LOCUS       NM_000578               3608 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens solute carrier family 11 member 1 (SLC11A1), mRNA.
ACCESSION   NM_000578
VERSION     NM_000578.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3608)
  AUTHORS   Wu,D., Zhou,Y., Shi,X., Yi,X., Sheng,Z., Fan,L., Ge,J., Cheng,W.,
            Zhou,W., He,H. and Fu,D.
  TITLE     SLC11A1 promotes kidney renal clear cell carcinoma (KIRC)
            progression by remodeling the tumor microenvironment
  JOURNAL   Toxicol Appl Pharmacol 487, 116975 (2024)
   PUBMED   38762191
  REMARK    GeneRIF: SLC11A1 promotes kidney renal clear cell carcinoma (KIRC)
            progression by remodeling the tumor microenvironment.
REFERENCE   2  (bases 1 to 3608)
  AUTHORS   Antony,B.S., Nagarajan,C., Devaraj,D.V. and Subbaraj,G.K.
  TITLE     A Systemic Review and Meta-analysis on Natural
            Resistance-associated Macrophage Protein 1 (3'-Untranslated Region)
            and Nucleotide-binding Oligomerization Domain-2 (rs8057341)
            Polymorphisms and Leprosy Susceptibility in Asian and Caucasian
            Populations
  JOURNAL   Int J Mycobacteriol 13 (2), 115-125 (2024)
   PUBMED   38916380
  REMARK    GeneRIF: A Systemic Review and Meta-analysis on Natural
            Resistance-associated Macrophage Protein 1 (3'-Untranslated Region)
            and Nucleotide-binding Oligomerization Domain-2 (rs8057341)
            Polymorphisms and Leprosy Susceptibility in Asian and Caucasian
            Populations.
            Review article
REFERENCE   3  (bases 1 to 3608)
  AUTHORS   Meng,C., Chen,G., Wen,D., Dong,L., Cui,X., Jing,X., Cui,J., Gao,Y.,
            Liu,Y., Bu,H. and Wu,C.
  TITLE     The expression of Nramp1 modulates the uptake of Mycobacterium
            tuberculosis by macrophages through alternating inflammatory
            responses
  JOURNAL   Tuberculosis (Edinb) 143, 102414 (2023)
   PUBMED   37820457
  REMARK    GeneRIF: The expression of Nramp1 modulates the uptake of
            Mycobacterium tuberculosis by macrophages through alternating
            inflammatory responses.
REFERENCE   4  (bases 1 to 3608)
  AUTHORS   Pauline,R., Devaraj,D.V., Sivasubramanian,J., Velmurugan,S.,
            Stephen,S.B., Yasam,S.K., Kulanthaivel,L. and Subbaraj,G.K.
  TITLE     Systemic assessment of solute carrier family 11-member A1
            (rs17235409) gene polymorphism and Mycobacterium Tuberculosis Risk
            in Asian and caucasian population: A comprehensive updated
            meta-analysis
  JOURNAL   Int J Mycobacteriol 12 (4), 467-477 (2023)
   PUBMED   38149545
  REMARK    GeneRIF: Systemic assessment of solute carrier family 11-member A1
            (rs17235409) gene polymorphism and Mycobacterium Tuberculosis Risk
            in Asian and caucasian population: A comprehensive updated
            meta-analysis.
REFERENCE   5  (bases 1 to 3608)
  AUTHORS   Waworuntu,W., Tanoerahardjo,F.S., Mallongi,A., Ahmad,A., Amin,M.,
            Djaharuddin,I., Bukhari,A., Tabri,N.A., Bahar,B., Hidayah,N.,
            Halik,H. and Massi,M.N.
  TITLE     Serum iron levels in tuberculosis patients and household contacts
            and its association with natural resistance-associated macrophage
            protein 1 polymorphism and expression
  JOURNAL   Clin Respir J 17 (9), 893-904 (2023)
   PUBMED   37607533
  REMARK    GeneRIF: Serum iron levels in tuberculosis patients and household
            contacts and its association with natural resistance-associated
            macrophage protein 1 polymorphism and expression.
