LOCUS       NM_170679               9386 bp    mRNA    linear   PRI 01-FEB-2025
DEFINITION  Homo sapiens S-phase kinase associated protein 1 (SKP1), transcript
            variant 2, mRNA.
ACCESSION   NM_170679
VERSION     NM_170679.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9386)
  AUTHORS   Luo,C., Chen,Z., Meng,L., Tan,C., He,W., Tu,C., Du,J., Lu,G.X.,
            Lin,G., Tan,Y.Q. and Hu,T.Y.
  TITLE     A hemizygous loss-of-function variant in BCORL1 is associated with
            male infertility and oligoasthenoteratozoospermia
  JOURNAL   Clin Genet 106 (1), 27-36 (2024)
   PUBMED   38342987
REFERENCE   2  (bases 1 to 9386)
  AUTHORS   Chen,Z., Li,Y., He,K., Yang,J., Deng,Q., Chen,Y. and Fu,Z.
  TITLE     CircGPRC5A enhances colorectal cancer progress by stabilizing
            PPP1CA and inducing YAP dephosphorylation
  JOURNAL   J Exp Clin Cancer Res 42 (1), 334 (2023)
   PUBMED   38057879
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9386)
  AUTHORS   Li,J., Krause,G.J., Gui,Q., Kaushik,S., Rona,G., Zhang,Q.,
            Liang,F.X., Dhabaria,A., Anerillas,C., Martindale,J.L.,
            Vasilyev,N., Askenazi,M., Ueberheide,B., Nudler,E., Gorospe,M.,
            Cuervo,A.M. and Pagano,M.
  TITLE     A noncanonical function of SKP1 regulates the switch between
            autophagy and unconventional secretion
  JOURNAL   Sci Adv 9 (41), eadh1134 (2023)
   PUBMED   37831778
  REMARK    GeneRIF: A noncanonical function of SKP1 regulates the switch
            between autophagy and unconventional secretion.
REFERENCE   4  (bases 1 to 9386)
  AUTHORS   Trepte,P., Secker,C., Kostova,S., Maseko,S.B., Choi,S.G.,
            Blavier,J., Minia,I., Ramos,E.S., Cassonnet,P., Golusik,S.,
            Zenkner,M., Beetz,S., Liebich,M.J., Scharek,N., Schutz,A.,
            Sperling,M., Lisurek,M., Wang,Y., Spirohn,K., Hao,T.,
            Calderwood,M.A., Hill,D.E., Landthaler,M., Olivet,J., Twizere,J.C.,
            Vidal,M. and Wanker,E.E.
  TITLE     AI-guided pipeline for protein-protein interaction drug discovery
            identifies a SARS-CoV-2 inhibitor
  JOURNAL   bioRxiv (2023)
   PUBMED   37398436
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9386)
  AUTHORS   Rashpa,R., Klages,N., Schvartz,D., Pasquarello,C. and Brochet,M.
  TITLE     The Skp1-Cullin1-FBXO1 complex is a pleiotropic regulator required
            for the formation of gametes and motile forms in Plasmodium berghei
  JOURNAL   Nat Commun 14 (1), 1312 (2023)
   PUBMED   36898988
  REMARK    GeneRIF: The Skp1-Cullin1-FBXO1 complex is a pleiotropic regulator
            required for the formation of gametes and motile forms in
            Plasmodium berghei.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9386)
  AUTHORS   Bai,C., Sen,P., Hofmann,K., Ma,L., Goebl,M., Harper,J.W. and
            Elledge,S.J.
  TITLE     SKP1 connects cell cycle regulators to the ubiquitin proteolysis
            machinery through a novel motif, the F-box
  JOURNAL   Cell 86 (2), 263-274 (1996)
   PUBMED   8706131
REFERENCE   7  (bases 1 to 9386)
  AUTHORS   Demetrick,D.J., Zhang,H. and Beach,D.H.
  TITLE     Chromosomal mapping of the genes for the human CDK2/cyclin
            A-associated proteins p19 (SKP1A and SKP1B) and p45 (SKP2)
  JOURNAL   Cytogenet Cell Genet 73 (1-2), 104-107 (1996)
   PUBMED   8646875
REFERENCE   8  (bases 1 to 9386)
  AUTHORS   Zhang,H., Kobayashi,R., Galaktionov,K. and Beach,D.
