LOCUS       NM_001010893            1428 bp    mRNA    linear   PRI 15-SEP-2020
DEFINITION  Homo sapiens solute carrier family 10 member 5 (SLC10A5), mRNA.
ACCESSION   NM_001010893 XM_376781
VERSION     NM_001010893.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1428)
  AUTHORS   Pharoah PD, Tsai YY, Ramus SJ, Phelan CM, Goode EL, Lawrenson K,
            Buckley M, Fridley BL, Tyrer JP, Shen H, Weber R, Karevan R, Larson
            MC, Song H, Tessier DC, Bacot F, Vincent D, Cunningham JM, Dennis
            J, Dicks E, Aben KK, Anton-Culver H, Antonenkova N, Armasu SM,
            Baglietto L, Bandera EV, Beckmann MW, Birrer MJ, Bloom G, Bogdanova
            N, Brenton JD, Brinton LA, Brooks-Wilson A, Brown R, Butzow R,
            Campbell I, Carney ME, Carvalho RS, Chang-Claude J, Chen YA, Chen
            Z, Chow WH, Cicek MS, Coetzee G, Cook LS, Cramer DW, Cybulski C,
            Dansonka-Mieszkowska A, Despierre E, Doherty JA, Dork T, du Bois A,
            Durst M, Eccles D, Edwards R, Ekici AB, Fasching PA, Fenstermacher
            D, Flanagan J, Gao YT, Garcia-Closas M, Gentry-Maharaj A, Giles G,
            Gjyshi A, Gore M, Gronwald J, Guo Q, Halle MK, Harter P, Hein A,
            Heitz F, Hillemanns P, Hoatlin M, Hogdall E, Hogdall CK, Hosono S,
            Jakubowska A, Jensen A, Kalli KR, Karlan BY, Kelemen LE, Kiemeney
            LA, Kjaer SK, Konecny GE, Krakstad C, Kupryjanczyk J, Lambrechts D,
            Lambrechts S, Le ND, Lee N, Lee J, Leminen A, Lim BK, Lissowska J,
            Lubinski J, Lundvall L, Lurie G, Massuger LF, Matsuo K, McGuire V,
            McLaughlin JR, Menon U, Modugno F, Moysich KB, Nakanishi T, Narod
            SA, Ness RB, Nevanlinna H, Nickels S, Noushmehr H, Odunsi K, Olson
            S, Orlow I, Paul J, Pejovic T, Pelttari LM, Permuth-Wey J, Pike MC,
            Poole EM, Qu X, Risch HA, Rodriguez-Rodriguez L, Rossing MA,
            Rudolph A, Runnebaum I, Rzepecka IK, Salvesen HB, Schwaab I, Severi
            G, Shen H, Shridhar V, Shu XO, Sieh W, Southey MC, Spellman P,
            Tajima K, Teo SH, Terry KL, Thompson PJ, Timorek A, Tworoger SS,
            van Altena AM, van den Berg D, Vergote I, Vierkant RA, Vitonis AF,
            Wang-Gohrke S, Wentzensen N, Whittemore AS, Wik E, Winterhoff B,
            Woo YL, Wu AH, Yang HP, Zheng W, Ziogas A, Zulkifli F, Goodman MT,
            Hall P, Easton DF, Pearce CL, Berchuck A, Chenevix-Trench G,
            Iversen E, Monteiro AN, Gayther SA, Schildkraut JM and Sellers TA.
  CONSRTM   Australian Cancer Study; Australian Ovarian Cancer Study Group
  TITLE     GWAS meta-analysis and replication identifies three new
            susceptibility loci for ovarian cancer
  JOURNAL   Nat. Genet. 45 (4), 362-370 (2013)
   PUBMED   23535730
REFERENCE   2  (bases 1 to 1428)
  AUTHORS   Fernandes CF, Godoy JR, Doring B, Cavalcanti MC, Bergmann M,
            Petzinger E and Geyer J.
  TITLE     The novel putative bile acid transporter SLC10A5 is highly
            expressed in liver and kidney
  JOURNAL   Biochem. Biophys. Res. Commun. 361 (1), 26-32 (2007)
   PUBMED   17632081
  REMARK    GeneRIF: Molecular cloning and characterization of SLC10A5 as an
            orphan carrier with yet non-identified substrates.
REFERENCE   3  (bases 1 to 1428)
  AUTHORS   Geyer J, Wilke T and Petzinger E.
  TITLE     The solute carrier family SLC10: more than a family of bile acid
            transporters regarding function and phylogenetic relationships
  JOURNAL   Naunyn Schmiedebergs Arch. Pharmacol. 372 (6), 413-431 (2006)
   PUBMED   16541252
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132219.3 and BC136625.1.
