LOCUS       NM_000617               4132 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens solute carrier family 11 member 2 (SLC11A2),
            transcript variant 4, mRNA.
ACCESSION   NM_000617
VERSION     NM_000617.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4132)
  AUTHORS   Fenaroli,F., Valerio,A. and Ingrassia,R.
  TITLE     Ischemic Neuroprotection by Insulin with Down-Regulation of
            Divalent Metal Transporter 1 (DMT1) Expression and Ferrous
            Iron-Dependent Cell Death
  JOURNAL   Biomolecules 14 (7), 856 (2024)
   PUBMED   39062570
  REMARK    GeneRIF: Ischemic Neuroprotection by Insulin with Down-Regulation
            of Divalent Metal Transporter 1 (DMT1) Expression and Ferrous
            Iron-Dependent Cell Death.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4132)
  AUTHORS   Barra,J., Crosbourne,I., Roberge,C.L., Bossardi-Ramos,R.,
            Warren,J.S.A., Matteson,K., Wang,L., Jourd'heuil,F., Borisov,S.M.,
            Bresnahan,E., Bravo-Cordero,J.J., Dmitriev,R.I., Jourd'heuil,D.,
            Adam,A.P., Lamar,J.M., Corr,D.T. and Barroso,M.M.
  TITLE     DMT1-dependent endosome-mitochondria interactions regulate
            mitochondrial iron translocation and metastatic outgrowth
  JOURNAL   Oncogene 43 (9), 650-667 (2024)
   PUBMED   38184712
  REMARK    GeneRIF: DMT1-dependent endosome-mitochondria interactions regulate
            mitochondrial iron translocation and metastatic outgrowth.
REFERENCE   3  (bases 1 to 4132)
  AUTHORS   Tan,Q., Zhang,X., Li,S., Liu,W., Yan,J., Wang,S., Cui,F., Li,D. and
            Li,J.
  TITLE     DMT1 differentially regulates mitochondrial complex activities to
            reduce glutathione loss and mitigate ferroptosis
  JOURNAL   Free Radic Biol Med 207, 32-44 (2023)
   PUBMED   37419216
  REMARK    GeneRIF: DMT1 differentially regulates mitochondrial complex
            activities to reduce glutathione loss and mitigate ferroptosis.
REFERENCE   4  (bases 1 to 4132)
  AUTHORS   Tian,L., Li,X., Lai,H., Sun,T., Li,X., Wu,L., Wu,C., Yao,S.,
            Ren,Y., He,S. and Yang,G.
  TITLE     SLC11A2: a promising biomarker and therapeutic target in ovarian
            cancer
  JOURNAL   Sci Rep 13 (1), 1132 (2023)
   PUBMED   36670142
  REMARK    GeneRIF: SLC11A2: a promising biomarker and therapeutic target in
            ovarian cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4132)
  AUTHORS   Tabuchi,M., Tanaka,N., Nishida-Kitayama,J., Ohno,H. and Kishi,F.
  TITLE     Alternative splicing regulates the subcellular localization of
            divalent metal transporter 1 isoforms
  JOURNAL   Mol Biol Cell 13 (12), 4371-4387 (2002)
   PUBMED   12475959
REFERENCE   6  (bases 1 to 4132)
  AUTHORS   Hubert,N. and Hentze,M.W.
  TITLE     Previously uncharacterized isoforms of divalent metal transporter
            (DMT)-1: implications for regulation and cellular function
  JOURNAL   Proc Natl Acad Sci U S A 99 (19), 12345-12350 (2002)
   PUBMED   12209011
  REMARK    GeneRIF: iron regulation of DMT1 involves the expression of a
            previously unrecognized upstream 5' exon (exon 1A) of the human and
            murine DMT1 gene
REFERENCE   7  (bases 1 to 4132)
  AUTHORS   Lee,P.L., Gelbart,T., West,C., Halloran,C. and Beutler,E.
