LOCUS       NM_014639               5677 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens SKI3 subunit of superkiller complex (SKIC3), mRNA.
ACCESSION   NM_014639
VERSION     NM_014639.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5677)
  AUTHORS   Kogel,A., Keidel,A., Bonneau,F., Schafer,I.B. and Conti,E.
  TITLE     The human SKI complex regulates channeling of ribosome-bound RNA to
            the exosome via an intrinsic gatekeeping mechanism
  JOURNAL   Mol Cell 82 (4), 756-769 (2022)
   PUBMED   35120588
REFERENCE   2  (bases 1 to 5677)
  AUTHORS   Dorum,S. and Gorukmez,O.
  TITLE     Expanding the clinical spectrum in trichohepatoenteric syndrome
  JOURNAL   Am J Med Genet A 185 (10), 2873-2877 (2021)
   PUBMED   34037310
  REMARK    GeneRIF: Expanding the clinical spectrum in trichohepatoenteric
            syndrome.
REFERENCE   3  (bases 1 to 5677)
  AUTHORS   Zinoviev,A., Ayupov,R.K., Abaeva,I.S., Hellen,C.U.T. and
            Pestova,T.V.
  TITLE     Extraction of mRNA from Stalled Ribosomes by the Ski Complex
  JOURNAL   Mol Cell 77 (6), 1340-1349 (2020)
   PUBMED   32006463
REFERENCE   4  (bases 1 to 5677)
  AUTHORS   Bourgeois,P., Esteve,C., Chaix,C., Beroud,C., Levy,N., Fabre,A. and
            Badens,C.
  CONSRTM   THES clinical consortium
  TITLE     Tricho-Hepato-Enteric Syndrome mutation update: Mutations spectrum
            of TTC37 and SKIV2L, clinical analysis and future prospects
  JOURNAL   Hum Mutat 39 (6), 774-789 (2018)
   PUBMED   29527791
  REMARK    GeneRIF: We then examined the lab diagnostic cohort in detail for
            clinical manifestations. For the first time, we are able to suggest
            that patients lacking SKIV2L seem more severely affected than those
            lacking TTC37, in terms of liver damage and prenatal growth
            impairment.
            Review article
REFERENCE   5  (bases 1 to 5677)
  AUTHORS   Fabre,A., Petit,L.M., Hansen,L.F., Wewer,A.V., Esteve,C., Chaix,C.,
            Bourgeois,P., Badens,C. and Paerregaard,A.
  TITLE     A new mutation in the C-terminal end of TTC37 leading to a mild
            form of syndromic diarrhea/tricho-hepato-enteric syndrome in seven
            patients from two families
  JOURNAL   Am J Med Genet A 176 (3), 727-732 (2018)
   PUBMED   29383842
  REMARK    GeneRIF: we present seven patients from two families with a new
            mutation in TTC37. The phenotype is classic, but the disease course
            is milder, with better intra- and extrauterine growth, less need
            for parenteral nutrition, and better chance of survival.
REFERENCE   6  (bases 1 to 5677)
  AUTHORS   Fabre,A., Martinez-Vinson,C., Roquelaure,B., Missirian,C.,
            Andre,N., Breton,A., Lachaux,A., Odul,E., Colomb,V., Lemale,J.,
            Cezard,J.P., Goulet,O., Sarles,J., Levy,N. and Badens,C.
  TITLE     Novel mutations in TTC37 associated with tricho-hepato-enteric
            syndrome
  JOURNAL   Hum Mutat 32 (3), 277-281 (2011)
   PUBMED   21120949
  REMARK    GeneRIF: TTC37 is widely expressed, with high levels in vascular
            tissues, lymph node, pituitary, lung, and intestine. In contrast,
            TTC37 is not expressed in the liver, an organ that is not
            consistently affected in tricho-hepato-enteric syndrome
REFERENCE   7  (bases 1 to 5677)
  AUTHORS   Hartley,J.L., Zachos,N.C., Dawood,B., Donowitz,M., Forman,J.,
            Pollitt,R.J., Morgan,N.V., Tee,L., Gissen,P., Kahr,W.H.,
            Knisely,A.S., Watson,S., Chitayat,D., Booth,I.W., Protheroe,S.,
            Murphy,S., de Vries,E., Kelly,D.A. and Maher,E.R.
