LOCUS       NM_001184714            2733 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens SLAM family member 6 (SLAMF6), transcript variant 1,
            mRNA.
ACCESSION   NM_001184714
VERSION     NM_001184714.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2733)
  AUTHORS   Oba,T., Long,M.D., Ito,K.I. and Ito,F.
  TITLE     Clinical and immunological relevance of SLAMF6 expression in the
            tumor microenvironment of breast cancer and melanoma
  JOURNAL   Sci Rep 14 (1), 2394 (2024)
   PUBMED   38287061
  REMARK    GeneRIF: Clinical and immunological relevance of SLAMF6 expression
            in the tumor microenvironment of breast cancer and melanoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2733)
  AUTHORS   Xia,G., Li,Y., Pan,W., Qian,C., Ma,L., Zhou,J., Xu,H. and Cheng,C.
  TITLE     SLAMF6 is associated with the susceptibility and severity of
            rheumatoid arthritis in the Chinese population
  JOURNAL   J Orthop Surg Res 17 (1), 13 (2022)
   PUBMED   35016729
  REMARK    GeneRIF: SLAMF6 is associated with the susceptibility and severity
            of rheumatoid arthritis in the Chinese population.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2733)
  AUTHORS   Liu,B., Zeng,L., Shao,Y. and Fu,R.
  TITLE     Expression and function of SLAMF6 in CD8+ T lymphocytes of patients
            with severe aplastic anemia
  JOURNAL   Cell Immunol 364, 104343 (2021)
   PUBMED   33774556
  REMARK    GeneRIF: Expression and function of SLAMF6 in CD8(+) T lymphocytes
            of patients with severe aplastic anemia.
REFERENCE   4  (bases 1 to 2733)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2733)
  AUTHORS   Dragovich,M.A., Adam,K., Strazza,M., Tocheva,A.S., Peled,M. and
            Mor,A.
  TITLE     SLAMF6 clustering is required to augment T cell activation
  JOURNAL   PLoS One 14 (6), e0218109 (2019)
   PUBMED   31199820
  REMARK    GeneRIF: SLAMF6 is an important regulator of T cell activation
            where both its ectodomain and its endodomain contribute
            differentially to T cell functions.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2733)
  AUTHORS   Fraser,C.C., Howie,D., Morra,M., Qiu,Y., Murphy,C., Shen,Q.,
            Gutierrez-Ramos,J.C., Coyle,A., Kingsbury,G.A. and Terhorst,C.
  TITLE     Identification and characterization of SF2000 and SF2001, two new
            members of the immune receptor SLAM/CD2 family
  JOURNAL   Immunogenetics 53 (10-11), 843-850 (2002)
   PUBMED   11862385
REFERENCE   7  (bases 1 to 2733)
  AUTHORS   Bottino,C., Falco,M., Parolini,S., Marcenaro,E., Augugliaro,R.,
            Sivori,S., Landi,E., Biassoni,R., Notarangelo,L.D., Moretta,L. and
            Moretta,A.
  TITLE     NTB-A [correction of GNTB-A], a novel SH2D1A-associated surface
            molecule contributing to the inability of natural killer cells to
            kill Epstein-Barr virus-infected B cells in X-linked
            lymphoproliferative disease
  JOURNAL   J Exp Med 194 (3), 235-246 (2001)
   PUBMED   11489943
  REMARK    Erratum:[J Exp Med 2001 Sep 3;194(5):following 703]
REFERENCE   8  (bases 1 to 2733)
  AUTHORS   Lee,Y.J., Luisiri,P. and Clark,M.R.
  TITLE     A novel complex, p40/42, is constitutively associated with the B
            cell antigen receptor and phosphorylated upon receptor stimulation
  JOURNAL   J Immunol 157 (9), 3828-3837 (1996)
   PUBMED   8892612
REFERENCE   9  (bases 1 to 2733)
  AUTHORS   Kong,G., Dalton,M., Bubeck Wardenburg,J., Straus,D., Kurosaki,T.
            and Chan,A.C.
  TITLE     Distinct tyrosine phosphorylation sites in ZAP-70 mediate
            activation and negative regulation of antigen receptor function
  JOURNAL   Mol Cell Biol 16 (9), 5026-5035 (1996)
   PUBMED   8756661
REFERENCE   10 (bases 1 to 2733)
  AUTHORS   Hercend,T., Meuer,S., Brennan,A., Edson,M.A., Acuto,O.,
            Reinherz,E.L., Schlossman,S.F. and Ritz,J.
  TITLE     Natural killer-like function of activated T lymphocytes:
            differential blocking effects of monoclonal antibodies specific for
            a 90-kDa clonotypic structure
  JOURNAL   Cell Immunol 86 (2), 381-392 (1984)
   PUBMED   6610481
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB197632.1, AY358159.1 and
            AK125624.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001184714.1.
            
            Summary: The protein encoded by this gene is a type I transmembrane
            protein, belonging to the CD2 subfamily of the immunoglobulin
            superfamily. This encoded protein is expressed on Natural killer
            (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation
            and associates with the Src homology 2 domain-containing protein
            (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs).
