LOCUS       NM_003037               3749 bp    mRNA    linear   PRI 19-MAR-2025
DEFINITION  Homo sapiens signaling lymphocytic activation molecule family
            member 1 (SLAMF1), transcript variant 1, mRNA.
ACCESSION   NM_003037
VERSION     NM_003037.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3749)
  AUTHORS   Liu,M., Jiang,Z., Liu,M., Ni,H., Li,Y., Fang,J., Du,Q. and Dong,Y.
  TITLE     SLAMF1 as a novel molecule mediating the causal association between
            rheumatoid arthritis and interstitial lung disease: A Mendelian
            randomization study combined with transcriptomics and in vivo
            validation
  JOURNAL   Int Immunopharmacol 142 (Pt A), 113082 (2024)
   PUBMED   39260308
  REMARK    GeneRIF: SLAMF1 as a novel molecule mediating the causal
            association between rheumatoid arthritis and interstitial lung
            disease: A Mendelian randomization study combined with
            transcriptomics and in vivo validation.
REFERENCE   2  (bases 1 to 3749)
  AUTHORS   Gomez-Torres,O., Amatya,S., Kamberov,L., Dhaibar,H.A., Khanna,P.,
            Rom,O., Yurdagul,A. Jr., Orr,A.W., Nunez,K., Thevenot,P., Cohen,A.,
            Samant,H., Alexander,J.S., Burgos-Ramos,E., Chapa-Rodriguez,A. and
            Cruz-Topete,D.
  TITLE     SLAMF1 is expressed and secreted by hepatocytes and the liver in
            nonalcoholic fatty liver disease
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 323 (3), G177-G187 (2022)
   PUBMED   35853010
  REMARK    GeneRIF: SLAMF1 is expressed and secreted by hepatocytes and the
            liver in nonalcoholic fatty liver disease.
REFERENCE   3  (bases 1 to 3749)
  AUTHORS   Li,A., Zhang,Z., Ru,X., Yi,Y., Li,X., Qian,J., Wang,J., Yang,X. and
            Yao,Y.
  TITLE     Identification of SLAMF1 as an immune-related key gene associated
            with rheumatoid arthritis and verified in mice collagen-induced
            arthritis model
  JOURNAL   Front Immunol 13, 961129 (2022)
   PUBMED   36110846
  REMARK    GeneRIF: Identification of SLAMF1 as an immune-related key gene
            associated with rheumatoid arthritis and verified in mice
            collagen-induced arthritis model.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3749)
  AUTHORS   Gordiienko,I.M., Lykhova,O.O., Shcherbina,V.M. and Shlapatska,L.M.
  TITLE     SLAMF1/CD150 expression and topology in prostate and breast cancer
            cell lines
  JOURNAL   Exp Oncol 43 (4), 312-316 (2021)
   PUBMED   34967540
  REMARK    GeneRIF: SLAMF1/CD150 expression and topology in prostate and
            breast cancer cell lines.
REFERENCE   5  (bases 1 to 3749)
  AUTHORS   Geng,L., Yang,J., Tang,X., Peng,H., Tian,J., Hu,Z., Liu,Y., Xu,H.
            and Wang,S.
  TITLE     SLAM/SAP Decreased Follicular Regulatory T Cells in Patients with
            Graves' Disease
  JOURNAL   J Immunol Res 2021, 5548463 (2021)
   PUBMED   33987447
  REMARK    GeneRIF: SLAM/SAP Decreased Follicular Regulatory T Cells in
            Patients with Graves' Disease.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3749)
  AUTHORS   Putlyaeva,L.V., Schwartz,A.M., Korneev,K.V., Covic,M.,
            Uroshlev,L.A., Makeev,V.Y., Dmitriev,S.E. and Kuprash,D.V.
  TITLE     Upstream open reading frames regulate translation of the long
            isoform of SLAMF1 mRNA that encodes costimulatory receptor CD150
  JOURNAL   Biochemistry (Mosc) 79 (12), 1405-1411 (2014)
   PUBMED   25716736
  REMARK    GeneRIF: Upstream open reading frames regulate translation of the
            long isoform of SLAMF1 mRNA that encodes costimulatory receptor
            CD150
REFERENCE   7  (bases 1 to 3749)
  AUTHORS   Sayos,J., Wu,C., Morra,M., Wang,N., Zhang,X., Allen,D., van
            Schaik,S., Notarangelo,L., Geha,R., Roncarolo,M.G., Oettgen,H., De
            Vries,J.E., Aversa,G. and Terhorst,C.