  TITLE     The human Nramp2 gene: characterization of the gene structure,
            alternative splicing, promoter region and polymorphisms
  JOURNAL   Blood Cells Mol Dis 24 (2), 199-215 (1998)
   PUBMED   9642100
REFERENCE   8  (bases 1 to 4132)
  AUTHORS   Kishi,F. and Tabuchi,M.
  TITLE     Complete nucleotide sequence of human NRAMP2 cDNA
  JOURNAL   Mol Immunol 34 (12-13), 839-842 (1997)
   PUBMED   9464519
REFERENCE   9  (bases 1 to 4132)
  AUTHORS   Fleming,M.D., Trenor,C.C. 3rd, Su,M.A., Foernzler,D., Beier,D.R.,
            Dietrich,W.F. and Andrews,N.C.
  TITLE     Microcytic anaemia mice have a mutation in Nramp2, a candidate iron
            transporter gene
  JOURNAL   Nat Genet 16 (4), 383-386 (1997)
   PUBMED   9241278
REFERENCE   10 (bases 1 to 4132)
  AUTHORS   Vidal,S., Belouchi,A.M., Cellier,M., Beatty,B. and Gros,P.
  TITLE     Cloning and characterization of a second human NRAMP gene on
            chromosome 12q13
  JOURNAL   Mamm Genome 6 (4), 224-230 (1995)
   PUBMED   7613023
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC100014.1, DA957633.1 and
            AB004857.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_000617.2.
            
            Summary: This gene encodes a member of the solute carrier family 11
            protein family. The product of this gene transports divalent metals
            and is involved in iron absorption. Mutations in this gene are
            associated with hypochromic microcytic anemia with iron overload. A
            related solute carrier family 11 protein gene is located on
            chromosome 2. Multiple transcript variants encoding different
            isoforms have been found for this gene.[provided by RefSeq, Apr
            2010].
            
            Transcript Variant: This variant (4) differs in the 5' UTR and 5'
            coding region compared to variant 1. The resulting protein (isoform
            3) has a shorter and distinct N-terminus compared to isoform 1.
            Variants 4, 5 and 6 encode isoform 3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100014.1, AB004857.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262052.9/ ENSP00000262052.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 BC100014.1         1-3
            4-557               DA957633.1         11-564
            558-2829            BC100014.1         558-2829
            2830-2969           AB004857.1         2805-2944
            2970-3241           BC100014.1         2970-3241
            3242-4130           AB004857.1         3215-4103
            4131-4132           BC100014.1         4130-4131
FEATURES             Location/Qualifiers
     source          1..4132
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.12"
     gene            1..4132
                     /gene="SLC11A2"
                     /gene_synonym="AHMIO1; DCT1; DMT1; NRAMP2"
                     /note="solute carrier family 11 member 2"
                     /db_xref="GeneID:4891"
                     /db_xref="HGNC:HGNC:10908"
                     /db_xref="MIM:600523"
     exon            1..75
                     /gene="SLC11A2"
                     /gene_synonym="AHMIO1; DCT1; DMT1; NRAMP2"
                     /inference="alignment:Splign:2.1.0"
     exon            76..147