            It functions as a coreceptor in the process of NK cell activation.
            It can also mediate inhibitory signals in NK cells from X-linked
            lymphoproliferative patients. Alternative splicing results in
            multiple transcript variants encoding distinct isoforms.[provided
            by RefSeq, May 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL832854.1, AY358159.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368057.8/ ENSP00000357036.3
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 DB197632.1         8-9
            3-1703              AY358159.1         1-1701
            1704-2733           AK125624.1         1707-2736
FEATURES             Location/Qualifiers
     source          1..2733
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.2-q23.3"
     gene            1..2733
                     /gene="SLAMF6"
                     /gene_synonym="CD352; KALI; KALIb; Ly108; NTB-A; NTBA;
                     SF2000"
                     /note="SLAM family member 6"
                     /db_xref="GeneID:114836"
                     /db_xref="HGNC:HGNC:21392"
                     /db_xref="MIM:606446"
     exon            1..112
                     /gene="SLAMF6"
                     /gene_synonym="CD352; KALI; KALIb; Ly108; NTB-A; NTBA;
                     SF2000"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1062
                     /gene="SLAMF6"
                     /gene_synonym="CD352; KALI; KALIb; Ly108; NTB-A; NTBA;
                     SF2000"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; activating NK receptor; natural killer-, T- and
                     B-cell antigen; NTBA receptor; NK-T-B-antigen"
                     /codon_start=1
                     /product="SLAM family member 6 isoform 1 precursor"
                     /protein_id="NP_001171643.1"
                     /db_xref="CCDS:CCDS53394.1"
                     /db_xref="GeneID:114836"
                     /db_xref="HGNC:HGNC:21392"
                     /db_xref="MIM:606446"
                     /translation="MLWLFQSLLFVFCFGPGNVVSQSSLTPLMVNGILGESVTLPLEF
                     PAGEKVNFITWLFNETSLAFIVPHETKSPEIHVTNPKQGKRLNFTQSYSLQLSNLKME
                     DTGSYRAQISTKTSAKLSSYTLRILRQLRNIQVTNHSQLFQNMTCELHLTCSVEDADD
                     NVSFRWEALGNTLSSQPNLTVSWDPRISSEQDYTCIAENAVSNLSFSVSAQKLCEDVK
                     IQYTDTKMILFMVSGICIVFGFIILLLLVLRKRRDSLSLSTQRTQGPAESARNLEYVS
                     VSPTNNTVYASVTHSNRETEIWTPRENDTITIYSTINHSKESKPTFSRATALDNVV"
     exon            113..445
                     /gene="SLAMF6"
                     /gene_synonym="CD352; KALI; KALIb; Ly108; NTB-A; NTBA;
                     SF2000"
                     /inference="alignment:Splign:2.1.0"
     exon            446..709
                     /gene="SLAMF6"
                     /gene_synonym="CD352; KALI; KALIb; Ly108; NTB-A; NTBA;
                     SF2000"
                     /inference="alignment:Splign:2.1.0"
     exon            710..820
                     /gene="SLAMF6"
                     /gene_synonym="CD352; KALI; KALIb; Ly108; NTB-A; NTBA;
                     SF2000"
                     /inference="alignment:Splign:2.1.0"
     exon            821..859
                     /gene="SLAMF6"
                     /gene_synonym="CD352; KALI; KALIb; Ly108; NTB-A; NTBA;
                     SF2000"
                     /inference="alignment:Splign:2.1.0"
     exon            860..942
                     /gene="SLAMF6"
                     /gene_synonym="CD352; KALI; KALIb; Ly108; NTB-A; NTBA;
                     SF2000"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1014
                     /gene="SLAMF6"
                     /gene_synonym="CD352; KALI; KALIb; Ly108; NTB-A; NTBA;
                     SF2000"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..2733
                     /gene="SLAMF6"
                     /gene_synonym="CD352; KALI; KALIb; Ly108; NTB-A; NTBA;
                     SF2000"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2705..2710
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLAMF6"
                     /gene_synonym="CD352; KALI; KALIb; Ly108; NTB-A; NTBA;