  TITLE     The X-linked lymphoproliferative-disease gene product SAP regulates
            signals induced through the co-receptor SLAM
  JOURNAL   Nature 395 (6701), 462-469 (1998)
   PUBMED   9774102
REFERENCE   8  (bases 1 to 3749)
  AUTHORS   Punnonen,J., Cocks,B.G., Carballido,J.M., Bennett,B., Peterson,D.,
            Aversa,G. and de Vries,J.E.
  TITLE     Soluble and membrane-bound forms of signaling lymphocytic
            activation molecule (SLAM) induce proliferation and Ig synthesis by
            activated human B lymphocytes
  JOURNAL   J Exp Med 185 (6), 993-1004 (1997)
   PUBMED   9091591
REFERENCE   9  (bases 1 to 3749)
  AUTHORS   Cocks,B.G., Chang,C.C., Carballido,J.M., Yssel,H., de Vries,J.E.
            and Aversa,G.
  TITLE     A novel receptor involved in T-cell activation
  JOURNAL   Nature 376 (6537), 260-263 (1995)
   PUBMED   7617038
REFERENCE   10 (bases 1 to 3749)
  AUTHORS   Sidorenko,S.P. and Clark,E.A.
  TITLE     Characterization of a cell surface glycoprotein IPO-3, expressed on
            activated human B and T lymphocytes
  JOURNAL   J Immunol 151 (9), 4614-4624 (1993)
   PUBMED   8409422
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL121985.13 and AL138930.15.
            
            On Nov 10, 2020 this sequence version replaced NM_003037.4.
            
            Transcript Variant: This variant (1) lacks an alternate coding exon
            compared to variant 5. The resulting isoform (b) has a shorter and
            distinct C-terminus compared to isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302035.11/ ENSP00000306190.6
            RefSeq Select criteria :: based on conservation, expression
            regulatory uORF        :: PMID: 25716736
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-175               AL121985.13        34144-34318         c
            176-514             AL121985.13        24465-24803         c
            515-799             AL121985.13        21887-22171         c
            800-889             AL121985.13        11370-11459         c
            890-963             AL121985.13        7050-7123           c
            964-1056            AL138930.15        173151-173243       c
            1057-3749           AL138930.15        168769-171461       c
FEATURES             Location/Qualifiers
     source          1..3749
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.3"
     gene            1..3749
                     /gene="SLAMF1"
                     /gene_synonym="CD150; CDw150; IPO3; SLAM"
                     /note="signaling lymphocytic activation molecule family
                     member 1"
                     /db_xref="GeneID:6504"
                     /db_xref="HGNC:HGNC:10903"
                     /db_xref="MIM:603492"
     exon            1..175
                     /gene="SLAMF1"
                     /gene_synonym="CD150; CDw150; IPO3; SLAM"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1107
                     /gene="SLAMF1"
                     /gene_synonym="CD150; CDw150; IPO3; SLAM"
                     /note="isoform b precursor is encoded by transcript
                     variant 1; IPO-3; SLAM family member 1"
                     /codon_start=1
                     /product="signaling lymphocytic activation molecule
                     isoform b precursor"
                     /protein_id="NP_003028.1"
                     /db_xref="CCDS:CCDS1207.1"
                     /db_xref="GeneID:6504"
                     /db_xref="HGNC:HGNC:10903"