  TITLE     p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S
            phase kinase
  JOURNAL   Cell 82 (6), 915-925 (1995)
   PUBMED   7553852
REFERENCE   9  (bases 1 to 9386)
  AUTHORS   Sowden,J., Morrison,K., Schofield,J., Putt,W. and Edwards,Y.
  TITLE     A novel cDNA with homology to an RNA polymerase II elongation
            factor maps to human chromosome 5q31 (TCEB1L) and to mouse
            chromosome 11 (Tceb1l)
  JOURNAL   Genomics 29 (1), 145-151 (1995)
   PUBMED   8530064
REFERENCE   10 (bases 1 to 9386)
  AUTHORS   Chen,H., Thalmann,I., Adams,J.C., Avraham,K.B., Copeland,N.G.,
            Jenkins,N.A., Beier,D.R., Corey,D.P., Thalmann,R. and Duyk,G.M.
  TITLE     cDNA cloning, tissue distribution, and chromosomal localization of
            Ocp2, a gene encoding a putative transcription-associated factor
            predominantly expressed in the auditory organs
  JOURNAL   Genomics 27 (3), 389-398 (1995)
   PUBMED   7558018
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            Z47087.1, BC065730.1, AI028694.1, BQ632052.1, AI025746.1 and
            AC011336.5.
            
            On Jun 2, 2019 this sequence version replaced NM_170679.2.
            
            Summary: This gene encodes a component of SCF complexes, which are
            composed of this protein, cullin 1, a ring-box protein, and one
            member of the F-box family of proteins. This protein binds directly
            to the F-box motif found in F-box proteins. SCF complexes are
            involved in the regulated ubiquitination of specific protein
            substrates, which targets them for degradation by the proteosome.
            Specific F-box proteins recognize different target protein(s), and
            many specific SCF substrates have been identified including
            regulators of cell cycle progression and development. Studies have
            also characterized the protein as an RNA polymerase II elongation
            factor. Alternative splicing of this gene results in two transcript
            variants. A related pseudogene has been identified on chromosome 7.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) utilizes an alternate splice
            site in the 3' coding region, compared to variant 1.  This results
            in a frameshift and slightly longer protein (isoform b), compared
            to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.197332.1,
                                           SRR1803617.267145.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000353411.11/ ENSP00000231487.9
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-741               Z47087.1           14-754
            742-1277            BC065730.1         746-1281
            1278-1335           AI028694.1         111-168             c
            1336-1923           BQ632052.1         1-588               c
            1924-1930           AI025746.1         16-22               c
            1931-9386           AC011336.5         19272-26727         c
FEATURES             Location/Qualifiers
     source          1..9386
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.1"
     gene            1..9386
                     /gene="SKP1"
                     /gene_synonym="EMC19; OCP-II; OCP2; p19A; SKP1A; TCEB1L"