  TITLE     Mutations in TTC37 cause trichohepatoenteric syndrome (phenotypic
            diarrhea of infancy)
  JOURNAL   Gastroenterology 138 (7), 2388-2398 (2010)
   PUBMED   20176027
  REMARK    GeneRIF: Mutations in TTC37 cause trichohepatoenteric syndrome
            (phenotypic diarrhea of infancy).
REFERENCE   8  (bases 1 to 5677)
  AUTHORS   Zhu,B., Mandal,S.S., Pham,A.D., Zheng,Y., Erdjument-Bromage,H.,
            Batra,S.K., Tempst,P. and Reinberg,D.
  TITLE     The human PAF complex coordinates transcription with events
            downstream of RNA synthesis
  JOURNAL   Genes Dev 19 (14), 1668-1673 (2005)
   PUBMED   16024656
REFERENCE   9  (bases 1 to 5677)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   10 (bases 1 to 5677)
  AUTHORS   Fabre,A., Bourgeois,P., Chaix,C., Bertaux,K., Goulet,O. and
            Badens,C.
  TITLE     Trichohepatoenteric Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   29334452
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB002370.1 and BC015163.2.
            
            On Nov 21, 2019 this sequence version replaced NM_014639.3.
            
            Summary: This gene encodes a protein with twenty tetratricopeptide
            (TPR) repeats. Tetratricopeptide repeat containing motifs are found
            in a variety of proteins and may mediate protein-protein
            interactions and chaperone activity. Mutations in this gene are
            associated with trichohepatoenteric syndrome. [provided by RefSeq,
            Jul 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB002370.1, BC056893.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358746.7/ ENSP00000351596.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5676              AB002370.1         29-5704
            5677-5677           BC015163.2         1334-1334
FEATURES             Location/Qualifiers
     source          1..5677
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q15"
     gene            1..5677
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /note="SKI3 subunit of superkiller complex"
                     /db_xref="GeneID:9652"
                     /db_xref="HGNC:HGNC:23639"
                     /db_xref="MIM:614589"
     exon            1..42
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /inference="alignment:Splign:2.1.0"
     exon            43..112
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /inference="alignment:Splign:2.1.0"
     exon            113..268
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /inference="alignment:Splign:2.1.0"
     exon            269..359
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /inference="alignment:Splign:2.1.0"
     CDS             270..4964
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /note="thespin; TPR repeat protein 37; SKI3 homolog;
                     tricho-hepatic-enteric syndrome protein; SKI complex
                     component SKI3; tetratricopeptide repeat domain 37; SKI3
                     subunit of superkiller complex protein"
                     /codon_start=1
                     /product="superkiller complex protein 3"
                     /protein_id="NP_055454.1"
                     /db_xref="CCDS:CCDS4072.1"
                     /db_xref="GeneID:9652"
                     /db_xref="HGNC:HGNC:23639"
                     /db_xref="MIM:614589"
