LOCUS       NM_020125               3116 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens SLAM family member 8 (SLAMF8), transcript variant 1,
            mRNA.
ACCESSION   NM_020125 NM_014036
VERSION     NM_020125.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3116)
  AUTHORS   Li,G., Li,Q., Ping,M., Jiao,Z., Wang,X., Cheng,J., Guo,J. and
            Cheng,Y.
  TITLE     SLAMF8 can predict prognosis of pan-cancer and the immunotherapy
            response effectivity of gastric cancer
  JOURNAL   Aging (Albany NY) 16 (10), 8944-8964 (2024)
   PUBMED   38787377
  REMARK    GeneRIF: SLAMF8 can predict prognosis of pan-cancer and the
            immunotherapy response effectivity of gastric cancer.
REFERENCE   2  (bases 1 to 3116)
  AUTHORS   Zheng,Y., Wang,L., Zhao,Y., Gong,H., Qi,Y. and Qi,L.
  TITLE     Upregulation of SLAMF8 aggravates ischemia/reperfusion-induced
            ferroptosis and injury in cardiomyocyte
  JOURNAL   Int J Cardiol 399, 131688 (2024)
   PUBMED   38158136
  REMARK    GeneRIF: Upregulation of SLAMF8 aggravates
            ischemia/reperfusion-induced ferroptosis and injury in
            cardiomyocyte.
REFERENCE   3  (bases 1 to 3116)
  AUTHORS   Liu,J., Huang,Y., Zeng,J., Chen,C., Li,P., Ning,Q., Guan,X. and
            Li,L.
  TITLE     SLAMF8 promotes the proliferation and migration of synovial
            fibroblasts by regulating the ERK/MMPs signalling pathway
  JOURNAL   Autoimmunity 55 (5), 294-300 (2022)
   PUBMED   35506438
  REMARK    GeneRIF: SLAMF8 promotes the proliferation and migration of
            synovial fibroblasts by regulating the ERK/MMPs signalling pathway.
REFERENCE   4  (bases 1 to 3116)
  AUTHORS   Qin,W., Rong,X., Yu,C., Jia,P., Yang,J. and Zhou,G.
  TITLE     Knockout of SLAMF8 attenuates collagen-induced rheumatoid arthritis
            in mice through inhibiting TLR4/NF-kappaB signaling pathway
  JOURNAL   Int Immunopharmacol 107, 108644 (2022)
   PUBMED   35259711
  REMARK    GeneRIF: Knockout of SLAMF8 attenuates collagen-induced rheumatoid
            arthritis in mice through inhibiting TLR4/NF-kappaB signaling
            pathway.
REFERENCE   5  (bases 1 to 3116)
  AUTHORS   Teng,L., Shen,L., Zhao,W., Wang,C., Feng,S., Wang,Y., Bi,Y.,
            Rong,S., Shushakova,N., Haller,H., Chen,J. and Jiang,H.
  TITLE     SLAMF8 Participates in Acute Renal Transplant Rejection via TLR4
            Pathway on Pro-Inflammatory Macrophages
  JOURNAL   Front Immunol 13, 846695 (2022)
   PUBMED   35432371
  REMARK    GeneRIF: SLAMF8 Participates in Acute Renal Transplant Rejection
            via TLR4 Pathway on Pro-Inflammatory Macrophages.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3116)
  AUTHORS   Sugimoto,A., Kataoka,T.R., Ueshima,C., Takei,Y., Kitamura,K.,
            Hirata,M., Nomura,T. and Haga,H.
  TITLE     SLAM family member 8 is involved in oncogenic KIT-mediated
            signalling in human mastocytosis
  JOURNAL   Exp Dermatol 27 (6), 641-646 (2018)
   PUBMED   29498772
  REMARK    GeneRIF: Thus, SLAMF8 is involved in oncogenic KIT-mediated
            RAS-RAF- ERK signalling and the subsequent growth of human
            neoplastic mast cells mediated by SHP-2.
REFERENCE   7  (bases 1 to 3116)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 3116)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   9  (bases 1 to 3116)
  AUTHORS   Tangye,S.G., Nichols,K.E., Hare,N.J. and van de Weerdt,B.C.
  TITLE     Functional requirements for interactions between CD84 and Src
            homology 2 domain-containing proteins and their contribution to
            human T cell activation
  JOURNAL   J Immunol 171 (5), 2485-2495 (2003)
   PUBMED   12928397
REFERENCE   10 (bases 1 to 3116)
  AUTHORS   Kingsbury,G.A., Feeney,L.A., Nong,Y., Calandra,S.A., Murphy,C.J.,
            Corcoran,J.M., Wang,Y., Prabhu Das,M.R., Busfield,S.J., Fraser,C.C.
            and Villeval,J.L.
