LOCUS       NM_017420               6491 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens SIX homeobox 4 (SIX4), mRNA.
ACCESSION   NM_017420
VERSION     NM_017420.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6491)
  AUTHORS   Heiat,M., Rezaei,E., Gharechahi,J., Abbasi,M., Behroozi,J.,
            Abyazi,M.A. and Baradaran,B.
  TITLE     Knockdown of SIX4 inhibits pancreatic cancer cells via apoptosis
            induction
  JOURNAL   Med Oncol 40 (10), 287 (2023)
   PUBMED   37656231
  REMARK    GeneRIF: Knockdown of SIX4 inhibits pancreatic cancer cells via
            apoptosis induction.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6491)
  AUTHORS   Li,B., Dang,X., Duan,J., Zhang,G., Zhang,J. and Song,Q.
  TITLE     SIX4 upregulates IDH1 and metabolic reprogramming to promote
            osteosarcoma progression
  JOURNAL   J Cell Mol Med 27 (2), 259-265 (2023)
   PUBMED   36601689
  REMARK    GeneRIF: SIX4 upregulates IDH1 and metabolic reprogramming to
            promote osteosarcoma progression.
REFERENCE   3  (bases 1 to 6491)
  AUTHORS   Han,J. and Hu,X.
  TITLE     IGF2BP3-stabilized SIX4 promotes the proliferation, migration,
            invasion and tube formation of ovarian cancer cells
  JOURNAL   Mol Med Rep 26 (1) (2022)
   PUBMED   35616130
  REMARK    GeneRIF: IGF2BP3stabilized SIX4 promotes the proliferation,
            migration, invasion and tube formation of ovarian cancer cells.
REFERENCE   4  (bases 1 to 6491)
  AUTHORS   Li,Y., Jiang,X., Yan,X. and Wang,Y.
  TITLE     Upregulation of SIX4 indicates poor clinical outcome and promotes
            tumor growth and cell metastasis in esophageal squamous cell
            carcinoma
  JOURNAL   Thorac Cancer 12 (6), 752-759 (2021)
   PUBMED   33481352
  REMARK    GeneRIF: Upregulation of SIX4 indicates poor clinical outcome and
            promotes tumor growth and cell metastasis in esophageal squamous
            cell carcinoma.
REFERENCE   5  (bases 1 to 6491)
  AUTHORS   He,Q., Lin,Z., Wang,Z., Huang,W., Tian,D., Liu,M. and Xia,L.
  TITLE     SIX4 promotes hepatocellular carcinoma metastasis through
            upregulating YAP1 and c-MET
  JOURNAL   Oncogene 39 (50), 7279-7295 (2020)
   PUBMED   33046796
  REMARK    GeneRIF: SIX4 promotes hepatocellular carcinoma metastasis through
            upregulating YAP1 and c-MET.
REFERENCE   6  (bases 1 to 6491)
  AUTHORS   Liu,Q., Li,A., Tian,Y., Liu,Y., Li,T., Zhang,C., Wu,J.D., Han,X.
            and Wu,K.
  TITLE     The expression profile and clinic significance of the SIX family in
            non-small cell lung cancer
  JOURNAL   J Hematol Oncol 9 (1), 119 (2016)
   PUBMED   27821176
  REMARK    GeneRIF: SIX4 and SIX6 were linked to the lymph node metastasis in
            NSCLC.
            Review article
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 6491)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   8  (bases 1 to 6491)
  AUTHORS   Gallardo,M.E., Lopez-Rios,J., Fernaud-Espinosa,I., Granadino,B.,
            Sanz,R., Ramos,C., Ayuso,C., Seller,M.J., Brunner,H.G.,
            Bovolenta,P. and Rodriguez de Cordoba,S.
  TITLE     Genomic cloning and characterization of the human homeobox gene
            SIX6 reveals a cluster of SIX genes in chromosome 14 and associates
            SIX6 hemizygosity with bilateral anophthalmia and pituitary
            anomalies
  JOURNAL   Genomics 61 (1), 82-91 (1999)
   PUBMED   10512683
REFERENCE   9  (bases 1 to 6491)
  AUTHORS   Ozaki,H., Yamada,K., Kobayashi,M., Asakawa,S., Minoshima,S.,
            Shimizu,N., Kajitani,M. and Kawakami,K.
