LOCUS       NM_006527               1810 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens stem-loop histone mRNA binding protein (SLBP),
            transcript variant 1, mRNA.
ACCESSION   NM_006527
VERSION     NM_006527.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1810)
  AUTHORS   Li,S., Jia,H., Zhang,Z. and Wu,D.
  TITLE     DRAIC promotes growth of breast cancer by sponging miR-432-5p to
            upregulate SLBP
  JOURNAL   Cancer Gene Ther 29 (7), 951-960 (2022)
   PUBMED   34645975
  REMARK    GeneRIF: DRAIC promotes growth of breast cancer by sponging
            miR-432-5p to upregulate SLBP.
REFERENCE   2  (bases 1 to 1810)
  AUTHORS   Declercq,M., Biquand,E., Karim,M., Pietrosemoli,N., Jacob,Y.,
            Demeret,C., Barbezange,C. and van der Werf,S.
  TITLE     Influenza A virus co-opts ERI1 exonuclease bound to histone mRNA to
            promote viral transcription
  JOURNAL   Nucleic Acids Res 48 (18), 10428-10440 (2020)
   PUBMED   32960265
  REMARK    GeneRIF: Influenza A virus co-opts ERI1 exonuclease bound to
            histone mRNA to promote viral transcription.
REFERENCE   3  (bases 1 to 1810)
  AUTHORS   Wang,Y., Huang,H. and Li,Y.
  TITLE     Knocking down miR-384 promotes growth and metastasis of
            osteosarcoma MG63 cells by targeting SLBP
  JOURNAL   Artif Cells Nanomed Biotechnol 47 (1), 1458-1465 (2019)
   PUBMED   31007083
  REMARK    GeneRIF: Knocking down miR-384 promotes growth and metastasis of
            osteosarcoma MG63 cells by targeting SLBP
REFERENCE   4  (bases 1 to 1810)
  AUTHORS   Jordan,A., Zhang,X., Li,J., Laulicht-Glick,F., Sun,H. and Costa,M.
  TITLE     Nickel and cadmium-induced SLBP depletion: A potential pathway to
            metal mediated cellular transformation
  JOURNAL   PLoS One 12 (3), e0173624 (2017)
   PUBMED   28306745
  REMARK    GeneRIF: showed that inhibiting the SLBP mRNA and protein levels
            were rescued by epigenetic modifiers suggesting that nickel's
            effects on SLBP may be mediated via epigenetic mechanisms
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1810)
  AUTHORS   Borchers,C.H., Thapar,R., Petrotchenko,E.V., Torres,M.P.,
            Speir,J.P., Easterling,M., Dominski,Z. and Marzluff,W.F.
  TITLE     Combined top-down and bottom-up proteomics identifies a
            phosphorylation site in stem-loop-binding proteins that contributes
            to high-affinity RNA binding
  JOURNAL   Proc Natl Acad Sci U S A 103 (9), 3094-3099 (2006)
   PUBMED   16492733
  REMARK    GeneRIF: Removal of the phosphoryl group from T230 by either
            dephosphorylation or mutation results in a 7-fold reduction in the
            affinity of SLBP for the stem-loop RNA
REFERENCE   6  (bases 1 to 1810)
  AUTHORS   Thapar,R., Marzluff,W.F. and Redinbo,M.R.
  TITLE     Electrostatic contribution of serine phosphorylation to the
            Drosophila SLBP--histone mRNA complex
  JOURNAL   Biochemistry 43 (29), 9401-9412 (2004)
   PUBMED   15260483
REFERENCE   7  (bases 1 to 1810)
  AUTHORS   Martin,F., Schaller,A., Eglite,S., Schumperli,D. and Muller,B.
  TITLE     The gene for histone RNA hairpin binding protein is located on
            human chromosome 4 and encodes a novel type of RNA binding protein
  JOURNAL   EMBO J 16 (4), 769-778 (1997)
   PUBMED   9049306
REFERENCE   8  (bases 1 to 1810)
  AUTHORS   Wang,Z.F., Whitfield,M.L., Ingledue,T.C. 3rd, Dominski,Z. and
            Marzluff,W.F.