                     /translation="MSSKEVKTALKSARDAIRNKEYKEALKHCKTVLKQEKNNYNAWV
                     FIGVAAAELEQPDQAQSAYKKAAELEPDQLLAWQGLANLYEKYNHINAKDDLPGVYQK
                     LLDLYESVDKQKWCDVCKKLVDLYYQEKKHLEVARTWHKLIKTRQEQGAENEELHQLW
                     RKLTQFLAESTEDQNNETQQLLFTAFENALGLSDKIPSEDHQVLYRHFIQSLSKFPHE
                     SARLKKACEGMINIYPTVQYPLEVLCLHLIESGNLTDEGQQYCCRLVEMDSKSGPGLI
                     GLGIKALQDKKYEDAVRNLTEGLKESPVCTSGWYHLAEAQVKMHRPKEAVLSCSQALK
                     IVDNLGASGNSLYQRNLCLHLKAEALIKLSDYDSSEEAIRTLDQISDADNIPGLLVLK
                     SLAYRNKGSFDEAAKIMEDLLSSYPDLAEVHALEALIHFTKKDYLQAEKCFQRALEKD
                     TEVAEYHYQLGLTYWFMGEETRKDKTKALTHFLKAARLDTYMGKVFCYLGHYYRDVVG
                     DKNRARGCYRKAFELDDTDAESGAAAVDLSVELEDMEMALAILTTVTQKASAGTAKWA
                     WLRRGLYYLKAGQHSQAVADLQAALRADPKDFNCWESLGEAYLSRGGYTTALKSFTKA
                     SELNPESIYSVFKVAAIQQILGKYKEAVAQYQMIIKKKEDYVPALKGLGECHLMMAKA
                     ALVDYLDGKAVDYIEKALEYFTCALQHRADVSCLWKLAGDACTCLYAVAPSKVNVHVL
                     GVLLGQKEGKQVLKKNELLHLGGRCYGRALKLMSTSNTWCDLGINYYRQAQHLAETGS
                     NMNDLKELLEKSLHCLKKAVRLDSNNHLYWNALGVVACYSGIGNYALAQHCFIKSIQS
                     EQINAVAWTNLGVLYLTNENIEQAHEAFKMAQSLDPSYLMCWIGQALIAEAVGSYDTM
                     DLFRHTTELNMHTEGALGYAYWVCTTLQDKSNRETELYQYNILQMNAIPAAQVILNKY
                     VERIQNYAPAFTMLGYLNEHLQLKKEAANAYQRAILLLQTAEDQDTYNVAIRNYGRLL
                     CSTGEYDKAIQAFKSTPLEVLEDIIGFALALFMKGLYKESSKAYERALSIVESEQDKA
                     HILTALAITEYKQGKTDVAKTLLFKCSILKEPTTESLQALCALGLAMQDATLSKAALN
                     ELLKHIKHKDSNYQRCLLTSAIYALQGRSVAVQKQISKAVHSNPGDPALWSLLSRVVA
                     QYAQRNAKGGVVAGNVAHILDSNHGKKALLYTAVNQLAMGSSSAEDEKNTALKTIQKA
                     ALLSPGDPAIWAGLMAACHADDKLALVNNTQPKRIDLYLALLSAVSASIKDEKFFENY
                     NQSLEKWSLSQAVTGLIDTGRISEAETLCTKNLKSNPDQPAVILLLRQVQCKPLLESQ
                     KPLPDAVLEELQKTVMSNSTSVPAWQWLAHVYQSQGMMRAAEMCYRKSLQLASQRGSW
                     SGKLSSLLRLALLALKVCMANISNDHWPSLVQEATTEALKLCFCPLAVLLQALLQFKR
                     KMGARETRRLLERVVYQPGYPKSIASTARWYLLRHLYAKDDYELIDVLVNNAKTHGDT
                     RALELNQRLSSQ"
     exon            360..503
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /inference="alignment:Splign:2.1.0"
     exon            504..595
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /inference="alignment:Splign:2.1.0"
     exon            596..671
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /inference="alignment:Splign:2.1.0"
     exon            672..812
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /inference="alignment:Splign:2.1.0"
     exon            813..911
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1020
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1161
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1263
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1403
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1490
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1594
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1721
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1901
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2026
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2280
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2383
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..2560
