LOCUS       NM_152679               2120 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens solute carrier family 10 member 4 (SLC10A4), mRNA.
ACCESSION   NM_152679
VERSION     NM_152679.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2120)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2120)
  AUTHORS   Schmidt,S., Moncada,M., Burger,S. and Geyer,J.
  TITLE     Expression, sorting and transport studies for the orphan carrier
            SLC10A4 in neuronal and non-neuronal cell lines and in Xenopus
            laevis oocytes
  JOURNAL   BMC Neurosci 16, 35 (2015)
   PUBMED   26084360
  REMARK    GeneRIF: SLC10A4 failed to show transport activity for a series of
            neurotransmitters and neuromodulators, indicating that SLC10A4 does
            not seem to represent a typical neurotransmitter transporter such
            as DAT, SERT, CHT1 or VMAT2
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2120)
  AUTHORS   Abe,T., Kanemitu,Y., Nakasone,M., Kawahata,I., Yamakuni,T.,
            Nakajima,A., Suzuki,N., Nishikawa,M., Hishinuma,T. and Tomioka,Y.
  TITLE     SLC10A4 is a protease-activated transporter that transports bile
            acids
  JOURNAL   J Biochem 154 (1), 93-101 (2013)
   PUBMED   23589386
  REMARK    GeneRIF: The extracellular N-terminus of SLC10A4 was predicted to
            be relatively longer at the amino acid level than those of SLC10A1,
            SLC10A2 and SLC10A6. We examined the relationship between the
            N-terminus and transport activity of SLC10A4.
REFERENCE   4  (bases 1 to 2120)
  AUTHORS   Popova,S.N. and Alafuzoff,I.
  TITLE     Distribution of SLC10A4, a synaptic vesicle protein in the human
            brain, and the association of this protein with Alzheimer's
            disease-related neuronal degeneration
  JOURNAL   J Alzheimers Dis 37 (3), 603-610 (2013)
   PUBMED   23948907
  REMARK    GeneRIF: Depletion of SLC10A4 is observed in the brain with
            increased severity of Alzheimer's disease-related neuronal
            degeneration.
REFERENCE   5  (bases 1 to 2120)
  AUTHORS   Jostins,L., Ripke,S., Weersma,R.K., Duerr,R.H., McGovern,D.P.,
            Hui,K.Y., Lee,J.C., Schumm,L.P., Sharma,Y., Anderson,C.A.,
            Essers,J., Mitrovic,M., Ning,K., Cleynen,I., Theatre,E.,
            Spain,S.L., Raychaudhuri,S., Goyette,P., Wei,Z., Abraham,C.,
            Achkar,J.P., Ahmad,T., Amininejad,L., Ananthakrishnan,A.N.,
            Andersen,V., Andrews,J.M., Baidoo,L., Balschun,T., Bampton,P.A.,
            Bitton,A., Boucher,G., Brand,S., Buning,C., Cohain,A., Cichon,S.,
            D'Amato,M., De Jong,D., Devaney,K.L., Dubinsky,M., Edwards,C.,
            Ellinghaus,D., Ferguson,L.R., Franchimont,D., Fransen,K.,
            Gearry,R., Georges,M., Gieger,C., Glas,J., Haritunians,T., Hart,A.,
            Hawkey,C., Hedl,M., Hu,X., Karlsen,T.H., Kupcinskas,L.,
            Kugathasan,S., Latiano,A., Laukens,D., Lawrance,I.C., Lees,C.W.,
            Louis,E., Mahy,G., Mansfield,J., Morgan,A.R., Mowat,C., Newman,W.,
            Palmieri,O., Ponsioen,C.Y., Potocnik,U., Prescott,N.J.,
            Regueiro,M., Rotter,J.I., Russell,R.K., Sanderson,J.D., Sans,M.,
            Satsangi,J., Schreiber,S., Simms,L.A., Sventoraityte,J.,
            Targan,S.R., Taylor,K.D., Tremelling,M., Verspaget,H.W., De Vos,M.,
            Wijmenga,C., Wilson,D.C., Winkelmann,J., Xavier,R.J., Zeissig,S.,
            Zhang,B., Zhang,C.K., Zhao,H., Silverberg,M.S., Annese,V.,
            Hakonarson,H., Brant,S.R., Radford-Smith,G., Mathew,C.G.,
            Rioux,J.D., Schadt,E.E., Daly,M.J., Franke,A., Parkes,M.,
            Vermeire,S., Barrett,J.C. and Cho,J.H.
