIF: Structure of the human cation-chloride cotransport KCC1 in
            an outward-open state.
REFERENCE   2  (bases 1 to 4708)
  AUTHORS   Chi,G., Ebenhoch,R., Man,H., Tang,H., Tremblay,L.E., Reggiano,G.,
            Qiu,X., Bohstedt,T., Liko,I., Almeida,F.G., Garneau,A.P., Wang,D.,
            McKinley,G., Moreau,C.P., Bountra,K.D., Abrusci,P.,
            Mukhopadhyay,S.M.M., Fernandez-Cid,A., Slimani,S., Lavoie,J.L.,
            Burgess-Brown,N.A., Tehan,B., DiMaio,F., Jazayeri,A., Isenring,P.,
            Robinson,C.V. and Durr,K.L.
  TITLE     Phospho-regulation, nucleotide binding and ion access control in
            potassium-chloride cotransporters
  JOURNAL   EMBO J 40 (14), e107294 (2021)
   PUBMED   34031912
REFERENCE   3  (bases 1 to 4708)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4708)
  AUTHORS   Garneau,A.P., Slimani,S., Tremblay,L.E., Fiola,M.J., Marcoux,A.A.
            and Isenring,P.
  TITLE     K+-Cl- cotransporter 1 (KCC1): a housekeeping membrane protein that
            plays key supplemental roles in hematopoietic and cancer cells
  JOURNAL   J Hematol Oncol 12 (1), 74 (2019)
   PUBMED   31296230
  REMARK    GeneRIF: The main goal of the review is to discuss the molecular
            features and tissue-specific functions of KCC1 from the
            hematological perspective for the greater part. As will be seen,
            the characterization of KCC1 has led the way to important findings
            and promising therapeutic avenues. [review]
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4708)
  AUTHORS   Zhou,G.P., Wong,C., Su,R., Crable,S.C., Anderson,K.P. and
            Gallagher,P.G.
  TITLE     Human potassium chloride cotransporter 1 (SLC12A4) promoter is
            regulated by AP-2 and contains a functional downstream promoter
            element
  JOURNAL   Blood 103 (11), 4302-4309 (2004)
   PUBMED   14976052
  REMARK    GeneRIF: the KCC1 gene promoter lacks a TATA box and is composed of
            an initiator element (InR) and a downstream promoter element (DPE)
REFERENCE   6  (bases 1 to 4708)
  AUTHORS   Casula,S., Shmukler,B.E., Wilhelm,S., Stuart-Tilley,A.K., Su,W.,
            Chernova,M.N., Brugnara,C. and Alper,S.L.
  TITLE     A dominant negative mutant of the KCC1 K-Cl cotransporter: both N-
            and C-terminal cytoplasmic domains are required for K-Cl
            cotransport activity
  JOURNAL   J Biol Chem 276 (45), 41870-41878 (2001)
   PUBMED   11551954
REFERENCE   7  (bases 1 to 4708)
  AUTHORS   Su,W., Shmukler,B.E., Chernova,M.N., Stuart-Tilley,A.K., de
            Franceschi,L., Brugnara,C. and Alper,S.L.
  TITLE     Mouse K-Cl cotransporter KCC1: cloning, mapping, pathological
            expression, and functional regulation
  JOURNAL   Am J Physiol 277 (5), C899-C912 (1999)
   PUBMED   10564083
REFERENCE   8  (bases 1 to 4708)
  AUTHORS   Pellegrino,C.M., Rybicki,A.C., Musto,S., Nagel,R.L. and
            Schwartz,R.S.
  TITLE     Molecular identification and expression of erythroid K:Cl
            cotransporter in human and mouse erythroleukemic cells
  JOURNAL   Blood Cells Mol Dis 24 (1), 31-40 (1998)
   PUBMED   9516379
REFERENCE   9  (bases 1 to 4708)
  AUTHORS   Gillen,C.M., Brill,S., Payne,J.A. and Forbush,B. 3rd.