  TITLE     Cloning, expression, and function of BLAME, a novel member of the
            CD2 family
  JOURNAL   J Immunol 166 (9), 5675-5680 (2001)
   PUBMED   11313408
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF146761.1.
            
            On Nov 22, 2018 this sequence version replaced NM_020125.2.
            
            Summary: This gene encodes a member of the CD2 family of cell
            surface proteins involved in lymphocyte activation. These proteins
            are characterized by Ig domains. This protein is expressed in
            lymphoid tissues, and studies of a similar protein in mouse suggest
            that it may function during B cell lineage commitment. The gene is
            found in a region of chromosome 1 containing many CD2 genes.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF146761.1, AK074669.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000289707.10/ ENSP00000289707.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2227              AF146761.1         63-2289
            2228-2291           AF146761.1         2291-2354
            2292-2297           AF146761.1         2356-2361
            2298-3116           AF146761.1         2363-3181
FEATURES             Location/Qualifiers
     source          1..3116
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.2"
     gene            1..3116
                     /gene="SLAMF8"
                     /gene_synonym="BLAME; CD353; SBBI42"
                     /note="SLAM family member 8"
                     /db_xref="GeneID:56833"
                     /db_xref="HGNC:HGNC:21391"
                     /db_xref="MIM:606620"
     exon            1..66
                     /gene="SLAMF8"
                     /gene_synonym="BLAME; CD353; SBBI42"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..884
                     /gene="SLAMF8"
                     /gene_synonym="BLAME; CD353; SBBI42"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; B lymphocyte activator macrophage expressed;
                     BCM-like membrane protein"
                     /codon_start=1
                     /product="SLAM family member 8 isoform 1 precursor"
                     /protein_id="NP_064510.1"
                     /db_xref="CCDS:CCDS1188.1"
                     /db_xref="GeneID:56833"
                     /db_xref="HGNC:HGNC:21391"
                     /db_xref="MIM:606620"
                     /translation="MVMRPLWSLLLWEALLPITVTGAQVLSKVGGSVLLVAARPPGFQ
                     VREAIWRSLWPSEELLATFFRGSLETLYHSRFLGRAQLHSNLSLELGPLESGDSGNFS
                     VLMVDTRGQPWTQTLQLKVYDAVPRPVVQVFIAVERDAQPSKTCQVFLSCWAPNISEI
                     TYSWRRETTMDFGMEPHSLFTDGQVLSISLGPGDRDVAYSCIVSNPVSWDLATVTPWD
                     SCHHEAAPGKASYKDVLLVVVPVSLLLMLVTLFSAWHWCPCSGKKKKDVHADRVGPET
                     ENPLVQDLP"
     exon            67..393
                     /gene="SLAMF8"
                     /gene_synonym="BLAME; CD353; SBBI42"
                     /inference="alignment:Splign:2.1.0"
     exon            394..699
                     /gene="SLAMF8"
                     /gene_synonym="BLAME; CD353; SBBI42"
                     /inference="alignment:Splign:2.1.0"
     exon            700..807
                     /gene="SLAMF8"
                     /gene_synonym="BLAME; CD353; SBBI42"
                     /inference="alignment:Splign:2.1.0"
     exon            808..3116
                     /gene="SLAMF8"
                     /gene_synonym="BLAME; CD353; SBBI42"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2851..2856
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLAMF8"
                     /gene_synonym="BLAME; CD353; SBBI42"
                     /note="hexamer: AATAAA"
     polyA_site      2873
                     /gene="SLAMF8"
                     /gene_synonym="BLAME; CD353; SBBI42"
                     /note="major polyA site"
     regulatory      3099..3104
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLAMF8"
                     /gene_synonym="BLAME; CD353; SBBI42"
                     /note="hexamer: AATAAA"
