LOCUS       NM_182620               2809 bp    mRNA    linear   PRI 13-MAY-2024
DEFINITION  Homo sapiens spindle and kinetochore associated complex subunit 2
            (SKA2), transcript variant 1, mRNA.
ACCESSION   NM_182620
VERSION     NM_182620.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2809)
  AUTHORS   Valenzuela-Garcia,L.I., Ayala-Garcia,V.M., Ramos-Rosales,D.F.,
            Jacquez-Flores,R.E., Urtiz-Estrada,N., Hernandez,E.M.M. and
            Barraza-Salas,M.
  TITLE     The rs7208505 Polymorphism and Differential Expression of the SKA2
            Gene in the Prefrontal Cortex of Suicide Victims from the Mexican
            Population
  JOURNAL   Arch Suicide Res 28 (2), 674-685 (2024)
   PUBMED   37204142
  REMARK    GeneRIF: The rs7208505 Polymorphism and Differential Expression of
            the SKA2 Gene in the Prefrontal Cortex of Suicide Victims from the
            Mexican Population.
REFERENCE   2  (bases 1 to 2809)
  AUTHORS   Hartmann,J., Bajaj,T., Otten,J., Klengel,C., Ebert,T.,
            Gellner,A.K., Junglas,E., Hafner,K., Anderzhanova,E.A., Tang,F.,
            Missig,G., Rexrode,L., Trussell,D.T., Li,K.X., Pohlmann,M.L.,
            Mackert,S., Geiger,T.M., Heinz,D.E., Lardenoije,R., Dedic,N.,
            McCullough,K.M., Prochnicki,T., Rhomberg,T., Martinelli,S.,
            Payton,A., Robinson,A.C., Stein,V., Latz,E., Carlezon,W.A. Jr.,
            Hausch,F., Schmidt,M.V., Murgatroyd,C., Berretta,S., Klengel,T.,
            Pantazopoulos,H., Ressler,K.J. and Gassen,N.C.
  TITLE     SKA2 regulated hyperactive secretory autophagy drives
            neuroinflammation-induced neurodegeneration
  JOURNAL   Nat Commun 15 (1), 2635 (2024)
   PUBMED   38528004
  REMARK    GeneRIF: SKA2 regulated hyperactive secretory autophagy drives
            neuroinflammation-induced neurodegeneration.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2809)
  AUTHORS   Goltser-Dubner,T., Shalev,A., Benarroch,F., Canetti,L., Yogev,M.,
            Kalla,C., Masarwa,R., Martin,J., Pevzner,D., Oz,O., Saloner,C.,
            Amer,R., Lavon,M., Lotan,A., Galili-Weisstub,E. and Segman,R.
  TITLE     Decreased mononuclear cell NR3C1 SKA2 and FKPB5 expression levels
            among adult survivors of suicide bombing terror attacks in
            childhood are associated with the development of PTSD
  JOURNAL   Mol Psychiatry 28 (9), 3851-3855 (2023)
   PUBMED   37845495
  REMARK    GeneRIF: Decreased mononuclear cell NR3C1 SKA2 and FKPB5 expression
            levels among adult survivors of suicide bombing terror attacks in
            childhood are associated with the development of PTSD.
REFERENCE   4  (bases 1 to 2809)
  AUTHORS   Kalla,C., Goltser-Dubner,T., Pevzner,D., Canetti,L., Mirman,A.,
            Ben-Yehuda,A., Itzhar,N., Benarroch,F., Shalev,A., Giesser,R.,
            Fruchter,E., Vashdi,I., Oz,O., Haber,R., Saloner,C., Lotan,A.,
            Galili-Weisstub,E., Bonne,O. and Segman,R.
  TITLE     Resting mononuclear cell NR3C1 and SKA2 expression levels predict
            blunted cortisol reactivity to combat training stress among elite
            army cadets exposed to childhood adversity
  JOURNAL   Mol Psychiatry 26 (11), 6680-6687 (2021)
   PUBMED   33981010
  REMARK    GeneRIF: Resting mononuclear cell NR3C1 and SKA2 expression levels
            predict blunted cortisol reactivity to combat training stress among
            elite army cadets exposed to childhood adversity.