            
            On Jun 4, 2019 this sequence version replaced NM_001010893.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC136631.1, SRR1803611.277196.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000518568.3/ ENSP00000428612.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC132219.3         4391-4396           c
            7-511               BC136625.1         1-505
            512-512             AC132219.3         3885-3885           c
            513-1428            BC136625.1         507-1422
FEATURES             Location/Qualifiers
     source          1..1428
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.13"
     gene            1..1428
                     /gene="SLC10A5"
                     /gene_synonym="P5"
                     /note="solute carrier family 10 member 5"
                     /db_xref="GeneID:347051"
                     /db_xref="HGNC:HGNC:22981"
                     /db_xref="MIM:618582"
     exon            1..1428
                     /gene="SLC10A5"
                     /gene_synonym="P5"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1403
                     /gene="SLC10A5"
                     /gene_synonym="P5"
                     /note="solute carrier family 10 (sodium/bile acid
                     cotransporter family), member 5; Na(+)/bile acid
                     cotransporter 5; sodium/bile acid cotransporter 5"
                     /codon_start=1
                     /product="sodium/bile acid cotransporter 5 precursor"
                     /protein_id="NP_001010893.1"
                     /db_xref="CCDS:CCDS34915.1"
                     /db_xref="GeneID:347051"
                     /db_xref="HGNC:HGNC:22981"
                     /db_xref="MIM:618582"
                     /translation="MIRKLFIVLLLLLVTIEEARMSSLSFLNIEKTEILFFTKTEETI
                     LVSSSYENKRPNSSHLFVKIEDPKILQMVNVAKKISSDATNFTINLVTDEEGETNVTI
                     QLWDSEGRQERLIEEIKNVKVKVLKQKDSLLQAPMHIDRNILMLILPLILLNKCAFGC
                     KIELQLFQTVWKRPLPVILGAVTQFFLMPFCGFLLSQIVALPEAQAFGVVMTCTCPGG
                     GGGYLFALLLDGDFTLAILMTCTSTLLALIMMPVNSYIYSRILGLSGTFHIPVSKIVS
                     TLLFILVPVSIGIVIKHRIPEKASFLERIIRPLSFILMFVGIYLTFTVGLVFLKTDNL
                     EVILLGLLVPALGLLFGYSFAKVCTLPLPVCKTVAIESGMLNSFLALAVIQLSFPQSK
                     ANLASVAPFTVAMCSGCEMLLIILVYKAKKRCIFFLQDKRKRNFLI"
     regulatory      1406..1411
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC10A5"
                     /gene_synonym="P5"
                     /note="hexamer: ATTAAA"
     polyA_site      1428
                     /gene="SLC10A5"
                     /gene_synonym="P5"
                     /note="major polyA site"
ORIGIN      
        1 agactgtcac tggaacacct gcatgaagaa tgttctttca ttttttaaaa acgattttgc
       61 atatatgatt tatttcagct ttcaaaatga ttagaaaact ttttattgtt ctacttttgt
      121 tgcttgtgac tatagaagaa gcaaggatgt catcgctcag ttttctgaat atagagaaga
      181 ctgaaatact atttttcaca aagactgaag aaaccatcct tgtaagttca agctacgaaa
      241 ataaacggcc taattccagc cacctctttg tgaaaataga agatcctaaa atactacaaa
      301 tggtgaatgt ggccaagaag atctcatcag atgctacaaa ctttaccata aatctggtga
      361 ctgatgaaga aggagaaaca aatgtgacta ttcaactctg ggattctgaa ggtaggcaag
      421 aaagactcat tgaagaaatc aagaatgtga aagtcaaagt gctcaaacaa aaagacagtc
      481 tactccaggc accaatgcat attgatagaa atatcctaat gcttatttta ccactaatac
      541 tattgaataa gtgtgcattt ggttgtaaga ttgaattaca gctgtttcaa acagtatgga
      601 agagaccttt gccagtaatt cttggggcag ttacacagtt ttttctgatg ccattttgcg
      661 ggtttctttt gtctcagatt gtggcattgc ctgaggcgca agcttttgga gttgtaatga
      721 cctgcacgtg cccaggaggg ggtgggggct atctctttgc tctgcttcta gatggagatt
      781 tcacattggc cattttgatg acttgcacat caacattatt ggctctgatc atgatgcctg
      841 tcaattctta tatatacagt aggatattag ggttgtcagg tacattccat attcctgttt
      901 ctaaaattgt gtcaacactc cttttcatac ttgtgccagt atcaattgga atagtcatca
      961 agcatagaat acctgaaaaa gcaagcttct tagagagaat aattagacct ctgagtttta
     1021 ttttaatgtt cgtaggaatt tatttgactt tcacagtggg attagtgttc ttaaaaacag
     1081 ataatctaga ggtgattctg ttgggtctct tagttcctgc tttgggtttg ctgtttgggt
     1141 actcctttgc taaagtttgt acgctgcctc ttcctgtttg taaaactgtt gctattgaaa
     1201 gtgggatgtt aaatagtttc ttagctcttg ccgttattca gctgtctttt ccacagtcca
     1261 aggccaattt agcttctgtg gctcctttta cagtagccat gtgttctgga tgtgaaatgt
     1321 tactgatcat tctagtttac aaggctaaga aaagatgtat ctttttctta caagataaaa
     1381 ggaaaagaaa tttcctaatc taacaattaa agcattactg aattccta
//
