LOCUS       NM_001184716            2400 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens SLAM family member 6 (SLAMF6), transcript variant 4,
            mRNA.
ACCESSION   NM_001184716
VERSION     NM_001184716.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2400)
  AUTHORS   Oba,T., Long,M.D., Ito,K.I. and Ito,F.
  TITLE     Clinical and immunological relevance of SLAMF6 expression in the
            tumor microenvironment of breast cancer and melanoma
  JOURNAL   Sci Rep 14 (1), 2394 (2024)
   PUBMED   38287061
  REMARK    GeneRIF: Clinical and immunological relevance of SLAMF6 expression
            in the tumor microenvironment of breast cancer and melanoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2400)
  AUTHORS   Xia,G., Li,Y., Pan,W., Qian,C., Ma,L., Zhou,J., Xu,H. and Cheng,C.
  TITLE     SLAMF6 is associated with the susceptibility and severity of
            rheumatoid arthritis in the Chinese population
  JOURNAL   J Orthop Surg Res 17 (1), 13 (2022)
   PUBMED   35016729
  REMARK    GeneRIF: SLAMF6 is associated with the susceptibility and severity
            of rheumatoid arthritis in the Chinese population.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2400)
  AUTHORS   Liu,B., Zeng,L., Shao,Y. and Fu,R.
  TITLE     Expression and function of SLAMF6 in CD8+ T lymphocytes of patients
            with severe aplastic anemia
  JOURNAL   Cell Immunol 364, 104343 (2021)
   PUBMED   33774556
  REMARK    GeneRIF: Expression and function of SLAMF6 in CD8(+) T lymphocytes
            of patients with severe aplastic anemia.
REFERENCE   4  (bases 1 to 2400)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2400)
  AUTHORS   Dragovich,M.A., Adam,K., Strazza,M., Tocheva,A.S., Peled,M. and
            Mor,A.
  TITLE     SLAMF6 clustering is required to augment T cell activation
  JOURNAL   PLoS One 14 (6), e0218109 (2019)
   PUBMED   31199820
  REMARK    GeneRIF: SLAMF6 is an important regulator of T cell activation
            where both its ectodomain and its endodomain contribute
            differentially to T cell functions.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2400)
  AUTHORS   Fraser,C.C., Howie,D., Morra,M., Qiu,Y., Murphy,C., Shen,Q.,
            Gutierrez-Ramos,J.C., Coyle,A., Kingsbury,G.A. and Terhorst,C.
  TITLE     Identification and characterization of SF2000 and SF2001, two new
            members of the immune receptor SLAM/CD2 family
  JOURNAL   Immunogenetics 53 (10-11), 843-850 (2002)
   PUBMED   11862385
REFERENCE   7  (bases 1 to 2400)
  AUTHORS   Bottino,C., Falco,M., Parolini,S., Marcenaro,E., Augugliaro,R.,
            Sivori,S., Landi,E., Biassoni,R., Notarangelo,L.D., Moretta,L. and
            Moretta,A.
  TITLE     NTB-A [correction of GNTB-A], a novel SH2D1A-associated surface
            molecule contributing to the inability of natural killer cells to
            kill Epstein-Barr virus-infected B cells in X-linked
            lymphoproliferative disease
  JOURNAL   J Exp Med 194 (3), 235-246 (2001)
   PUBMED   11489943
  REMARK    Erratum:[J Exp Med 2001 Sep 3;194(5):following 703]
REFERENCE   8  (bases 1 to 2400)
  AUTHORS   Lee,Y.J., Luisiri,P. and Clark,M.R.
  TITLE     A novel complex, p40/42, is constitutively associated with the B
            cell antigen receptor and phosphorylated upon receptor stimulation
  JOURNAL   J Immunol 157 (9), 3828-3837 (1996)
   PUBMED   8892612
REFERENCE   9  (bases 1 to 2400)
  AUTHORS   Kong,G., Dalton,M., Bubeck Wardenburg,J., Straus,D., Kurosaki,T.
            and Chan,A.C.
  TITLE     Distinct tyrosine phosphorylation sites in ZAP-70 mediate
            activation and negative regulation of antigen receptor function
  JOURNAL   Mol Cell Biol 16 (9), 5026-5035 (1996)
   PUBMED   8756661
REFERENCE   10 (bases 1 to 2400)
  AUTHORS   Hercend,T., Meuer,S., Brennan,A., Edson,M.A., Acuto,O.,
            Reinherz,E.L., Schlossman,S.F. and Ritz,J.
  TITLE     Natural killer-like function of activated T lymphocytes:
            differential blocking effects of monoclonal antibodies specific for
            a 90-kDa clonotypic structure
  JOURNAL   Cell Immunol 86 (2), 381-392 (1984)
   PUBMED   6610481
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB197632.1, AK301026.1,
            AW402723.1 and AK125624.1.