                     /note="S-phase kinase associated protein 1"
                     /db_xref="GeneID:6500"
                     /db_xref="HGNC:HGNC:10899"
                     /db_xref="MIM:601434"
     exon            1..96
                     /gene="SKP1"
                     /gene_synonym="EMC19; OCP-II; OCP2; p19A; SKP1A; TCEB1L"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..588
                     /gene="SKP1"
                     /gene_synonym="EMC19; OCP-II; OCP2; p19A; SKP1A; TCEB1L"
                     /EC_number="3.1.1.3"
                     /note="isoform b is encoded by transcript variant 2; organ
                     of Corti protein 2; RNA polymerase II elongation
                     factor-like protein OCP2; cyclin A/CDK2-associated p19;
                     SIII; OCP-2; p19skp1; organ of Corti protein II;
                     cyclin-A/CDK2-associated protein p19; transcription
                     elongation factor B polypeptide 1-like"
                     /codon_start=1
                     /product="S-phase kinase-associated protein 1 isoform b"
                     /protein_id="NP_733779.1"
                     /db_xref="CCDS:CCDS4171.1"
                     /db_xref="GeneID:6500"
                     /db_xref="HGNC:HGNC:10899"
                     /db_xref="MIM:601434"
                     /translation="MPSIKLQSSDGEIFEVDVEIAKQSVTIKTMLEDLGMDDEGDDDP
                     VPLPNVNAAILKKVIQWCTHHKDDPPPPEDDENKEKRTDDIPVWDQEFLKVDQGTLFE
                     LILAANYLDIKGLLDVTCKTVANMIKGKTPEEIRKTFNIKNDFTEEEEAQVRKENQWC
                     EEK"
     exon            97..193
                     /gene="SKP1"
                     /gene_synonym="EMC19; OCP-II; OCP2; p19A; SKP1A; TCEB1L"
                     /inference="alignment:Splign:2.1.0"
     exon            194..267
                     /gene="SKP1"
                     /gene_synonym="EMC19; OCP-II; OCP2; p19A; SKP1A; TCEB1L"
                     /inference="alignment:Splign:2.1.0"
     exon            268..411
                     /gene="SKP1"
                     /gene_synonym="EMC19; OCP-II; OCP2; p19A; SKP1A; TCEB1L"
                     /inference="alignment:Splign:2.1.0"
     exon            412..552
                     /gene="SKP1"
                     /gene_synonym="EMC19; OCP-II; OCP2; p19A; SKP1A; TCEB1L"
                     /inference="alignment:Splign:2.1.0"
     exon            553..9386
                     /gene="SKP1"
                     /gene_synonym="EMC19; OCP-II; OCP2; p19A; SKP1A; TCEB1L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      814..819
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SKP1"
                     /gene_synonym="EMC19; OCP-II; OCP2; p19A; SKP1A; TCEB1L"
                     /note="hexamer: AATAAA"
     polyA_site      848
                     /gene="SKP1"
                     /gene_synonym="EMC19; OCP-II; OCP2; p19A; SKP1A; TCEB1L"
                     /note="major polyA site"
     regulatory      1260..1265
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SKP1"
                     /gene_synonym="EMC19; OCP-II; OCP2; p19A; SKP1A; TCEB1L"
                     /note="hexamer: ATTAAA"
     polyA_site      1280
                     /gene="SKP1"
                     /gene_synonym="EMC19; OCP-II; OCP2; p19A; SKP1A; TCEB1L"