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /inference="alignment:Splign:2.1.0"
     exon            2561..2705
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /inference="alignment:Splign:2.1.0"
     exon            2706..2784
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /inference="alignment:Splign:2.1.0"
     exon            2785..2846
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /inference="alignment:Splign:2.1.0"
     exon            2847..2903
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /inference="alignment:Splign:2.1.0"
     exon            2904..2972
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /inference="alignment:Splign:2.1.0"
     exon            2973..3047
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /inference="alignment:Splign:2.1.0"
     exon            3048..3189
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /inference="alignment:Splign:2.1.0"
     exon            3190..3283
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /inference="alignment:Splign:2.1.0"
     exon            3284..3361
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /inference="alignment:Splign:2.1.0"
     exon            3362..3486
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /inference="alignment:Splign:2.1.0"
     exon            3487..3610
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /inference="alignment:Splign:2.1.0"
     exon            3611..3832
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /inference="alignment:Splign:2.1.0"
     exon            3833..3905
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /inference="alignment:Splign:2.1.0"
     exon            3906..3959
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /inference="alignment:Splign:2.1.0"
     exon            3960..4071
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /inference="alignment:Splign:2.1.0"
     exon            4072..4200
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /inference="alignment:Splign:2.1.0"
     exon            4201..4322
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /inference="alignment:Splign:2.1.0"
     exon            4323..4481
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /inference="alignment:Splign:2.1.0"
     exon            4482..4634
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /inference="alignment:Splign:2.1.0"
     exon            4635..4765
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /inference="alignment:Splign:2.1.0"
     exon            4766..4889
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /inference="alignment:Splign:2.1.0"
     exon            4890..5677
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5658..5663
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /note="hexamer: AATAAA"
     polyA_site      5677
                     /gene="SKIC3"
                     /gene_synonym="KIAA0372; Ski3; THES; TTC37"
                     /note="major polyA site"
ORIGIN      
        1 attgcagcct cggcgtttgt agaagaggag catctgctcc agatggaaaa tgggtaagga
       61 acaatcaaat tcaattcggg aagaatatag aggtggtaat aattggtaaa agtctgcagg
      121 gtttttttta accaaaggaa actggtttga gaaaattgtg aaatcagcat tgaaatttgt
      181 tacctactcc aatcaagatt tgcaaactac aaaaaaatca ttctgaagct ttcacctata
      241 aatatatacc aagataattt cagataagaa tgtccagcaa ggaagtgaag actgctctaa
