LOCUS       NM_021181               2707 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens SLAM family member 7 (SLAMF7), transcript variant 1,
            mRNA.
ACCESSION   NM_021181
VERSION     NM_021181.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2707)
  AUTHORS   Chu,E., Wu,J., Kang,S.S. and Kang,Y.
  TITLE     SLAMF7 as a Promising Immunotherapeutic Target in Multiple Myeloma
            Treatments
  JOURNAL   Curr Oncol 30 (9), 7891-7903 (2023)
   PUBMED   37754488
  REMARK    GeneRIF: SLAMF7 as a Promising Immunotherapeutic Target in Multiple
            Myeloma Treatments.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2707)
  AUTHORS   Choe,U., Pham,Q., Kim,Y.S., Yu,L. and Wang,T.T.Y.
  TITLE     Identification and elucidation of cross talk between SLAM Family
            Member 7 (SLAMF7) and Toll-like receptor (TLR) pathways in
            monocytes and macrophages
  JOURNAL   Sci Rep 13 (1), 11007 (2023)
   PUBMED   37420084
  REMARK    GeneRIF: Identification and elucidation of cross talk between SLAM
            Family Member 7 (SLAMF7) and Toll-like receptor (TLR) pathways in
            monocytes and macrophages.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2707)
  AUTHORS   O'Connell,P., Blake,M.K., Godbehere,S., Amalfitano,A. and
            Aldhamen,Y.A.
  TITLE     SLAMF7 modulates B cells and adaptive immunity to regulate
            susceptibility to CNS autoimmunity
  JOURNAL   J Neuroinflammation 19 (1), 241 (2022)
   PUBMED   36199066
  REMARK    GeneRIF: SLAMF7 modulates B cells and adaptive immunity to regulate
            susceptibility to CNS autoimmunity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2707)
  AUTHORS   Simmons,D.P., Nguyen,H.N., Gomez-Rivas,E., Jeong,Y., Jonsson,A.H.,
            Chen,A.F., Lange,J.K., Dyer,G.S., Blazar,P., Earp,B.E.,
            Coblyn,J.S., Massarotti,E.M., Sparks,J.A., Todd,D.J., Rao,D.A.,
            Kim,E.Y. and Brenner,M.B.
  CONSRTM   Accelerating Medicines Partnership (AMP) RA/SLE Network
  TITLE     SLAMF7 engagement superactivates macrophages in acute and chronic
            inflammation
  JOURNAL   Sci Immunol 7 (68), eabf2846 (2022)
   PUBMED   35148199
  REMARK    GeneRIF: SLAMF7 engagement superactivates macrophages in acute and
            chronic inflammation.
REFERENCE   5  (bases 1 to 2707)
  AUTHORS   Roh,S.A., Kwon,Y.H., Lee,J.L., Kim,S.K. and Kim,J.C.
  TITLE     SLAMF7 and TREM1 Mediate Immunogenic Cell Death in Colorectal
            Cancer Cells: Focus on Microsatellite Stability
  JOURNAL   Anticancer Res 41 (11), 5431-5444 (2021)
   PUBMED   34732412
  REMARK    GeneRIF: SLAMF7 and TREM1 Mediate Immunogenic Cell Death in
            Colorectal Cancer Cells: Focus on Microsatellite Stability.
REFERENCE   6  (bases 1 to 2707)
  AUTHORS   Lee,J.K., Boles,K.S. and Mathew,P.A.
  TITLE     Molecular and functional characterization of a CS1 (CRACC) splice
            variant expressed in human NK cells that does not contain
            immunoreceptor tyrosine-based switch motifs
  JOURNAL   Eur J Immunol 34 (10), 2791-2799 (2004)
   PUBMED   15368295
  REMARK    GeneRIF: CS1-L and CS1-S may differentially regulate human NK cell
            functions
REFERENCE   7  (bases 1 to 2707)
  AUTHORS   Tovar,V., del Valle,J., Zapater,N., Martin,M., Romero,X.,
            Pizcueta,P., Bosch,J., Terhorst,C. and Engel,P.
  TITLE     Mouse novel Ly9: a new member of the expanding CD150 (SLAM) family
            of leukocyte cell-surface receptors
  JOURNAL   Immunogenetics 54 (6), 394-402 (2002)
   PUBMED   12242590
REFERENCE   8  (bases 1 to 2707)
  AUTHORS   Murphy,J.J., Hobby,P., Vilarino-Varela,J., Bishop,B.,
            Iordanidou,P., Sutton,B.J. and Norton,J.D.
  TITLE     A novel immunoglobulin superfamily receptor (19A) related to CD2 is
            expressed on activated lymphocytes and promotes homotypic B-cell
            adhesion
  JOURNAL   Biochem J 361 (Pt 3), 431-436 (2002)
   PUBMED   11802771
REFERENCE   9  (bases 1 to 2707)
  AUTHORS   Bouchon,A., Cella,M., Grierson,H.L., Cohen,J.I. and Colonna,M.
