LOCUS       NM_016538               1725 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens sirtuin 7 (SIRT7), mRNA.
ACCESSION   NM_016538
VERSION     NM_016538.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1725)
  AUTHORS   Du,J., Yi,X., Guo,S., Wang,H., Shi,Q., Zhang,J., Tian,Y., Wang,H.,
            Zhang,H., Zhang,B., Gao,T., Li,C., Guo,W. and Yang,Y.
  TITLE     SIRT7 promotes mitochondrial biogenesis to render the adaptive
            resistance to MAPK inhibition in melanoma
  JOURNAL   Biochem Biophys Res Commun 722, 150161 (2024)
   PUBMED   38797153
  REMARK    GeneRIF: SIRT7 promotes mitochondrial biogenesis to render the
            adaptive resistance to MAPK inhibition in melanoma.
REFERENCE   2  (bases 1 to 1725)
  AUTHORS   Wang,M.D., Gao,T.Y., Huang,W., Yang,Y.K. and Wang,Y.
  TITLE     [Effect of SIRT7 on inhibiting the epithelial-mesenchymal
            transformation in pancreatic cancer cells and related mechanism]
  JOURNAL   Zhonghua Zhong Liu Za Zhi 46 (6), 566-582 (2024)
   PUBMED   38880736
  REMARK    GeneRIF: [Effect of SIRT7 on inhibiting the epithelial-mesenchymal
            transformation in pancreatic cancer cells and related mechanism].
REFERENCE   3  (bases 1 to 1725)
  AUTHORS   Kumari,P., Tarighi,S., Fuchshuber,E., Li,L., Fernandez-Duran,I.,
            Wang,M., Ayoson,J., Castello-Garcia,J.M., Gamez-Garcia,A.,
            Espinosa-Alcantud,M., Sreenivasan,K., Guenther,S., Olivella,M.,
            Savai,R., Yue,S., Vaquero,A., Braun,T. and Ianni,A.
  TITLE     SIRT7 promotes lung cancer progression by destabilizing the tumor
            suppressor ARF
  JOURNAL   Proc Natl Acad Sci U S A 121 (25), e2409269121 (2024)
   PUBMED   38870055
  REMARK    GeneRIF: SIRT7 promotes lung cancer progression by destabilizing
            the tumor suppressor ARF.
REFERENCE   4  (bases 1 to 1725)
  AUTHORS   Lu,L., Zhu,M., Wu,Q., Sun,Z., Chen,X. and Miao,C.
  TITLE     Sirt7/HIC1 complex participates in hyperglycaemia-mediated EndMT
            via modulation of SDC1 expression in diabetic kidney disease and
            metabolic memory
  JOURNAL   J Cell Mol Med 28 (9), e18336 (2024)
   PUBMED   38686489
  REMARK    GeneRIF: Sirt7/HIC1 complex participates in hyperglycaemia-mediated
            EndMT via modulation of SDC1 expression in diabetic kidney disease
            and metabolic memory.
REFERENCE   5  (bases 1 to 1725)
  AUTHORS   Xu,B., Cai,X., Cai,G. and Huang,G.
  TITLE     SIRT7: A potential prognostic marker and therapeutic target in
            gallbladder cancer
  JOURNAL   Pathol Res Pract 256, 155233 (2024)
   PUBMED   38452583
  REMARK    GeneRIF: SIRT7: A potential prognostic marker and therapeutic
            target in gallbladder cancer.
REFERENCE   6  (bases 1 to 1725)
  AUTHORS   Michishita,E., Park,J.Y., Burneskis,J.M., Barrett,J.C. and
            Horikawa,I.
  TITLE     Evolutionarily conserved and nonconserved cellular localizations
            and functions of human SIRT proteins
  JOURNAL   Mol Biol Cell 16 (10), 4623-4635 (2005)
   PUBMED   16079181
REFERENCE   7  (bases 1 to 1725)
  AUTHORS   De Nigris,F., Cerutti,J., Morelli,C., Califano,D., Chiariotti,L.,
            Viglietto,G., Santelli,G. and Fusco,A.
  TITLE     Isolation of a SIR-like gene, SIR-T8, that is overexpressed in
            thyroid carcinoma cell lines and tissues
  JOURNAL   Br J Cancer 87 (12), 1479 (2002)
   PUBMED   12454780
  REMARK    Correction to:[Br J Cancer. 2002 Mar 18;86(6):917-23. doi:
            10.1038/sj.bjc.6600156.. PMID: 11953824]
REFERENCE   8  (bases 1 to 1725)
  AUTHORS   de Nigris,F., Cerutti,J., Morelli,C., Califano,D., Chiariotti,L.,
            Viglietto,G., Santelli,G. and Fusco,A.