  TITLE     Molecular cloning and functional expression of the K-Cl
            cotransporter from rabbit, rat, and human. A new member of the
            cation-chloride cotransporter family
  JOURNAL   J Biol Chem 271 (27), 16237-16244 (1996)
   PUBMED   8663127
REFERENCE   10 (bases 1 to 4708)
  AUTHORS   Larsen,F., Solheim,J., Kristensen,T., Kolsto,A.B. and Prydz,H.
  TITLE     A tight cluster of five unrelated human genes on chromosome 16q22.1
  JOURNAL   Hum Mol Genet 2 (10), 1589-1595 (1993)
   PUBMED   8268911
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC321966.1, AF047338.1,
            CF272417.1, AK310027.1 and AI368074.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005072.4.
            
            Summary: This gene encodes a member of the SLC12A transporter
            family. The encoded protein mediates the coupled movement of
            potassium and chloride ions across the plasma membrane. This gene
            is expressed ubiquitously. Multiple alternatively spliced
            transcript variants encoding distinct isoforms have been found for
            this gene. [provided by RefSeq, Jan 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021193.2, SRR1803614.234883.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000316341.8/ ENSP00000318557.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                DC321966.1         59-142
            85-3697             AF047338.1         1-3613
            3698-4013           CF272417.1         476-791
            4014-4635           AK310027.1         353-974
            4636-4708           AI368074.1         9-81                c
FEATURES             Location/Qualifiers
     source          1..4708
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..4708
                     /gene="SLC12A4"
                     /gene_synonym="CTC-479C5.17; hKCC1; KCC1"
                     /note="solute carrier family 12 member 4"
                     /db_xref="GeneID:6560"
                     /db_xref="HGNC:HGNC:10913"
                     /db_xref="MIM:604119"
     exon            1..199
                     /gene="SLC12A4"
                     /gene_synonym="CTC-479C5.17; hKCC1; KCC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..3342
                     /gene="SLC12A4"
                     /gene_synonym="CTC-479C5.17; hKCC1; KCC1"
                     /note="isoform a is encoded by transcript variant 1;
                     potassium/chloride cotransporter 1; erythroid K-Cl
                     cotransporter 1; solute carrier family 12
                     (potassium/chloride transporter), member 4; solute carrier
                     family 12 (potassium/chloride transporters), member 4;
                     electroneutral potassium-chloride cotransporter 1"
                     /codon_start=1
                     /product="solute carrier family 12 member 4 isoform a"
                     /protein_id="NP_005063.1"
                     /db_xref="CCDS:CCDS10855.1"
                     /db_xref="GeneID:6560"
                     /db_xref="HGNC:HGNC:10913"
                     /db_xref="MIM:604119"
                     /translation="MPHFTVVPVDGPRRGDYDNLEGLSWVDYGERAELDDSDGHGNHR
                     ESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEA
                     ESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLIC
                     CCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYIL
                     GAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKF
                     ASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETV
                     ATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVE
                     KHGLPSADAPSLKESLPLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKS
