LOCUS       NM_033438               1139 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens SLAM family member 9 (SLAMF9), transcript variant 1,
            mRNA.
ACCESSION   NM_033438
VERSION     NM_033438.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1139)
  AUTHORS   Zhao,C., Zhu,X., Liu,H., Dong,Q., Sun,J., Sun,B., Wang,G. and
            Wang,X.
  TITLE     The prognostic and immune significance of SLAMF9 in pan-cancer and
            validation of its role in colorectal cancer
  JOURNAL   Sci Rep 14 (1), 17899 (2024)
   PUBMED   39095516
  REMARK    GeneRIF: The prognostic and immune significance of SLAMF9 in
            pan-cancer and validation of its role in colorectal cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1139)
  AUTHORS   Wilson,T.J., Clare,S., Mikulin,J., Johnson,C.M., Harcourt,K.,
            Lyons,P.A., Dougan,G. and Smith,K.G.C.
  TITLE     Signalling lymphocyte activation molecule family member 9 is found
            on select subsets of antigen-presenting cells and promotes
            resistance to Salmonella infection
  JOURNAL   Immunology 159 (4), 393-403 (2020)
   PUBMED   31880316
  REMARK    GeneRIF: SLAMF9 is found on select subsets of antigen-presenting
            cells and promotes resistance to Salmonella infection.
REFERENCE   3  (bases 1 to 1139)
  AUTHORS   Calpe,S., Wang,N., Romero,X., Berger,S.B., Lanyi,A., Engel,P. and
            Terhorst,C.
  TITLE     The SLAM and SAP gene families control innate and adaptive immune
            responses
  JOURNAL   Adv Immunol 97, 177-250 (2008)
   PUBMED   18501771
  REMARK    Review article
REFERENCE   4  (bases 1 to 1139)
  AUTHORS   Fraser,C.C., Howie,D., Morra,M., Qiu,Y., Murphy,C., Shen,Q.,
            Gutierrez-Ramos,J.C., Coyle,A., Kingsbury,G.A. and Terhorst,C.
  TITLE     Identification and characterization of SF2000 and SF2001, two new
            members of the immune receptor SLAM/CD2 family
  JOURNAL   Immunogenetics 53 (10-11), 843-850 (2002)
   PUBMED   11862385
REFERENCE   5  (bases 1 to 1139)
  AUTHORS   Fennelly,J.A., Tiwari,B., Davis,S.J. and Evans,E.J.
  TITLE     CD2F-10: a new member of the CD2 subset of the immunoglobulin
            superfamily
  JOURNAL   Immunogenetics 53 (7), 599-602 (2001)
   PUBMED   11685473
REFERENCE   6  (bases 1 to 1139)
  AUTHORS   Zhang,W., Wan,T., Li,N., Yuan,Z., He,L., Zhu,X., Yu,M. and Cao,X.
  TITLE     Genetic approach to insight into the immunobiology of human
            dendritic cells and identification of CD84-H1, a novel CD84
            homologue
  JOURNAL   Clin Cancer Res 7 (3 Suppl), 822s-829s (2001)
   PUBMED   11300479
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY034613.1, AL513485.10 and
            CB528634.1.
            
            On Nov 22, 2018 this sequence version replaced NM_033438.3.
            
            Summary: This gene encodes a member of the signaling lymphocytic
            activation molecule family. The encoded protein is a cell surface
            molecule that consists of two extracellular immunoglobulin domains,
            a transmembrane domain and a short cytoplasmic tail that lacks the
            signal transduction motifs found in other family members.