                     /db_xref="MIM:603492"
                     /translation="MDPKGLLSLTFVLFLSLAFGASYGTGGRMMNCPKILRQLGSKVL
                     LPLTYERINKSMNKSIHIVVTMAKSLENSVENKIVSLDPSEAGPPRYLGDRYKFYLEN
                     LTLGIRESRKEDEGWYLMTLEKNVSVQRFCLQLRLYEQVSTPEIKVLNKTQENGTCTL
                     ILGCTVEKGDHVAYSWSEKAGTHPLNPANSSHLLSLTLGPQHADNIYICTVSNPISNN
                     SQTFSPWPGCRTDPSETKPWAVYAGLLGGVIMILIMVVILQLRRRGKTNHYQTTVEKK
                     SLTIYAQVQKPGPLQKKLDSFPAQDPCTTIYVAATEPVPESVQETNSITVYASVTLPE
                     S"
     exon            176..514
                     /gene="SLAMF1"
                     /gene_synonym="CD150; CDw150; IPO3; SLAM"
                     /inference="alignment:Splign:2.1.0"
     exon            515..799
                     /gene="SLAMF1"
                     /gene_synonym="CD150; CDw150; IPO3; SLAM"
                     /inference="alignment:Splign:2.1.0"
     exon            800..889
                     /gene="SLAMF1"
                     /gene_synonym="CD150; CDw150; IPO3; SLAM"
                     /inference="alignment:Splign:2.1.0"
     exon            890..963
                     /gene="SLAMF1"
                     /gene_synonym="CD150; CDw150; IPO3; SLAM"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1056
                     /gene="SLAMF1"
                     /gene_synonym="CD150; CDw150; IPO3; SLAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..3749
                     /gene="SLAMF1"
                     /gene_synonym="CD150; CDw150; IPO3; SLAM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1731..1736
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLAMF1"
                     /gene_synonym="CD150; CDw150; IPO3; SLAM"
                     /note="hexamer: AATAAA"
     polyA_site      1754
                     /gene="SLAMF1"
                     /gene_synonym="CD150; CDw150; IPO3; SLAM"
                     /note="major polyA site"
     regulatory      3726..3731
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLAMF1"
                     /gene_synonym="CD150; CDw150; IPO3; SLAM"
                     /note="hexamer: ATTACA"
     polyA_site      3749
                     /gene="SLAMF1"
                     /gene_synonym="CD150; CDw150; IPO3; SLAM"
ORIGIN      
        1 agacagcctc tgctgcatga cacgaagctt gcttctgcct ggcatctgtg agcagctgcc
       61 aggctccggc caggatccct tccttctcct cattggctga tggatcccaa ggggctcctc
      121 tccttgacct tcgtgctgtt tctctccctg gcttttgggg caagctacgg aacaggtggg
      181 cgcatgatga actgcccaaa gattctccgg cagttgggaa gcaaagtgct gctgcccctg
      241 acatatgaaa ggataaataa gagcatgaac aaaagcatcc acattgtcgt cacaatggca
      301 aaatcactgg agaacagtgt cgagaacaaa atagtgtctc ttgatccatc cgaagcaggc
      361 cctccacgtt atctaggaga tcgctacaag ttttatctgg agaatctcac cctggggata
      421 cgggaaagca ggaaggagga tgagggatgg taccttatga ccctggagaa aaatgtttca
      481 gttcagcgct tttgcctgca gttgaggctt tatgagcagg tctccactcc agaaattaaa
      541 gttttaaaca agacccagga gaacgggacc tgcaccttga tactgggctg cacagtggag
      601 aagggggacc atgtggctta cagctggagt gaaaaggcgg gcacccaccc actgaaccca
      661 gccaacagct cccacctcct gtccctcacc ctcggccccc agcatgctga caatatctac
      721 atctgcaccg tgagcaaccc tatcagcaac aattcccaga ccttcagccc gtggcccgga
      781 tgcaggacag acccctcaga aacaaaacca tgggcagtgt atgctgggct gttagggggt
      841 gtcatcatga ttctcatcat ggtggtaata ctacagttga gaagaagagg taaaacgaac
      901 cattaccaga caacagtgga aaaaaaaagc cttacgatct atgcccaagt ccagaaacca