            
            On May 31, 2019 this sequence version replaced NM_001184716.1.
            
            Summary: The protein encoded by this gene is a type I transmembrane
            protein, belonging to the CD2 subfamily of the immunoglobulin
            superfamily. This encoded protein is expressed on Natural killer
            (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation
            and associates with the Src homology 2 domain-containing protein
            (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs).
            It functions as a coreceptor in the process of NK cell activation.
            It can also mediate inhibitory signals in NK cells from X-linked
            lymphoproliferative patients. Alternative splicing results in
            multiple transcript variants encoding distinct isoforms.[provided
            by RefSeq, May 2010].
            
            Transcript Variant: This variant (4) lacks an alternate exon in the
            5' coding region, compared to variant 1, which result in an isoform
            (4) with a shorter extracellular domain than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK301026.1, BI834685.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 DB197632.1         8-10
            4-867               AK301026.1         1-864
            868-900             AW402723.1         127-159
            901-2400            AK125624.1         1237-2736
FEATURES             Location/Qualifiers
     source          1..2400
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.2-q23.3"
     gene            1..2400
                     /gene="SLAMF6"
                     /gene_synonym="CD352; KALI; KALIb; Ly108; NTB-A; NTBA;
                     SF2000"
                     /note="SLAM family member 6"
                     /db_xref="GeneID:114836"
                     /db_xref="HGNC:HGNC:21392"
                     /db_xref="MIM:606446"
     exon            1..112
                     /gene="SLAMF6"
                     /gene_synonym="CD352; KALI; KALIb; Ly108; NTB-A; NTBA;
                     SF2000"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..729
                     /gene="SLAMF6"
                     /gene_synonym="CD352; KALI; KALIb; Ly108; NTB-A; NTBA;
                     SF2000"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 4; activating NK receptor; natural killer-, T- and
                     B-cell antigen; NTBA receptor; NK-T-B-antigen"
                     /codon_start=1
                     /product="SLAM family member 6 isoform 4 precursor"
                     /protein_id="NP_001171645.1"
                     /db_xref="CCDS:CCDS53393.1"
                     /db_xref="GeneID:114836"
                     /db_xref="HGNC:HGNC:21392"
                     /db_xref="MIM:606446"
                     /translation="MLWLFQSLLFVFCFGPGQLRNIQVTNHSQLFQNMTCELHLTCSV
                     EDADDNVSFRWEALGNTLSSQPNLTVSWDPRISSEQDYTCIAENAVSNLSFSVSAQKL
                     CEDVKIQYTDTKMILFMVSGICIVFGFIILLLLVLRKRRDSLSLSTQRTQGPAESARN
                     LEYVSVSPTNNTVYASVTHSNRETEIWTPRENDTITIYSTINHSKESKPTFSRATALD
                     NVV"
     exon            113..376
                     /gene="SLAMF6"
                     /gene_synonym="CD352; KALI; KALIb; Ly108; NTB-A; NTBA;
                     SF2000"
                     /inference="alignment:Splign:2.1.0"
     exon            377..487
                     /gene="SLAMF6"
                     /gene_synonym="CD352; KALI; KALIb; Ly108; NTB-A; NTBA;
                     SF2000"
                     /inference="alignment:Splign:2.1.0"
     exon            488..526
                     /gene="SLAMF6"
                     /gene_synonym="CD352; KALI; KALIb; Ly108; NTB-A; NTBA;
                     SF2000"
                     /inference="alignment:Splign:2.1.0"
     exon            527..609
                     /gene="SLAMF6"
                     /gene_synonym="CD352; KALI; KALIb; Ly108; NTB-A; NTBA;
                     SF2000"
                     /inference="alignment:Splign:2.1.0"
     exon            610..681
                     /gene="SLAMF6"
                     /gene_synonym="CD352; KALI; KALIb; Ly108; NTB-A; NTBA;