                     /gene="SLC11A2"
                     /gene_synonym="AHMIO1; DCT1; DMT1; NRAMP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..1799
                     /gene="SLC11A2"
                     /gene_synonym="AHMIO1; DCT1; DMT1; NRAMP2"
                     /note="isoform 3 is encoded by transcript variant 4;
                     natural resistance-associated macrophage protein 2; DMT-1;
                     NRAMP 2; divalent cation transporter 1; solute carrier
                     family 11 (proton-coupled divalent metal ion
                     transporters), member 2; solute carrier family 11
                     (proton-coupled divalent metal ion transporter), member 2"
                     /codon_start=1
                     /product="natural resistance-associated macrophage protein
                     2 isoform 3"
                     /protein_id="NP_000608.1"
                     /db_xref="CCDS:CCDS8805.1"
                     /db_xref="GeneID:4891"
                     /db_xref="HGNC:HGNC:10908"
                     /db_xref="MIM:600523"
                     /translation="MVLGPEQKMSDDSVSGDHGESASLGNINPAYSNPSLSQSPGDSE
                     EYFATYFNEKISIPEEEYSCFSFRKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGF
                     KLLWILLLATLVGLLLQRLAARLGVVTGLHLAEVCHRQYPKVPRVILWLMVELAIIGS
                     DMQEVIGSAIAINLLSVGRIPLWGGVLITIADTFVFLFLDKYGLRKLEAFFGFLITIM
                     ALTFGYEYVTVKPSQSQVLKGMFVPSCSGCRTPQIEQAVGIVGAVIMPHNMYLHSALV
                     KSRQVNRNNKQEVREANKYFFIESCIALFVSFIINVFVVSVFAEAFFGKTNEQVVEVC
                     TNTSSPHAGLFPKDNSTLAVDIYKGGVVLGCYFGPAALYIWAVGILAAGQSSTMTGTY
                     SGQFVMEGFLNLKWSRFARVVLTRSIAIIPTLLVAVFQDVEHLTGMNDFLNVLQSLQL
                     PFALIPILTFTSLRPVMSDFANGLGWRIAGGILVLIICSINMYFVVVYVRDLGHVALY
                     VVAAVVSVAYLGFVFYLGWQCLIALGMSFLDCGHTVSISKGLLTEEATRGYVK"
     exon            148..296
                     /gene="SLC11A2"
                     /gene_synonym="AHMIO1; DCT1; DMT1; NRAMP2"
                     /inference="alignment:Splign:2.1.0"
     exon            297..422
                     /gene="SLC11A2"
                     /gene_synonym="AHMIO1; DCT1; DMT1; NRAMP2"
                     /inference="alignment:Splign:2.1.0"
     exon            423..542
                     /gene="SLC11A2"
                     /gene_synonym="AHMIO1; DCT1; DMT1; NRAMP2"
                     /inference="alignment:Splign:2.1.0"
     exon            543..649
                     /gene="SLC11A2"
                     /gene_synonym="AHMIO1; DCT1; DMT1; NRAMP2"
                     /inference="alignment:Splign:2.1.0"
     exon            650..720
                     /gene="SLC11A2"
                     /gene_synonym="AHMIO1; DCT1; DMT1; NRAMP2"
                     /inference="alignment:Splign:2.1.0"
     exon            721..788
                     /gene="SLC11A2"
                     /gene_synonym="AHMIO1; DCT1; DMT1; NRAMP2"
                     /inference="alignment:Splign:2.1.0"
     exon            789..944
                     /gene="SLC11A2"
                     /gene_synonym="AHMIO1; DCT1; DMT1; NRAMP2"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1103
                     /gene="SLC11A2"