REFERENCE   5  (bases 1 to 2809)
  AUTHORS   Yu,D.C., Chen,X.Y., Li,X., Zhou,H.Y., Yu,D.Q., Yu,X.L., Hu,Y.C.,
            Zhang,R.H., Zhang,X.B., Zhang,K. and An,J.D.
  TITLE     Transcript levels of spindle and kinetochore-associated complex 1/3
            as prognostic biomarkers correlated with immune infiltrates in
            hepatocellular carcinoma
  JOURNAL   Sci Rep 11 (1), 11165 (2021)
   PUBMED   34045512
  REMARK    GeneRIF: Transcript levels of spindle and kinetochore-associated
            complex 1/3 as prognostic biomarkers correlated with immune
            infiltrates in hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2809)
  AUTHORS   Cao,G., Huang,B., Liu,Z., Zhang,J., Xu,H., Xia,W., Li,J., Li,S.,
            Chen,L., Ding,H., Zhao,Q., Fan,M., Shen,B. and Shao,N.
  TITLE     Intronic miR-301 feedback regulates its host gene, ska2, in A549
            cells by targeting MEOX2 to affect ERK/CREB pathways
  JOURNAL   Biochem Biophys Res Commun 396 (4), 978-982 (2010)
   PUBMED   20470754
  REMARK    GeneRIF: blocking of miR-301 in A549 cells leads to a decrease in
            the expression of the host gene, ska2.
REFERENCE   7  (bases 1 to 2809)
  AUTHORS   Gaitanos,T.N., Santamaria,A., Jeyaprakash,A.A., Wang,B., Conti,E.
            and Nigg,E.A.
  TITLE     Stable kinetochore-microtubule interactions depend on the Ska
            complex and its new component Ska3/C13Orf3
  JOURNAL   EMBO J 28 (10), 1442-1452 (2009)
   PUBMED   19360002
REFERENCE   8  (bases 1 to 2809)
  AUTHORS   Welburn,J.P., Grishchuk,E.L., Backer,C.B., Wilson-Kubalek,E.M.,
            Yates,J.R. 3rd and Cheeseman,I.M.
  TITLE     The human kinetochore Ska1 complex facilitates microtubule
            depolymerization-coupled motility
  JOURNAL   Dev Cell 16 (3), 374-385 (2009)
   PUBMED   19289083
REFERENCE   9  (bases 1 to 2809)
  AUTHORS   Rice,L., Waters,C.E., Eccles,J., Garside,H., Sommer,P., Kay,P.,
            Blackhall,F.H., Zeef,L., Telfer,B., Stratford,I., Clarke,R.,
            Singh,D., Stevens,A., White,A. and Ray,D.W.
  TITLE     Identification and functional analysis of SKA2 interaction with the
            glucocorticoid receptor
  JOURNAL   J Endocrinol 198 (3), 499-509 (2008)
   PUBMED   18583474
  REMARK    GeneRIF: Study discovered that FAM33A is protein partners for GRs
            and is involved in cell proliferation and GC signalling.
REFERENCE   10 (bases 1 to 2809)
  AUTHORS   Hanisch,A., Sillje,H.H. and Nigg,E.A.
  TITLE     Timely anaphase onset requires a novel spindle and kinetochore
            complex comprising Ska1 and Ska2
  JOURNAL   EMBO J 25 (23), 5504-5515 (2006)
   PUBMED   17093495
  REMARK    GeneRIF: These data suggest that the Ska1/Ska2 complex plays a
            critical role in the maintenance of the metaphase plate and/or
            spindle checkpoint silencing.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB158057.1, BC106003.1, AC099850.7 and BQ019350.1.