                     SF2000"
                     /note="hexamer: AATAAA"
     regulatory      2713..2718
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLAMF6"
                     /gene_synonym="CD352; KALI; KALIb; Ly108; NTB-A; NTBA;
                     SF2000"
                     /note="hexamer: AATAAA"
     polyA_site      2724
                     /gene="SLAMF6"
                     /gene_synonym="CD352; KALI; KALIb; Ly108; NTB-A; NTBA;
                     SF2000"
     polyA_site      2733
                     /gene="SLAMF6"
                     /gene_synonym="CD352; KALI; KALIb; Ly108; NTB-A; NTBA;
                     SF2000"
                     /note="major polyA site"
ORIGIN      
        1 gacagaaggg caaaaacatt gactgcctca aggtctcaag caccagtctt caccgcggaa
       61 agcatgttgt ggctgttcca atcgctcctg tttgtcttct gctttggccc agggaatgta
      121 gtttcacaaa gcagcttaac cccattgatg gtgaacggga ttctggggga gtcagtaact
      181 cttcccctgg agtttcctgc aggagagaag gtcaacttca tcacttggct tttcaatgaa
      241 acatctcttg ccttcatagt accccatgaa accaaaagtc cagaaatcca cgtgactaat
      301 ccgaaacagg gaaagcgact gaacttcacc cagtcctact ccctgcaact cagcaacctg
      361 aagatggaag acacaggctc ttacagagcc cagatatcca caaagacctc tgcaaagctg
      421 tccagttaca ctctgaggat attaagacaa ctgaggaaca tacaagttac caatcacagt
      481 cagctatttc agaatatgac ctgtgagctc catctgactt gctctgtgga ggatgcagat
      541 gacaatgtct cattcagatg ggaggccttg ggaaacacac tttcaagtca gccaaacctc
      601 actgtctcct gggaccccag gatttccagt gaacaggact acacctgcat agcagagaat
      661 gctgtcagta atttatcctt ctctgtctct gcccagaagc tttgcgaaga tgttaaaatt
      721 caatatacag ataccaaaat gattctgttt atggtttctg ggatatgcat agtcttcggt
      781 ttcatcatac tgctgttact tgttttgagg aaaagaagag attccctatc tttgtctact
      841 cagcgaacac agggccccgc agagtccgca aggaacctag agtatgtttc agtgtctcca
      901 acgaacaaca ctgtgtatgc ttcagtcact cattcaaaca gggaaacaga aatctggaca
      961 cctagagaaa atgatactat cacaatttac tccacaatta atcattccaa agagagtaaa
     1021 cccacttttt ccagggcaac tgcccttgac aatgtcgtgt aagttgctga aaggcctcag
     1081 aggaattcgg gaatgacacg tcttctgatc ccatgagaca gaacaaagaa caggaagctt
     1141 ggttcctgtt gttcctggca acagaatttg aatatctagg ataggatgat cacctccagt
     1201 ccttcggact taaacctgcc tacctgagtc aaacacctaa ggataacatc atttccagca
     1261 tgtggttcaa ataatatttt ccaatccact tcaggccaaa acatgctaaa gataacacac
     1321 cagcacattg actctctctt tgataactaa gcaaatggaa ttatggttga cagagagttt
     1381 atgatccaga agacaaccac ttctctcctt ttagaaagca gcaggattga cttattgaga
     1441 aataatgcag tgtgttggtt acatgtgtag tctctggagt tggatgggcc catcctgata
     1501 caagttgagc atcccttgtc tgaaatgctt gggattagaa atgtttcaga tttcaatttt
     1561 ttttcagatt ttggaatatt tgcattatat ttagcggttg agtatccaaa tccaaaaatc
     1621 caaaattcaa aatgctccaa taagcatttc ccttgagttt cattgatgtc gatgcagtgc
     1681 tcaaaatctc agattttgga gcattttgga tattggattt ttggatttgg gatgctcaac
     1741 ttgtacaatg tttattagac acatctcctg ggacatactg cctaaccttt tggagcctta
     1801 gtctcccaga ctgaaaaagg aagaggatgg tattacatca gctccattgt ttgagccaag
     1861 aatctaagtc atccctgact ccagtgtctt tgtcaccagg ccctttggac tctacctcag
     1921 aaatatttct tggaccttcc acttctcctc caactccttg accaccatcc tgtatccaac
     1981 catcaccacc tctaacctga atcctacctt aagatcagaa cagttgtcct cacttttgtt
     2041 cttgtccctc tccaacccac tctccacaag atggccagag taatgttttt aatataaatt
     2101 ggatccttca gtttcctgct taaaaccctg caggtttccc aatgcactca gaaagaaatc
     2161 cagtttccat ggccctggat ggtctggccc acctccagcc tcagctagca ttacccttct
     2221 gacactctct atgtagcctc cctgatcttc tttcagctcc tctattaaag gaaaagttct
     2281 ttatgttaat tatttacatc ttcctgcagg cccttcctct gcctgctggg gtcctcctat
     2341 tctttaggtt taattttaaa tatgtcacct cctaagagaa accttcccag accactcttt
     2401 ctaaaatgaa tcttctaggc tgggcatggt ggctcacacc tgtaatccct gtactttggg
     2461 aggccaaggg gggagatcac ttgaggtcag gagttcaaga ccagcctggc caacttggtg
     2521 aaaccccgtc tttactaaaa atacaaaaaa attagccagg cgtggtggtg cacccctaaa
     2581 atcccagcta cttgagagac tgaggcagga gaatcgcttg aacccaggag gtggaggttc
     2641 cagtgagcca aaatcatgcc aatgtattcc agtctgggtg acagagtgag actctgtctc
     2701 aaaaaataaa taaataaaat aaaatgaaat aga
//
