LOCUS       NM_003049               2002 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens solute carrier family 10 member 1 (SLC10A1), mRNA.
ACCESSION   NM_003049
VERSION     NM_003049.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2002)
  AUTHORS   Ibrahim,M.K., Liu,C.-D., Zhang,L., Yu,X., Kim,E.S., Liu,Z., Jo,S.,
            Liu,Y., Huang,Y., Gao,S.-J. and Guo,H.
  TITLE     The loss of hepatitis B virus receptor NTCP/SLC10A1 in human liver
            cancer cells is due to epigenetic silencing
  JOURNAL   J Virol 98 (10), e0118724 (2024)
   PUBMED   39297647
  REMARK    GeneRIF: The loss of hepatitis B virus receptor NTCP/SLC10A1 in
            human liver cancer cells is due to epigenetic silencing.
REFERENCE   2  (bases 1 to 2002)
  AUTHORS   Ko,Y.L., Tuan,W.L., Teng,M.S., Su,W.C., Wang,C.C., Er,L.K., Wu,S.
            and Hsu,L.A.
  TITLE     SLC10A1 rs2296651 variant (S267F mutation) predicts biochemical
            traits, hepatitis B virus infection susceptibility and the risk of
            gallstone disease
  JOURNAL   Mol Genet Genomics 299 (1), 62 (2024)
   PUBMED   38869622
  REMARK    GeneRIF: SLC10A1 rs2296651 variant (S267F mutation) predicts
            biochemical traits, hepatitis B virus infection susceptibility and
            the risk of gallstone disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2002)
  AUTHORS   Xu,Z.M., Gnouamozi,G.E., Rueger,S., Shea,P.R., Buti,M., Chan,H.L.,
            Marcellin,P., Lawless,D., Naret,O., Zeller,M., Schneuing,A.,
            Scheck,A., Junier,T., Moradpour,D., Podlaha,O., Suri,V., Gaggar,A.,
            Subramanian,M., Correia,B., Gfeller,D., Urban,S. and Fellay,J.
  TITLE     Joint host-pathogen genomic analysis identifies hepatitis B virus
            mutations associated with human NTCP and HLA class I variation
  JOURNAL   Am J Hum Genet 111 (6), 1018-1034 (2024)
   PUBMED   38749427
  REMARK    GeneRIF: Joint host-pathogen genomic analysis identifies hepatitis
            B virus mutations associated with human NTCP and HLA class I
            variation.
REFERENCE   4  (bases 1 to 2002)
  AUTHORS   Lu,X. and Huang,J.
  TITLE     Molecular mechanisms of Na+-driven bile acid transport in human
            NTCP
  JOURNAL   Biophys J 123 (10), 1195-1210 (2024)
   PUBMED   38544409
  REMARK    GeneRIF: Molecular mechanisms of Na[+]-driven bile acid transport
            in human NTCP.
REFERENCE   5  (bases 1 to 2002)
  AUTHORS   Jung,D., Hagenbuch,B., Fried,M., Meier,P.J. and Kullak-Ublick,G.A.
  TITLE     Role of liver-enriched transcription factors and nuclear receptors
            in regulating the human, mouse, and rat NTCP gene
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 286 (5), G752-G761 (2004)
   PUBMED   14701722
  REMARK    GeneRIF: Conserved NTCP/Ntcp 5'-regulatory region transcription
            regulation differs among species and is not directly regulated by
            small heterodimer partner. Bile acids may regulate NTCP/Ntcp
            indirectly by modulating nuclear factor regulation of gene
            expression.
REFERENCE   6  (bases 1 to 2002)
  AUTHORS   Ho,R.H., Leake,B.F., Roberts,R.L., Lee,W. and Kim,R.B.
  TITLE     Ethnicity-dependent polymorphism in Na+-taurocholate cotransporting
            polypeptide (SLC10A1) reveals a domain critical for bile acid
            substrate recognition
  JOURNAL   J Biol Chem 279 (8), 7213-7222 (2004)
   PUBMED   14660639
  REMARK    GeneRIF: a domain critical for bile acid substrate recognition of
            SLC10A1 has an ethnicity-dependent polymorphism
REFERENCE   7  (bases 1 to 2002)
  AUTHORS   Trauner,M. and Boyer,J.L.
  TITLE     Bile salt transporters: molecular characterization, function, and
            regulation
  JOURNAL   Physiol Rev 83 (2), 633-671 (2003)
   PUBMED   12663868
  REMARK    Review article
REFERENCE   8  (bases 1 to 2002)
  AUTHORS   Hallen,S., Mareninova,O., Branden,M. and Sachs,G.