            
            On Nov 22, 2018 this sequence version replaced NM_182620.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and it encodes the longer protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.506682.1, AK056473.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155974, SAMEA2157511
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330137.12/ ENSP00000333433.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                DB158057.1         254-275
            23-320              BC106003.1         1-298
            321-2298            AC099850.7         151881-153858
            2299-2719           BQ019350.1         19-439              c
            2720-2809           AC099850.7         154280-154369
FEATURES             Location/Qualifiers
     source          1..2809
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q22"
     gene            1..2809
                     /gene="SKA2"
                     /gene_synonym="FAM33A"
                     /note="spindle and kinetochore associated complex subunit
                     2"
                     /db_xref="GeneID:348235"
                     /db_xref="HGNC:HGNC:28006"
                     /db_xref="MIM:616674"
     exon            1..56
                     /gene="SKA2"
                     /gene_synonym="FAM33A"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..389
                     /gene="SKA2"
                     /gene_synonym="FAM33A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     spindle and KT (kinetochore) associated 2; family with
                     sequence similarity 33, member A; spindle and
                     kinetochore-associated protein 2"
                     /codon_start=1
                     /product="spindle and kinetochore-associated protein 2
                     isoform 1"
                     /protein_id="NP_872426.1"
                     /db_xref="CCDS:CCDS45747.1"
                     /db_xref="GeneID:348235"
                     /db_xref="HGNC:HGNC:28006"
                     /db_xref="MIM:616674"
                     /translation="MEAEVDKLELMFQKAESDLDYIQYRLEYEIKTNHPDSASEKNPV
                     TLLKELSVIKSRYQTLYARFKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSP
                     LTKEEKTAAEQFKFHMPDL"
     exon            57..143
                     /gene="SKA2"
                     /gene_synonym="FAM33A"
                     /inference="alignment:Splign:2.1.0"
     exon            144..320
                     /gene="SKA2"
                     /gene_synonym="FAM33A"
                     /inference="alignment:Splign:2.1.0"
     exon            321..2809
                     /gene="SKA2"
                     /gene_synonym="FAM33A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      573..578
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SKA2"
                     /gene_synonym="FAM33A"
                     /note="hexamer: AATAAA"
     polyA_site      593
                     /gene="SKA2"
                     /gene_synonym="FAM33A"
                     /note="major polyA site"
     regulatory      2643..2648
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SKA2"
                     /gene_synonym="FAM33A"
                     /note="hexamer: ATTAAA"
     polyA_site      2662
                     /gene="SKA2"
                     /gene_synonym="FAM33A"
     regulatory      2688..2693
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SKA2"
                     /gene_synonym="FAM33A"
                     /note="hexamer: AATAAA"
     polyA_site      2715
                     /gene="SKA2"
                     /gene_synonym="FAM33A"
                     /note="major polyA site"
     polyA_site      2737
                     /gene="SKA2"
                     /gene_synonym="FAM33A"
     regulatory      2785..2790
