LOCUS       NM_005414               7155 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens SKI like proto-oncogene (SKIL), transcript variant 1,
            mRNA.
ACCESSION   NM_005414
VERSION     NM_005414.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7155)
  AUTHORS   Chi,C., Liang,X., Cui,T., Gao,X., Liu,R. and Yin,C.
  TITLE     SKIL/SnoN attenuates TGF-beta1/SMAD signaling-dependent collagen
            synthesis in hepatic fibrosis
  JOURNAL   Biomol Biomed 23 (6), 1014-1025 (2023)
   PUBMED   37389959
  REMARK    GeneRIF: SKIL/SnoN attenuates TGF-beta1/SMAD signaling-dependent
            collagen synthesis in hepatic fibrosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7155)
  AUTHORS   Lu,Z., Zhang,Y., Yan,H., Su,Y., Guo,L., Liao,Y., Lu,T., Yu,H.,
            Wang,L., Li,J., Li,W., Yang,Y., Xiao,X., Lv,L., Tan,Y., Zhang,D.
            and Yue,W.
  TITLE     ATAD3B and SKIL polymorphisms associated with antipsychotic-induced
            QTc interval change in patients with schizophrenia: a genome-wide
            association study
  JOURNAL   Transl Psychiatry 12 (1), 56 (2022)
   PUBMED   35136033
  REMARK    GeneRIF: ATAD3B and SKIL polymorphisms associated with
            antipsychotic-induced QTc interval change in patients with
            schizophrenia: a genome-wide association study.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7155)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 7155)
  AUTHORS   Ma,F., Ding,M.G., Lei,Y.Y., Luo,L.H., Jiang,S., Feng,Y.H. and
            Liu,X.L.
  TITLE     SKIL facilitates tumorigenesis and immune escape of NSCLC via
            upregulating TAZ/autophagy axis
  JOURNAL   Cell Death Dis 11 (12), 1028 (2020)
   PUBMED   33268765
  REMARK    GeneRIF: SKIL facilitates tumorigenesis and immune escape of NSCLC
            via upregulating TAZ/autophagy axis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7155)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 7155)
  AUTHORS   Cohen,S.B., Zheng,G., Heyman,H.C. and Stavnezer,E.
  TITLE     Heterodimers of the SnoN and Ski oncoproteins form preferentially
            over homodimers and are more potent transforming agents
  JOURNAL   Nucleic Acids Res 27 (4), 1006-1014 (1999)
   PUBMED   9927733
REFERENCE   7  (bases 1 to 7155)
  AUTHORS   Pearson-White,S. and Crittenden,R.
  TITLE     Proto-oncogene Sno expression, alternative isoforms and immediate
            early serum response
  JOURNAL   Nucleic Acids Res 25 (14), 2930-2937 (1997)
   PUBMED   9207045
REFERENCE   8  (bases 1 to 7155)
  AUTHORS   Pearson-White,S.
  TITLE     SnoI, a novel alternatively spliced isoform of the ski
            protooncogene homolog, sno
  JOURNAL   Nucleic Acids Res 21 (19), 4632-4638 (1993)
   PUBMED   8233802
REFERENCE   9  (bases 1 to 7155)
  AUTHORS   Nagase,T., Nomura,N. and Ishii,S.
  TITLE     Complex formation between proteins encoded by the ski gene family
  JOURNAL   J Biol Chem 268 (18), 13710-13716 (1993)
   PUBMED   8514802
REFERENCE   10 (bases 1 to 7155)
  AUTHORS   Nomura,N., Sasamoto,S., Ishii,S., Date,T., Matsui,M. and
            Ishizaki,R.
  TITLE     Isolation of human cDNA clones of ski and the ski-related gene, sno
  JOURNAL   Nucleic Acids Res 17 (14), 5489-5500 (1989)
   PUBMED   2762147
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA464211.1, AC073288.27,
            BC059386.1, X15219.1 and AI245308.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005414.4.
            
            Summary: The protein encoded by this gene is a component of the
            SMAD pathway, which regulates cell growth and differentiation
            through transforming growth factor-beta (TGFB). In the absence of
            ligand, the encoded protein binds to the promoter region of
            TGFB-responsive genes and recruits a nuclear repressor complex.