     regulatory      1425..1430
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SKP1"
                     /gene_synonym="EMC19; OCP-II; OCP2; p19A; SKP1A; TCEB1L"
                     /note="hexamer: AATAAA"
     polyA_site      1451
                     /gene="SKP1"
                     /gene_synonym="EMC19; OCP-II; OCP2; p19A; SKP1A; TCEB1L"
     regulatory      1902..1907
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SKP1"
                     /gene_synonym="EMC19; OCP-II; OCP2; p19A; SKP1A; TCEB1L"
                     /note="hexamer: AATAAA"
     polyA_site      1930
                     /gene="SKP1"
                     /gene_synonym="EMC19; OCP-II; OCP2; p19A; SKP1A; TCEB1L"
     regulatory      2891..2896
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SKP1"
                     /gene_synonym="EMC19; OCP-II; OCP2; p19A; SKP1A; TCEB1L"
                     /note="hexamer: AATAAA"
     polyA_site      2917
                     /gene="SKP1"
                     /gene_synonym="EMC19; OCP-II; OCP2; p19A; SKP1A; TCEB1L"
     regulatory      9345..9350
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SKP1"
                     /gene_synonym="EMC19; OCP-II; OCP2; p19A; SKP1A; TCEB1L"
                     /note="hexamer: AATAAA"
     polyA_site      9386
                     /gene="SKP1"
                     /gene_synonym="EMC19; OCP-II; OCP2; p19A; SKP1A; TCEB1L"
ORIGIN      
        1 gctgtagtgg cttcgtcttc ggtttttctc ttccttcgct aacgcctccc ggctctcgtc
       61 agcctcccgc cggccgtctc cttaacaccg aacaccatgc cttcaattaa gttgcagagt
      121 tctgatggag agatatttga agttgatgtg gaaattgcca aacaatctgt gactattaag
      181 accatgttgg aagatttggg aatggatgat gaaggagatg atgacccagt tcctctacca
      241 aatgtgaatg cagcaatatt aaaaaaggtc attcagtggt gcacccacca caaggatgac
      301 cctcctcctc ctgaagatga tgagaacaaa gaaaagcgaa cagatgatat ccctgtttgg
      361 gaccaagaat tcctgaaagt tgaccaagga acactttttg aactcattct ggctgcaaac
      421 tacttagaca tcaaaggttt gcttgatgtt acatgcaaga ctgttgccaa tatgatcaag
      481 gggaaaactc ctgaggagat tcgcaagacc ttcaatatca aaaatgactt tactgaagag
      541 gaggaagccc aggtacgcaa agagaaccag tggtgtgaag agaagtgaaa tgttgtgcct
      601 gacactgtaa cactgtaagg attgttccaa atactagttg cactgctctg tttataattg
      661 ttaatattag acaaacagta gacaaatgca gcagcaagtc aattgtatta gcagaatatt
      721 gtcctcattg catgtgtagt ttgagcacag atcccaaacc ttacggccaa gtttcttcta
      781 gtatgatgga aagtttcttt tttctttgct ctgaataaaa ctgaactgtg ggttctctat
      841 aagtggcatt ttgggctttc cctctttttt gtaaagcaat gtctgcctag tttattgtcc
      901 agttaacttt agtgaccttt taaaagttgg cattgtaaat aaaacaactt gcaaaaaagt
      961 tttctggaat agaattaaca aaatattatc tttattcatg agttggaaac tggaaaaagg
     1021 cttcttgaag taaatgttct gagtggagct actaggatgt cttccagcct cctgcagtca
     1081 aggagtacca ctgtattgat tagcctgtat gtagcagggc tcccttcatt gcatctgagg
     1141 acttgttttc tttttcttta tttttaatcc tcttagtttt aaatatattg cctagagact
     1201 cagttactac ccagtttgtg gttttttggg agaaatgtaa ctggacagtt agcttttcaa
     1261 ttaaaaagac acttaaccca tgtgggatgt catcttttta taattagtgt tcccatgtgg
     1321 agaaaattat tcacactact tgcatgtaaa gaataattta acttttaaca ttaaaatatg
     1381 tggtaaaacc cagaaagcat ccatcatgaa tgcaagatac tttcaataaa aagtaagtta
     1441 tatagtaggt agttaagttt gcttttgtgg acttaaatgt gtctcttcac ttaaatgggt
