LOCUS       NM_020846               6081 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens SLAIN motif family member 2 (SLAIN2), mRNA.
ACCESSION   NM_020846 XM_044434 XM_941571
VERSION     NM_020846.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6081)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 6081)
  AUTHORS   Bouchet,B.P., Noordstra,I., van Amersfoort,M., Katrukha,E.A.,
            Ammon,Y.C., Ter Hoeve,N.D., Hodgson,L., Dogterom,M., Derksen,P.W.B.
            and Akhmanova,A.
  TITLE     Mesenchymal Cell Invasion Requires Cooperative Regulation of
            Persistent Microtubule Growth by SLAIN2 and CLASP1
  JOURNAL   Dev Cell 39 (6), 708-723 (2016)
   PUBMED   27939686
  REMARK    GeneRIF: catastrophe inhibition by SLAIN2 and CLASP1 supports
            mesenchymal cell shape in soft 3D matrices by enabling microtubules
            to perform a load-bearing function.
REFERENCE   3  (bases 1 to 6081)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   4  (bases 1 to 6081)
  AUTHORS   Jostins,L., Ripke,S., Weersma,R.K., Duerr,R.H., McGovern,D.P.,
            Hui,K.Y., Lee,J.C., Schumm,L.P., Sharma,Y., Anderson,C.A.,
            Essers,J., Mitrovic,M., Ning,K., Cleynen,I., Theatre,E.,
            Spain,S.L., Raychaudhuri,S., Goyette,P., Wei,Z., Abraham,C.,
            Achkar,J.P., Ahmad,T., Amininejad,L., Ananthakrishnan,A.N.,
            Andersen,V., Andrews,J.M., Baidoo,L., Balschun,T., Bampton,P.A.,
            Bitton,A., Boucher,G., Brand,S., Buning,C., Cohain,A., Cichon,S.,
            D'Amato,M., De Jong,D., Devaney,K.L., Dubinsky,M., Edwards,C.,
            Ellinghaus,D., Ferguson,L.R., Franchimont,D., Fransen,K.,
            Gearry,R., Georges,M., Gieger,C., Glas,J., Haritunians,T., Hart,A.,
            Hawkey,C., Hedl,M., Hu,X., Karlsen,T.H., Kupcinskas,L.,
            Kugathasan,S., Latiano,A., Laukens,D., Lawrance,I.C., Lees,C.W.,
            Louis,E., Mahy,G., Mansfield,J., Morgan,A.R., Mowat,C., Newman,W.,
            Palmieri,O., Ponsioen,C.Y., Potocnik,U., Prescott,N.J.,
            Regueiro,M., Rotter,J.I., Russell,R.K., Sanderson,J.D., Sans,M.,
            Satsangi,J., Schreiber,S., Simms,L.A., Sventoraityte,J.,
            Targan,S.R., Taylor,K.D., Tremelling,M., Verspaget,H.W., De Vos,M.,
            Wijmenga,C., Wilson,D.C., Winkelmann,J., Xavier,R.J., Zeissig,S.,
            Zhang,B., Zhang,C.K., Zhao,H., Silverberg,M.S., Annese,V.,
            Hakonarson,H., Brant,S.R., Radford-Smith,G., Mathew,C.G.,
            Rioux,J.D., Schadt,E.E., Daly,M.J., Franke,A., Parkes,M.,
            Vermeire,S., Barrett,J.C. and Cho,J.H.
  CONSRTM   International IBD Genetics Consortium (IIBDGC)
  TITLE     Host-microbe interactions have shaped the genetic architecture of
            inflammatory bowel disease
  JOURNAL   Nature 491 (7422), 119-124 (2012)
   PUBMED   23128233
REFERENCE   5  (bases 1 to 6081)
  AUTHORS   van der Vaart,B., Manatschal,C., Grigoriev,I., Olieric,V.,
            Gouveia,S.M., Bjelic,S., Demmers,J., Vorobjev,I., Hoogenraad,C.C.,
            Steinmetz,M.O. and Akhmanova,A.
  TITLE     SLAIN2 links microtubule plus end-tracking proteins and controls
            microtubule growth in interphase
  JOURNAL   J Cell Biol 193 (6), 1083-1099 (2011)
   PUBMED   21646404
  REMARK    GeneRIF: Results identify SLAIN2 as a key component of microtubule
            plus end interaction networks.