  TITLE     Structure and chromosome mapping of the human SIX4 and murine Six4
            genes
  JOURNAL   Cytogenet Cell Genet 87 (1-2), 108-112 (1999)
   PUBMED   10640827
REFERENCE   10 (bases 1 to 6491)
  AUTHORS   Kawakami,K., Ohto,H., Ikeda,K. and Roeder,R.G.
  TITLE     Structure, function and expression of a murine homeobox protein
            AREC3, a homologue of Drosophila sine oculis gene product, and
            implication in development
  JOURNAL   Nucleic Acids Res 24 (2), 303-310 (1996)
   PUBMED   8628654
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL132777.4, BC099722.1 and
            AA424469.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_017420.4.
            
            Summary: This gene encodes a member of the homeobox family,
            subfamily SIX. The drosophila homolog is a nuclear homeoprotein
            required for eye development. Studies in mouse show that this gene
            product functions as a transcription factor, and may have a role in
            the differentiation or maturation of neuronal cells. [provided by
            RefSeq, May 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.140483.1, BC098135.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467146 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216513.5/ ENSP00000216513.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-341               AL132777.4         136957-137297
            342-2623            BC099722.1         2-2283
            2624-6409           AL132777.4         147902-151687
            6410-6491           AA424469.1         4-85                c
FEATURES             Location/Qualifiers
     source          1..6491
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q23.1"
     gene            1..6491
                     /gene="SIX4"
                     /gene_synonym="AREC3"
                     /note="SIX homeobox 4"
                     /db_xref="GeneID:51804"
                     /db_xref="HGNC:HGNC:10890"
                     /db_xref="MIM:606342"
     exon            1..1140
                     /gene="SIX4"
                     /gene_synonym="AREC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             278..2623
                     /gene="SIX4"
                     /gene_synonym="AREC3"
                     /note="sine oculis homeobox homolog 4"
                     /codon_start=1
                     /product="homeobox protein SIX4"
                     /protein_id="NP_059116.3"
                     /db_xref="CCDS:CCDS9749.2"
                     /db_xref="GeneID:51804"
                     /db_xref="HGNC:HGNC:10890"
                     /db_xref="MIM:606342"
                     /translation="MSSSSPTGQIASAADIKQENGMESASEGQEAHREVAGGAAVGLS
                     PPAPAPFPLEPGDAATAAARVSGEEGAVAAAAAGAAADQVQLHSELLGRHHHAAAAAA
                     QTPLAFSPDHVACVCEALQQGGNLDRLARFLWSLPQSDLLRGNESLLKARALVAFHQG
                     IYPELYSILESHSFESANHPLLQQLWYKARYTEAERARGRPLGAVDKYRLRRKFPLPR
                     TIWDGEETVYCFKEKSRNALKELYKQNRYPSPAEKRHLAKITGLSLTQVSNWFKNRRQ
                     RDRNPSETQSKSESDGNPSTEDESSKGHEDLSPHPLSSSSDGITNLSLSSHMEPVYMQ
                     QIGNAKISLSSSGVLLNGSLVPASTSPVFLNGNSFIQGPSGVILNGLNVGNTQAVALN