     1501 tgaatgtgta tatatttgtt cagcttgaaa agacttagtt tatatcctag ctcactggag
     1561 gctgctgaca taaccataac ttctgtccct tctaattgtc atttatatgc ctaactggag
     1621 ctagtacttt aattcttaac acaaaattac tctgccattg tttccagctt ccctcctaca
     1681 atagaatgaa gtttttttga tggcttgaga tggctcacaa attttgattt ttttttcttc
     1741 cttgtgctcc ctttttttct ccttgctttt ccagttaaca tctatattca catgtaatct
     1801 tgttttctct tcacattcac tgagttgttc aggctcagat catcccttga cagtagtttg
     1861 ccttcatctc acctttcatt tgtcccaaat tcaccttatt taataaagtc ccatatgttg
     1921 tctcacttaa ttccaatttg ttgtctgtac cagagatagg aaactataat gtgtgggtca
     1981 aatcaggccc atagcctgtt tttgtagtct ttgagctaaa aatggttttt acgttgtaaa
     2041 gagttattta aaattctctc tctctctctc tctctctctc aggagataag cttgttttct
     2101 gtttgtcctg gttttagtgg ggaaggtagc ggtgtatagt cctagctgaa ttgtctcatc
     2161 taccaattcc tgctattata agatcaactt ctgcaaaaac cttatccacc tcaagtatcc
     2221 ttagcagctg ggcatggtgg cttatgcctg taatctcaac attttgggag gacaagacag
     2281 gaggatcgtt tgagcccagg agttcaagac cagcctgggc aacacagaaa gtccctgtct
     2341 ctccaaaaaa aaaaaaaaaa attagcagtc atatggtgca tgcctataat cccaactact
     2401 tgagaggctg aggtgggaag atggcttgag cctgagaggt cgaggctgca gtgagctggc
     2461 attgcaccac tgcactccag tctaggcaat agagcgagac cttgtctcaa aaacaaacca
     2521 gaagtatcct tagcagtatt atgacaaaca aatcttcact gaaggtccag gattactgcc
     2581 atatgccatg tttaacttgt aaaggaagta tcaccttcta agaaactgga gcttgttatt
     2641 accacttgat ctgtataata ctcagcagta gttagaatta tatgagtaaa taacgtcact
     2701 atccgtattt aaaggataat gagatctttc agaaagattg gatggacaga caatatagta
     2761 gtaatttaaa tttttgtttc ctgactttct gtagtcccta aacaaacaac aaaaaatcct
     2821 agtaatctta aacttttaca ttaatagaga tccaagagaa aataagccat ttttcaccat
     2881 tgtggaccca aataaatcat agacatggta ttaagaagcc cttttcagtc tggttgcagt
     2941 attattttcc tacctttctt tttcctgttc cctgctgtat gcccactatt cctttaatat
     3001 atctactaga acttttctag gctttcacct ggagtgagtg gtcctttctc attatcacag
     3061 tagccaaacc tcagtcttca aaactccact catttctggc tactctctta cttcccaact
     3121 attcttctaa actaatattg tggcattaag tcataccttg aggctggagt tttagtgtct
     3181 tcatggcctt gggcaagttg gaaataggta ctacggtttt atagatctag tgcagtctgc
     3241 tttatattag ttccagaact tcattggaag tcacttgaca gcaggattta acttgtattt
     3301 agcagcacta ctccatgaat ttcagtataa gtaacagaag tgaaaagtcc ttgtgaaatg
     3361 caggtacagg gcataatgaa aacaagaaga gtagttttaa tgcatgagag gggagagctt
     3421 gataatagct gataatagcc ttggtttgga gagtggttac tgatgaatta tgaagacttt
     3481 ctctaattac tgttatagta gtaaaggaaa gaaaaccctt gttgataaag taaacttagg
     3541 gattaattag gaaatgcctt ttatttcacc aggaaagaga atgagaggaa gaaggtattt
     3601 ggcagatttg ggtgattgaa ggatgtttgt cggtttcctc tgtaaacaac atgctgcttt
     3661 ctgcagtgtg ctgcttttaa tgatgaagtc ctttcaagga ctccatggca gtcctttggc
     3721 ttctcacctt ttcattgatt atgtcacttg tgatctaaaa gtaaaccaaa accttcctga
     3781 atgttagctt attattttct ccttaacatt gtcataggct aaagatgtgc cccctcaaat
     3841 tctaataatt tttttttttt tttttttttt tttgagacag agtctcactc tgtcgcccag
     3901 actggaatgc agtggtgcga tctcagctca ctgcaacctc cgcctcctgg gttcaagtga
     3961 ttctcctgcc tcagcctccc gagtagctgg gattacaggc acatgccacc atgcctggct
     4021 aatttttttg tgtttttatt agagatggag ttttaccata ttggccaggc tggtcttgaa
     4081 ctcctgacct tgtgatccgc ccgccttagc ctccgaaagt gctgaggtta cacgtgtgac
