LOCUS       NM_016539               1600 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens sirtuin 6 (SIRT6), transcript variant 1, mRNA.
ACCESSION   NM_016539
VERSION     NM_016539.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1600)
  AUTHORS   Shi,J., Hao,X.Y., Tong,Y., Qian,W.B. and Sun,Y.
  TITLE     SIRT6 alleviates senescence induced by Porphyromonas gingivalis in
            human gingival fibroblasts
  JOURNAL   Mol Biol Rep 51 (1), 976 (2024)
   PUBMED   39259343
  REMARK    GeneRIF: SIRT6 alleviates senescence induced by Porphyromonas
            gingivalis in human gingival fibroblasts.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1600)
  AUTHORS   Liu,N., Li,Y., Luo,G., Jiang,M., Liu,C., Zhang,Y. and Zhang,L.
  TITLE     SIRT6 suppresses colon cancer growth by inducing apoptosis and
            autophagy through transcriptionally down-regulating Survivin
  JOURNAL   Mitochondrion 78, 101932 (2024)
   PUBMED   38986922
  REMARK    GeneRIF: SIRT6 suppresses colon cancer growth by inducing apoptosis
            and autophagy through transcriptionally down-regulating Survivin.
REFERENCE   3  (bases 1 to 1600)
  AUTHORS   Du,Y., He,J., Xu,Y., Wu,X., Cheng,H., Yu,J., Wang,X., An,Y., Wu,Y.
            and Guo,W.
  TITLE     SIRT6 prevent chronic cerebral hypoperfusion induced cognitive
            impairment by remodeling mitochondrial dynamics in a
            STAT5-PGAM5-Drp1 dependent manner
  JOURNAL   J Transl Med 22 (1), 788 (2024)
   PUBMED   39183280
  REMARK    GeneRIF: SIRT6 prevent chronic cerebral hypoperfusion induced
            cognitive impairment by remodeling mitochondrial dynamics in a
            STAT5-PGAM5-Drp1 dependent manner.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1600)
  AUTHORS   Frohlich,J., Liorni,N., Mangoni,M., Lochmanova,G., Pirek,P.,
            Kastankova,N., Pata,P., Kucera,J., Chaldakov,G.N., Tonchev,A.B.,
            Pata,I., Gorbunova,V., Leire,E., Zdrahal,Z., Mazza,T. and
            Vinciguerra,M.
  TITLE     Epigenetic and transcriptional control of adipocyte function by
            centenarian-associated SIRT6 N308K/A313S mutant
  JOURNAL   Clin Epigenetics 16 (1), 96 (2024)
   PUBMED   39033117
  REMARK    GeneRIF: Epigenetic and transcriptional control of adipocyte
            function by centenarian-associated SIRT6 N308K/A313S mutant.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1600)
  AUTHORS   Yang,Z., Li,S., Zhao,C., Zhao,Z., Tan,J., Zhang,L. and Huang,Y.
  TITLE     X-Box binding protein 1 downregulates SIRT6 to promote injury in
            pancreatic ductal epithelial cells
  JOURNAL   Immun Inflamm Dis 12 (7), e1301 (2024)
   PUBMED   38967361
  REMARK    GeneRIF: X-Box binding protein 1 downregulates SIRT6 to promote
            injury in pancreatic ductal epithelial cells.
REFERENCE   6  (bases 1 to 1600)
  AUTHORS   Yamamoto,H., Schoonjans,K. and Auwerx,J.
  TITLE     Sirtuin functions in health and disease
  JOURNAL   Mol Endocrinol 21 (8), 1745-1755 (2007)
   PUBMED   17456799
  REMARK    Review article
REFERENCE   7  (bases 1 to 1600)
  AUTHORS   Michishita,E., Park,J.Y., Burneskis,J.M., Barrett,J.C. and
            Horikawa,I.
  TITLE     Evolutionarily conserved and nonconserved cellular localizations
            and functions of human SIRT proteins
  JOURNAL   Mol Biol Cell 16 (10), 4623-4635 (2005)
   PUBMED   16079181
REFERENCE   8  (bases 1 to 1600)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
REFERENCE   9  (bases 1 to 1600)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
REFERENCE   10 (bases 1 to 1600)
  AUTHORS   Frye,R.A.