  CONSRTM   International IBD Genetics Consortium (IIBDGC)
  TITLE     Host-microbe interactions have shaped the genetic architecture of
            inflammatory bowel disease
  JOURNAL   Nature 491 (7422), 119-124 (2012)
   PUBMED   23128233
REFERENCE   6  (bases 1 to 2120)
  AUTHORS   Splinter,P.L., Lazaridis,K.N., Dawson,P.A. and LaRusso,N.F.
  TITLE     Cloning and expression of SLC10A4, a putative organic anion
            transport protein
  JOURNAL   World J Gastroenterol 12 (42), 6797-6805 (2006)
   PUBMED   17106928
  REMARK    GeneRIF: Northern analysis revealed that SLC10A4 mRNA is
            ubiquitously expressed in human tissues with the highest levels of
            mRNA expression in brain, placenta, and liver.
REFERENCE   7  (bases 1 to 2120)
  AUTHORS   Geyer,J., Wilke,T. and Petzinger,E.
  TITLE     The solute carrier family SLC10: more than a family of bile acid
            transporters regarding function and phylogenetic relationships
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 372 (6), 413-431 (2006)
   PUBMED   16541252
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK126542.1, BC019066.2, AA776274.1, AI421729.1 and AC096952.5.
            
            On Nov 23, 2018 this sequence version replaced NM_152679.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK126542.1, BC019066.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000273861.5/ ENSP00000273861.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                AK126542.1         1-89
            90-1741             BC019066.2         1-1652
            1742-1911           AA776274.1         10-179              c
            1912-2118           AI421729.1         1-207               c
            2119-2120           AC096952.5         93302-93303
FEATURES             Location/Qualifiers
     source          1..2120
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p11"
     gene            1..2120
                     /gene="SLC10A4"
                     /gene_synonym="P4"
                     /note="solute carrier family 10 member 4"
                     /db_xref="GeneID:201780"
                     /db_xref="HGNC:HGNC:22980"
                     /db_xref="MIM:618563"
     exon            1..809
                     /gene="SLC10A4"
                     /gene_synonym="P4"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..1533
                     /gene="SLC10A4"
                     /gene_synonym="P4"
                     /note="bile acid transporter SLC10A4; solute carrier
                     family 10 (sodium/bile acid cotransporter family), member
                     4; Na(+)/bile acid cotransporter 4"
                     /codon_start=1
                     /product="sodium/bile acid cotransporter 4"
                     /protein_id="NP_689892.1"
                     /db_xref="CCDS:CCDS3482.1"
                     /db_xref="GeneID:201780"
                     /db_xref="HGNC:HGNC:22980"
                     /db_xref="MIM:618563"
                     /translation="MDGNDNVTLLFAPLLRDNYTLAPNASSLGPGTDLALAPASSAGP
                     GPGLSLGPGPSFGFSPGPTPTPEPTTSGLAGGAASHGPSPFPRPWAPHALPFWDTPLN
                     HGLNVFVGAALCITMLGLGCTVDVNHFGAHVRRPVGALLAALCQFGLLPLLAFLLALA
                     FKLDEVAAVAVLLCGCCPGGNLSNLMSLLVDGDMNLSIIMTISSTLLALVLMPLCLWI
                     YSWAWINTPIVQLLPLGTVTLTLCSTLIPIGLGVFIRYKYSRVADYIVKVSLWSLLVT
                     LVVLFIMTGTMLGPELLASIPAAVYVIAIFMPLAGYASGYGLATLFHLPPNCKRTVCL
                     ETGSQNVQLCTAILKLAFPPQFIGSMYMFPLLYALFQSAEAGIFVLIYKMYGSEMLHK
                     RDPLDEDEDTDISYKKLKEEEMADTSYGTVKAENIIMMETAQTSL"