                     SF2000"
                     /inference="alignment:Splign:2.1.0"
     exon            682..2400
                     /gene="SLAMF6"
                     /gene_synonym="CD352; KALI; KALIb; Ly108; NTB-A; NTBA;
                     SF2000"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2372..2377
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLAMF6"
                     /gene_synonym="CD352; KALI; KALIb; Ly108; NTB-A; NTBA;
                     SF2000"
                     /note="hexamer: AATAAA"
     regulatory      2380..2385
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLAMF6"
                     /gene_synonym="CD352; KALI; KALIb; Ly108; NTB-A; NTBA;
                     SF2000"
                     /note="hexamer: AATAAA"
     polyA_site      2391
                     /gene="SLAMF6"
                     /gene_synonym="CD352; KALI; KALIb; Ly108; NTB-A; NTBA;
                     SF2000"
     polyA_site      2400
                     /gene="SLAMF6"
                     /gene_synonym="CD352; KALI; KALIb; Ly108; NTB-A; NTBA;
                     SF2000"
                     /note="major polyA site"
ORIGIN      
        1 gacagaaggg caaaaacatt gactgcctca aggtctcaag caccagtctt caccgcggaa
       61 agcatgttgt ggctgttcca atcgctcctg tttgtcttct gctttggccc aggacaactg
      121 aggaacatac aagttaccaa tcacagtcag ctatttcaga atatgacctg tgagctccat
      181 ctgacttgct ctgtggagga tgcagatgac aatgtctcat tcagatggga ggccttggga
      241 aacacacttt caagtcagcc aaacctcact gtctcctggg accccaggat ttccagtgaa
      301 caggactaca cctgcatagc agagaatgct gtcagtaatt tatccttctc tgtctctgcc
      361 cagaagcttt gcgaagatgt taaaattcaa tatacagata ccaaaatgat tctgtttatg
      421 gtttctggga tatgcatagt cttcggtttc atcatactgc tgttacttgt tttgaggaaa
      481 agaagagatt ccctatcttt gtctactcag cgaacacagg gccccgcaga gtccgcaagg
      541 aacctagagt atgtttcagt gtctccaacg aacaacactg tgtatgcttc agtcactcat
      601 tcaaacaggg aaacagaaat ctggacacct agagaaaatg atactatcac aatttactcc
      661 acaattaatc attccaaaga gagtaaaccc actttttcca gggcaactgc ccttgacaat
      721 gtcgtgtaag ttgctgaaag gcctcagagg aattcgggaa tgacacgtct tctgatccca
      781 tgagacagaa caaagaacag gaagcttggt tcctgttgtt cctggcaaca gaatttgaat
      841 atctaggata ggatgatcac ctccagtcct tcggacttaa acctgcctac ctgagtcaaa
      901 cacctaagga taacatcatt tccagcatgt ggttcaaata atattttcca atccacttca
      961 ggccaaaaca tgctaaagat aacacaccag cacattgact ctctctttga taactaagca
     1021 aatggaatta tggttgacag agagtttatg atccagaaga caaccacttc tctcctttta
     1081 gaaagcagca ggattgactt attgagaaat aatgcagtgt gttggttaca tgtgtagtct
     1141 ctggagttgg atgggcccat cctgatacaa gttgagcatc ccttgtctga aatgcttggg
     1201 attagaaatg tttcagattt caattttttt tcagattttg gaatatttgc attatattta
     1261 gcggttgagt atccaaatcc aaaaatccaa aattcaaaat gctccaataa gcatttccct
     1321 tgagtttcat tgatgtcgat gcagtgctca aaatctcaga ttttggagca ttttggatat
     1381 tggatttttg gatttgggat gctcaacttg tacaatgttt attagacaca tctcctggga
     1441 catactgcct aaccttttgg agccttagtc tcccagactg aaaaaggaag aggatggtat
     1501 tacatcagct ccattgtttg agccaagaat ctaagtcatc cctgactcca gtgtctttgt
     1561 caccaggccc tttggactct acctcagaaa tatttcttgg accttccact tctcctccaa
     1621 ctccttgacc accatcctgt atccaaccat caccacctct aacctgaatc ctaccttaag
     1681 atcagaacag ttgtcctcac ttttgttctt gtccctctcc aacccactct ccacaagatg
     1741 gccagagtaa tgtttttaat ataaattgga tccttcagtt tcctgcttaa aaccctgcag
     1801 gtttcccaat gcactcagaa agaaatccag tttccatggc cctggatggt ctggcccacc
     1861 tccagcctca gctagcatta cccttctgac actctctatg tagcctccct gatcttcttt
     1921 cagctcctct attaaaggaa aagttcttta tgttaattat ttacatcttc ctgcaggccc
     1981 ttcctctgcc tgctggggtc ctcctattct ttaggtttaa ttttaaatat gtcacctcct
     2041 aagagaaacc ttcccagacc actctttcta aaatgaatct tctaggctgg gcatggtggc
     2101 tcacacctgt aatccctgta ctttgggagg ccaagggggg agatcacttg aggtcaggag
     2161 ttcaagacca gcctggccaa cttggtgaaa ccccgtcttt actaaaaata caaaaaaatt
     2221 agccaggcgt ggtggtgcac ccctaaaatc ccagctactt gagagactga ggcaggagaa
     2281 tcgcttgaac ccaggaggtg gaggttccag tgagccaaaa tcatgccaat gtattccagt
     2341 ctgggtgaca gagtgagact ctgtctcaaa aaataaataa ataaaataaa atgaaataga
//