     4141 ccaccgcaca cggccctaat aattcttaag ttgtagaagc aagttactct tttgaagtgc
     4201 catgtgttag cttgccttaa tctattcttg gtatacaaaa tagatactgc tttacagttc
     4261 ttatattttc tcagagattc acaaaatcat cctgtagctc cctgtgtggg attatagctg
     4321 tgacttttta ctctacaact gtcagaatac accagctcct ggaattaagc aagaactata
     4381 ttgtgacttg gttggacagg taactgcagc cttgtaacat gacatcatag taatgctgag
     4441 cttatcttaa aactagctgg ggagggagga tagtaacagt gagtcactgt gggcatctca
     4501 cttagggcag gcagatattc caaatcacat tgatttttca gtttacgtaa aaattgacca
     4561 atcctatggg ctgtgttctg atcccaacat aaattttgtt taagttaatt tgcctaggct
     4621 ctcaataagg cagtttggga atataaggtg attttccacc agaaaagaga aaattgagag
     4681 agcagcagac ctcttgctct cagcaccctt tacaagctta acttttgctt gccaccatta
     4741 gcttttgaag atttttttta actgctcctt gcagagcagg actaccccat aggcagtgtg
     4801 cccagagtag cccgaagagc tttttgattc ttcttttaag agacaaggtc tcacctctgc
     4861 cccccaggct ggagtgcagt gatgtgatca cagctcattg cagcctcgaa ctcttgggct
     4921 ccaacagtcc tcctgcctca gcctcctgaa tagctaggac tacatgtgtg tgctaccatg
     4981 ccttgctagt ttttgttttt ttaaattgat ttttatagag atgaggtctc ctcatgttgc
     5041 ccaggctgtt ttcgaattcc tgggctcaag atcctcctgc ctcaacctcc caaagtgctg
     5101 gtattacaga tgtgagccac agcacccacc aatttttcct tttctaaagc tcagtgtaca
     5161 ttctggtagg aaggaatcaa ccaagtaaat gttctcccta caaagttgtt tgaggatttg
     5221 aaaagttaat cttcaattat ctggatttga aaccagtcta taacttttta agctaggaag
     5281 aagtcaagaa taagaagatt gcaagcaaag ggaaagctta caaaatggct gaatccttaa
     5341 agtgtagctc ctggcttctc cttggtagga agcattagac atggtttccc tctagggagc
     5401 tgggagcttt tggtgtagtt caggagagaa ggcataaata ctgctgggag ggagtggata
     5461 actctaataa aaatgttcct gggctgggca cggtggctca cgcctgtaat cccaacattt
     5521 tcagaggctg aggtgtgcag atcacgaggt caagagatcg agaccatcct ggccaacatg
     5581 gtgaaacctc atctctacta aaaatacaaa aattagctgg gcgtggtggc acatgcctgt
     5641 agtcccagca actcgggagg ctgaggcagg agaaccgctt gaacccggga ggcggaagtt
     5701 gcagtgagcc gacatcacgc cactgactgc agtccagcct ggcgacagag cgagactccg
     5761 tttcaaaaaa aaaaagtttc tggacagaac agattaatga gccaatgggg ggctacagag
     5821 ctgaaaggtg ctacgaaagg ttttgtaaag tgaaactaat ttggtttcaa gaatcaagtt
     5881 ggatttgttt gggggtggac agatgccaaa gtgaggaaaa agcagtgcac agtcaggaac
     5941 taacagcaga aggttgggtg ttggtacatt tccctgagaa tatagactaa agagaaatta
     6001 gggcaggatt agtcacagta ctttgctgac actcagtagt attttatcag catttattca
     6061 tcagacccac attaggcagg gcaatttttg agtgagctaa attctaattt ttttaatttt
     6121 aatttttatt tatttatttt ttggctgttc aactaaacca gtcttttgaa tgttgggggt
     6181 tttacagtta gagtcctgat gactttttct tgtttactgt tgttaaaaat cactacctcc
     6241 agtggtcaca gagaatgagt aagagaactg gctgtgcata tcaagatgaa gtatggtgta
     6301 agaaatattt cagagcatgt cctttggccc aagattgagc catttggaca cctaagcagg
     6361 attggctgaa tgttatcctt tctgctgagg catcagtgga gatgatcatt agtggtggcc
     6421 gaaaagtgtt gtcgaaggtg ctcttgcttg acacacttcc aatgcgggac atagtttgag
     6481 tgatagatgg ctaattcatt gataatgtac ttgttgcctt gcagtcttgt gtactgctgg
     6541 ctacctctgg tctgtgtgcc agtattgagc agcattctat gggaggaatg tagttgctca
     6601 taacagtgtc tgcttccaca tctgtagttc ttgcgacctt ctgatatctg tcaactttaa
     6661 attttctgga agtatttaag tatattcaga ccttctgata tctcttaact tcaaattttc
     6721 aacctgctat atagcagcct cttattgcac actgaggatc agcttatttc cttaaagtgc