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SKA2"
                     /gene_synonym="FAM33A"
                     /note="hexamer: ATTATA"
     polyA_site      2809
                     /gene="SKA2"
                     /gene_synonym="FAM33A"
ORIGIN      
        1 ctgcggaatg tcaactattc aacatggagg cggaggtcga taagctggaa ctgatgttcc
       61 agaaagctga gtctgatctg gattacattc aatacaggct ggaatatgaa atcaagacta
      121 atcatcctga ttcagcaagt gagaaaaatc cagttacact cttaaaggaa ttgtcagtga
      181 taaagtctcg atatcaaact ttgtatgccc gctttaaacc agttgctgtt gagcagaaag
      241 agagtaagag ccgcatttgt gctactgtga aaaagactat gaatatgata caaaaactac
      301 agaagcaaac agacctggag ctgtcaccac tgactaaaga agagaaaact gcggcagagc
      361 aattcaaatt tcacatgcca gatttatgaa gaaatggact tggaaaggaa attctaacag
      421 agaagagctt aattccggag aaatttagga agatgtcttg ttaacccttg atgtctagag
      481 attgggggct ggtgaagggg gtttggcttc aatgactgga taatgatatc tttcatgaga
      541 gagattataa gaagaagggc agataatata tgaataaagt tcagccaaaa ggatcaaatg
      601 agaataaaac gatttaaata tatgtacaca cgcatgcaca cacacactta gtcttgtaat
      661 ttcaggccag aaattctcaa cactattttg catctgtttt ctttttctaa gtcatgataa
      721 tatagatgtt ctggtctatc ataaaagaat gtttatgtac atttcagtca ttcggtatgt
      781 ggctttgtaa attaaagtat aggcaaaaca tttgtgttat acatgatata taatttcatt
      841 ttgtaaatgt tgattgcaca tgtggtcaca ttattgttga gactgctttt atgtgacctg
      901 tagtctccca cagaacctaa agtaataagc tggcttttct gtgatagcca cgtttgcgta
      961 tttctttccc tatttccctt gcctgctaat gttgaacagc atgaacttgc tttctgatgc
     1021 tgttttagac tgtccctgtt gtatctcaat aatatctttg ttttccttca gcctttatta
     1081 ctataattgt tcattctaca tgaaagctag gaaactgaaa ttagaagagc acttatctgc
     1141 tacttgccag ttttgcgtga gtgtgttata tgtatgtgtc aatttccctt taaaataact
     1201 atttatttta aaataactat tggcaataag gaaactgttc aaagtagagg cagatcttga
     1261 tagaaagatg ttaatcacag ggttgtttat aatagcaata tacatacaca tttggctagt
     1321 actaggtgaa taggaaaata aatcatgctg tatgtataca ataagaggtc aagttgccaa
     1381 taaattatta ctgttaatgt tctgggaaat gctgaaacta tgctaagtgg gggagaggga
     1441 aagcaggtat tgcagttttg tagtgaagat tgggctttgg agtcatatct gagatgtaag
     1501 tagcagcttt taaattctag ctatgaccct gtgcagatca cttaactttt gagtgtcagg
     1561 atgtttggaa ggacaagaca ggaaagtgtt ttaatacagg gttcagtatt tagtaagcct
     1621 tcaataagtg atattacata catgtaataa aaactaagca ttgaaaggac taggaaaaat
     1681 gcatcaaatg ttagttctgc aggttataga attatacttt tatgtaattt taaaatttca
     1741 gttatgaaca tgtttgtcca ttaacaaact tataatagct gaaaaacagg gttgtgagaa
     1801 cagcttcagt taaaattgtc ctgtctagtt tgaatatttc aagaacagaa agcctttttt
     1861 tttttttttt tttttttgag acggagtctc actctgttgc ccaggctgga atgcagtggt
     1921 acgctctcag ctcactgcaa cctccacctc ccaggttcaa gcagttctct gccccaccct
     1981 cccgagtagc tgggattaca ggcgcccgcc accacgcccg gctatttttt tgtattttta
     2041 gtagagatgg ggcttcacca tcttgaccag gctggtcttt aactcctgat ggtgatccac
     2101 ccacctcggc ctcccaaagt gctgggatta caggcatgag ctaccgtgcc tggccccctt
     2161 ttttttaatt acagagaaat aagttacacc ttagtatcag atattaattt tcttcagtgt
     2221 tcaggcaatt agtatttaga aagctcttgt catgagatgg ctctgggatg tgatgatgat
     2281 tgttgggatt gaaaaaacgg tagtatcatg gagagatcat aataaattct tagtattaaa
     2341 agtggttttg ctttcagtta gggagaaaaa ttagattgta ctatttttcc tctatgattt
     2401 ccttcagtta tcttccaaat gttgtttttt ccccacagcc cccttaacat tgttctctat
     2461 gcacttctca atacattttc atttgtttct caagcctctt tgtggatgac tcctaaatat
     2521 aacttcttcc actagctcta gatccgtatt tccaataaaa tcccctacct gaatattcaa
     2581 gttaaacatg tccagaatac ttactgattt tattgttaat agccactatt ctgttgtctg
     2641 gaattaaaac ctgtataact aatttgcatc cctttatctt cttagtcaat aaaacctaca
     2701 atcctctttc taaaatggtc atagtataca acctctacat tatcttcaca cctccttaat
     2761 ttagatcttt tgtttctcat ttggattata attgttttct cctatgtga
//