REFERENCE   6  (bases 1 to 6081)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   7  (bases 1 to 6081)
  AUTHORS   Segat,L., Brandao,L.A.C., Guimaraes,R.L., Pontillo,A.,
            Athanasakis,E., de Oliveira,R.M., Arraes,L.C., de Lima Filho,J.L.
            and Crovella,S.
  TITLE     Polymorphisms in innate immunity genes and patients response to
            dendritic cell-based HIV immuno-treatment
  JOURNAL   Vaccine 28 (10), 2201-2206 (2010)
   PUBMED   20056178
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   8  (bases 1 to 6081)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   9  (bases 1 to 6081)
  AUTHORS   Hirst,C.E., Ng,E.S., Azzola,L., Voss,A.K., Thomas,T., Stanley,E.G.
            and Elefanty,A.G.
  TITLE     Transcriptional profiling of mouse and human ES cells identifies
            SLAIN1, a novel stem cell gene
  JOURNAL   Dev Biol 293 (1), 90-103 (2006)
   PUBMED   16546155
REFERENCE   10 (bases 1 to 6081)
  AUTHORS   Auffray,C., Behar,G., Bois,F., Bouchier,C., Da Silva,C.,
            Devignes,M.D., Duprat,S., Houlgatte,R., Jumeau,M.N., Lamy,B. et al.
  TITLE     [IMAGE: molecular integration of the analysis of the human genome
            and its expression]
  JOURNAL   C R Acad Sci III 318 (2), 263-272 (1995)
   PUBMED   7757816
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC098873.3, BC040993.1, AB040891.1, CB157681.1, Z25182.1 and
            AC096952.5.
            
            On Nov 23, 2018 this sequence version replaced NM_020846.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB040891.1, SRR1660807.16165.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264313.11/ ENSP00000264313.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AC098873.3         93533-93599
            68-97               BC040993.1         280-309
            98-2935             AB040891.1         1-2838
            2936-3277           CB157681.1         228-569
            3278-4949           AB040891.1         3181-4852
            4950-5939           AB040891.1         4854-5843
            5940-6078           Z25182.1           115-253
            6079-6081           AC096952.5         29976-29978
FEATURES             Location/Qualifiers
     source          1..6081
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p11"
     gene            1..6081
                     /gene="SLAIN2"
                     /gene_synonym="KIAA1458"
                     /note="SLAIN motif family member 2"
                     /db_xref="GeneID:57606"
                     /db_xref="HGNC:HGNC:29282"
                     /db_xref="MIM:610492"
     exon            1..600
                     /gene="SLAIN2"
                     /gene_synonym="KIAA1458"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..1957
                     /gene="SLAIN2"
                     /gene_synonym="KIAA1458"
                     /codon_start=1
                     /product="SLAIN motif-containing protein 2"
                     /protein_id="NP_065897.1"
                     /db_xref="CCDS:CCDS47051.1"
                     /db_xref="GeneID:57606"
                     /db_xref="HGNC:HGNC:29282"
                     /db_xref="MIM:610492"
                     /translation="MEDVNSNVNADQEVRKLQELVKKLEKQNEQLRSRSGAVQGAGSL
                     GPGSPVRAGASIPSSGAASPRGFPLGLSAKSGGGPGSGPRRTSSEELRDATSLLAAGE
                     GGLLDEVEPLRPDELERLSGWEEEEESWLYSSPKKKLTPMQKSVSPLVWCRQVLDYPS
                     PDVECAKKSLIHKLDQTMSALKRQNLYNNPFNSMSYTSPYSPNASSPYSSGFNSPSST
                     PVRPPIVKQLILPGNSGNLKSSDRNPPLSPQSSIDSELSASELDEDSIGSNYKLNDVT