                     /gene_synonym="AHMIO1; DCT1; DMT1; NRAMP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1190
                     /gene="SLC11A2"
                     /gene_synonym="AHMIO1; DCT1; DMT1; NRAMP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1310
                     /gene="SLC11A2"
                     /gene_synonym="AHMIO1; DCT1; DMT1; NRAMP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1460
                     /gene="SLC11A2"
                     /gene_synonym="AHMIO1; DCT1; DMT1; NRAMP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1534
                     /gene="SLC11A2"
                     /gene_synonym="AHMIO1; DCT1; DMT1; NRAMP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1688
                     /gene="SLC11A2"
                     /gene_synonym="AHMIO1; DCT1; DMT1; NRAMP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..4132
                     /gene="SLC11A2"
                     /gene_synonym="AHMIO1; DCT1; DMT1; NRAMP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4108..4113
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC11A2"
                     /gene_synonym="AHMIO1; DCT1; DMT1; NRAMP2"
                     /note="hexamer: ATTAAA"
     polyA_site      4132
                     /gene="SLC11A2"
                     /gene_synonym="AHMIO1; DCT1; DMT1; NRAMP2"
                     /note="major polyA site"
ORIGIN      
        1 agcgtggcgc tggctcccgg aatatggagc cctgggcgcg ggggcggcgt gtcaggtggt
       61 tgcggagctg gtaagaatca tattctaaga actcagccac tcaggtatcc accatggtgc
      121 tgggtcctga acagaagatg tcagatgaca gtgtttctgg agatcatggg gagtctgcca
      181 gtcttggtaa catcaaccct gcctatagta atccctctct ttcacagtcc cctggggact
      241 cagaggagta cttcgccact tactttaatg agaagatctc cattcctgag gaggagtact
      301 cttgttttag ctttcgtaaa ctctgggctt tcaccggacc aggttttctt atgagcattg
      361 cctacctgga tccaggaaat attgaatccg atttgcagtc tggagcagtg gctggattta
      421 agttgctctg gatccttctg ttggccaccc ttgtggggct gctgctccag cggcttgcag
      481 ctagactggg agtggttact gggctgcatc ttgctgaagt atgtcaccgt cagtatccca
      541 aggtcccacg agtcatcctg tggctgatgg tggagttggc tatcatcggc tcagacatgc
      601 aagaagtcat tggctcagcc attgctatca atcttctgtc tgtaggaaga attcctctgt
      661 ggggtggcgt tctcatcacc attgcagata cttttgtatt tctcttcttg gacaaatatg
      721 gcttgcggaa gctagaagca ttttttggct ttctcatcac tattatggcc ctcacatttg
      781 gatatgagta tgttacagtg aaacccagcc agagccaggt actcaagggc atgttcgtac
      841 catcctgttc aggctgtcgc actccacaga ttgaacaggc tgtgggcatc gtgggagctg
      901 tcatcatgcc acacaacatg tacctgcatt ctgccttagt caagtctaga caggtaaacc
      961 ggaacaataa gcaggaagtt cgagaagcca ataagtactt tttcattgaa tcctgcattg
     1021 cactctttgt ttccttcatc atcaatgtct ttgttgtctc agtctttgct gaagcatttt
     1081 ttgggaaaac caacgagcag gtggttgaag tctgtacaaa taccagcagt cctcatgctg
     1141 gcctctttcc taaagataac tcgacactgg ctgtggacat ctacaaaggg ggtgttgtgc
     1201 tgggatgtta ctttgggcct gctgcactct acatttgggc agtggggatc ctggctgcag
     1261 gacagagctc caccatgaca ggaacctatt ctggccagtt tgtcatggag ggattcctga
     1321 acctaaagtg gtcacgcttt gcccgagtgg ttctgactcg ctctattgcc atcatcccca
     1381 ctctgcttgt tgctgtcttc caagatgtag agcatctaac agggatgaat gactttctga
     1441 atgttctaca gagcttacag cttccctttg ctctcatacc catcctcaca tttacgagct
