LOCUS       NM_001282590            2386 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens SLAM family member 7 (SLAMF7), transcript variant 4,
            mRNA.
ACCESSION   NM_001282590 XM_005245388
VERSION     NM_001282590.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2386)
  AUTHORS   Chu,E., Wu,J., Kang,S.S. and Kang,Y.
  TITLE     SLAMF7 as a Promising Immunotherapeutic Target in Multiple Myeloma
            Treatments
  JOURNAL   Curr Oncol 30 (9), 7891-7903 (2023)
   PUBMED   37754488
  REMARK    GeneRIF: SLAMF7 as a Promising Immunotherapeutic Target in Multiple
            Myeloma Treatments.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2386)
  AUTHORS   Choe,U., Pham,Q., Kim,Y.S., Yu,L. and Wang,T.T.Y.
  TITLE     Identification and elucidation of cross talk between SLAM Family
            Member 7 (SLAMF7) and Toll-like receptor (TLR) pathways in
            monocytes and macrophages
  JOURNAL   Sci Rep 13 (1), 11007 (2023)
   PUBMED   37420084
  REMARK    GeneRIF: Identification and elucidation of cross talk between SLAM
            Family Member 7 (SLAMF7) and Toll-like receptor (TLR) pathways in
            monocytes and macrophages.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2386)
  AUTHORS   O'Connell,P., Blake,M.K., Godbehere,S., Amalfitano,A. and
            Aldhamen,Y.A.
  TITLE     SLAMF7 modulates B cells and adaptive immunity to regulate
            susceptibility to CNS autoimmunity
  JOURNAL   J Neuroinflammation 19 (1), 241 (2022)
   PUBMED   36199066
  REMARK    GeneRIF: SLAMF7 modulates B cells and adaptive immunity to regulate
            susceptibility to CNS autoimmunity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2386)
  AUTHORS   Simmons,D.P., Nguyen,H.N., Gomez-Rivas,E., Jeong,Y., Jonsson,A.H.,
            Chen,A.F., Lange,J.K., Dyer,G.S., Blazar,P., Earp,B.E.,
            Coblyn,J.S., Massarotti,E.M., Sparks,J.A., Todd,D.J., Rao,D.A.,
            Kim,E.Y. and Brenner,M.B.
  CONSRTM   Accelerating Medicines Partnership (AMP) RA/SLE Network
  TITLE     SLAMF7 engagement superactivates macrophages in acute and chronic
            inflammation
  JOURNAL   Sci Immunol 7 (68), eabf2846 (2022)
   PUBMED   35148199
  REMARK    GeneRIF: SLAMF7 engagement superactivates macrophages in acute and
            chronic inflammation.
REFERENCE   5  (bases 1 to 2386)
  AUTHORS   Roh,S.A., Kwon,Y.H., Lee,J.L., Kim,S.K. and Kim,J.C.
  TITLE     SLAMF7 and TREM1 Mediate Immunogenic Cell Death in Colorectal
            Cancer Cells: Focus on Microsatellite Stability
  JOURNAL   Anticancer Res 41 (11), 5431-5444 (2021)
   PUBMED   34732412
  REMARK    GeneRIF: SLAMF7 and TREM1 Mediate Immunogenic Cell Death in
            Colorectal Cancer Cells: Focus on Microsatellite Stability.
REFERENCE   6  (bases 1 to 2386)
  AUTHORS   Lee,J.K., Boles,K.S. and Mathew,P.A.
  TITLE     Molecular and functional characterization of a CS1 (CRACC) splice
            variant expressed in human NK cells that does not contain
            immunoreceptor tyrosine-based switch motifs
  JOURNAL   Eur J Immunol 34 (10), 2791-2799 (2004)
   PUBMED   15368295
  REMARK    GeneRIF: CS1-L and CS1-S may differentially regulate human NK cell
            functions
REFERENCE   7  (bases 1 to 2386)
  AUTHORS   Tovar,V., del Valle,J., Zapater,N., Martin,M., Romero,X.,
            Pizcueta,P., Bosch,J., Terhorst,C. and Engel,P.
  TITLE     Mouse novel Ly9: a new member of the expanding CD150 (SLAM) family
            of leukocyte cell-surface receptors
  JOURNAL   Immunogenetics 54 (6), 394-402 (2002)
   PUBMED   12242590
REFERENCE   8  (bases 1 to 2386)
  AUTHORS   Murphy,J.J., Hobby,P., Vilarino-Varela,J., Bishop,B.,
            Iordanidou,P., Sutton,B.J. and Norton,J.D.