            TGFB signaling causes SMAD3 to enter the nucleus and degrade this
            protein, allowing these genes to be activated. Four transcript
            variants encoding three different isoforms have been found for this
            gene. [provided by RefSeq, Oct 2011].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1, also known as snoN).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.112482.1,
                                           SRR1660809.15608.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000259119.9/ ENSP00000259119.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-275               DA464211.1         31-305
            276-276             AC073288.27        116262-116262
            277-794             BC059386.1         266-783
            795-795             AC073288.27        116781-116781
            796-2813            X15219.1           823-2840
            2814-6932           AC073288.27        148831-152949
            6933-7155           AI245308.1         18-240              c
FEATURES             Location/Qualifiers
     source          1..7155
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q26.2"
     gene            1..7155
                     /gene="SKIL"
                     /gene_synonym="SNO; SnoA; SnoI; SnoN"
                     /note="SKI like proto-oncogene"
                     /db_xref="GeneID:6498"
                     /db_xref="HGNC:HGNC:10897"
                     /db_xref="MIM:165340"
     exon            1..49
                     /gene="SKIL"
                     /gene_synonym="SNO; SnoA; SnoI; SnoN"
                     /inference="alignment:Splign:2.1.0"
     exon            50..1780
                     /gene="SKIL"
                     /gene_synonym="SNO; SnoA; SnoI; SnoN"
                     /inference="alignment:Splign:2.1.0"
     CDS             683..2737
                     /gene="SKIL"
                     /gene_synonym="SNO; SnoA; SnoI; SnoN"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ski-like protein; ski-related oncogene snoN; SKI-like
                     oncogene"
                     /codon_start=1
                     /product="ski-like protein isoform 1"
                     /protein_id="NP_005405.2"
                     /db_xref="CCDS:CCDS33890.1"
                     /db_xref="GeneID:6498"
                     /db_xref="HGNC:HGNC:10897"
                     /db_xref="MIM:165340"
                     /translation="MENLQTNFSLVQGSTKKLNGMGDDGSPPAKKMITDIHANGKTIN
                     KVPTVKKEHLDDYGEAPVETDGEHVKRTCTSVPETLHLNPSLKHTLAQFHLSSQSSLG
                     GPAAFSARHSQESMSPTVFLPLPSPQVLPGPLLIPSDSSTELTQTVLEGESISCFQVG
                     GEKRLCLPQVLNSVLREFTLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSC
                     GLITLTDAQRLCNALLRPRTFPQNGSVLPAKSSLAQLKETGSAFEVEHECLGKCQGLF
                     APQFYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPDKRTCHWGFESAKWHCYLHVNQK
                     YLGTPEEKKLKIILEEMKEKFSMRSGKRNQSKTDAPSGMELQSWYPVIKQEGDHVSQT
                     HSFLHPSYYLYMCDKVVAPNVSLTSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKT
                     VSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGL
                     VAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSK
                     SMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKD
                     KEAEYAGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTA
                     KE"
     exon            1781..1878
                     /gene="SKIL"
                     /gene_synonym="SNO; SnoA; SnoI; SnoN"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..2111
                     /gene="SKIL"
                     /gene_synonym="SNO; SnoA; SnoI; SnoN"
                     /inference="alignment:Splign:2.1.0"
     exon            2112..2353
                     /gene="SKIL"
                     /gene_synonym="SNO; SnoA; SnoI; SnoN"
                     /inference="alignment:Splign:2.1.0"
     exon            2354..2578
                     /gene="SKIL"
                     /gene_synonym="SNO; SnoA; SnoI; SnoN"
                     /inference="alignment:Splign:2.1.0"
     exon            2579..7155
                     /gene="SKIL"
                     /gene_synonym="SNO; SnoA; SnoI; SnoN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7130..7135
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SKIL"
                     /gene_synonym="SNO; SnoA; SnoI; SnoN"
                     /note="hexamer: AATAAA"
     polyA_site      7155
                     /gene="SKIL"
                     /gene_synonym="SNO; SnoA; SnoI; SnoN"
                     /note="major polyA site"
ORIGIN      
        1 acagccgaag ggagcgggcg agcggcgacg gcggcggcgg cgggcacaga ttaattaaaa
       61 gaagaatgaa ctataatcct tgaagataac tgggcaattt tttaagtcgg aggctgttct
      121 tactggtgtg aggatttaca cacgtcttca gtttttcagc acagaccagc agaccatcat
      181 ttttagagga aatactccct ctgccctcct ttttggtttc cttggtggta aagattaaat
      241 ttggttgcat cattttgact tgtgtttgag tctagatttt atggcacaag gaatggcata
      301 aacttttcat gtgttttggt taaaacaaac cagaccattg cattgaccct ggacatcttt
      361 aattgagaaa ttggtaactt tattttaata tgtatatctg aagaattcaa gaaaacaaag
      421 gcatcctcag aggtgtgcct cttttcttta ttattagagg caaaacgaac aattttatag
      481 gatttgtagt gaaattatac cagattataa ggagaaccaa aactaagtcg caaaatttat
      541 taatttaagg ggctctcgct ttgaaagttt gagagtaagt tacgataggc atttgtatcc
      601 attcattact ttcctctttt caaataagca actaaataga aatgctaatc tcagacttaa
      661 ttatttaaca gaagagtgta ccatggaaaa cctccagaca aatttctcct tggttcaggg
      721 ctcaactaaa aaactgaatg ggatgggaga tgatggcagc cccccagcga aaaaaatgat
      781 aacggacatt catgcaaatg gaaaaacgat aaacaaggtg ccaacagtta agaaggaaca
      841 cttggatgac tatggagaag caccagtgga aactgatgga gagcatgtta agcgaacctg
      901 tacttctgtt cctgaaactt tgcatttaaa tcccagtttg aaacacacat tggcacaatt
      961 ccatttaagt agtcagagct cgctgggtgg accagcagca ttttctgctc ggcattccca
     1021 agaaagcatg tcgcctactg tatttctgcc tcttccatca cctcaggttc ttcctggccc
     1081 attgctcatc ccttcagata gctccacaga actcactcag actgtgttgg aaggggaatc
     1141 tatttcttgt tttcaagttg gaggagaaaa gagactctgt ttgccccaag tcttaaattc
     1201 tgttctccga gaatttacac tccagcaaat aaatacagtg tgtgatgaac tgtacatata
     1261 ttgttcaagg tgtacttcag accagcttca tatcttaaag gtactgggca tacttccatt
     1321 caatgcccca tcctgtgggc tgattacatt aactgatgca caaagattat gtaatgcttt
     1381 attgcggcca cgaacttttc ctcaaaatgg tagcgtactt cctgctaaaa gctcattggc
     1441 ccagttaaag gaaactggca gtgcctttga agtggagcat gaatgcctag gcaaatgtca
     1501 gggtttattt gcaccccagt tttatgttca gcctgatgct ccgtgtattc aatgtctgga
     1561 gtgttgtgga atgtttgcac cccagacgtt tgtgatgcat tctcacagat cacctgacaa
     1621 aagaacttgc cactggggct ttgaatcagc taaatggcat tgctatcttc atgtgaacca
     1681 aaaatactta ggaacacctg aagaaaagaa actgaagata attttagaag aaatgaagga