      961 ggtcctcttc agaagaaact tgactccttc ccagctcagg acccttgcac caccatatat
     1021 gttgctgcca cagagcctgt cccagagtct gtccaggaaa caaattccat cacagtctat
     1081 gctagtgtga cacttccaga gagctgacac cagagaccaa caaagggact ttctgaagga
     1141 aaatggaaaa accaaaatga acactgaact tggccacagg ccccaagttt cctctggcag
     1201 acatgctgca cgtctgtacc cttctcagat caactccctg gtgatgtttc ttccacatac
     1261 atctgtgaaa tgaacaagga agtgaggctt cccaagaatt tagcttgctg tgcagtggct
     1321 gcaggcgcag aacagagcgt tacttgataa cagcgttcca tctttgtgtt gtagcagatg
     1381 aaatggacag taatgtgagt tcagactttg ggcatcttgc tcttggctgg aactggataa
     1441 taaaaatcag actgaaagcc aggacatctg agtacctatc tcacacactg gaccaccagt
     1501 cacaaagtct ggaaaagttt acattttggc tatctttact ttgttctggg agctgatcat
     1561 gataacctgc agacctgatc aagcctctgt gcctcagttt ctctctcagg ataaagagtg
     1621 aatagaggct gaagggtgaa tttcttatta tacataaaac actctgatat tattgtataa
     1681 aggaagctaa gaatattatt ttatttgcaa aacccagaag ctaaaaagtc aataaacaga
     1741 aagaatgatt ttgagatctc tgagttttga acagtggact ggaaaccatg taagagcctt
     1801 aaaagtacag ttctgtgcaa atggcattca gttttaaaga aaaacgtagc aaatgtttga
     1861 tggtgctgtt acaaaggagc ttggaatact cagaggaact tgtcccatgg tgatttttca
     1921 cttctcaaaa tgatgtttaa atcccagttc tctgttgatt cccttgaaca acaaacctgg
     1981 aacctcagct aagactctct gtgaccagat tctgaacctc ttatatccag ggcttcaagg
     2041 ggtattgcag gtcaaggtct ttcctaggca ctttctactc cctgcatacc tctcctcaca
     2101 ctaaatttat cctctagtag aaaattaagt tattttggtc taacagcttc aaatctttga
     2161 atgctcaata acttattttg caagctgcag gcagaaagag actttttaag taaagtcctt
     2221 tgttttttcc tattctctgc ttttagacag gctgtcctca atttaagccc tgctttttct
     2281 tattgtttct tatataaact tggtaagtac tgtaagaaac agccactatc ataccattgc
     2341 ataataagga gcaccaactt cccagctcaa aactcaggtc cttattgcct tgtatcttac
     2401 ctcctctatg aggtcaattc acattgtaag cctgttgctt agtgcatctc gtttcctggt
     2461 accagcttct ttaatagagt tcttagttgc aatcaacaga agctggcttt ggctttttta
     2521 tgtagaaaag gaacctattg aaaagatact gattggttcc aataactgct agaagtttct
     2581 gcaaaaccat gctttgaaag tgagcaggaa aagaagagac taggctgtgg ctgggagcac
     2641 agccaaaatt acaaaaccag cccagggatg atgatcctgt tcatgcacag ccactgtccc
     2701 cagcactagg cacagactct accactgcct cactgtctct gctggacttg gaaacttgat
     2761 attactgtta ctgctgcact gtctgccatg aaaatgaatt ctccagggtc ccttcttcat
     2821 cctttcatct ctagcttata attcaaagtc tgggattgag tggccaatcc taggtcacat
     2881 gtccatgtcc tatctccaag gggggctggg aattgaatat ctggcatttt ccactttcac
     2941 ttcttatgaa ttaaggaatt ctacaaataa tagaagtggg attcaggtgg taggcagaca
     3001 aaaaagcctc acaattatcc actacgccac ccttgtataa ccttaccctc attcactgtc
     3061 tactctcaaa actgtggagc tactaatgaa gatttgtaaa cccgggctta tgagcaccca
     3121 ttcctttact acaactcaga ttgctctaga agctcagttc ccagcacttg gatttttcca
     3181 gtagctgaat tctacctgaa ggaagggcag aaacaaaggg tgaagaagag gctatcactt
     3241 ccaagtatcc tgcacccctg ggctcaagac ctcactgggg agggagtctt ttgggccacc
     3301 caccaaacag cactggcatt atgcctctca ccctagacca tggttacacg tggtaaaaca
     3361 accccttctg gtgatacatt cacaactctc tagtttcccc caaatggcac tatggggagc
     3421 gggagcttgc cttttcctca gacttaaaac aataagtttt ccccgtgttt cccctctaat
     3481 gctgttttct tttgaccaag catgtctgaa ttctagagaa gtcaggagga acacacccat
     3541 tctcggtttg aagggactga tgttctgaag tacaactggg cacagtccca ggctcttcag
     3601 gacgcttcct ccattcacac agcggggatg tgattgttac agcgggtggt gtgtgctggc
     3661 tgagaagcca ctgtgaattg attcttcttc tgaagtttat gtttctactt tttggaaatg
     3721 aataaattac agccagtcca tcaaggaaa
//