  TITLE     Organization of the membrane domain of the human liver sodium/bile
            acid cotransporter
  JOURNAL   Biochemistry 41 (23), 7253-7266 (2002)
   PUBMED   12044156
  REMARK    GeneRIF: Translation/insertion scanning, alanine insertion, and
            glycosylation site mutagenesis studies of liver sodium/bile acid
            cotransporter support a topography with nine membrane-spanning or
            membrane-associated segments.
REFERENCE   9  (bases 1 to 2002)
  AUTHORS   Shiao,T., Iwahashi,M., Fortune,J., Quattrochi,L., Bowman,S.,
            Wick,M., Qadri,I. and Simon,F.R.
  TITLE     Structural and functional characterization of liver cell-specific
            activity of the human sodium/taurocholate cotransporter
  JOURNAL   Genomics 69 (2), 203-213 (2000)
   PUBMED   11031103
REFERENCE   10 (bases 1 to 2002)
  AUTHORS   Hagenbuch,B. and Meier,P.J.
  TITLE     Molecular cloning, chromosomal localization, and functional
            characterization of a human liver Na+/bile acid cotransporter
  JOURNAL   J Clin Invest 93 (3), 1326-1331 (1994)
   PUBMED   8132774
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK314028.1, BC069799.1,
            L21893.1 and AL157789.6.
            
            On Nov 23, 2018 this sequence version replaced NM_003049.3.
            
            Summary: The protein encoded by this gene belongs to the
            sodium/bile acid cotransporter family, which are integral membrane
            glycoproteins that participate in the enterohepatic circulation of
            bile acids. Two homologous transporters are involved in the
            reabsorption of bile acids; the ileal sodium/bile acid
            cotransporter with an apical cell localization that absorbs bile
            acids from the intestinal lumen, bile duct and kidney, and the
            liver-specific sodium/bile acid cotransporter, represented by this
            protein, that is found in the basolateral membranes of hepatocytes.
            Bile acids are the catabolic product of cholesterol metabolism,
            hence this protein is important for cholesterol homeostasis.
            [provided by RefSeq, Oct 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189664.103981.1,
                                           SRR5189664.104510.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145122, SAMEA2155590
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216540.5/ ENSP00000216540.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AK314028.1         50-53
            5-1544              BC069799.1         1-1540
            1545-1583           L21893.1           1541-1579
            1584-2002           AL157789.6         72294-72712         c
FEATURES             Location/Qualifiers
     source          1..2002
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.1"
     gene            1..2002
                     /gene="SLC10A1"
                     /gene_synonym="FHCA2; NTCP"
                     /note="solute carrier family 10 member 1"
                     /db_xref="GeneID:6554"
                     /db_xref="HGNC:HGNC:10905"
                     /db_xref="MIM:182396"
     exon            1..442
                     /gene="SLC10A1"
                     /gene_synonym="FHCA2; NTCP"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1136
                     /gene="SLC10A1"
                     /gene_synonym="FHCA2; NTCP"
                     /note="sodium/taurocholate cotransporter; Na/taurocholate
                     cotransporting polypeptide; growth-inhibiting protein 29;
                     sodium/bile acid cotransporter; cell growth-inhibiting
                     gene 29 protein; sodium/taurocholate cotransporting
                     polypeptide; Na(+)/bile acid cotransporter;
                     Na(+)/taurocholate transport protein; solute carrier
                     family 10 (sodium/bile acid cotransporter), member 1;
                     solute carrier family 10 (sodium/bile acid cotransporter
                     family), member 1"
                     /codon_start=1
                     /product="hepatic sodium/bile acid cotransporter"
                     /protein_id="NP_003040.1"
                     /db_xref="CCDS:CCDS9797.1"
                     /db_xref="GeneID:6554"
                     /db_xref="HGNC:HGNC:10905"