     exon            810..1020
                     /gene="SLC10A4"
                     /gene_synonym="P4"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..2120
                     /gene="SLC10A4"
                     /gene_synonym="P4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1757..1762
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC10A4"
                     /gene_synonym="P4"
                     /note="hexamer: ATTAAA"
     polyA_site      1786
                     /gene="SLC10A4"
                     /gene_synonym="P4"
                     /note="major polyA site"
     regulatory      2093..2098
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC10A4"
                     /gene_synonym="P4"
                     /note="hexamer: AATGAA"
     polyA_site      2120
                     /gene="SLC10A4"
                     /gene_synonym="P4"
                     /note="major polyA site"
ORIGIN      
        1 acccgggggg ccgcgctgcg cggagtgcca ggctgcgggc ggctgcagac ctgggagcgg
       61 agaccggccc gccgcccccg acgccgccga gcacgtcagc ggcgcgcagc cggggctcgg
      121 agaccgacgg gcagaacgac gggcggcgac tgcggcgacc gcgggacggc gagaggcacg
      181 cggcgggagg ggaccggaat ccgcagctcc ggccgcgcca tggacggcaa cgacaacgtg
      241 accctgctct tcgcccctct gctgcgggac aactacaccc tggcgcccaa tgccagcagc
      301 ctgggccccg gcacggacct cgccctcgcc cctgcctcca gcgccggccc cggccctggg
      361 ctcagcctcg ggccgggtcc gagcttcggc ttcagccccg gccccactcc gaccccggag
      421 cccacgacca gcggcctcgc gggcggcgcg gcgagccacg gcccttcccc gttccctcgg
      481 ccctgggcgc cccacgcgct cccgttctgg gacacgccgc tgaaccacgg gctgaacgtg
      541 ttcgtgggcg ccgccctgtg catcaccatg ctgggcctgg gctgcacggt ggacgtgaac
      601 cacttcgggg cgcacgtccg tcggcccgtg ggcgcgctgc tggcagcgct ctgccagttc
      661 ggcctcctgc cgctgctggc cttcctgctg gccctcgcct tcaagctgga cgaggtggcc
      721 gccgtggcgg tgctcctgtg tggctgctgt cccggcggca atctctccaa tcttatgtcc
      781 ctgctggttg acggcgacat gaacctcagc atcatcatga ccatctcctc cacgcttctg
      841 gccctcgtct tgatgcccct gtgcctgtgg atctacagct gggcttggat caacacccct
      901 atcgtgcagt tactacccct agggaccgtg accctgactc tctgcagcac tctcatacct
      961 atcgggttgg gcgtcttcat tcgctacaaa tacagccggg tggctgacta cattgtgaag
     1021 gtttccctgt ggtctctgct agtgactctg gtggtccttt tcataatgac cggcactatg
     1081 ttaggacctg aactgctggc aagtatccct gcagctgttt atgtgatagc aatttttatg
     1141 cctttggcag gctacgcttc aggttatggt ttagctactc tcttccatct tccacccaac
     1201 tgcaagagga ctgtatgtct ggaaacaggt agtcagaatg tgcagctctg tacagccatt
     1261 ctaaaactgg cctttccacc gcaattcata ggaagcatgt acatgtttcc tttgctgtat
     1321 gcacttttcc agtctgcaga agcggggatt tttgttttaa tctataaaat gtatggaagt
     1381 gaaatgttgc acaagcgaga tcctctagat gaagatgaag atacagatat ttcttataaa
     1441 aaactaaaag aagaggaaat ggcagacact tcctatggca cagtgaaagc agaaaatata
     1501 ataatgatgg aaaccgctca gacttctctc taaatgtgga gatacacagg agcttctatc
     1561 ttgctgaaat attgcttcat atttatagcc tgtggtagtg cacatggtta acataaaaga
     1621 taacactggt tcacatcata catgtaacaa ttctgatctt tttaaggttc actggtgtat
     1681 taaccaaacg ttgtcacaaa ttacaaatca atgctgtaat ataatttgca cctggaatgg
     1741 ctaacgtgaa gcctgaatta aatgtggttt ttagttttta ccatcaccaa tttctatgac
     1801 tgttgcaaat acagaatcta ttagaaaaca gggtcttgga aatgtagaat tttggcgcac
     1861 tatgaggaaa aacaagctat ctttgtaaag cataattgag tttaatgtaa ttgttgtaaa
     1921 aaaaaaagtg tgcttgctct acttaaaatt cctcacaatg ttgaattttg acctgtattc
     1981 agaagaattc caaaacaggt cagttaaata aggaaatata gtatttgtca aaccagtatc
     2041 agagaaaagt tacattaatg tatttgatta cttgatctgg tatctactta ttaatgaata
     2101 atcaacattt ttctagtgga
//