                     IPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIV
                     IGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAE
                     LGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMS
                     LCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEE
                     GPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYG
                     EAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYG
                     WRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGG
                     MLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEVVEMH
                     NSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEEDE
                     SAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIV
                     TRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS"
     exon            200..294
                     /gene="SLC12A4"
                     /gene_synonym="CTC-479C5.17; hKCC1; KCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            295..426
                     /gene="SLC12A4"
                     /gene_synonym="CTC-479C5.17; hKCC1; KCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            427..573
                     /gene="SLC12A4"
                     /gene_synonym="CTC-479C5.17; hKCC1; KCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            574..628
                     /gene="SLC12A4"
                     /gene_synonym="CTC-479C5.17; hKCC1; KCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            629..759
                     /gene="SLC12A4"
                     /gene_synonym="CTC-479C5.17; hKCC1; KCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            760..1001
                     /gene="SLC12A4"
                     /gene_synonym="CTC-479C5.17; hKCC1; KCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1216
                     /gene="SLC12A4"
                     /gene_synonym="CTC-479C5.17; hKCC1; KCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1381
                     /gene="SLC12A4"
                     /gene_synonym="CTC-479C5.17; hKCC1; KCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1480
                     /gene="SLC12A4"
                     /gene_synonym="CTC-479C5.17; hKCC1; KCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1538
                     /gene="SLC12A4"
                     /gene_synonym="CTC-479C5.17; hKCC1; KCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1713
                     /gene="SLC12A4"
                     /gene_synonym="CTC-479C5.17; hKCC1; KCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1832
                     /gene="SLC12A4"
                     /gene_synonym="CTC-479C5.17; hKCC1; KCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..1931
                     /gene="SLC12A4"
                     /gene_synonym="CTC-479C5.17; hKCC1; KCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2051
                     /gene="SLC12A4"
                     /gene_synonym="CTC-479C5.17; hKCC1; KCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2052..2156
                     /gene="SLC12A4"
                     /gene_synonym="CTC-479C5.17; hKCC1; KCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..2325
                     /gene="SLC12A4"
                     /gene_synonym="CTC-479C5.17; hKCC1; KCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2326..2521
                     /gene="SLC12A4"
                     /gene_synonym="CTC-479C5.17; hKCC1; KCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2522..2691
                     /gene="SLC12A4"