  TITLE     The protein that binds the 3' end of histone mRNA: a novel
            RNA-binding protein required for histone pre-mRNA processing
  JOURNAL   Genes Dev 10 (23), 3028-3040 (1996)
   PUBMED   8957003
REFERENCE   9  (bases 1 to 1810)
  AUTHORS   Hanson,R.J., Sun,J., Willis,D.G. and Marzluff,W.F.
  TITLE     Efficient extraction and partial purification of the
            polyribosome-associated stem-loop binding protein bound to the 3'
            end of histone mRNA
  JOURNAL   Biochemistry 35 (7), 2146-2156 (1996)
   PUBMED   8652556
REFERENCE   10 (bases 1 to 1810)
  AUTHORS   McCombie,W.R., Martin-Gallardo,A., Gocayne,J.D., FitzGerald,M.,
            Dubnick,M., Kelley,J.M., Castilla,L., Liu,L.I., Wallace,S.,
            Trapp,S. et al.
  TITLE     Expressed genes, Alu repeats and polymorphisms in cosmids sequenced
            from chromosome 4p16.3
  JOURNAL   Nat Genet 1 (5), 348-353 (1992)
   PUBMED   1338771
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK094257.1, U75679.1,
            AK093314.1 and BM976632.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006527.3.
            
            Summary: This gene encodes a protein that binds to the stem-loop
            structure in replication-dependent histone mRNAs. Histone mRNAs do
            not contain introns or polyadenylation signals, and are processed
            by endonucleolytic cleavage. The stem-loop structure is essential
            for efficient processing but this structure also controls the
            transport, translation and stability of histone mRNAs. Expression
            of the protein is regulated during the cell cycle, increasing more
            than 10-fold during the latter part of G1. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.40646.1,
                                           SRR1660805.241584.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000489418.6/ ENSP00000417686.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AK094257.1         237-252
            17-1504             U75679.1           1-1488
            1505-1505           AK093314.1         1400-1400
            1506-1741           U75679.1           1490-1725
            1742-1810           BM976632.1         15-83               c
FEATURES             Location/Qualifiers
     source          1..1810
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.3"
     gene            1..1810
                     /gene="SLBP"
                     /gene_synonym="HBP"
                     /note="stem-loop histone mRNA binding protein"
                     /db_xref="GeneID:7884"
                     /db_xref="HGNC:HGNC:10904"
                     /db_xref="MIM:602422"
     exon            1..190
                     /gene="SLBP"
                     /gene_synonym="HBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..944
                     /gene="SLBP"
                     /gene_synonym="HBP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     histone binding protein; stem-loop (histone) binding
                     protein; hairpin binding protein, histone; histone
                     stem-loop binding protein; histone RNA hairpin-binding
                     protein"
                     /codon_start=1
                     /product="histone RNA hairpin-binding protein isoform 1"
                     /protein_id="NP_006518.1"
                     /db_xref="CCDS:CCDS3350.1"
                     /db_xref="GeneID:7884"
                     /db_xref="HGNC:HGNC:10904"
                     /db_xref="MIM:602422"
                     /translation="MACRPRSPPRHQSRCDGDASPPSPARWSLGRKRRADGRRWRPED
                     AEEAEHRGAERRPESFTTPEGPKPRSRCSDWASAVEEDEMRTRVNKEMARYKRKLLIN
                     DFGRERKSSSGSSDSKESMSTVPADFETDESVLMRRQKQINYGKNTIAYDRYIKEVPR
                     HLRQPGIHPKTPNKFKKYSRRSWDQQIKLWKVALHFWDPPAEEGCDLQEIHPVDLESA
                     ESSSEPQTSSQDDFDVYSGTPTKVRHMDSQVEDEFDLEACLTEPLRDFSAMS"