  TITLE     Activation of NK cell-mediated cytotoxicity by a SAP-independent
            receptor of the CD2 family
  JOURNAL   J Immunol 167 (10), 5517-5521 (2001)
   PUBMED   11698418
REFERENCE   10 (bases 1 to 2707)
  AUTHORS   Boles,K.S. and Mathew,P.A.
  TITLE     Molecular cloning of CS1, a novel human natural killer cell
            receptor belonging to the CD2 subset of the immunoglobulin
            superfamily
  JOURNAL   Immunogenetics 52 (3-4), 302-307 (2001)
   PUBMED   11220635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC388332.1, AB027233.1, AL121985.13 and BQ000581.1.
            
            On Nov 22, 2018 this sequence version replaced NM_021181.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a, also known as
            CS1-L).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.315385.1, AB027233.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368043.8/ ENSP00000357022.3
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                DC388332.1         173-212
            41-1351             AB027233.1         1-1311
            1352-2401           AL121985.13        140740-141789
            2402-2707           BQ000581.1         12-317              c
FEATURES             Location/Qualifiers
     source          1..2707
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.3"
     gene            1..2707
                     /gene="SLAMF7"
                     /gene_synonym="19A; CD319; CRACC; CS1"
                     /note="SLAM family member 7"
                     /db_xref="GeneID:57823"
                     /db_xref="HGNC:HGNC:21394"
                     /db_xref="MIM:606625"
     exon            1..110
                     /gene="SLAMF7"
                     /gene_synonym="19A; CD319; CRACC; CS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..1063
                     /gene="SLAMF7"
                     /gene_synonym="19A; CD319; CRACC; CS1"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; CD2-like receptor activating cytotoxic cells;
                     19A24 protein; novel LY9 (lymphocyte antigen 9) like
                     protein; protein 19A; CD2 subset 1; membrane protein
                     FOAP-12"
                     /codon_start=1
                     /product="SLAM family member 7 isoform a precursor"
                     /protein_id="NP_067004.3"
                     /db_xref="CCDS:CCDS1209.1"
                     /db_xref="GeneID:57823"
                     /db_xref="HGNC:HGNC:21394"
                     /db_xref="MIM:606625"
                     /translation="MAGSPTCLTLIYILWQLTGSAASGPVKELVGSVGGAVTFPLKSK
                     VKQVDSIVWTFNTTPLVTIQPEGGTIIVTQNRNRERVDFPDGGYSLKLSKLKKNDSGI
                     YYVGIYSSSLQQPSTQEYVLHVYEHLSKPKVTMGLQSNKNGTCVTNLTCCMEHGEEDV
                     IYTWKALGQAANESHNGSILPISWRWGESDMTFICVARNPVSRNFSSPILARKLCEGA
                     ADDPDSSMVLLCLLLVPLLLSLFVLGLFLWFLKRERQEEYIEEKKRVDICRETPNICP
                     HSGENTEYDTIPHTNRTILKEDPANTVYSTVEIPKKMENPHSLLTMPDTPRLFAYENV
                     I"
     exon            111..431
                     /gene="SLAMF7"
                     /gene_synonym="19A; CD319; CRACC; CS1"
                     /inference="alignment:Splign:2.1.0"
     exon            432..704
                     /gene="SLAMF7"
                     /gene_synonym="19A; CD319; CRACC; CS1"
                     /inference="alignment:Splign:2.1.0"
     exon            705..824
                     /gene="SLAMF7"
                     /gene_synonym="19A; CD319; CRACC; CS1"
                     /inference="alignment:Splign:2.1.0"
     exon            825..928
                     /gene="SLAMF7"
                     /gene_synonym="19A; CD319; CRACC; CS1"
                     /inference="alignment:Splign:2.1.0"
     exon            929..991
                     /gene="SLAMF7"
                     /gene_synonym="19A; CD319; CRACC; CS1"
                     /inference="alignment:Splign:2.1.0"