REFERENCE   6  (bases 1 to 3608)
  AUTHORS   Liu,J., Fujiwara,T.M., Buu,N.T., Sanchez,F.O., Cellier,M.,
            Paradis,A.J., Frappier,D., Skamene,E., Gros,P., Morgan,K. et al.
  TITLE     Identification of polymorphisms and sequence variants in the human
            homologue of the mouse natural resistance-associated macrophage
            protein gene
  JOURNAL   Am J Hum Genet 56 (4), 845-853 (1995)
   PUBMED   7717395
REFERENCE   7  (bases 1 to 3608)
  AUTHORS   Blackwell,J.M., Barton,C.H., White,J.K., Searle,S., Baker,A.M.,
            Williams,H. and Shaw,M.A.
  TITLE     Genomic organization and sequence of the human NRAMP gene:
            identification and mapping of a promoter region polymorphism
  JOURNAL   Mol Med 1 (2), 194-205 (1995)
   PUBMED   8529098
REFERENCE   8  (bases 1 to 3608)
  AUTHORS   Kishi,F.
  TITLE     Isolation and characterization of human Nramp cDNA
  JOURNAL   Biochem Biophys Res Commun 204 (3), 1074-1080 (1994)
   PUBMED   7980580
REFERENCE   9  (bases 1 to 3608)
  AUTHORS   Cellier,M., Govoni,G., Vidal,S., Kwan,T., Groulx,N., Liu,J.,
            Sanchez,F., Skamene,E., Schurr,E. and Gros,P.
  TITLE     Human natural resistance-associated macrophage protein: cDNA
            cloning, chromosomal mapping, genomic organization, and
            tissue-specific expression
  JOURNAL   J Exp Med 180 (5), 1741-1752 (1994)
   PUBMED   7964458
REFERENCE   10 (bases 1 to 3608)
  AUTHORS   Vidal,S.M., Malo,D., Vogan,K., Skamene,E. and Gros,P.
  TITLE     Natural resistance to infection with intracellular parasites:
            isolation of a candidate for Bcg
  JOURNAL   Cell 73 (3), 469-485 (1993)
   PUBMED   8490962
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB284801.1, L32185.1,
            AC021016.5 and CA307182.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_000578.3.
            
            Summary: This gene is a member of the solute carrier family 11
            (proton-coupled divalent metal ion transporters) family and encodes
            a multi-pass membrane protein. The protein functions as a divalent
            transition metal (iron and manganese) transporter involved in iron
            metabolism and host resistance to certain pathogens. Mutations in
            this gene have been associated with susceptibility to infectious
            diseases such as tuberculosis and leprosy, and inflammatory
            diseases such as rheumatoid arthritis and Crohn disease.