                     PPKMSSNIVSNGISMTDILGSTSQDVKEFKVLQSSANSATTTSYSPSVPVSFPGLIPS
                     TEVKREGIQTVASQDGGSVVTFTTPVQINQYGIVQIPNSGANSQFLNGSIGFSPLQLP
                     PVSVAASQGNISVSSSTSDGSTFTSESTTVQQGKVFLSSLAPSAVVYTVPNTGQTIGS
                     VKQEGLERSLVFSQLMPVNQNAQVNANLSSENISGSGLHPLASSLVNVSPTHNFSLSP
                     STLLNPTELNRDIADSQPMSAPVASKSTVTSVSNTNYATLQNCSLITGQDLLSVPMTQ
                     AALGEIVPTAEDQVGHPSPAVHQDFVQEHRLVLQSVANMKENFLSNSESKATSSLMML
                     DSKSKYVLDGMVDTVCEDLETDKKELAKLQTVQLDEDMQDL"
     exon            1141..1826
                     /gene="SIX4"
                     /gene_synonym="AREC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..6491
                     /gene="SIX4"
                     /gene_synonym="AREC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4104..4109
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIX4"
                     /gene_synonym="AREC3"
                     /note="hexamer: AATAAA"
     polyA_site      4126
                     /gene="SIX4"
                     /gene_synonym="AREC3"
                     /note="major polyA site"
     regulatory      6469..6474
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIX4"
                     /gene_synonym="AREC3"
                     /note="hexamer: AATAAA"
     polyA_site      6491
                     /gene="SIX4"
                     /gene_synonym="AREC3"
                     /note="major polyA site"
ORIGIN      
        1 gccatatagt atgcagcaac cggaggagtc acgttggggg aacggcagaa agcagctatc
       61 cgtttacact actttgctct aacagctatc ttaatggtga ctgcgtggcc ggggggaaac
      121 ctgatcggcc agatacagcc gaaaccagga gggagggagt gggctttccg gagggggaga
      181 ggagggaggg agacgaagga ggaggagtaa gagaggagga aagaaagagg aaaagagtgc
      241 gagggagtga gggagggagg aaaataaaca acaaaaaatg tcctcttcct cccccaccgg
      301 gcagatcgca agtgcggcgg acatcaagca agagaatggg atggaaagcg cctcggaagg
      361 gcaggaggcg caccgagaag tggcgggggg cgcggcggta gggctgagcc ccccggctcc
      421 agcccctttt cccctggagc cgggggacgc cgcgaccgct gccgccaggg tgagcggaga
      481 ggaaggggca gtggcggcgg cggcggccgg agcggcggcg gatcaggtac aactccactc
      541 ggaacttctg ggcaggcacc accacgccgc cgccgccgcc gcgcagaccc cgctggcctt
      601 ctcgcccgac cacgtcgcct gcgtgtgcga ggcactgcag caggggggca acctggaccg
      661 cctggcccgg ttcctgtggt ccctgcccca gagcgacctg ctacgtggca acgagagcct
      721 gctgaaggcg cgggcgctcg tggccttcca ccagggcatc taccccgagc tctacagcat
      781 cctcgagagc cacagcttcg agtcggccaa ccacccgctg ctgcagcagc tctggtacaa
      841 ggcgcgctac accgaggccg agcgagcccg cggccggccg ctgggagccg tagacaagta
      901 ccggctgcgc aggaaattcc ccctgccccg caccatctgg gacggcgagg agacggtgta
      961 ttgtttcaag gagaagtcgc gcaacgcgct caaggagctc tacaagcaga atcgctaccc
     1021 ttcgcccgcc gagaagcggc acctggccaa gatcaccggc ctctccctca cccaggtcag
     1081 caactggttc aagaaccgcc ggcagcgcga caggaacccc tccgagaccc agtccaaaag
     1141 tgagtcagat ggcaacccca gcactgaaga tgaatccagc aagggacatg aggatttatc
     1201 tcctcaccca ctctccagtt catctgatgg catcaccaac ctcagccttt ccagtcatat
     1261 ggagccagta tatatgcaac aaattggaaa tgctaagata tcattaagct cttctggagt
     1321 tctgttgaat ggaagcttgg tacctgcaag tacttcacct gtcttcctta atggaaattc