                     /gene_synonym="CTC-479C5.17; hKCC1; KCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2692..2823
                     /gene="SLC12A4"
                     /gene_synonym="CTC-479C5.17; hKCC1; KCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2824..2931
                     /gene="SLC12A4"
                     /gene_synonym="CTC-479C5.17; hKCC1; KCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2932..3116
                     /gene="SLC12A4"
                     /gene_synonym="CTC-479C5.17; hKCC1; KCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3117..3250
                     /gene="SLC12A4"
                     /gene_synonym="CTC-479C5.17; hKCC1; KCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3251..4708
                     /gene="SLC12A4"
                     /gene_synonym="CTC-479C5.17; hKCC1; KCC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3831..3836
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC12A4"
                     /gene_synonym="CTC-479C5.17; hKCC1; KCC1"
                     /note="hexamer: AATAAA"
     polyA_site      3854
                     /gene="SLC12A4"
                     /gene_synonym="CTC-479C5.17; hKCC1; KCC1"
                     /note="major polyA site"
     regulatory      4687..4692
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC12A4"
                     /gene_synonym="CTC-479C5.17; hKCC1; KCC1"
                     /note="hexamer: AATAAA"
     polyA_site      4708
                     /gene="SLC12A4"
                     /gene_synonym="CTC-479C5.17; hKCC1; KCC1"
ORIGIN      
        1 gtgtcggccc ggggcggcgg ggacagcggc ggggacagcg gcgggcggct gggacggcgg
       61 gtgcggcggg gccgagcccg cacgatgcct cacttcaccg tggtgccagt ggacgggccg
      121 aggcgcggcg actatgacaa cctcgagggg ctcagttggg tggactacgg ggagcgcgcc
      181 gagctggatg actcggacgg acatggcaac cacagagaga gcagcccttt tctttccccc
      241 ttggaggctt ccagaggaat tgactactat gacaggaacc tggcactgtt tgaggaagag
      301 ctggacatcc gcccaaaggt atcgtctctt ctgggaaagc tcgtcagcta caccaacctc
      361 acccagggcg ccaaagagca tgaggaggcc gagagtgggg agggcacccg ccggagggca
      421 gccgaggcac ccagcatggg caccctcatg ggggtgtacc tgccctgcct gcagaatatc
      481 tttggggtta tcctcttcct gcggctgacc tggatggtgg gcacagcagg tgtgctacag
      541 gccctcctca tcgtgcttat ctgctgctgt tgtaccctgc tgacggccat ctccatgagt
      601 gccatcgcca ccaacggtgt ggttccagct gggggctcct atttcatgat ctctcgttca
      661 ctggggccag aatttggagg tgctgtgggc ctgtgcttct acctgggaac aacattcgca
      721 gcagccatgt acatcctggg ggccatcgag atcttgctga cctacattgc cccaccagct
      781 gccatttttt acccatcggg tgctcatgac acgtcgaatg ccactttgaa caatatgcgt
      841 gtgtatggga ccattttcct gaccttcatg accctggtgg tgtttgtggg ggtcaagtat
      901 gtgaacaaat ttgcctcgct cttcctggcc tgtgtgatca tctccatcct ctccatctat
      961 gctgggggca taaagtctat atttgaccct cccgtgtttc cggtatgcat gctgggcaac
     1021 aggaccctgt cccgggacca gtttgacatc tgtgccaaga cagctgtagt ggacaatgag
     1081 acagtggcca cccagctatg gagtttcttc tgccacagcc ccaaccttac gaccgactcc
     1141 tgtgacccct acttcatgct caacaatgtg accgagatcc ctggcatccc cggggcagct
     1201 gctggtgtgc tccaggaaaa cctgtggagc gcctacctgg agaagggtga catcgtggag
     1261 aagcatgggc tgccctccgc agatgccccg agcctgaagg agagcctgcc tctgtacgtg
     1321 gtcgctgaca tcgccacatc cttcaccgtg ctggtcggca tcttcttccc ttctgtaaca
     1381 ggcatcatgg ctggctcaaa ccgctctggg gaccttcgtg acgcccagaa gtctatccct
     1441 gtggggacca ttctggccat cattacaact tccctcgtgt acttcagcag tgtggttctc
     1501 tttggtgcct gcattgaggg tgtggttctc cgggacaagt atggcgatgg tgtcagcagg
     1561 aacttggtgg tgggcacact ggcctggcct tcaccctggg tcatcgtcat cggctccttc
     1621 ttttcaacgt gtggcgctgg cctccagagc ctcacagggg caccacgcct attgcaggcc
     1681 attgccaagg acaacatcat ccccttcctc cgggtgtttg gccacgggaa ggtgaatggt