                     DVQILARMQEESLRQEYAATTSRRSSGSSCNSTRRGTFSDQELDAQSLDDEDDNMHHA
                     VYPAVNRFSPSPRNSPRPSPKQSPRNSPRSRSPARGIEYSRVSPQPMISRLQQPRLSL
                     QGHPTDLQTSNVKNEEKLRRSLPNLSRTSNTQVDSVKSSRSDSNFQVPNGGIPRMQPQ
                     ASAIPSPGKFRSPAAPSPLALRQPVKAFSNHGSGSPGSQEITQLTQTTSSPGPPMVQS
                     TVSANPPSNINSATLTRPAGTTAMRSGLPRPSAPSAGGIPVPRSKLAQPVRRSLPAPK
                     TYGSMKDDSWKDGCY"
     exon            601..749
                     /gene="SLAIN2"
                     /gene_synonym="KIAA1458"
                     /inference="alignment:Splign:2.1.0"
     exon            750..914
                     /gene="SLAIN2"
                     /gene_synonym="KIAA1458"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1073
                     /gene="SLAIN2"
                     /gene_synonym="KIAA1458"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1433
                     /gene="SLAIN2"
                     /gene_synonym="KIAA1458"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1571
                     /gene="SLAIN2"
                     /gene_synonym="KIAA1458"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1890
                     /gene="SLAIN2"
                     /gene_synonym="KIAA1458"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..6081
                     /gene="SLAIN2"
                     /gene_synonym="KIAA1458"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2385..2390
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLAIN2"
                     /gene_synonym="KIAA1458"
                     /note="hexamer: AATAAA"
     polyA_site      2412
                     /gene="SLAIN2"
                     /gene_synonym="KIAA1458"
                     /note="major polyA site"
     regulatory      4459..4464
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLAIN2"
                     /gene_synonym="KIAA1458"
                     /note="hexamer: TATAAA"
     polyA_site      4478
                     /gene="SLAIN2"
                     /gene_synonym="KIAA1458"
     regulatory      4862..4867
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLAIN2"
                     /gene_synonym="KIAA1458"
                     /note="hexamer: AATAAA"
     polyA_site      4881
                     /gene="SLAIN2"
                     /gene_synonym="KIAA1458"
                     /note="major polyA site"
     regulatory      4890..4895
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLAIN2"
                     /gene_synonym="KIAA1458"
                     /note="hexamer: ATTAAA"
     polyA_site      4921
                     /gene="SLAIN2"
                     /gene_synonym="KIAA1458"
     regulatory      6059..6064
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLAIN2"
                     /gene_synonym="KIAA1458"
                     /note="hexamer: AATAAA"
     polyA_site      6081
                     /gene="SLAIN2"
                     /gene_synonym="KIAA1458"
ORIGIN      
        1 aatcccggag ccggcgcaga tgaggcagtt cggctggggc cagcggcgct ttggaacccg
       61 aggtgggggg accctggcgg tggggcctgg tcctgctata tgccggcgcc tcggctagag
      121 tgagcggcgg cgacgcctct ttcctccgtc tctttccctg tcgctgcgag agcgagcggg
      181 cggcggaggc ggcggcggcg gcggggccgg gatggaggac gttaactcca acgtgaacgc
      241 ggaccaggag gtgcggaagc tgcaggagct ggtgaagaag ctggagaagc agaacgaaca
      301 gctgaggagc cgctcggggg ccgtgcaggg cgccggctcc cttgggcccg gcagcccggt
      361 tcgggccggc gcgtccattc cctcctccgg cgcggcgtct cctcggggct tccccttggg