            Alternatively spliced variants that encode different protein
            isoforms have been described but the full-length nature of only one
            has been determined. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.36007.1, D50402.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA2142363
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000233202.11/ ENSP00000233202.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                DB284801.1         245-273
            30-920              L32185.1           10-900
            921-1050            AC021016.5         135774-135903
            1051-1140           AC021016.5         137073-137162
            1141-1260           AC021016.5         137251-137370
            1261-1410           AC021016.5         138856-139005
            1411-1484           AC021016.5         139995-140068
            1485-1638           AC021016.5         140507-140660
            1639-3037           AC021016.5         140800-142198
            3038-3608           CA307182.1         14-584              c
FEATURES             Location/Qualifiers
     source          1..3608
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q35"
     gene            1..3608
                     /gene="SLC11A1"
                     /gene_synonym="LSH; NRAMP; NRAMP1"
                     /note="solute carrier family 11 member 1"
                     /db_xref="GeneID:6556"
                     /db_xref="HGNC:HGNC:10907"
                     /db_xref="MIM:600266"
     exon            1..103
                     /gene="SLC11A1"
                     /gene_synonym="LSH; NRAMP; NRAMP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1749
                     /gene="SLC11A1"
                     /gene_synonym="LSH; NRAMP; NRAMP1"
                     /note="solute carrier family 11 (sodium/phosphate
                     symporters), member 1; NRAMP 1; solute carrier family 11
                     (proton-coupled divalent metal ion transporters), member
                     1; solute carrier family 11 (proton-coupled divalent metal
                     ion transporter), member 1; Leishmaniasis resistance"
                     /codon_start=1
                     /product="natural resistance-associated macrophage protein
                     1"
                     /protein_id="NP_000569.3"
                     /db_xref="CCDS:CCDS2415.1"
                     /db_xref="GeneID:6556"
                     /db_xref="HGNC:HGNC:10907"
                     /db_xref="MIM:600266"
                     /translation="MTGDKGPQRLSGSSYGSISSPTSPTSPGPQQAPPRETYLSEKIP
                     IPDTKPGTFSLRKLWAFTGPGFLMSIAFLDPGNIESDLQAGAVAGFKLLWVLLWATVL
                     GLLCQRLAARLGVVTGKDLGEVCHLYYPKVPRTVLWLTIELAIVGSDMQEVIGTAIAF
                     NLLSAGRIPLWGGVLITIVDTFFFLFLDNYGLRKLEAFFGLLITIMALTFGYEYVVAR
                     PEQGALLRGLFLPSCPGCGHPELLQAVGIVGAIIMPHNIYLHSALVKSREIDRARRAD
                     IREANMYFLIEATIALSVSFIINLFVMAVFGQAFYQKTNQAAFNICANSSLHDYAKIF
                     PMNNATVAVDIYQGGVILGCLFGPAALYIWAIGLLAAGQSSTMTGTYAGQFVMEGFLR
                     LRWSRFARVLLTRSCAILPTVLVAVFRDLRDLSGLNDLLNVLQSLLLPFAVLPILTFT
                     SMPTLMQEFANGLLNKVVTSSIMVLVCAINLYFVVSYLPSLPHPAYFGLAALLAAAYL
                     GLSTYLVWTCCLAHGATFLAHSSHHHFLYGLLEEDQKGETSG"
     exon            104..246
                     /gene="SLC11A1"
                     /gene_synonym="LSH; NRAMP; NRAMP1"
                     /inference="alignment:Splign:2.1.0"