                     /db_xref="MIM:182396"
                     /translation="MEAHNASAPFNFTLPPNFGKRPTDLALSVILVFMLFFIMLSLGC
                     TMEFSKIKAHLWKPKGLAIALVAQYGIMPLTAFVLGKVFRLKNIEALAILVCGCSPGG
                     NLSNVFSLAMKGDMNLSIVMTTCSTFCALGMMPLLLYIYSRGIYDGDLKDKVPYKGIV
                     ISLVLVLIPCTIGIVLKSKRPQYMRYVIKGGMIIILLCSVAVTVLSAINVGKSIMFAM
                     TPLLIATSSLMPFIGFLLGYVLSALFCLNGRCRRTVSMETGCQNVQLCSTILNVAFPP
                     EVIGPLFFFPLLYMIFQLGEGLLLIAIFWCYEKFKTPKDKTKMIYTAATTEETIPGAL
                     GNGTYKGEDCSPCTA"
     exon            443..653
                     /gene="SLC10A1"
                     /gene_synonym="FHCA2; NTCP"
                     /inference="alignment:Splign:2.1.0"
     exon            654..832
                     /gene="SLC10A1"
                     /gene_synonym="FHCA2; NTCP"
                     /inference="alignment:Splign:2.1.0"
     exon            833..1029
                     /gene="SLC10A1"
                     /gene_synonym="FHCA2; NTCP"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..2002
                     /gene="SLC10A1"
                     /gene_synonym="FHCA2; NTCP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1560..1565
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC10A1"
                     /gene_synonym="FHCA2; NTCP"
                     /note="hexamer: ATTAAA"
     polyA_site      1588
                     /gene="SLC10A1"
                     /gene_synonym="FHCA2; NTCP"
                     /note="major polyA site"
     regulatory      1976..1981
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC10A1"
                     /gene_synonym="FHCA2; NTCP"
                     /note="hexamer: AATAAA"
     polyA_site      2002
                     /gene="SLC10A1"
                     /gene_synonym="FHCA2; NTCP"
ORIGIN      
        1 gattaaagaa ggcatccagc aagaactgca caagaaacgg agtcagccgg agaacaagga
       61 gtggtcttcc actgcctcac aggaggatgg aggcccacaa cgcgtctgcc ccattcaact
      121 tcaccctgcc acccaacttt ggcaagcgcc ccacagacct ggcactgagc gtcatcctgg
      181 tgttcatgtt gttcttcatc atgctctcgc tgggctgcac catggagttc agcaagatca
      241 aggctcactt atggaagcct aaagggctgg ccatcgccct ggtggcacag tatggcatca
      301 tgcccctcac ggcctttgtg ctgggcaagg tcttccggct gaagaacatt gaggcactgg
      361 ccatcttggt ctgtggctgc tcacctggag ggaacctgtc caatgtcttc agtctggcca
      421 tgaaggggga catgaacctc agcattgtga tgaccacctg ctccaccttc tgtgcccttg
      481 gcatgatgcc tctcctcctg tacatctact ccagggggat ctatgatggg gacctgaagg
      541 acaaggtgcc ctataaaggc atcgtgatat cactggtcct ggttctcatt ccttgcacca
      601 tagggatcgt cctcaaatcc aaacggccac aatacatgcg ctatgtcatc aagggaggga
      661 tgatcatcat tctcttgtgc agtgtggccg tcacagttct ctctgccatc aatgtgggga
      721 agagcatcat gtttgccatg acaccactct tgattgccac ctcctccctg atgcctttta
      781 ttggctttct gctgggttat gttctctctg ctctcttctg cctcaatgga cggtgcagac
      841 gcactgtcag catggagact ggatgccaaa atgtccaact ctgttccacc atcctcaatg
      901 tggcctttcc acctgaagtc attggaccac ttttcttctt tcccctcctc tacatgattt
      961 tccagcttgg agaagggctt ctcctcattg ccatattttg gtgctatgag aaattcaaga
     1021 ctcccaagga taaaacaaaa atgatctaca cagctgccac aactgaagaa acaattccag
     1081 gagctctggg aaatggcacc tacaaagggg aggactgctc cccttgcaca gcctagccct
     1141 tcccctggtg gcctggattc tggtcccaaa gcaattctga aagccagtgt ggtaaactag
     1201 agagagcagc aaaaacacca gtcttgcctg agtctttctc cagcatttcc agtacatcta
     1261 tcagaatcat caagtcttgg ccgggaacac agacagggtg tctacccaag aagcctcacc
     1321 tatccccaac ttagaatttg ctacttattt taaagacttg ttcagtgact gtaaactcta
     1381 tgaaaccaga aaccgaatct gcctcttgct gggatctcta aaagtgtctg ataagcatct
     1441 taaagtcact caattcctga actaatcaat atatatgttt aacccattac tcaaataccc
     1501 aaatcccatt ccaagttttg tgacccaaaa gagaaataaa tgctcacaag tgctgtagaa
     1561 ttaaacttca gaagttctaa cctaaaaagt tcagatccta ttccttccct tttgacatta
     1621 ttgggatgat gctcccgaaa agtcaaattt gacatcaagt atgcaaaagt gaacacagta
     1681 agatgcaatc aggcaaaaca aactcaaaaa atagctaatg aaatgaaaaa actgggcgaa
     1741 tgcatcatgt tagtagagga ggaaaacttt tgacaaggaa aaaccaggaa acaaacacat
     1801 acattaacac aatgttacct cactaataat ctctttttta agttcagtag gtatttggtt
     1861 ttaacacaag gcgcccccaa aactgggtac agcaaactac tgccaaaatg agtcgtttcc
     1921 caattcaaag aaaaatgttc aaatacctag aattcacaaa tttcaaattg tctctaataa
     1981 aatttaaaca ttttgcatat ca
//
