LOCUS       NM_197965               1623 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens solute carrier family 10 member 6 (SLC10A6), mRNA.
ACCESSION   NM_197965 XM_293769
VERSION     NM_197965.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1623)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1623)
  AUTHORS   Grosser,G., Bennien,J., Sanchez-Guijo,A., Bakhaus,K., Doring,B.,
            Hartmann,M., Wudy,S.A. and Geyer,J.
  TITLE     Transport of steroid 3-sulfates and steroid 17-sulfates by the
            sodium-dependent organic anion transporter SOAT (SLC10A6)
  JOURNAL   J Steroid Biochem Mol Biol 179, 20-25 (2018)
   PUBMED   28951227
  REMARK    GeneRIF: SOAT substrates from the group of sulfated steroids are
            characterized by a planar and lipophilic steroid backbone in
            trans-trans-trans conformation of the rings and a negatively
            charged mono-sulfate group at positions 3' or 17' with flexibility
            for alpha- or beta- orientation. Furthermore, 5alpha-reduction,
            16alpha-hydroxylation, and 17alpha-hydroxylation are acceptable for
            SOAT substrate recognition, whereas addition ...
REFERENCE   3  (bases 1 to 1623)
  AUTHORS   Bakhaus,K., Fietz,D., Kliesch,S., Weidner,W., Bergmann,M. and
            Geyer,J.
  TITLE     The polymorphism L204F affects transport and membrane expression of
            the sodium-dependent organic anion transporter SOAT (SLC10A6)
  JOURNAL   J Steroid Biochem Mol Biol 179, 36-44 (2018)
   PUBMED   28951225
  REMARK    GeneRIF: SOAT-L204F polymorphism was found in men with normal
            spermatogenesis and with hypospermatogenesisSOAT-L204F polymorphism
            showed impaired membrane expression.The SOAT-L204F polymorphism
            showed reduced transport activity for dehydroepiandrosterone
            sulfate.
REFERENCE   4  (bases 1 to 1623)
  AUTHORS   Bennien,J., Fischer,T. and Geyer,J.
  TITLE     Rare genetic variants in the sodium-dependent organic anion
            transporter SOAT (SLC10A6): Effects on transport function and
            membrane expression
  JOURNAL   J Steroid Biochem Mol Biol 179, 26-35 (2018)
   PUBMED   28893621
  REMARK    GeneRIF: SOAT genetic variants L44P, Q75R, P107L, G109S, S112F,
            N113K, S133F, G241D, G263E, G294R, and Y308N showed no transport
            activity for dehydroepiandrosterone sulfate at all. In the case of
            P107L, G241D, G263E, and Y308N, this was most likely due to
            significantly reduced expression in the plasma membrane.
REFERENCE   5  (bases 1 to 1623)
  AUTHORS   Chen,G., Bentley,A., Adeyemo,A., Shriner,D., Zhou,J., Doumatey,A.,
            Huang,H., Ramos,E., Erdos,M., Gerry,N., Herbert,A., Christman,M.
            and Rotimi,C.
  TITLE     Genome-wide association study identifies novel loci association
            with fasting insulin and insulin resistance in African Americans
  JOURNAL   Hum Mol Genet 21 (20), 4530-4536 (2012)
   PUBMED   22791750
REFERENCE   6  (bases 1 to 1623)
  AUTHORS   Geyer,J., Doring,B., Meerkamp,K., Ugele,B., Bakhiya,N.,
            Fernandes,C.F., Godoy,J.R., Glatt,H. and Petzinger,E.
  TITLE     Cloning and functional characterization of human sodium-dependent
            organic anion transporter (SLC10A6)
  JOURNAL   J Biol Chem 282 (27), 19728-19741 (2007)
   PUBMED   17491011
REFERENCE   7  (bases 1 to 1623)
  AUTHORS   Geyer,J., Wilke,T. and Petzinger,E.
  TITLE     The solute carrier family SLC10: more than a family of bile acid
            transporters regarding function and phylogenetic relationships
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 372 (6), 413-431 (2006)
   PUBMED   16541252
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093827.3 and EF437223.1.