     1381 ttttattcag ggacccagtg gagttatcct taatggatta aatgtgggaa atacacaggc
     1441 agtggcattg aacccaccaa aaatgtcatc aaacattgtg agcaatggta tatccatgac
     1501 tgacatactg gggtctactt cccaggacgt gaaggaattc aaagtcctcc agagttctgc
     1561 taactcagca accaccacgt cctacagccc cagtgtccct gtctcattcc caggcctgat
     1621 acccagcact gaggtgaaaa gagaaggcat tcaaacagtg gcttcccaag atggagggtc
     1681 tgtagtgact tttactacac cagtgcaaat taaccagtat ggcattgtcc agatccccaa
     1741 ttccggagca aacagccagt tccttaatgg gagcattgga ttctctccac tgcagctgcc
     1801 ccctgtgtca gtggcagctt cacaaggtaa tatctcagta agctcaagca cttcagatgg
     1861 aagcacattt acaagtgagt ctaccacagt ccagcaagga aaggttttct tgagctctct
     1921 tgctcccagt gcagtggtat acacggttcc taatacaggc cagactatag gatctgtgaa
     1981 acaggaaggc ttggaaagga gcctggtatt ttctcagttg atgcctgtca atcagaatgc
     2041 acaagtaaat gcaaacctgt cttctgaaaa catctcgggg agtggcctgc atccactggc
     2101 ctcctcatta gttaatgtat ctccaactca caatttttct ctcagtccct ctacactact
     2161 aaatcccact gagctaaacc gcgacattgc cgatagccaa ccaatgtctg caccggtggc
     2221 aagcaaatct actgtgacat ctgtcagcaa cactaactat gcaactcttc agaactgctc
     2281 ccttattact ggtcaagacc tattgtcagt ccctatgact caggctgccc ttggggaaat
     2341 agttcctaca gctgaagatc aggtaggtca cccctcccca gcagtacatc aggattttgt
     2401 ccaagaacat cgtttggttc tgcaatcggt agctaacatg aaagagaatt tcttatcaaa
     2461 ttctgagagc aaagcaacaa gtagcttaat gatgctggac tctaaatcca agtatgtctt
     2521 agatggcatg gttgatactg tctgtgaaga cctggaaaca gacaaaaaag agcttgccaa
     2581 gctccagact gtccagctgg atgaagatat gcaagactta tgaactttat ttcctcctca
     2641 cctctttttg gcatcagcgg caaatctttt catgaagccc caaggacaca aaacattttc
     2701 ccatttaaag gaaaacactc tagttttgca agtatatgca tacaagagac tttagattga
     2761 tctgcatgaa gatcacagtt aagtatacag gagtagaact gcattattgc agcctttttg
     2821 ttcacttata aatttctctt ttaaatagat ggagacaaag gacaaggtga aatgtatcaa
     2881 gtcaaagtga atcatttagt tgactctata attctaaggt caaaatggaa cttgatagtt
     2941 ttttaaatta aaaaatgtat acacctaaca tagaaaatta aagatagctg cagaccatta
     3001 gaaataatac aattgttttt gtttactttt actccatggg cattgaaaag gttaagaaac
     3061 ataaatggta catattttta aagttaagta gcatgcatat atatatgcac acacacctct
     3121 ttttcagcat tttttgagaa agtcttgggt ctcaaacaca tttgtctcaa cacatttcca
     3181 aatgtgattt ctaatagctc agtgtggctg agaaagtgcg gaactccact aaaaactctg
     3241 aaacttcagt ataaatgtaa atatatcagt tctataagca ggatttgagt aattacagtg
     3301 aattttattt ttaatgtata tgtttctctt caggcgctat gaactgaaaa atatgttttc
     3361 ttactgttta atttattttt attgtttgaa caggaagtga acatagtcgt ttccaacaaa
     3421 gttttacttt ttgtaggatt ttaaaaataa tgatttttac caggaatcta ttaaggtcaa
     3481 tattaataac actgaaacag gaaatctaac tcccaatatt ggaattttgg tacttttttt
     3541 cacatccttg ttctttattt agcaactctg attcatttaa atatgttttt tatagaattc
     3601 tatgtgcctt tttacctcgt ggccttttta ttggtagtaa ggtacagaag tgtcaacaga
     3661 agcactgatg gttcttttct actatctaac agggttaatt tcaccacaaa attgctttaa
     3721 atctgaagaa cttaagtttc actaaataat atatatgaca tttatcacac aaatggataa
     3781 acaactaatt attgttgata cttttcatta caaggaaaat aagttataaa taccatgtca
     3841 aattgattat acaggctatg aaaaccattt taaaggaaag aaaatatgta aattctattg
     3901 agcaaaattc tgtcctgttg aaacttagtt ctaaaggttt tgaatcagtt gttacactct