     1741 gaagtttagc atgagaagtg gaaagagaaa tcaatccaag acagatgcac catcaggaat
     1801 ggaattacag tcatggtatc ctgttataaa gcaggaaggt gaccatgttt ctcagacaca
     1861 ttcattttta caccccagct actacttata catgtgtgat aaagtggttg ccccaaatgt
     1921 gtcacttact tctgctgtat cccagtctaa agagctcaca aagacagagg caagtaagtc
     1981 catatcaaga cagtcagaga aggctcacag tagtggtaaa cttcaaaaaa cagtgtctta
     2041 tccagatgtc tcacttgagg aacaggagaa aatggattta aaaacaagta gagaattatg
     2101 tagccgttta gatgcatcaa tctcaaataa ttctacaagt aaaaggaaat ctgagtctgc
     2161 cacttgcaac ttagtcagag acataaacaa agtgggaatt ggccttgttg ctgccgcttc
     2221 atctccgctt cttgtgaaag atgtcatttg tgaggatgat aagggaaaaa tcatggaaga
     2281 agtaatgaga acttatttaa aacaacagga aaaactaaac ttgattttgc aaaagaagca
     2341 acaacttcag atggaagtaa aaatgttgag tagttcaaaa tctatgaagg aactcactga
     2401 agaacagcag aatttacaga aagagcttga atctttgcag aatgaacatg ctcaaagaat
     2461 ggaagaattt tatgttgaac agaaagactt agagaaaaaa ttggagcaga taatgaagca
     2521 aaaatgtacc tgtgactcaa atttagaaaa agacaaagag gctgaatatg caggacagtt
     2581 ggcagaactg aggcagagat tggaccatgc tgaggccgat aggcaagaac tccaagatga
     2641 actcagacag gaacgggaag caagacagaa gttagagatg atgataaaag agctaaagct
     2701 gcaaattctg aaatcatcaa agactgctaa agaatagaaa ctgttaaaga gattcatctg
     2761 tgtattactg acaaggtttt ttttgtttgt tgcttgcttt ggtaattgaa ttctgaagaa
     2821 tttatctgca tgacgataac taggcattct atccatttgt agatcagaga aagtgaagag
     2881 attatatatt agtacttaaa tttttacatt ttccaaatga atgaaaatgt atgtttcttt
     2941 gtactttttt aaaaaaatca gcttagtaac aatactatat ggtttcaact agtaggtaat
     3001 ctgcttatat ttctaatgca aacttaacaa ttgtgtactt tttaaaagct gcaatatgtg
     3061 ttggaaaata gctgtggtca attttgttat ccatatttca gactcaattt tagatacaat
     3121 ggtggcttta tattttaagt atatagagct actcaaggag ttgaatctcc ccttttctca
     3181 ttaacacaat ttttctaagt tgatatggtg tactcattaa catacaccaa atttactttt
     3241 actttgttca gattgtggaa tgaatttcca ccagttctct tctttttaat gtgtacccta
     3301 ggaggaattt tactgaggtt atagcatacc ccatgagcac agtggggaag aagaatgtgt
     3361 tgttatgtgc tgctgctaaa cagaagcagc agttgtaatt tgtttttcag tttaaatgtg
     3421 gttatagtta gatttttttt taagcagcaa cttttcaaaa ataaaatgtg ataatttctg
     3481 aacttttgtt tgtgttgtta atagtggtgt gaaaatatta acgttcttga gaaaaactga
     3541 taccactgtt gtgtatcagt ttctatacaa tccataatcc tcctgtacag tttttacatg
     3601 tagttatgag tcttactaaa atttatataa tggacttgtt ttcctttaag ttgtaaaatg
     3661 ttaaacacct tgaaggttat tttggacttc tgtatgttta aatgttgtct taccaaaatt
     3721 tgcacgaatg gaccattttc atttactact taatatcaaa atcaggaatt tacagtcaac
     3781 tgatagtaca tgataggtgc atataggaca gtttagttac ctgctactaa aagattttta
     3841 gataagtttt agaagataaa ggaattccat agtttcagga gggacaacat cttctgcact
     3901 ttttttttgc acagaaaagt ctgtcattct ctaatggcaa atttcatatt tgttaattct
     3961 tggctcaaaa tatattaggt aaaattctta gatctgtttt taaagggagt ttcctgaaac
     4021 tatcattaat tgacattatt accccatgga ttttatggga taataaatgt ttttcatgtt
     4081 ctcttataag atactatgta tgaaattact tcagagagct atatttattt taaaataaat
     4141 tagctagggt taaggttata ttctatttcc agcatagaag gtagataatc taatggtgta
     4201 gaaagaatca ctaggttgtc atttaaccag ttattttcat attttgctta atagtacata
     4261 tccaaaaaga attttgtact tccccaaatg taatttattt actaaattga gtataaccta
     4321 aatgtgtgtt ttctattttc catttaaatt ttgctatatt aagactaatt taattcgttg
     4381 agtcttggaa tcttctcaag gaggaacaaa tattaaaatg acatgtagaa acaaattttt