  TITLE     Isolation of a SIR-like gene, SIR-T8, that is overexpressed in
            thyroid carcinoma cell lines and tissues
  JOURNAL   Br J Cancer 86 (6), 917-923 (2002)
   PUBMED   11953824
  REMARK    Erratum:[Br J Cancer. 2002 Dec 2;87(12):1479. doi:
            10.1038/sj.bjc.6600636.. PMID: 12454780]
REFERENCE   9  (bases 1 to 1725)
  AUTHORS   Frye,R.A.
  TITLE     Phylogenetic classification of prokaryotic and eukaryotic Sir2-like
            proteins
  JOURNAL   Biochem Biophys Res Commun 273 (2), 793-798 (2000)
   PUBMED   10873683
REFERENCE   10 (bases 1 to 1725)
  AUTHORS   Bussow,K., Cahill,D., Nietfeld,W., Bancroft,D., Scherzinger,E.,
            Lehrach,H. and Walter,G.
  TITLE     A method for global protein expression and antibody screening on
            high-density filters of an arrayed cDNA library
  JOURNAL   Nucleic Acids Res 26 (21), 5007-5008 (1998)
   PUBMED   9776767
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BQ890203.1, BC101791.1,
            CD579273.2 and BC017305.2.
            
            On Nov 22, 2018 this sequence version replaced NM_016538.2.
            
            Summary: This gene encodes a member of the sirtuin family of
            proteins, homologs to the yeast Sir2 protein. Members of the
            sirtuin family are characterized by a sirtuin core domain and
            grouped into four classes. The functions of human sirtuins have not
            yet been determined; however, yeast sirtuin proteins are known to
            regulate epigenetic gene silencing and suppress recombination of
            rDNA. Studies suggest that the human sirtuins may function as
            intracellular regulatory proteins with mono-ADP-ribosyltransferase
            activity. The protein encoded by this gene is included in class IV
            of the sirtuin family. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.960718.1,
                                           SRR3476690.230925.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154405 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328666.11/ ENSP00000329466.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                BQ890203.1         7-19
            14-789              BC101791.1         1-776
            790-790             CD579273.2         767-767
            791-1330            BC101791.1         778-1317
            1331-1725           BC017305.2         1301-1695
FEATURES             Location/Qualifiers
     source          1..1725
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..1725
                     /gene="SIRT7"
                     /gene_synonym="SIR2L7"
                     /note="sirtuin 7"
                     /db_xref="GeneID:51547"
                     /db_xref="HGNC:HGNC:14935"
                     /db_xref="MIM:606212"
     exon            1..138
                     /gene="SIRT7"
                     /gene_synonym="SIR2L7"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1248
                     /gene="SIRT7"
                     /gene_synonym="SIR2L7"
                     /EC_number="2.3.1.286"
                     /note="silent mating type information regulation 2,
                     S.cerevisiae, homolog 7; sir2-related protein type 7;
                     sirtuin type 7; NAD-dependent deacetylase sirtuin-7;
                     SIR2-like protein 7; regulatory protein SIR2 homolog 7;
                     NAD-dependent protein deacylase sirtuin-7"
                     /codon_start=1
                     /product="NAD-dependent protein deacetylase sirtuin-7"
                     /protein_id="NP_057622.1"
                     /db_xref="CCDS:CCDS11792.1"
                     /db_xref="GeneID:51547"
                     /db_xref="HGNC:HGNC:14935"
                     /db_xref="MIM:606212"
                     /translation="MAAGGLSRSERKAAERVRRLREEQQRERLRQVSRILRKAAAERS
                     AEEGRLLAESADLVTELQGRSRRREGLKRRQEEVCDDPEELRGKVRELASAVRNAKYL
                     VVYTGAGISTAASIPDYRGPNGVWTLLQKGRSVSAADLSEAEPTLTHMSITRLHEQKL
                     VQHVVSQNCDGLHLRSGLPRTAISELHGNMYIEVCTSCVPNREYVRVFDVTERTALHR