     3961 gacacatgac tgttgtttgc actatattat catgtcttct ttaaaagtaa atatttttgg
     4021 tttctgtaag aagcttgttt aataatgttg taagccgtgg ctatagtttt atcaagactc
     4081 tgaacacaag atgtaacaat gcaaataaat ttatgtagtg agtaaagttg ctctctagtc
     4141 tctgaaaagc aaaaaaagtg agaaaataat ttcttcagag ataacttcaa gttgttgaac
     4201 ataaaggtgt tagatgttag cacatcttgc tttttttttt tttttgagat ggagtctcgc
     4261 tctgttgccc aggctggagt gcagtggcac gatcttggct cactgcaagc tctgcctcct
     4321 gggttcacgc cattctcctg cctcagcctc ccgagtagct gggactacag gcacctgcca
     4381 ccatgcccgg ctaaattttt gtatttttag tagagacggg gtttcaccgt gttagccagg
     4441 atggtcttga tctcctgacc tcgtgatctg cccgcctcgg cctcccaaag tgctgggatt
     4501 ataggcatga gccactgtgc ctggccacat cttgcttttt tttttatgat cagaacaaag
     4561 ggcccactct agttctctac atgtcaatca atcaagcatg ttgaataagg gacatagagg
     4621 atttaacttt tgttatcata aatggaactt gcaggcatat atcaagaacc ctatgaagaa
     4681 ttcctctccc atcattttga taaagaacta catcattttt gatagaattg gtgaatgttc
     4741 ctaaactgct gaagctacat gttttttgtt ttgttttaca aagtcaggtg tttgagagtt
     4801 cttttccact ctactactac tcatagagct tgttttttct ttgggtgtgt gctgatcctg
     4861 ttactgagat taattacatg gctctgcagt gtagtttaca taaaaatgat gttttccact
     4921 tgattgctgc agatatcaag agtttgttat tttcaaatac ccatccaaca agagagatgg
     4981 ggaggttttt agttatatat gctatatata tatatataac tggaaatgtt ttatatgttt
     5041 tccgaaaata caataagcct ctcttttatt cagtgttctt cctcttttct cccttatgaa
     5101 aaagaaaaga tagcacaaaa cttaagactt acctaggaaa cccattcata ttcccaccat
     5161 gatgtaatta taaccctaca attacttcag gtagctacac aatataccag gtaagaatca
     5221 atgcacagta taaagaactt attgttcttt tctattcttt cagttgaata agggccagtt
     5281 ggtatgcagc ccatgtatat gtgaatggag taagataaac cccatgatct ccttgcacag
     5341 aattgcaaat gtcttttgcc ataccaaggg ccagactcag aacccttgga gtcatgtggc
     5401 agaatttccc tcttacataa accaatgctt gaaaatgctg caaatgaccc tctaatgatc
     5461 cctgaagatc aaaacagggg taaatgactc cctgcaaaac ccaacccatg ctgctggctg
     5521 tgggattttt ggtgtaagcc tatctatgca ctctatcagc cagaatttgg catttagctc
     5581 ttagttaaat ctagtaaagg acagtctatt gtttaaagag aaggtgcatt tgttcctcaa
     5641 tcaagcaaga gcacctgtgt tgtactgctt tatatctcat gtatatttat agtaatgaaa
     5701 agacttttta aattgtacac gtttcagtgc ctttcttgtg ttatgaaagg caggtagata
     5761 ttatagccat aggtaaaaat ccatagttaa attgcacact gaccttaaat ctctctgtgt
     5821 atgcccttgt atcttgcatg ttaaaagttg gattattggg catgtgtggc agcctgccct
     5881 gctacatgct agacaagtgt gctttagtac atagccacaa gttcttcatt ctttaaaatg
     5941 ttttgacaga tcatctcata ataaaaataa ttcaggaaaa ctatggggaa atagttacat
     6001 ttcacaaaag atattttaaa ctctttgtaa aacttagata atagagccta gcagttactt
     6061 tgtatctaat tgatacattt tatgttaatt taccaccata cattttatta atcaaaattg
     6121 tatagcatgt gactcttttg gctttcagag ttctcaaaaa tattattttg ttgcatgtac
     6181 tgtatgttta gaggcaacca attatatact caatatggtt ttactgtgcc ttacacaaag
     6241 agaaactcta tacagaatgt atatcatggg gtggggtaac agagtcttta ctgcactgtt
     6301 aggtgatggc acacagagca tgtcccagaa catttctgtg cttaattacc caaccaaaga
     6361 gatctgaagt atgtatgtcg tactgtaatg ggggtttatg cctggacaat taagtgtttt
     6421 atttgttttc tgaaatgatg tgaacttatt tttctaaaca ctatgctaaa taaactttat
     6481 atttatacat a
//