      301 aaagtgctag agatgcaatc agaaacaaag aatacaaaga agctttgaaa cactgtaaga
      361 cagtgttaaa gcaagagaaa aataactata atgcctgggt ttttattggc gttgctgcag
      421 ctgaactaga acaacctgat caggcccaga gtgcctataa aaaagctgct gaattagagc
      481 cagaccaatt actagcttgg caggggttag caaacttgta tgagaaatat aatcacataa
      541 atgctaagga tgacttgcct ggtgtttacc aaaagctcct ggatctttat gagagtgttg
      601 acaagcagaa gtggtgtgat gtctgcaaga aacttgtgga tctatattac caagaaaaga
      661 aacacctaga ggtggctcga acatggcaca agttgataaa aacacggcag gaacaaggtg
      721 cagaaaatga agagcttcat caactatgga gaaaattgac tcagttcctg gctgaaagta
      781 cagaggacca gaataatgaa actcagcaat tgctttttac tgcttttgag aatgcactgg
      841 gattatcaga taagattcct agtgaagatc accaagtact ttataggcat ttcattcaga
      901 gtttatccaa atttcctcat gagtctgcta gattgaagaa ggcctgtgaa ggaatgataa
      961 acatctatcc tactgtacag tatccattag aagtgctttg tttgcattta attgaatcag
     1021 gaaatcttac tgatgagggg cagcagtatt gttgtagatt agtggaaatg gattcaaaaa
     1081 gtggtccagg cctcattggc ttaggcatta aagcattaca agacaaaaag tatgaagatg
     1141 ctgttaggaa cctaacagaa gggttaaagg aaagccctgt ctgcacaagt ggatggtatc
     1201 atctggcaga agcccaagtc aaaatgcata gacctaaaga agctgttctt tcatgcagtc
     1261 aagctctgaa gatcgtagat aatcttggtg cgtctggtaa cagtctttat cagaggaatc
     1321 tttgtcttca tttgaaagca gaggctttga ttaaactctc agattatgac tcttcagagg
     1381 aagcaattcg tacgcttgat cagatttctg atgcagataa tatcccagga cttttggttc
     1441 tcaaaagctt ggcctatcgg aacaaaggtt catttgatga agctgcaaag attatggaag
     1501 accttctctc ttcttaccct gacctagctg aagttcatgc ccttgaggct ttgattcatt
     1561 tcaccaaaaa ggactatcta caagcagaaa aatgttttca gagagctctt gagaaagata
     1621 ccgaagttgc agaatatcat taccaacttg gattaacata ctggttcatg ggtgaagaga
     1681 caagaaaaga taaaacaaag gctcttaccc actttctgaa ggctgcaaga ctggatacat
     1741 atatgggcaa agttttctgc tatttaggtc attattatag agacgtagtg ggagataaaa
     1801 acagagctcg tggatgttat aggaaagcct ttgaattaga tgacactgat gctgaatctg
     1861 gagctgcagc agttgaccta agtgtggagc ttgaagatat ggaaatggct ttagctatcc
     1921 taacaacagt aactcaaaag gcaagtgctg gaacggcaaa atgggcctgg cttaggcgag
     1981 gactatacta tttgaaagct ggtcagcatt ctcaagcagt ggctgattta caggcagcat
     2041 taagagcaga cccaaaggac ttcaattgtt gggaatcgtt aggagaagca tacttaagca
     2101 gaggaggcta cacaacagcc ttgaagtcct tcacaaaagc cagtgagctg aacccagaat
     2161 ccatatacag tgtgtttaag gttgcagcaa tacagcaaat cctaggcaaa tataaggagg
     2221 ctgtagctca ataccagatg atcattaaaa agaaagaaga ttatgtgcct gctttaaaag
     2281 gtttgggtga atgccatctt atgatggcaa aagcagctct agttgattat cttgatggaa
     2341 aagccgtaga ctacatagaa aaagcactgg aatattttac ttgtgctcta cagcatcgag
     2401 ctgatgtgtc ctgcctctgg aagctagctg gggatgcttg tacctgtctg tatgctgtcg
     2461 caccatctaa agtgaatgtt catgttttag gagtccttct aggtcagaaa gaaggaaaac
     2521 aagtattaaa gaaaaatgag ctcctccacc ttggaggaag gtgttatggt cgtgcattaa
     2581 aactgatgtc tacatctaat acatggtgtg accttggaat taattattat cgccaagcac
     2641 aacatctagc agaaacaggc agcaacatga atgatcttaa ggagttgctg gagaaatctt
     2701 tacattgtct gaaaaaagca gtgagactcg acagtaataa tcacttatac tggaatgctc
     2761 ttggtgtggt tgcatgttac agtggtattg gaaattatgc ccttgctcag cactgtttca
     2821 tcaaatcaat ccagtcagaa caaattaatg ctgttgcatg gaccaacttg ggagtgttat
     2881 acctcacaaa tgaaaacatt gagcaagctc atgaggcttt caaaatggct caatcccttg
     2941 atccatctta tttaatgtgc tggattggac aagctcttat tgctgaggca gttggaagtt