      421 cctcagcgcc aagtcgggcg gcgggcccgg gtcgggcccg aggcggacga gtagcgaaga
      481 gctgcgggac gccacctcct tgctagcggc gggcgagggc ggcttgctgg acgaggtgga
      541 gccgctgcgg cccgacgagc tggagcgcct gtcaggctgg gaggaggagg aggagagctg
      601 gctgtattca tcaccaaaga aaaaacttac accaatgcag aaatcggtta gtccattagt
      661 ttggtgcagg caagttttgg attacccaag tcctgatgtt gagtgtgcta aaaaatctct
      721 tatccacaaa cttgatcaaa ctatgtcagc tctcaagagg cagaatttat ataataatcc
      781 tttcaactct atgagttaca ccagtcctta cagtccaaat gccagtagcc catacagcag
      841 tggcttcaat tctccatcct caaccccagt gcgacctcct atagtcaaac agcttatact
      901 tcctggaaat tcaggtaact tgaaaagctc agacagaaat cctccactca gtcctcagtc
      961 ctctatagat agtgagttaa gtgcttcaga attagatgaa gattcaattg gatccaatta
     1021 taagctaaat gatgtaactg atgtacagat tctagcccgg atgcaggaag aaagtctccg
     1081 gcaagaatat gcagccacca cgtctcggcg cagttctggt tcatcttgca attctacaag
     1141 acggggtact tttagtgatc aggaacttga tgcacaaagt ttagatgatg aagatgacaa
     1201 tatgcatcat gcagtatacc ctgctgttaa caggttttca ccatcaccac gcaattcacc
     1261 tcgaccgtca cctaagcagt cacccagaaa ttcacctcgt tcacgatctc ctgctcgggg
     1321 aatagaatat agtagagtgt ccccacagcc tatgattagc cgcttacagc aacctcgcct
     1381 ttcacttcaa ggccatccca cagatttaca gacaagcaat gttaaaaatg aagaaaaact
     1441 aagacgcagt cttccaaacc tgtcccgaac atctaataca caagttgact cagtgaaaag
     1501 cagcagaagt gactcaaatt ttcaagtgcc aaacggagga atacctcgta tgcaacctca
     1561 ggcttcagcc ataccttctc caggcaaatt ccgttcccct gcagcaccat ctcctttggc
     1621 tcttcggcaa ccagtgaaag catttagtaa ccatggctct ggttctcctg gtagccaaga
     1681 aataacacag ctcacacaaa ccacctcctc acctgggcct cctatggttc agagcacagt
     1741 ctcagcaaat cctcccagca atatcaacag cgctactcta accagacctg cagggacaac
     1801 tgcaatgaga agtggcttgc ccagacccag tgccccttct gctgggggca taccagtgcc
     1861 tcgcagcaaa cttgcacagc ctgttcgcag atccttgcca gctcctaaaa cctatggtag
     1921 catgaaagat gacagttgga aagatggctg ttactgacca gcaaagacaa gaatgcagaa
     1981 gtccacggct tcatggatac ccttcaccag gctaaaaaac aacttttata tgcagactgt
     2041 tcagataaga ctcttgggat ttataaaatc ccagccctct ctgtcttaat tagcacaaac
     2101 cgacagagat catcaaacag cactttaatg acatttaaca tcagatgtgt ttggtaatca
     2161 tacaatcact ctccatagaa tcacttttag ttttgtttaa tagaaactag gttgattttt
     2221 aaaaaatatt tgacagaggc caatatctgg gcaaatacct aatggatgcc aaagagaaat
     2281 gcccatttgt aaatgagaaa aatgcccatt tgtgcacaag aaaatggtga attcaggcta
     2341 tccaaaactt cacattcaac ctaatttact gtataaatag tatcaataaa tatttgtgtt
     2401 aatgagaact aatattctga ctaattatct aaagtgtttc actagtacac caggaaacta
     2461 cagattgaga ttagggggtg ggaggaaaga aacctgggct agagattaaa acattcctaa
     2521 atttagcaga atttcagaaa tgatttttgc agattcatta gaaaagaaaa attgtcattt
     2581 aatcttaagt tttggatgta gctcacatgt caccaccacc agatagtgtt acagcatgta
     2641 tccatcatgt tgcattgaca catcaaactt gtgtgtgttt gttttgattg ccaaaagggc
     2701 ttaatatcag ttgtacaatc tttctgaact ttatagttcc tggctcagga aagatggcct
     2761 ttgctattga agccaacttc ttcacatgct gttatcttta cagaactaag agatcttgtt
     2821 tctattagca ggttttcatg ataggaaaga acaagtagtg tgtgtcttta ttcttgatac
     2881 aacaccacct cggtgcttgc aacctggaac aaaaccatac catgagagag agggggaaaa
     2941 aaatctatgc acttaaccta caaaatctct ggtgatgaca gttgtattgt tgctattaca
     3001 tggcataacg gtctattatg tggtaggaaa atatagcctg ctaaatccta cttaagttga
     3061 tccactttaa actgagtaac tgtataaaac atctattgaa aattcttttc cttttgactt
     3121 agattctgcc ttacatcaat ttttgcattt ttggtaaaaa aaaaacccta ctacgtatga
     3181 ctctaacctg atacttgctc tctaatggct cttaatatat ccttgaaatc ggctatttca