     exon            191..307
                     /gene="SLBP"
                     /gene_synonym="HBP"
                     /inference="alignment:Splign:2.1.0"
     exon            308..412
                     /gene="SLBP"
                     /gene_synonym="HBP"
                     /inference="alignment:Splign:2.1.0"
     exon            413..472
                     /gene="SLBP"
                     /gene_synonym="HBP"
                     /inference="alignment:Splign:2.1.0"
     exon            473..610
                     /gene="SLBP"
                     /gene_synonym="HBP"
                     /inference="alignment:Splign:2.1.0"
     exon            611..760
                     /gene="SLBP"
                     /gene_synonym="HBP"
                     /inference="alignment:Splign:2.1.0"
     exon            761..827
                     /gene="SLBP"
                     /gene_synonym="HBP"
                     /inference="alignment:Splign:2.1.0"
     exon            828..1810
                     /gene="SLBP"
                     /gene_synonym="HBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1721..1726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLBP"
                     /gene_synonym="HBP"
                     /note="hexamer: AATAAA"
     polyA_site      1741
                     /gene="SLBP"
                     /gene_synonym="HBP"
                     /note="major polyA site"
     polyA_site      1791
                     /gene="SLBP"
                     /gene_synonym="HBP"
     polyA_site      1810
                     /gene="SLBP"
                     /gene_synonym="HBP"
ORIGIN      
        1 agagctcgtg agcgccggcg cggggacgcg ggtttctgcc tcaggccctg ccctgctcta
       61 ctctgcgctc tctgcccgcg ccgccgccgc ctcagcctcg gccctgcgct gcgcgcccgg
      121 cccgtgctgc catggcctgc cgcccgcgaa gcccgccgag gcatcagagc cgctgcgacg
      181 gtgacgccag cccgccgtcc cccgcgcgat ggagcctggg acggaagcgc agagccgacg
      241 gcaggcgctg gaggcccgaa gacgccgagg aggcagagca ccgcggcgcc gagcgcagac
      301 ccgagagctt taccactcct gaaggcccta aaccccgttc cagatgctct gactgggcaa
      361 gtgcagttga agaagatgaa atgaggacca gagttaacaa agaaatggca agatataaaa
      421 ggaaactcct catcaatgac tttggaagag agagaaaatc atcatcagga agttctgatt
      481 caaaggagtc tatgtctact gtgccggctg actttgagac agatgaaagt gtcctaatga
      541 ggagacagaa gcagatcaac tatgggaaga acacaattgc ctacgatcgt tatattaaag
      601 aagtcccaag acaccttcga caacctggca ttcatcccaa gacccctaat aaatttaaga
      661 agtatagtcg acgttcatgg gaccagcaaa tcaaactctg gaaggtggct ctgcattttt
      721 gggatcctcc agcggaagaa ggatgtgatt tgcaagaaat acaccctgta gaccttgaat
      781 ctgcagaaag cagctccgag ccccagacca gctctcagga tgactttgat gtgtactctg
      841 gcacacccac caaggtgaga cacatggaca gtcaagtgga ggatgagttt gatttggaag
      901 cttgtttaac tgaacccttg agagacttct cagccatgag ctaactgccc cctggcggcc
      961 aggaagagaa acagctcctc cccgactagg tggaaggctg gccaggcacc aagcatgtgt
     1021 gtgcacttgt acctggtggt ttctctgtta gcagtccatt agctcatgct gaattatttt
     1081 tgccttactt tcttaagaaa cattaatttt atgtatagtg agtatatttt gcatgtttta
     1141 aattgtaaat ggagctaagt ccaagaaagt acttgaagct ctcttccagc gagcttaatt
     1201 gcgtaatccc tgttgtcctc cagggtaagc tgacacgtct acataactgg ttttccacag
     1261 gcatcttcag ttattgcttg tcaggtggac tgttttggat ttaaccatgt aatccatggg
     1321 accaattgag agtcagctac ttttataggc atcaaagtat tctcagacac ctttaatatc
     1381 tttatggaaa cttaattttt ggccttttat caatatgtca taacagcatt ctgaagtcag
     1441 acattgttaa attgagctat taaactaatg agttttatgt aagttatatg gtcttaattt
     1501 ggtacttgta aatagcacta gttagactct ttagaatact ccaagagtta gggcagcaga
     1561 gtggagcgat ttagaaagaa cattttaaaa caatcagtta atttaccatg taaaattgct
     1621 gtaaatgata atgtgtacag attttctgtt caaatattca attgtaaact tcttgttaag
     1681 actgttacgt ttctattgct tttgtatggg atattgcaaa aataaaaagg aaagaaccct
     1741 ctttcactga ctggggctgt tgccaggtgg gccagctgcc gtgagagctg acatgtttgg
     1801 agggtcagaa
//