     exon            247..369
                     /gene="SLC11A1"
                     /gene_synonym="LSH; NRAMP; NRAMP1"
                     /inference="alignment:Splign:2.1.0"
     exon            370..489
                     /gene="SLC11A1"
                     /gene_synonym="LSH; NRAMP; NRAMP1"
                     /inference="alignment:Splign:2.1.0"
     exon            490..596
                     /gene="SLC11A1"
                     /gene_synonym="LSH; NRAMP; NRAMP1"
                     /inference="alignment:Splign:2.1.0"
     exon            597..667
                     /gene="SLC11A1"
                     /gene_synonym="LSH; NRAMP; NRAMP1"
                     /inference="alignment:Splign:2.1.0"
     exon            668..735
                     /gene="SLC11A1"
                     /gene_synonym="LSH; NRAMP; NRAMP1"
                     /inference="alignment:Splign:2.1.0"
     exon            736..891
                     /gene="SLC11A1"
                     /gene_synonym="LSH; NRAMP; NRAMP1"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1050
                     /gene="SLC11A1"
                     /gene_synonym="LSH; NRAMP; NRAMP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1140
                     /gene="SLC11A1"
                     /gene_synonym="LSH; NRAMP; NRAMP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1260
                     /gene="SLC11A1"
                     /gene_synonym="LSH; NRAMP; NRAMP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1410
                     /gene="SLC11A1"
                     /gene_synonym="LSH; NRAMP; NRAMP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1484
                     /gene="SLC11A1"
                     /gene_synonym="LSH; NRAMP; NRAMP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1638
                     /gene="SLC11A1"
                     /gene_synonym="LSH; NRAMP; NRAMP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..3608
                     /gene="SLC11A1"
                     /gene_synonym="LSH; NRAMP; NRAMP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3585..3590
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC11A1"
                     /gene_synonym="LSH; NRAMP; NRAMP1"
                     /note="hexamer: ATTAAA"
     polyA_site      3608
                     /gene="SLC11A1"
                     /gene_synonym="LSH; NRAMP; NRAMP1"
                     /note="major polyA site"
ORIGIN      
        1 acacttactt gcaccagtgc ccagagaggg ggtgcaggct gaggagctgc ccagagcacc
       61 gctcacactc ccagagtacc tgaagtcggc atttcaatga caggtgacaa gggtccccaa
      121 aggctaagcg ggtccagcta tggttccatc tccagcccga ccagcccgac cagcccaggg
      181 ccacagcaag cacctcccag agagacctac ctgagtgaga agatccccat cccagacaca
      241 aaaccgggca ccttcagcct gcggaagcta tgggccttca cggggcctgg cttcctcatg
      301 agcattgctt tcctggaccc aggaaacatc gagtcagatc ttcaggctgg cgccgtggcg
      361 ggattcaaac ttctctgggt gctgctctgg gccaccgtgt tgggcttgct ctgccagcga
      421 ctggctgcac gtctgggcgt ggtgacaggc aaggacttgg gcgaggtctg ccatctctac
      481 taccctaagg tgccccgcac cgtcctctgg ctgaccatcg agctagccat tgtgggctcc
      541 gacatgcagg aagtcatcgg cacggccatt gcattcaatc tgctctcagc tggacgaatc
      601 ccactctggg gtggcgtcct catcaccatc gtggacacct tcttcttcct cttcctcgat
      661 aactacgggc tgcggaagct ggaagctttt tttggactcc ttataaccat tatggccttg
      721 acctttggct atgagtatgt ggtggcgcgt cctgagcagg gagcgcttct tcggggcctg
      781 ttcctgccct cgtgcccggg ctgcggccac cccgagctgc tgcaggcggt gggcattgtt