     3241 attttatcag acttttacca gagtaaaact tgcttctgta gcaggcctct cattttttat
     3301 tatgaggtct gtttttaaat acttaatttg aacagctcta agatattgtc acttaggtca
     3361 tctaaaagct tttagagatt tgaacataag ttcatttcct gttaatcaaa gacattccgt
     3421 aagttggcaa aagaaattgg gagagagaaa tagaaggctt gatattctgg acagcattaa
     3481 ggttgatagg ttgatgataa aaacttaaaa ccaggacctc cattctgtca tgactgacac
     3541 catggtagtc tgtcagcttg accagtggag agtcattcat ttagcacaag cagctggaga
     3601 tttaaactgc cagtactatg tatttggtgt ataatgcaag gaagaaactt tatccttgaa
     3661 tttgagggtg atggggtggg tcaggaaagg atggcgccag aattctacat gataatgaac
     3721 taaaaaatgt tgcttttcag aggaagataa agcatcttct tttgggaggg gggtatctca
     3781 tgtctaagta agtaaaagaa agaagtagct actgtctctt ttaaaaacca cgtacaaaac
     3841 agaacaagtc tcagttttca gtgcaacatt tcaaaaaata tatatgctgc aatctaataa
     3901 ttaaaaggaa ttttacctat tatgaaacat attacatttt ttaagttaga taatcagttt
     3961 caaaaggagt attcaggtta tttaactttg tttttaaatg gctgcatcag aaaaaaatgt
     4021 ctattttttt ttattaaaat atttcatcac ttgttaaaac atatttttga tctgagtttg
     4081 gtaaagtatt attttacctg ctgttgtact accacagact gttgactttt agtttcttaa
     4141 agagaaaaat tgccttttta ctagaaagcc tttgtatatt gcaatttttc tgtttgggaa
     4201 aatctaagga tttactgtgg ttagtcttac agaagaaatg tggatttgat aaactagtgc
     4261 ctatgatttt aacttatgtt tgatatatag tagtaagggt tttatgaatg ttgattattt
     4321 tgtgccaaca gcccagaatt gtcacttata tgtaagcaga aaacaatgag ctctgcttcc
     4381 aaagttattt aattttctca gtgtttgaat gttatttttt gtaagtgtgt taataaaagt
     4441 gtaaagaatt ggaaaaaata taaatattct taactcaagc atttgctgga tcatttttct
     4501 acaaaacttg tttgtacaat ataaaacact ctctgaagag ttgacttttt ttcagtttcg
     4561 tatcctggaa atcacatttt gtaaaactgg ggaccattca taattgtcag atacttttta
     4621 aaattatctc aatacatcac ttttataaaa aaaaaaagtt tttttgaaag aaaattagat
     4681 acatatgtgg ccccagatgt ttgtataact ctagaatgat ctagactatg tatgtttaaa
     4741 ttaacttttt attgaatgta caggtgtcca tttttgacgt taagcatggt cctttaaggt
     4801 cacatgacgt ttgatttgca aacatttcta tagccgaact tgtatatgtg gttgcctcct
     4861 taataaacag cctgaccata atgtttatta ttaaatttat attctttaag tgtttaatta
     4921 atctctggat atggtaagat tccttttttc ctctcagttg cctacacttg gttttaataa
     4981 attactcagt tgagtttttc tttaaccaca gaaacccaaa tcatattgcc ctttcagatt
     5041 tagtcttcat ggggttggat tatgtcttat attttctctg tcagagttat ttcatatatg
     5101 gattttactt gaaggaaatt tacagtttac tctaaattga tttgttcttg gaactttttt
     5161 acctgctgtg aattgatacc tagttataaa aagctagcat ttgcctagat cataactatg
     5221 tatggtatct agttagaaaa aaacaagcaa aaagctatta tgagtttcca agagggacaa
     5281 ttaatgcatt ttcataccaa atgcgaatat ttaggtgatc acgtgcatct tttcttgtat
     5341 ggatggaaaa atcaagaatt gtacactgtt taatgagttc tccatattcc tttaggagat
     5401 atttgctttg caattacatg ttacaattag aataattaca attaaaataa tattacatgt
     5461 tacaattaga ttaatagtga tgagagggaa aaaagacacc cttctgtttt tttctctcaa
     5521 gccagtctaa aaacttgaag agccatttaa aattaaatgt cactatactt gtattataaa
     5581 tcaatacata agtttaaacc tgttatatac tcagtgcaac agaaaaaccc atatggaggt
     5641 tcaaccactg atgtattttg aatgatccta aatataagtc ttgggtggct aaatggccct
     5701 ctgcttacca gtctgaaaat gaaaccgatt atactcatcg gccttattta ctgtaataca
     5761 aactggttaa aactatgtta actgaatgct agtttgaaac aaattatcta cattaagtca
     5821 tcttaatgtt ttctctttaa aagaaataaa aaaatctgtt tcttctgatt tcgaaagtaa
     5881 tagaaactct gctgtagaac ataaactaaa aatattaaaa agtataaagg taaaaaatga
     5941 tagttgtctg caatcccata atccggaaat attgaagtac tgtccgtaac atggttatga
     6001 catgttaagt ggaagggtag aaggtctttt tttttttaag gagaaaatgt ttcttttaaa
     6061 taaatgtttc ttatgtaaaa a
//