  TITLE     A novel immunoglobulin superfamily receptor (19A) related to CD2 is
            expressed on activated lymphocytes and promotes homotypic B-cell
            adhesion
  JOURNAL   Biochem J 361 (Pt 3), 431-436 (2002)
   PUBMED   11802771
REFERENCE   9  (bases 1 to 2386)
  AUTHORS   Bouchon,A., Cella,M., Grierson,H.L., Cohen,J.I. and Colonna,M.
  TITLE     Activation of NK cell-mediated cytotoxicity by a SAP-independent
            receptor of the CD2 family
  JOURNAL   J Immunol 167 (10), 5517-5521 (2001)
   PUBMED   11698418
REFERENCE   10 (bases 1 to 2386)
  AUTHORS   Boles,K.S. and Mathew,P.A.
  TITLE     Molecular cloning of CS1, a novel human natural killer cell
            receptor belonging to the CD2 subset of the immunoglobulin
            superfamily
  JOURNAL   Immunogenetics 52 (3-4), 302-307 (2001)
   PUBMED   11220635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC388332.1, AL834424.1, AL121985.13 and BQ000581.1.
            
            On May 31, 2019 this sequence version replaced NM_001282590.1.
            
            Transcript Variant: This variant (4) lacks an alternate in-frame
            exon in the 5' coding region, compared to variant 1, resulting in
            an isoform (d) that is shorter than isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL834424.1, SRR1163657.21906.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                DC388332.1         173-193
            22-1030             AL834424.1         1-1009
            1031-2080           AL121985.13        140740-141789
            2081-2386           BQ000581.1         12-317              c
FEATURES             Location/Qualifiers
     source          1..2386
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.3"
     gene            1..2386
                     /gene="SLAMF7"
                     /gene_synonym="19A; CD319; CRACC; CS1"
                     /note="SLAM family member 7"
                     /db_xref="GeneID:57823"
                     /db_xref="HGNC:HGNC:21394"
                     /db_xref="MIM:606625"
     exon            1..110
                     /gene="SLAMF7"
                     /gene_synonym="19A; CD319; CRACC; CS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..742
                     /gene="SLAMF7"
                     /gene_synonym="19A; CD319; CRACC; CS1"
                     /note="isoform d precursor is encoded by transcript
                     variant 4; CD2-like receptor activating cytotoxic cells;
                     19A24 protein; novel LY9 (lymphocyte antigen 9) like
                     protein; protein 19A; CD2 subset 1; membrane protein
                     FOAP-12"
                     /codon_start=1
                     /product="SLAM family member 7 isoform d precursor"
                     /protein_id="NP_001269519.1"
                     /db_xref="CCDS:CCDS60324.1"
                     /db_xref="GeneID:57823"
                     /db_xref="HGNC:HGNC:21394"
                     /db_xref="MIM:606625"
                     /translation="MAGSPTCLTLIYILWQLTEHLSKPKVTMGLQSNKNGTCVTNLTC
                     CMEHGEEDVIYTWKALGQAANESHNGSILPISWRWGESDMTFICVARNPVSRNFSSPI
                     LARKLCEGAADDPDSSMVLLCLLLVPLLLSLFVLGLFLWFLKRERQEEYIEEKKRVDI
                     CRETPNICPHSGENTEYDTIPHTNRTILKEDPANTVYSTVEIPKKMENPHSLLTMPDT
                     PRLFAYENVI"
     exon            111..383
                     /gene="SLAMF7"
                     /gene_synonym="19A; CD319; CRACC; CS1"
                     /inference="alignment:Splign:2.1.0"
     exon            384..503
                     /gene="SLAMF7"
                     /gene_synonym="19A; CD319; CRACC; CS1"
                     /inference="alignment:Splign:2.1.0"
     exon            504..607
                     /gene="SLAMF7"