     1741 gaacccacat gggcactcct cctgacggca ctcatcgccg agctgggcat cctcatcgcc
     1801 tccctcgaca tggtggcccc catcttatcc atgttctttc tgatgtgcta cctgttcgtg
     1861 aacctcgcct gtgcggtgca gacactcctg aggaccccca actggcggcc ccggttcaag
     1921 tactatcact gggcgctgtc cttcctgggc atgagtctct gcctggccct tatgtttgtc
     1981 tcctcctggt actatgccct ggtggccatg ctcatcgccg gcatgatcta caaatacatc
     2041 gagtaccaag gggctgagaa ggagtggggt gacgggatcc gaggcctgtc cctgagcgct
     2101 gcccgctacg cgctgttgcg gctggaggag gggcctcctc acaccaagaa ctggcggccg
     2161 cagctgctgg tgctgctgaa gctggacgag gacctccacg tgaagtaccc gcggctcctc
     2221 accttcgcct cccagctcaa ggctggcaag ggcctgacca ttgttggttc tgtcatccag
     2281 gggagcttct tggagagcta tggcgaggct caggccgccg agcagaccat caagaacatg
     2341 atggaaattg agaaggtgaa gggcttctgc caggtggtgg tggccagcaa ggtgcgggag
     2401 gggctggccc acctcatcca gtcctgtggc ctgggaggca tgcggcataa ctccgtggtg
     2461 ctgggctggc cctacggctg gcgacagagc gaggaccccc gtgcctggaa gaccttcatt
     2521 gacaccgtgc gctgcactac ggctgcccac ctggccctgc tcgtgcccaa gaacatcgcc
     2581 ttctacccca gcaaccacga gcgctacctg gagggccaca tagacgtgtg gtggatcgtg
     2641 cacgatggtg gcatgctcat gcttctgccc ttcctgctgc gccagcataa ggtctggagg
     2701 aagtgccgga tgcgcatctt cacagtggcc cagatggatg acaacagcat ccagatgaag
     2761 aaggacctgg ctgtctttct gtaccatctg cgccttgagg ccgaggtgga ggtggtggag
     2821 atgcataaca gtgacatctc tgcatacacc tacgagcgga cgctgatgat ggagcagcgg
     2881 tcgcagatgc tgcggcagat gagactgacc aagactgagc gggagcgaga agcccagctg
     2941 gtcaaggatc ggcactcggc cctgcggctg gagagcctgt actcggacga ggaagatgag
     3001 tctgcagtgg gggctgacaa gatccagatg acgtggacca gggacaagta catgactgag
     3061 acctgggacc ccagccatgc ccctgacaat ttccgggagc tggtgcacat taagccggac
     3121 caatccaatg tgcggcgcat gcacactgct gtgaagctca atgaagtcat tgtcacgcgc
     3181 tcccacgacg cccgcctggt tctcctaaac atgcctggcc cacccaggaa cagtgagggc
     3241 gacgagaact acatggagtt cctcgaggtg ctgaccgagg gccttgagcg ggtgctgttg
     3301 gtgcgcggtg gtggccgtga agtcatcacc atctactcct gagcccagtg tcatcttgtg
     3361 gcctggagtc gaggtcttgg ccaggacata acaagctgtg gtctggggta acagcctctt
     3421 cccagcaccc acctgccagc cctgcttgcc tggccctgtc ctggacccag ctttgctagg
     3481 tctccttgga aaccaggcct gggcctcaaa atggagatgg atcccaggtc ttgtgggacc
     3541 ctgggatgtt tggggacttt actatctagc accccagtag gcctgtcctg gccagagaag
     3601 actggtaggg gccgagtggg gtttgaaggc agccggcccg gcccagccca ggagcgctat
     3661 ttattgcata tttattgttt ggatgtcacc atcagagacg aagggaaggg tagccaggga
     3721 gggagtccag cccagctgcc tgcaggaaga tctggctcag tctactatgg gcagggcccc
     3781 ccaccaagct gagccgaatg gagacagctg agctgaggcc tgactttttc aataaaacat
     3841 tgtgtagttc tgggcctcct gctgccccgg ctctgtttcc cctggcgcca agagaagaag
     3901 gcggaactga acccaggccc agagccggct ccctgaggct gtgccccttt ccggcaatct
     3961 ctggccacaa cccccactgg ccaggccgtc cctcccactg gccctagggc ccctcccact
     4021 cccacaccag ataaggacag cccagtgccg ctttctctgg cagtaggcac cagggctgga
     4081 atggggccgc ccggctcccc atggcagtgg gtgacgctgc tgctggggct gctgctccct
     4141 cctgccgccc ccttctggct cctcaatgtg ctcttccccc cgcacaccac gcccaaggct
     4201 gagctcagta accacacacg gcccgtcatc ctcggtaagc ccccaccagg cccctgatgc
     4261 accacgccag accctgggga gcctgggccc cagcccctgg cagctgacct ggccaaagcc
     4321 cttctgccct gcataagccc cgacataagt acctgccctg gtgtggggag gggccaaaag
     4381 cttgtccctt agaggaatga cgtcccttct cccaccacac tgtgactctc agttgtctaa
     4441 cccagggggg gcggagtggg ggacggggtg tgcctgaggt cttggctggg gcatcacaag
     4501 ctgtggtcag tcacagccac accagactct gggccaagcc ccaccactcc ttccttggcc
     4561 cccacccacc aaggacaaga tgcccagccc aggatcggtg agcaggagag gcccatccat
     4621 gcccggcccc tattaggccc agcccccatg cccccagacc tatctgttcc caccttggac
     4681 tttggcaata aaggagcgcc agactggg
//