     1501 tgcggccagt aatgagtgac tttgccaatg gactaggctg gcggattgca ggaggaatct
     1561 tggtccttat catctgttcc atcaatatgt actttgtagt ggtttatgtc cgggacctag
     1621 ggcatgtggc attatatgtg gtggctgctg tggtcagcgt ggcttatctg ggctttgtgt
     1681 tctacttggg ttggcaatgt ttgattgcac tgggcatgtc cttcctggac tgtgggcata
     1741 cggtaagcat ctctaaaggc ctgctgacag aagaagccac ccgtggctac gttaaataac
     1801 actggattag tctgtcttct gcaggtagcc atcagagcca gtgtgtttct atggtttact
     1861 gtgtgaacat agccaaaagt atgtgccgtt gcacagactg tgtttatgac tcaaccgttg
     1921 gttggaaaag actttgtttc atgtgtattt gaaagatgga attatttttt ccttcctgac
     1981 ctaaccttag aactggatta gggtgggatc tttgaaaagc tgacatttgc tgctatcatt
     2041 ccaacactaa attcttaagt agttgcccaa gggccagctc agtttatcct tcggagagac
     2101 aaggatatgc atgattctta accaggctat atgttaaaaa aaaattggaa aatgcaatac
     2161 attttttatt atacaaacta cagaatgagt atgcaagttt tatttatcaa aatgtaatgg
     2221 atttttaaag gctgagaaat tttccttata cctacctttt cagttatttt aattatacca
     2281 aattatcaac tagaatagct tcatccatat gaaatataaa atgaagagac acctagctct
     2341 atcaggctta ggattctttg aacttatttc cactttaatt tctcagtgga agttaagagg
     2401 ggtgagaaaa caaagaaggg gaaaaactga caactaacaa aaccagcacc acatcgctag
     2461 gtggtgctta ctaattacct tctcaggatt ttcctcagat tgaaaagctt atgaggattt
     2521 cttgggagtc ttaataacct gcctgttagt acagagcttt cctgatgata tttactcttg
     2581 agcacatgtg gttgtaaaac cttaactttc tttctccagg agggtggtga tagaaacaga
     2641 tggtagtatt tatgaactga tgttctcgtg aaatgttgag ggtggggaga aaagacttta
     2701 agggaggaga gccatctatt ttgttcctaa agccacctct cagcagaatc gtcatgtttt
     2761 tctgatgcac cgctctgctt catgcccaag atgacttgcg aggcaatctc aggagctgtg
     2821 gacttaaccg ttgcaaagca cactgtcttt ctcagcgttc tctgcaagtc agtaggtgtt
     2881 agtatggttg caaagttcac tgtctcagca aagttgaact gggctacctc tctacagctg
     2941 tttcctcaga gggaaaaatc ttgagaccag atggtggagc tctggagtca gaggaaatgg
     3001 gtgtcttcag cacaaagctg ctgcttttac ttcagccact tctgacattt ttacataccg
     3061 agcctgagat tgtgtgatta tctcaaatca aatcactttg atggagataa ataatcaaaa
     3121 ctgttttata gtcattgatt tggtgagaac agtaatggaa aatggtgttg aaggacttct
     3181 catttttgga gctttccttc cagagtcctg gctgattggt gttcgctgtt catctgagcc
     3241 cccaaaagca ttattactga tacttgcaca cagtcaaaag cgcagactgg atggatggtc
     3301 ttttataagg catttaaggg tacactactg tgtttcactg accatacatt tttcttagcc
     3361 cctcaagtaa tatagcacag agttatgaat gacaattccc ctaaccattc ctcttcatat
     3421 ctgcctcttc cccttaccat cgtaattctc caaactggtc ataaaggcac tctgtgaaga
     3481 tattggggac tgacatctta agctctcacc tggctgcagt aggaaaggcc aaactgacga
     3541 caaaaaaaaa attctttata aagatgatat ggtaacatgt atctttgccc tgggtctggg
     3601 tgggtccagt cagtctcaga tttacaagca tttaggagcc taggtaaaag ctgctagtat
     3661 tcttttaaaa gttatattta tgacttgcaa tgatagaaaa ctccttccaa ttaaatggca
     3721 ttttataata ttatgtgtgt acttcacagt gttaaaaata ccctcatacg ttattgcatt
     3781 tgatcttcac agaaagtgca ttttaaccag tactctgggt gcaataaata atatgtagaa
     3841 atttaagtcc tccaattcca gcatatccag tgagttttga cagtgtgttt atgtggaatg
     3901 tttaaggata tacaattgta ctttatataa attggttctt gttcttctta aatgtgacat
     3961 gaaataattg tgctgctaca ttatactgga aattaacagg ggaaaaggga agagctcttg
     4021 gctcccttga ggttctgcta gtggtgttag gagtggttac aactgagctt ttagtaacca
     4081 tttaaccgta tgtaaacttg gtttctaatt aaaaaaaaat ttctttttcc aa
//