     exon            992..2707
                     /gene="SLAMF7"
                     /gene_synonym="19A; CD319; CRACC; CS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2673..2678
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLAMF7"
                     /gene_synonym="19A; CD319; CRACC; CS1"
                     /note="hexamer: AATAAA"
     polyA_site      2707
                     /gene="SLAMF7"
                     /gene_synonym="19A; CD319; CRACC; CS1"
                     /note="major polyA site"
ORIGIN      
        1 gtaataccta agagggaagt ggcttcattt cagtggctga cttccagaga gcaatatggc
       61 tggttcccca acatgcctca ccctcatcta tatcctttgg cagctcacag ggtcagcagc
      121 ctctggaccc gtgaaagagc tggtcggttc cgttggtggg gccgtgactt tccccctgaa
      181 gtccaaagta aagcaagttg actctattgt ctggaccttc aacacaaccc ctcttgtcac
      241 catacagcca gaagggggca ctatcatagt gacccaaaat cgtaataggg agagagtaga
      301 cttcccagat ggaggctact ccctgaagct cagcaaactg aagaagaatg actcagggat
      361 ctactatgtg gggatataca gctcatcact ccagcagccc tccacccagg agtacgtgct
      421 gcatgtctac gagcacctgt caaagcctaa agtcaccatg ggtctgcaga gcaataagaa
      481 tggcacctgt gtgaccaatc tgacatgctg catggaacat ggggaagagg atgtgattta
      541 tacctggaag gccctggggc aagcagccaa tgagtcccat aatgggtcca tcctccccat
      601 ctcctggaga tggggagaaa gtgatatgac cttcatctgc gttgccagga accctgtcag
      661 cagaaacttc tcaagcccca tccttgccag gaagctctgt gaaggtgctg ctgatgaccc
      721 agattcctcc atggtcctcc tgtgtctcct gttggtgccc ctcctgctca gtctctttgt
      781 actggggcta tttctttggt ttctgaagag agagagacaa gaagagtaca ttgaagagaa
      841 gaagagagtg gacatttgtc gggaaactcc taacatatgc ccccattctg gagagaacac
      901 agagtacgac acaatccctc acactaatag aacaatccta aaggaagatc cagcaaatac
      961 ggtttactcc actgtggaaa taccgaaaaa gatggaaaat ccccactcac tgctcacgat
     1021 gccagacaca ccaaggctat ttgcctatga gaatgttatc tagacagcag tgcactcccc
     1081 taagtctctg ctcaaaaaaa aaacaattct cggcccaaag aaaacaatca gaagaattca
     1141 ctgatttgac tagaaacatc aaggaagaat gaagaacgtt gacttttttc caggataaat
     1201 tatctctgat gcttctttag atttaagagt tcataattcc atccactgct gagaaatctc
     1261 ctcaaaccca gaaggtttaa tcacttcatc ccaaaaatgg gattgtgaat gtcagcaaac
     1321 cataaaaaaa gtgcttagaa gtattcctat aaaaatgtaa atgcaaggtc acacatatta
     1381 atgacagcct gttgtattaa tgatggctcc aggtcagtgt ctggagtttc attccatccc
     1441 agggcttgga tgtcaggatt ataccaagag tcttgctacc aggagggcaa gaagaccaaa
     1501 acagacagac aagtccagca gaagcagatg cacctgacaa aaatggatgt attaattggc
     1561 tctataaact atgtgcccag cactatgctg agcttacact aattggtcag acatgctgtc
     1621 tgccctcatg aaattggctc caaatgaatg aactactttc atgagcagtt gtagcaggcc
     1681 tgaccacaga ttcccagagg gccaggtgtg gatccacagg acttgaaggt caaagttcac
     1741 aaagatgaag aatcagggta gctgaccatg tttggcagat actataatgg agacacagaa
     1801 gtgtgcatgg cccaaggaca aggacctcca gccaggcttc atttatgcac ttgtgctgca
     1861 aaagaaaagt ctaggtttta aggctgtgcc agaacccatc ccaataaaga gaccgagtct
     1921 gaagtcacat tgtaaatcta gtgtaggaga cttggagtca ggcagtgaga ctggtggggc
     1981 acggggggca gtgggtactt gtaaaccttt aaagatggtt aattcattca atagatattt
     2041 attaagaacc tatgcggccc ggcatggtgg ctcacacctg taatcccagc actttgggag
     2101 gccaaggtgg gtgggtcatc tgaggtcagg agttcaagac cagcctggcc aacatggtga
     2161 aaccccatct ctactaaaga tacaaaaatt tgctgagcgt ggtggtgtgc acctgtaatc
     2221 ccagctactc gagaggccaa ggcatgagaa tcgcttgaac ctgggaggtg gaggttgcag
     2281 tgagctgaga tggcaccact gcactccggc ctaggcaacg agagcaaaac tccaatacaa
     2341 acaaacaaac aaacacctgt gctaggtcag tctggcacgt aagatgaaca tccctaccaa
     2401 tacagagctc accatctctt atacttaagt gaaaaacatg gggaagggga aaggggaatg
     2461 gctgcttttg atatgttccc tgacacatat cttgaatgga gacctcccta ccaagtgatg
     2521 aaagtgttga aaaacttaat aacaaatgct tgttgggcaa gaatgggatt gaggattatc
     2581 ttctctcaga aaggcattgt gaaggaattg agccagatct ctctccctac tgcaaaaccc
     2641 tattgtagta aaaaagtctt ctttactatc ttaataaaac agatattgtg agattcacat
     2701 acaaaaa
//