      841 ggcgccatca tcatgcccca caacatctac ctgcactcgg ccctggtcaa gtctcgagag
      901 atagaccggg cccgccgagc agacatcaga gaagccaaca tgtacttcct gattgaggcc
      961 accatcgccc tgtccgtctc ctttatcatc aacctctttg tcatggctgt ctttgggcag
     1021 gccttctacc agaaaaccaa ccaggctgcg ttcaacatct gtgccaacag cagcctccac
     1081 gactacgcca agatcttccc catgaacaac gccaccgtgg ccgtggacat ttaccagggg
     1141 ggcgtgatcc tgggctgcct gttcggcccc gcggccctct acatctgggc cataggtctc
     1201 ctggcggctg ggcagagctc caccatgacg ggcacctacg cgggacagtt cgtgatggag
     1261 ggcttcctga ggctgcggtg gtcacgcttc gcccgtgtcc tcctcacccg ctcctgcgcc
     1321 atcctgccca ccgtgctcgt ggctgtcttc cgggacctga gggacttgtc gggcctcaat
     1381 gatctgctca acgtgctgca gagcctgctg ctcccgttcg ccgtgctgcc catcctcacg
     1441 ttcaccagca tgcccaccct catgcaggag tttgccaatg gcctgctgaa caaggtcgtc
     1501 acctcttcca tcatggtgct agtctgcgcc atcaacctct acttcgtggt cagctatctg
     1561 cccagcctgc cccaccctgc ctacttcggc cttgcagcct tgctggccgc agcctacctg
     1621 ggcctcagca cctacctggt ctggacctgt tgccttgccc acggagccac ctttctggcc
     1681 cacagctccc accaccactt cctgtatggg ctccttgaag aggaccagaa aggggagacc
     1741 tctggctagg cccacaccag ggcctggctg ggagtggcat gtatgacgtg actggcctgc
     1801 tggatgtgga gggggcgcgt gcaggcagca ggatagagtg ggacagttcc tgagaccagc
     1861 caacctgggg gctttaggga cctgctgttt cctagcgcag ccatgtgatt accctctggg
     1921 tctcagtgtc ctcatctgta aaatggagac accaccaccc ttgccatgga ggttaagcac
     1981 tttaacacag tgtctggcac ttgggacaaa aacaaacaaa cgaaaaacat ttcaaaaggt
     2041 atttattgag cacctgcagg cgtgacctga cagcccaagg gtgggtgggg tgagggcttg
     2101 aggacttggg cgggacacag gctccaaact ggagcttgaa atagtgtctg atgaatgtta
     2161 aattatctat ctatctattt atttatttat ttgagacagg gaaagggtct ccctctgttg
     2221 ccaaggctgg agtgcagtgg cgcaatctta actcattgca acctccacct tctgggttca
     2281 agcgattctc tttattcagc cccgggagtg gcgcgcgcca ccacgcccag ctaatttgtg
     2341 tattttcagc agagacgggg tttgccatgc tggccaggct ggtctcgaac tgctggattc
     2401 aagtgatccg cccatctccg tctcccaaag tgctgggaat tacaggcgtg agccaccaaa
     2461 cccggcctga ttaaagttaa ataaatacta gttcccttct cgtccaaagg agcagggaat
     2521 gggaaccggg aaggcacgaa gtctctaaag catccagaag acccctacac cagggtctgg
     2581 tccgctccta ttcgccgcag cctttctgtt ccgcctgcaa cccattttcc agacagtaaa
     2641 acggcggcgc acttctttct ccgtcaggca ccaggtcata aggaacccaa gagtctgtgc
     2701 ctctgaggcc caaattattt gctgtttcct caggggagcc ggcggccgcg actcccacgc
     2761 cgcgccgtta ccgctccctc tctgctgact gctcccccta ggggcagaga cggtcccgac
     2821 gcccgccatc ccgccccggc ctcacccctc cccgccaggc ggaacgacgc ggggaggcgg
     2881 gcgctcgggg ctcgcgccag gggccccaga atccttcggg gagagtgggt gggaggaagc
     2941 tgtgtgggcg gggagccccc tctgccttag ggagcggctg ggcacccatt cgccccattc
     3001 aggggctgca ctttatagac gttccctagg ctgtttctag gctcccccaa gtccctcctc
     3061 cagcctcgtc gggtccctca gaccccagcc caggacctgc ggagggccgc agcgaggaga
     3121 ggccaacagg cctttcccta gagttgaacc tgggccgggt gttgcacctg gaagaacccc
     3181 cgatttcctg gggacccagc agggcaggcg gcctggctcc gcgctcaggt ccggacgctt
     3241 gtttatgaga agaatttcct ctttcttaaa agggcaacga tgcgagtggg tccctcaagg
     3301 agagaagaga tgggaccggt ctggtgcgac ctgggcaagc gctgcagagg gtacctgggc
     3361 aagagggccg cccgcctcct ctgggtttgg cactggagaa gatgggtcca tgccagctga
     3421 aggaggagat ggatggggga cgtttagcga agaaaggcat ctcccagatc ctttagcctc
     3481 ctggaagtgc ccccgttgta ccccctacac acccctcttg gcattgagtg ccagtcctct
     3541 gccaggctct gtgttacaag ttggggaggg cggcaaagtc ccgaattaaa gatgtcagtt
     3601 ctcaagga
//