     6781 tctcactttg aatacctccc acctatctgg tgaaaattct tatttgtcct ttctttcctg
     6841 aatgtaccat ttcacaacct ctaactgcct tcttcagttg ctttgcagat ttttctgttc
     6901 caggaagctt acggaaaggg gtgggaaaat agagaagctg tactctatcc tcaagtactc
     6961 aagcagggtt tccagagtgg ctttgtaaaa atttttattt atttatttat ttatttttgg
     7021 tgagtggaac ctggcttttc ctcttccctc cccaagcccc accccgcttc ctgacattgc
     7081 acatgcctga aagaactagg cttcagataa aagaatgaga acacttgaat gaaaaaggaa
     7141 gacttggtcc agagcccctg gtgaatatga aagaagtatt ggcctggact atctcccgca
     7201 taattcacag ctgctatctt gtcttcagaa gtgaaacatc ccttaccaat agtgacctaa
     7261 cttgtgagga ctgcttgtga tagtatagtt cccaccccca ggacataagt tttccctttc
     7321 cagttaacat gcctaatccc atgctatctt taagagcttg aaaatccttc ctgacctgag
     7381 ctaggctttt attctaaggg actgtgtatg tgaacatccc caccatctat gtttcctgtt
     7441 ttcaaactcg gtgccgtttt gagtattttc agatgctcac tgccagtaat ggtttgttag
     7501 tagctccaaa ctattagaga agagctcagg agtcagaatt tgaaagatgc ccatagggtg
     7561 atttgagatt tggaacaagg ttatcacaat aagttgggat tgggggagtt gacacaacca
     7621 gggtctgctt gggtgggcag ctgtttcaga aacccttggt gaactcttaa agccctgaag
     7681 agcttaaaaa atgctctgaa gagatctgag agtcgcagtt aaggactctc aaagaacctc
     7741 aaagaaaagc caacttagcc tttttataca attaactaga tttgggtctt aaattctact
     7801 ttgacatata ggcctaagag gtagtttaac atggccttgt tacccttacc ccttctgttc
     7861 tgtgctgttt tctgagaaac ggatgcagga actgattccc tttcttcctc tctggaacag
     7921 gatataaaga acccttccgc ttccctttac ttgtggcctt cctggccagg cttatgtata
     7981 ctgaacaaag ctagggtgca gtgcttctga gctagctgtt aggggtccac agccagaagg
     8041 aatgggagac cacaggagcc attcaaaaga taattacatg tcagaagaga gtccatccat
     8101 ggggttctgt taaagtagac accttcacgt tgggagacat aggctttgtc tgcttgctgg
     8161 gctgaaccct caccatatcc acagagaaca aaatggggag cagctgtacc aggggaggga
     8221 tgaacgtctt tcacccaagt tgccagtctg ctagttgtct ggaaatgttc aagggaggct
     8281 aaggtatctt gtcttatgat gtctcaggaa acagggttgg ttctcagctg gcagtgaagg
     8341 gggactggtg tggtattagc agttgaactt gaggttgcaa tctcaagtca ccctctggcc
     8401 tcgcaggaat gcaccagggt gatttgggag gatctgagtt tcctttatga agtcagatta
     8461 aaaaaaaaaa aagctgatct gatttaaaca gagttgccaa agacttcccc gccaatacac
     8521 aaagactgca ttgttcaggt accctgtgta ctctaagtga gacaccaaat cagatgcagc
     8581 aacctggtct tgcataagcc ctggttagaa tgtaggtttt ttaaacaact aggccagtag
     8641 ccagaacaga attctttaaa atgggacaga tgtccagaga atggctagtg tcctctagca
     8701 ctctctcaga agcaaaagca agtctggggt tacaacttcc agtggcctac tttaaataga
     8761 cgctgttctg gaaaatgact ttatacttta aacacaaaat ccaaaaaata gaactcagtg
     8821 gagtgacaat gacaatgcat gatggtggcc cagtggctgt cccatgtgaa atacttcttg
     8881 cctgacatgt atcatctact tgttgactga cctattgagg tgccttcatg acacctttta
     8941 cattcatgat aggtctcagg aagacagcag tgtacttggt ggaaactcat gtaaaaagtg
     9001 ggttgtaggg agctaaacag tgagtacaca tggtatatgg atacggaatg gaataataga
     9061 cattggagac ttcaaaaggt gggagatgaa agggggatga ggtatgaaat cctacctgtt
     9121 gagtacaatg tacactactt acgtgcacag tacactgttt gggtgagagg cacactaaaa
     9181 gcccggacct caccgctacc cagtatgttc atgtaacaca gctgcacttg taccccctaa
     9241 atgtatacaa ataatctaaa aatagcccgg acctcaccgc tacacaatat attcatgtaa
     9301 cacagctgca tttgtacccc ctaaatgtat acaaataatc taaaaataaa gtggatatgg
     9361 tggctgtcgt gtccaccaac agcgta
//