                     HQTGRTCHKCGTQLRDTIVHFGERGTLGQPLNWEAATEAASRADTILCLGSSLKVLKK
                     YPRLWCMTKPPSRRPKLYIVNLQWTPKDDWAALKLHGKCDDVMRLLMAELGLEIPAYS
                     RWQDPIFSLATPLRAGEEGSHSRKSLCRSREEAPPGDRGAPLSSAPILGGWFGRGCTK
                     RTKRKKVT"
     exon            139..276
                     /gene="SIRT7"
                     /gene_synonym="SIR2L7"
                     /inference="alignment:Splign:2.1.0"
     exon            277..381
                     /gene="SIRT7"
                     /gene_synonym="SIR2L7"
                     /inference="alignment:Splign:2.1.0"
     exon            382..452
                     /gene="SIRT7"
                     /gene_synonym="SIR2L7"
                     /inference="alignment:Splign:2.1.0"
     exon            453..525
                     /gene="SIRT7"
                     /gene_synonym="SIR2L7"
                     /inference="alignment:Splign:2.1.0"
     exon            526..624
                     /gene="SIRT7"
                     /gene_synonym="SIR2L7"
                     /inference="alignment:Splign:2.1.0"
     exon            625..861
                     /gene="SIRT7"
                     /gene_synonym="SIR2L7"
                     /inference="alignment:Splign:2.1.0"
     exon            862..942
                     /gene="SIRT7"
                     /gene_synonym="SIR2L7"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1049
                     /gene="SIRT7"
                     /gene_synonym="SIR2L7"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1725
                     /gene="SIRT7"
                     /gene_synonym="SIR2L7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1705..1710
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIRT7"
                     /gene_synonym="SIR2L7"
                     /note="hexamer: ATTAAA"
     polyA_site      1725
                     /gene="SIRT7"
                     /gene_synonym="SIR2L7"
                     /note="major polyA site"
ORIGIN      
        1 ctgccgtgtg aggcggaagc ggaagagcag gtctccaggg gagcgatggc agccgggggt
       61 ctgagccgct ccgagcgcaa agcggcggag cgggtccgga ggttgcggga ggagcagcag
      121 agggagcgcc tccgccaggt gtcgcgcatc ctgaggaagg cggcggcgga gcgcagcgcc
      181 gaggagggcc ggctgctggc cgagagcgcg gacctggtaa cggagctgca gggccggagc
      241 cggcggcgcg agggcctgaa gcggcggcag gaggaggtgt gcgacgaccc ggaggagctg
      301 cgggggaagg tccgggagct ggccagcgcc gtccggaacg ccaaatactt ggtcgtctac
      361 acaggcgcgg gaatcagcac ggcagcgtct atcccagact accggggccc taatggagtg
      421 tggacactgc ttcagaaagg gagaagcgtt agtgctgccg acctgagcga ggccgagcca
      481 accctcaccc acatgagcat cacccgtctg catgagcaga agctggtgca gcatgtggtg
      541 tctcagaact gtgacgggct ccacctgagg agtgggctgc cgcgcacggc catctccgag
      601 ctccacggga acatgtacat tgaagtctgt acctcctgcg ttcccaacag ggagtacgtg
      661 cgggtgttcg atgtgacgga gcgcactgcc ctccacagac accagacagg ccggacctgc
      721 cacaagtgtg ggacccagct gcgggacacc attgtgcact ttggggagag ggggacgttg
      781 gggcagcctt tgaactggga agcggcgacc gaggctgcca gcagagcaga caccatcctg
      841 tgtctagggt ccagcctgaa ggttctaaag aagtacccac gcctctggtg catgaccaag
      901 ccccctagcc ggcggccgaa gctttacatc gtgaacctgc agtggacccc gaaggatgac
      961 tgggctgccc tgaagctaca tgggaagtgt gatgacgtca tgcggctcct catggccgag
     1021 ctgggcttgg agatccccgc ctatagcagg tggcaggatc ccattttctc actggcgact
     1081 cccctgcgtg ctggtgaaga aggcagccac agtcggaagt cgctgtgcag aagcagagag
     1141 gaggccccgc ctggggaccg gggtgcaccg cttagctcgg cccccatcct agggggctgg
     1201 tttggcaggg gctgcacaaa acgcacaaaa aggaagaaag tgacgtaatc acgtgctcga
     1261 tgaagaacag ttggcacttt gcagatggcc agtgtcacgg tgaaggctgg gttgccccca
     1321 cgggtctagg gagaacgaac tctttgggga tgacattttc accgtgacat ttttagccat
     1381 ttgtccttga ggaagcccct tgcactgctg cggttgtacc ctgatacggc ctggccatcg
     1441 aggacacctg cccatccggc ctctgtgtca agaggtggca gccgcacctt tctgtgagaa
     1501 cggaactcgg gttatttcag ccccggcctg cagagtggaa gcgcccagcg gcctttcctc
     1561 gctcaccagg ccagtctcag ggcctcaccg tatttctact actacttaat gaaaaagtgt
     1621 gaactttata gaatcctctc tgtactggat gtgcggcaga ggggtggctc cgagcctcgg
     1681 ctctatgcag acctttttat ttctattaaa cgtttctgca ctggc
//