     3001 atgacaccat ggatctcttc aggcacacta cagaactaaa tatgcatact gaaggagcat
     3061 taggttatgc gtattgggtc tgcacaacat tgcaagataa aagcaacaga gaaacagagc
     3121 tgtaccagta caacatcctc cagatgaatg ctattccagc agcacaagtt attttgaata
     3181 aatatgtaga aagaattcag aattatgccc cagctttcac aatgttgggt tacttaaacg
     3241 aacatctaca actgaaaaag gaagcagcaa atgcatacca aagggcaatt ttgttgttac
     3301 agactgcaga agaccaagat acttacaatg ttgcaataag aaattacggc agattgttat
     3361 gttccactgg tgaatatgat aaagctatcc aggcttttaa gtcaacaccc cttgaagtgt
     3421 tagaagacat cataggtttt gcattggctt tattcatgaa ggggctttat aaagagagca
     3481 gcaaagccta tgagagagcc ttgtctattg ttgaatcgga gcaagacaaa gcccatatct
     3541 tgacagctct ggcaataact gaatataaac aaggaaaaac ggatgtagcc aagacattgc
     3601 tatttaaatg ctctatctta aaggaaccaa ccacagaaag ccttcaagcc ctgtgtgctc
     3661 tagggttggc aatgcaggat gctacactgt caaaagcagc acttaatgag ttactgaagc
     3721 acatcaaaca caaagacagt aattatcaga ggtgccttct tacatcagcg atttatgcac
     3781 tccaaggccg cagtgtggct gtgcaaaaac aaatatctaa agctgttcac agcaaccctg
     3841 gtgaccctgc tctttggtct ctgttgtctc gagttgttgc acagtatgct caacgaaatg
     3901 caaagggagg tgttgtagca ggaaatgtgg ctcatattct ggactcaaat catggaaaga
     3961 aggcattact gtacactgcg gtaaatcagt tggctatggg aagcagttca gcagaagatg
     4021 aaaaaaatac tgcactaaag accattcaga aggcagctct cctttctcca ggtgatcctg
     4081 ctatctgggc tgggctaatg gcagcctgtc acgctgatga taaactggcc ttagtgaaca
     4141 acactcagcc aaagaggata gatttatact tggcactgtt atctgctgtt tctgcttcaa
     4201 ttaaagacga aaaattcttt gaaaattaca accagtccct tgaaaagtgg tctctctcac
     4261 aagctgtcac tggtctaata gacacaggaa gaatatctga agctgaaact ctctgcacaa
     4321 agaatttaaa aagtaaccct gatcagccag ccgttatctt acttttgaga caagttcagt
     4381 gtaaaccact cctggagtca caaaagccac tcccagatgc tgtacttgaa gaactacaaa
     4441 aaacagtcat gtccaactca acctctgttc cagcttggca gtggctggca catgtgtatc
     4501 aatcccaagg aatgatgaga gctgcagaga tgtgttacag aaagagtcta caattggcat
     4561 cccaacgggg cagttggagt gggaagctct caagtctgtt gagactagca ctacttgcat
     4621 taaaagtctg tatggctaac atttccaatg atcactggcc atctttggtt caagaggcta
     4681 caactgaggc cttgaagctt tgcttttgtc cactggctgt tcttttacaa gctttgttac
     4741 aattcaaacg caaaatgggg gcaagagaga cacggcgtct tttggaaaga gtggtatatc
     4801 agcctgggta tcccaaatct attgcatcaa ctgcacgttg gtacctactg agacacttat
     4861 atgccaaaga tgactatgag cttattgacg tgctggtaaa caatgccaaa actcatggag
     4921 atacaagagc attggaactg aatcagagat tgtcctcaca ataacattgg attattttat
     4981 agtaaggaag caaagaaaaa gctgtaagaa tgaagcaatg aatcaagact tctacccaaa
     5041 gcaacatttt tttaaactat atttattcct tttctaaagg aatctagaga agttgaagtt
     5101 tttaagttag gaatgcaatt ttctgttaac tccaaacctg attttaatct gaaaaaaaaa
     5161 aaatttaatt tgggaaaacc agaatgaaag gaaaaccatt attgccttgg ttgcttaaca
     5221 ttatttgtaa accattattt tctgcatctt gcatggtgca caatagaata tcttttactg
     5281 taatccctta caataaagcc ttaatagcca ttttctatgt aatatgcaaa agtagattag
     5341 cacaatgcac aattttcttt tgttaaaaat caaattcaaa gatttaattc ttgctatgaa
     5401 ttctaaagtt cggcaaacca attcatcata aaatccaaat aatcttgtaa cctatttatc
     5461 tagtgattca tctccaattc tgttgaaaaa gcataatata aatgttgatg agactagact
     5521 ctaatggata tgtttatata attccaaaca ctcaggtgtg tgaatgcatt taaaaacatt
     5581 aatggaaaat aatgctgata atatttaatt gatcatgcaa ttccttcaat tatgatggaa
     5641 agacttgaac tttctgaaat aaaacaaaaa tacagca
//