            
            On May 17, 2019 this sequence version replaced NM_197965.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF437223.1, SRR1803616.309206.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000273905.7/ ENSP00000273905.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               AC093827.3         2134-2254           c
            122-1623            EF437223.1         1-1502
FEATURES             Location/Qualifiers
     source          1..1623
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.3"
     gene            1..1623
                     /gene="SLC10A6"
                     /gene_synonym="SOAT"
                     /note="solute carrier family 10 member 6"
                     /db_xref="GeneID:345274"
                     /db_xref="HGNC:HGNC:30603"
                     /db_xref="MIM:613366"
     exon            1..646
                     /gene="SLC10A6"
                     /gene_synonym="SOAT"
                     /inference="alignment:Splign:2.1.0"
     CDS             270..1403
                     /gene="SLC10A6"
                     /gene_synonym="SOAT"
                     /note="solute carrier family 10 (sodium/bile acid
                     cotransporter family), member 6; solute carrier family 10
                     (sodium/bile acid cotransporter), member 6"
                     /codon_start=1
                     /product="sodium-dependent organic anion transporter"
                     /protein_id="NP_932069.1"
                     /db_xref="CCDS:CCDS3614.1"
                     /db_xref="GeneID:345274"
                     /db_xref="HGNC:HGNC:30603"
                     /db_xref="MIM:613366"
                     /translation="MRANCSSSSACPANSSEEELPVGLEVHGNLELVFTVVSTVMMGL
                     LMFSLGCSVEIRKLWSHIRRPWGIAVGLLCQFGLMPFTAYLLAISFSLKPVQAIAVLI
                     MGCCPGGTISNIFTFWVDGDMDLSISMTTCSTVAALGMMPLCIYLYTWSWSLQQNLTI
                     PYQNIGITLVCLTIPVAFGVYVNYRWPKQSKIILKIGAVVGGVLLLVVAVAGVVLAKG
                     SWNSDITLLTISFIFPLIGHVTGFLLALFTHQSWQRCRTISLETGAQNIQMCITMLQL
                     SFTAEHLVQMLSFPLAYGLFQLIDGFLIVAAYQTYKRRLKNKHGKKNSGCTEVCHTRK
                     STSSRETNAFLEVNEEGAITPGPPGPMDCHRALEPVGHITSCE"
     exon            647..765
                     /gene="SLC10A6"
                     /gene_synonym="SOAT"
                     /inference="alignment:Splign:2.1.0"
     exon            766..854
                     /gene="SLC10A6"
                     /gene_synonym="SOAT"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1030
                     /gene="SLC10A6"
                     /gene_synonym="SOAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1188
                     /gene="SLC10A6"
                     /gene_synonym="SOAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1623
                     /gene="SLC10A6"
                     /gene_synonym="SOAT"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acatacatat tcagtggtga gtaagaacag aagtggaaag ccttacttac cacagtttat
       61 tatatgtttc atgcctgtga taattacttt tataatgcca cttgtgaaaa aattgatcag
      121 attaggatga atcaccttgc tggccaacag ttattggaat gattctccat gtgtgacttc
      181 gttgcactat tacaaaatgt ggcaggatag acctgcccag ccattgttgc cgatgttcat
      241 ttgtaatgct gccttaagga gatgaggaga tgagagccaa ttgttccagc agctcagcct
      301 gccctgccaa cagttcagag gaggagctgc cagtgggact ggaggtgcat ggaaacctgg
      361 agctcgtttt cacagtggtg tccactgtga tgatggggct gctcatgttc tctttgggat
      421 gttccgtgga gatccggaag ctgtggtcgc acatcaggag accctggggc attgctgtgg
      481 gactgctctg ccagtttggg ctcatgcctt ttacagctta tctcctggcc attagctttt
      541 ctctgaagcc agtccaagct attgctgttc tcatcatggg ctgctgcccg gggggcacca
      601 tctctaacat tttcaccttc tgggttgatg gagatatgga tctcagcatc agtatgacaa
      661 cctgttccac cgtggccgcc ctgggaatga tgccactctg catttatctc tacacctggt
      721 cctggagtct tcagcagaat ctcaccattc cttatcagaa cataggaatt acccttgtgt
      781 gcctgaccat tcctgtggcc tttggtgtct atgtgaatta cagatggcca aaacaatcca
      841 aaatcattct caagattggg gccgttgttg gtggggtcct ccttctggtg gtcgcagttg
      901 ctggtgtggt cctggcgaaa ggatcttgga attcagacat cacccttctg accatcagtt
      961 tcatctttcc tttgattggc catgtcacgg gttttctgct ggcacttttt acccaccagt
     1021 cttggcaaag gtgcaggaca atttccttag aaactggagc tcagaatatt cagatgtgca
     1081 tcaccatgct ccagttatct ttcactgctg agcacttggt ccagatgttg agtttcccac
     1141 tggcctatgg actcttccag ctgatagatg gatttcttat tgttgcagca tatcagacgt
     1201 acaagaggag attgaagaac aaacatggaa aaaagaactc aggttgcaca gaagtctgcc
     1261 atacgaggaa atcgacttct tccagagaga ccaatgcctt cttggaggtg aatgaagaag
     1321 gtgccatcac tcctgggcca ccagggccaa tggattgcca cagggctctc gagccagttg
     1381 gccacatcac ttcatgtgaa tagcagggac tagctggctg gactggcccc cttctttttc
     1441 agtggccagt aaagacagtg tgcagctgac acatgaatct tgttggtagg gccagtgtga
     1501 atatttaagt gttcaatgtt agaatattta tattttcatg tggattgtga attgtgatgg
     1561 gatcactttt ggagattccc atttcaggga gtttcttctg ggggttaaca taacgtatca
     1621 atg
//