            Alternative splicing results in multiple transcript
            variants.[provided by RefSeq, Apr 2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY034613.1, AF275725.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368093.4/ ENSP00000357072.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-478               AY034613.1         18-495
            479-479             AL513485.10        41429-41429         c
            480-1132            AY034613.1         497-1149
            1133-1139           CB528634.1         15-21               c
FEATURES             Location/Qualifiers
     source          1..1139
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.2"
     gene            1..1139
                     /gene="SLAMF9"
                     /gene_synonym="CD2F-10; CD2F10; CD84-H1; CD84H1; SF2001"
                     /note="SLAM family member 9"
                     /db_xref="GeneID:89886"
                     /db_xref="HGNC:HGNC:18430"
                     /db_xref="MIM:608589"
     exon            1..146
                     /gene="SLAMF9"
                     /gene_synonym="CD2F-10; CD2F10; CD84-H1; CD84H1; SF2001"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..970
                     /gene="SLAMF9"
                     /gene_synonym="CD2F-10; CD2F10; CD84-H1; CD84H1; SF2001"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; signaling lymphocytic activation molecule
                     family member 9; cluster of differentiation 2 antigen
                     family member 10; signaling lymphocytic activation
                     molecule family member 2001; cluster of differentiation 84
                     homolog 1; CD84 homolog 1; CD2 family member 10"
                     /codon_start=1
                     /product="SLAM family member 9 isoform 1 precursor"
                     /protein_id="NP_254273.2"
                     /db_xref="CCDS:CCDS1191.1"
                     /db_xref="GeneID:89886"
                     /db_xref="HGNC:HGNC:18430"
                     /db_xref="MIM:608589"
                     /translation="MCAFPWLLLLLLLQEGSQRRLWRWCGSEEVVAVLQESISLPLEI
                     PPDEEVENIIWSSHKSLATVVPGKEGHPATIMVTNPHYQGQVSFLDPSYSLHISNLSW
                     EDSGLYQAQVNLRTSQISTMQQYNICVYRWLSEPQITVNFESSGEGACSMSLVCSVEK
                     AGMDMTYSWLSRGDSTYTFHEGPVLSTSWRPGDSALSYTCRANNPISNVSSCPIPDGP
                     FYADPNYASEKPSTAFCLLAKGLLIFLLLVILAMGLWVIRVQKRHKMPRMKKLMRNRM
                     KLRKEAKPGSSPA"
     exon            147..491
                     /gene="SLAMF9"
                     /gene_synonym="CD2F-10; CD2F10; CD84-H1; CD84H1; SF2001"
                     /inference="alignment:Splign:2.1.0"
     exon            492..764
                     /gene="SLAMF9"
                     /gene_synonym="CD2F-10; CD2F10; CD84-H1; CD84H1; SF2001"
                     /inference="alignment:Splign:2.1.0"
     exon            765..1139
                     /gene="SLAMF9"
                     /gene_synonym="CD2F-10; CD2F10; CD84-H1; CD84H1; SF2001"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1114..1119
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLAMF9"
                     /gene_synonym="CD2F-10; CD2F10; CD84-H1; CD84H1; SF2001"
                     /note="hexamer: AATAAA"
     polyA_site      1139
                     /gene="SLAMF9"
                     /gene_synonym="CD2F-10; CD2F10; CD84-H1; CD84H1; SF2001"
                     /note="major polyA site"
ORIGIN      
        1 agtcaggctc tttgtgtcta ggagcctcct aatgcagtct tctgcacagt cctggggact
       61 gactgactga atcacacctc tggggctggg ggctgctgac atgtgtgcct ttccttggct
      121 gcttcttctc ctgctgctcc aggagggcag ccaaaggaga ctctggagat ggtgtggatc
      181 cgaggaagtg gttgcggtcc ttcaggagtc catcagcctc cccctggaaa taccaccaga
      241 tgaagaggtt gagaacatca tctggtcctc tcacaaaagt cttgccactg tggtgccagg
      301 gaaagaggga catccagcta ccatcatggt gaccaatcca cactaccagg gccaagtgag
      361 cttcctggac cccagctatt ccctgcatat cagcaatctg agctgggagg attcagggct
      421 ttaccaagct caagtcaacc tgagaacatc ccagatctct accatgcagc agtacaatat
      481 atgtgtctac cgatggctgt cagagcccca gatcactgtg aactttgaga gttctgggga
      541 aggtgcctgc agtatgtccc tggtgtgctc tgtggagaag gcaggcatgg atatgaccta
      601 cagctggctc tcccgggggg atagcactta tacattccat gaaggccctg tcctcagcac
      661 atcctggagg ccgggggaca gtgccctctc ctacacctgc agagccaaca accccatcag
      721 caacgtcagt tcttgcccca tccctgatgg gcccttctat gcagatccta actatgcttc
      781 tgagaagcct tcaacagcct tctgcctcct ggccaaggga ttgctcatct tcttgctctt
      841 ggtaattctg gccatgggac tctgggtcat ccgagtccag aaaagacaca aaatgccaag
      901 gatgaagaaa ctcatgagaa acagaatgaa attgaggaag gaggcaaagc ctggctccag
      961 ccctgcctga ctgctccttg ggaaccccag tcctgagctt ggtttcttcc cagcacccag
     1021 agaatccttc ctcagctctc ttctttccag gggaaggagg tgctcagggg tgggtatcca
     1081 gagagccata cttctgaggg aagactggct ggcaataaag tcaaattaag tgaccacaa
//