     4441 tttttttttt tttttttttt ttttttgaga cagagtctcg ctgtctccca ggctggagtt
     4501 cagtggtgca atctcggctc actgcaagct ctgcctcctg ggttcaagcc attctcctgc
     4561 ctcagcctcc cgagtagctg ggactacagg cacccaccac cactcccggc taatttttag
     4621 aaacaaatat ttaaaatgac atattctccc aatacaatct atttagatct ggagaaggaa
     4681 aaatcagata tttatgatat agttttattt taattttgaa ttatttgtgt cacagctcag
     4741 ctttttggaa gacaaactca aacacctata atttcattta tatttctaat tcacttggaa
     4801 cctttctgct ttatgttacc tagaaaatga taatttgttt aacccaaaac ttctaaaata
     4861 aattgcttaa tccttgaaat atgttattgg aaaattttaa gcagtgctta aacaccatta
     4921 aattattatg aacttgtaat tcagaattga gtaaagaaat attttttcta gtccttcata
     4981 tattgaaaac ttgccacatg acattgtatc gtcttcattt tccagaagat gcgttggtgt
     5041 gccataggtt tctaacttcc ttgaaaatag ttttttaagt caattgtaaa tatacgtatt
     5101 attgttaaaa gtaactttaa actgcaacac atagcttcaa aacaatatag agattttgta
     5161 ataccttata agtggagttg gctaaaatac cttatccata taaaacttat tctattcttt
     5221 gcatgcttat tttgtgtgtt ggttgctagc ttaaagtttg atttgttgtt actctttgtg
     5281 tgccaaattc actaggcaag cggatttttc ctcagacttc aaaaaataat tcttttaaga
     5341 aaaaatgtaa aaatgtttat tctaaaaagc tgcattaaag ggacaaccta taaaaagttt
     5401 tgctagctca tctttagaag gaagaaagaa tattagcttg ggtgatgttt aatttgggtg
     5461 gcgatagttt ctgtaggcta aactttatga gaaaagtgta cctactctat aaaggtaata
     5521 aatgtaaaac ctcttgctgt tattgaggaa gctcttcaac taccctaaat ttcacaaatg
     5581 taacttataa cactatgaaa agatttgacc aacaatttac gtttgctgtg tgctttagtt
     5641 tttgtttaag catattcttt tgcttgaatt tctgtgttca tgagagttag ggtgttttat
     5701 gcttcttgaa ctaattttat aacatattta atatattacc agttaagata taaaatcatt
     5761 tgtacatagc gaattgtaaa gcagctatta aagtaggtga aataaagtat atatttgccg
     5821 gttatccata tcttttagaa gtcctgacag aacaaccagt ttatttgcac ataggtagct
     5881 tctgtttgaa ggaaggtaaa gttataagga aactcaaata ctataagatg tgtcaaggta
     5941 tttctccaga attaattgca aagctagtgc tgaaggattt taatcagctt ctaaaatttt
     6001 cttctcaata aggcatatgt tttgattact tagggaagat tcctcatttt tatttgccct
     6061 ttatgcattt aatccacatg ataggacatt aaaaattaat ataaagaaaa atcgtgctca
     6121 tactgtacat ctgtttctgt gcttggaact acttgttaat agtttttatc gaagctgtca
     6181 gcaataaggg acataaaact gctgtattat acattgtgga attgaataaa cagcctaatt
     6241 ttttttttct agtatagggt acttaagcat ttccactttt ggaagaaaag tgtattagta
     6301 ttttatattg catttcattt aaaaggacag tttttttttt ttttttgtaa atccattcat
     6361 tgaaatggtt tctaaactgt ataatgtaat ttggagccta tttagtaata gaattaaatg
     6421 tcctatgtag tgctacaatt tttgaattag aaagtgatca aatgtaagaa aaaaatttaa
     6481 aaattcagcc cagaaaacaa aatagtgtat taaattagtt taatgtaaaa ggaatttata
     6541 agattttttt cctcaatata gatacctcac ttgaaaagaa agcacagcat acttaaagta
     6601 gttctagtaa acatgtccta gaaaacagtt gctaaatgta ggacatcttt tgaggaatta
     6661 gtttatgaga aataaaattt tacttgtttt tactatcctg ttagaagtat ttgtttatcc
     6721 tgataatttt aagccaacat agtagtctta aattactttt gaatttctaa tctgtgaagg
     6781 cagtaaatga aatatctgtt ctgcaactgt tgaaacaaat aattggctac attgaccata
     6841 attaaagtta aaattttgcc aatgatgtac agttttatgg ttaaagttgc tgtggttggt
     6901 tgcattacat gacacagaaa actgtcctct acctcacgtg aaataaatat tttatatggt
     6961 tttactaaaa ataagactca tgtatctggt cacctagttt acaaattttg aattatattt
     7021 attgaaacat gacatactgt gctctgagct tatacctcaa ttgtattttg tgctgttttc
     7081 cattttcatg ccttgtaaat aacttgtata gattgtggat caaatactaa ataaaaactt
     7141 ttaatgccaa ttaaa
//