                     /gene_synonym="19A; CD319; CRACC; CS1"
                     /inference="alignment:Splign:2.1.0"
     exon            608..670
                     /gene="SLAMF7"
                     /gene_synonym="19A; CD319; CRACC; CS1"
                     /inference="alignment:Splign:2.1.0"
     exon            671..2386
                     /gene="SLAMF7"
                     /gene_synonym="19A; CD319; CRACC; CS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2352..2357
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLAMF7"
                     /gene_synonym="19A; CD319; CRACC; CS1"
                     /note="hexamer: AATAAA"
     polyA_site      2386
                     /gene="SLAMF7"
                     /gene_synonym="19A; CD319; CRACC; CS1"
                     /note="major polyA site"
ORIGIN      
        1 gtaataccta agagggaagt ggcttcattt cagtggctga cttccagaga gcaatatggc
       61 tggttcccca acatgcctca ccctcatcta tatcctttgg cagctcacag agcacctgtc
      121 aaagcctaaa gtcaccatgg gtctgcagag caataagaat ggcacctgtg tgaccaatct
      181 gacatgctgc atggaacatg gggaagagga tgtgatttat acctggaagg ccctggggca
      241 agcagccaat gagtcccata atgggtccat cctccccatc tcctggagat ggggagaaag
      301 tgatatgacc ttcatctgcg ttgccaggaa ccctgtcagc agaaacttct caagccccat
      361 ccttgccagg aagctctgtg aaggtgctgc tgatgaccca gattcctcca tggtcctcct
      421 gtgtctcctg ttggtgcccc tcctgctcag tctctttgta ctggggctat ttctttggtt
      481 tctgaagaga gagagacaag aagagtacat tgaagagaag aagagagtgg acatttgtcg
      541 ggaaactcct aacatatgcc cccattctgg agagaacaca gagtacgaca caatccctca
      601 cactaataga acaatcctaa aggaagatcc agcaaatacg gtttactcca ctgtggaaat
      661 accgaaaaag atggaaaatc cccactcact gctcacgatg ccagacacac caaggctatt
      721 tgcctatgag aatgttatct agacagcagt gcactcccct aagtctctgc tcaaaaaaaa
      781 aacaattctc ggcccaaaga aaacaatcag aagaattcac tgatttgact agaaacatca
      841 aggaagaatg aagaacgttg acttttttcc aggataaatt atctctgatg cttctttaga
      901 tttaagagtt cataattcca tccactgctg agaaatctcc tcaaacccag aaggtttaat
      961 cacttcatcc caaaaatggg attgtgaatg tcagcaaacc ataaaaaaag tgcttagaag
     1021 tattcctata aaaatgtaaa tgcaaggtca cacatattaa tgacagcctg ttgtattaat
     1081 gatggctcca ggtcagtgtc tggagtttca ttccatccca gggcttggat gtcaggatta
     1141 taccaagagt cttgctacca ggagggcaag aagaccaaaa cagacagaca agtccagcag
     1201 aagcagatgc acctgacaaa aatggatgta ttaattggct ctataaacta tgtgcccagc
     1261 actatgctga gcttacacta attggtcaga catgctgtct gccctcatga aattggctcc
     1321 aaatgaatga actactttca tgagcagttg tagcaggcct gaccacagat tcccagaggg
     1381 ccaggtgtgg atccacagga cttgaaggtc aaagttcaca aagatgaaga atcagggtag
     1441 ctgaccatgt ttggcagata ctataatgga gacacagaag tgtgcatggc ccaaggacaa
     1501 ggacctccag ccaggcttca tttatgcact tgtgctgcaa aagaaaagtc taggttttaa
     1561 ggctgtgcca gaacccatcc caataaagag accgagtctg aagtcacatt gtaaatctag
     1621 tgtaggagac ttggagtcag gcagtgagac tggtggggca cggggggcag tgggtacttg
     1681 taaaccttta aagatggtta attcattcaa tagatattta ttaagaacct atgcggcccg
     1741 gcatggtggc tcacacctgt aatcccagca ctttgggagg ccaaggtggg tgggtcatct
     1801 gaggtcagga gttcaagacc agcctggcca acatggtgaa accccatctc tactaaagat
     1861 acaaaaattt gctgagcgtg gtggtgtgca cctgtaatcc cagctactcg agaggccaag
     1921 gcatgagaat cgcttgaacc tgggaggtgg aggttgcagt gagctgagat ggcaccactg
     1981 cactccggcc taggcaacga gagcaaaact ccaatacaaa caaacaaaca aacacctgtg
     2041 ctaggtcagt ctggcacgta agatgaacat ccctaccaat acagagctca ccatctctta
     2101 tacttaagtg aaaaacatgg ggaaggggaa aggggaatgg ctgcttttga tatgttccct
     2161 gacacatatc ttgaatggag acctccctac caagtgatga aagtgttgaa aaacttaata
     2221 acaaatgctt gttgggcaag aatgggattg aggattatct tctctcagaa aggcattgtg
     2281 aaggaattga gccagatctc tctccctact gcaaaaccct attgtagtaa aaaagtcttc
     2341 tttactatct taataaaaca gatattgtga gattcacata caaaaa
//