     polyA_site      3116
                     /gene="SLAMF8"
                     /gene_synonym="BLAME; CD353; SBBI42"
ORIGIN      
        1 gagtttgcct gcctctccag agaaagatgg tcatgaggcc cctgtggagt ctgcttctct
       61 gggaagccct acttcccatt acagttactg gtgcccaagt gctgagcaaa gtcgggggct
      121 cggtgctgct ggtggcagcg cgtccccctg gcttccaagt ccgtgaggct atctggcgat
      181 ctctctggcc ttcagaagag ctcctggcca cgtttttccg aggctccctg gagactctgt
      241 accattcccg cttcctgggc cgagcccagc tacacagcaa cctcagcctg gagctcgggc
      301 cgctggagtc tggagacagc ggcaacttct ccgtgttgat ggtggacaca aggggccagc
      361 cctggaccca gaccctccag ctcaaggtgt acgatgcagt gcccaggccc gtggtacaag
      421 tgttcattgc tgtagaaagg gatgctcagc cctccaagac ctgccaggtt ttcttgtcct
      481 gttgggcccc caacatcagc gaaataacct atagctggcg acgggagaca accatggact
      541 ttggtatgga accacacagc ctcttcacag acggacaggt gctgagcatt tccctgggac
      601 caggagacag agatgtggcc tattcctgca ttgtctccaa ccctgtcagc tgggacttgg
      661 ccacagtcac gccctgggat agctgtcatc atgaggcagc accagggaag gcctcctaca
      721 aagatgtgct gctggtggtg gtgcctgtct cgctgctcct gatgctggtt actctcttct
      781 ctgcctggca ctggtgcccc tgctcaggga aaaagaaaaa ggatgtccat gctgacagag
      841 tgggtccaga gacagagaac ccccttgtgc aggatctgcc ataaaggaca atatgaactg
      901 atgcctggac tatcagtaac cccactgcac aggcacacga tgctctggga cataactggt
      961 gcctggaaat caccatggtc ctcatatctc ccatgggaat cctgtcctgc ctcgaaggag
     1021 cagcctgggc agccatcaca ccacgaggac aggaagcacc agcacgtttc acacctcccc
     1081 cttccctctc ccatcttctc atatcctggc tcttctctgg gcaagatgag ccaagcagaa
     1141 cattccatcc aggacactgg aagttctcca ggatccagat ccatggggac attaatagtc
     1201 caaggcattc cctcccccac cactattcat aaagtattaa ccaactggca ccaaggaatt
     1261 gcctccagcc tgagtcctag gctctaaaag atattacata tttgaactaa tagaggaact
     1321 ctgagtcacc catgccagca tcagcttcag ccccagaccc tgcagtttga gatctgatgc
     1381 ttcctgaggg ccaaggcatt gctgtaagaa aaggtctaga aataggtgaa agtgagaggt
     1441 gggggacagg ggtttctctt tctggcctaa ggactttcag gtaatcagag ttcatgggcc
     1501 ctcaaaggta aattgcagtt gtagacaccg aggatggttg acaacccatg gttgagatgg
     1561 gcaccgtttt gcaggaaaca ccatattaat agacatcctc accatctcca tccgctctca
     1621 cgcctcctgc aggatctggg agtgagggtg gagagtcttt cctcacgctc cagcacagtg
     1681 gccaggaaaa gaaatactga atttgcccca gccaacagga cgttcttgca caacttcaag
     1741 aaaagcagct cagctcagga tgagtcttcc tgcctgaaac tgagagagtg aagaaccata
     1801 aaacgctatg cagaaggaac attatggaga gaaagggtac tgaggcactc tagaatctgc
     1861 cacattcatt ttcaaatgca aatgcagaag acttacctta gttcaagggg aggggacaaa
     1921 gaccccacag cccaacagca ggactgtaga ggtcactctg actccatcaa actttttatt
     1981 gtggccatct taggaaaata cattctgccc ctgaatgatt ctgtctagaa aagctctgga
     2041 gtattgatca ctactggaaa aacacttaag gagctaaact taccttcggg gattattagc
     2101 tgataaggtt cacagtttct ctcacccagg tgtaactgga ttttttctgg ggcctcaatc
     2161 cagtcttgat aacagcgagg aaagaggtat tgaagaaaca ggggtgggtt tgaagtacta
     2221 ttttcccagg gtggcttcaa tctccccacc taggatgtca gccctgtcca aggaccttcc
     2281 ctcttctccc cagttcctgg gcaatcactt caccttggac aaaggatcag cacagctggc
     2341 ctccagatcc acatcaccac tcttccactc gattgttccc agatcctccc tgcctggcct
     2401 gctcagaggt tccctgttgg taacctggct ttatcaaatt ctcatccctt tcccacaccc
     2461 acttctctcc tatcaccttc ccccaagatt acctgaacag ggtccatggc cactcaacct
     2521 gtcagcttgc accatcccca cctgccacct acagtcaggc cacatgcctg gtcactgaat
     2581 catgcaaaac tggcctcagt ccctaaaaat gatgtggaaa ggaaagccca ggatctgaca
     2641 atgagccctg gtggatttgt ggggaaaaaa tacacagcac tccccacctt tctttcgttc
     2701 atctccaggg ccccacctca gatcaaagca gctctggatg agatgggacc tgcagctctc
     2761 cctccacaag gtgactctta gcaacctcat ttcgacagtg gtttgtagcg tggtgcacca
     2821 gggccttgtt gaacagatcc acactgctct aataaagttc ccatccttaa tgactcactt
     2881 gtcaactagt ggactaatta accctccacc aaaaaaacac aaagtgcttc tgtgagacca
     2941 attttgtgct aatgagcatt gagactgatg ctttgtaagt cacaccacaa caaatattga
     3001 ttgagggcgc tgcatgtgct gggtacattt cttggcactt gggaatcagt agtcaagcga
     3061 aacccttgcc tttgagagtt tatggtctgg ataatataaa taaacaagta agcata
//