  TITLE     Phylogenetic classification of prokaryotic and eukaryotic Sir2-like
            proteins
  JOURNAL   Biochem Biophys Res Commun 273 (2), 793-798 (2000)
   PUBMED   10873683
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN364177.1, BC005026.1 and
            AK074810.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_016539.3.
            
            Summary: This gene encodes a member of the sirtuin family of
            NAD-dependent enzymes that are implicated in cellular stress
            resistance, genomic stability, aging and energy homeostasis. The
            encoded protein is localized to the nucleus, exhibits ADP-ribosyl
            transferase and histone deacetylase activities, and plays a role in
            DNA repair, maintenance of telomeric chromatin, inflammation, lipid
            and glucose metabolism. Alternative splicing results in multiple
            transcript variants encoding different isoforms. [provided by
            RefSeq, Mar 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF233396.1, SRR3476690.1062951.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2152568, SAMEA2159931
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000337491.7/ ENSP00000337332.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                CN364177.1         44-64
            22-1307             BC005026.1         1-1286
            1308-1599           AK074810.1         1312-1603
            1600-1600           BC005026.1         1579-1579
FEATURES             Location/Qualifiers
     source          1..1600
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..1600
                     /gene="SIRT6"
                     /gene_synonym="hSIRT6; SIR2L6"
                     /note="sirtuin 6"
                     /db_xref="GeneID:51548"
                     /db_xref="HGNC:HGNC:14934"
                     /db_xref="MIM:606211"
     exon            1..90
                     /gene="SIRT6"
                     /gene_synonym="hSIRT6; SIR2L6"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..1092
                     /gene="SIRT6"
                     /gene_synonym="hSIRT6; SIR2L6"
                     /EC_number="2.3.1.286"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sir2-related protein type 6; sirtuin type 6; SIR2-like
                     protein 6; protein mono-ADP-ribosyltransferase sirtuin-6;
                     NAD-dependent protein deacylase sirtuin-6; regulatory
                     protein SIR2 homolog 6; NAD-dependent protein deacetylase
                     sirtuin-6"
                     /codon_start=1
                     /product="NAD-dependent protein deacylase sirtuin-6
                     isoform 1"
                     /protein_id="NP_057623.2"
                     /db_xref="CCDS:CCDS12122.1"
                     /db_xref="GeneID:51548"
                     /db_xref="HGNC:HGNC:14934"
                     /db_xref="MIM:606211"
                     /translation="MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQS
                     SSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLE
                     RVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLK
                     ATGRLCTVAKARGLRACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQ
                     IRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAW
                     DGPRVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRE
                     RPTSPAPHRPPKRVKAKAVPS"
     exon            91..218
                     /gene="SIRT6"
                     /gene_synonym="hSIRT6; SIR2L6"
                     /inference="alignment:Splign:2.1.0"
     exon            219..401
                     /gene="SIRT6"
                     /gene_synonym="hSIRT6; SIR2L6"
                     /inference="alignment:Splign:2.1.0"
     exon            402..461
                     /gene="SIRT6"
                     /gene_synonym="hSIRT6; SIR2L6"
                     /inference="alignment:Splign:2.1.0"
     exon            462..557
                     /gene="SIRT6"
                     /gene_synonym="hSIRT6; SIR2L6"
                     /inference="alignment:Splign:2.1.0"
     exon            558..638
                     /gene="SIRT6"
                     /gene_synonym="hSIRT6; SIR2L6"
                     /inference="alignment:Splign:2.1.0"
     exon            639..762
                     /gene="SIRT6"
                     /gene_synonym="hSIRT6; SIR2L6"
                     /inference="alignment:Splign:2.1.0"
     exon            763..1600
                     /gene="SIRT6"
                     /gene_synonym="hSIRT6; SIR2L6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1577..1582
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIRT6"
                     /gene_synonym="hSIRT6; SIR2L6"
                     /note="hexamer: AATAAA"
     polyA_site      1600
                     /gene="SIRT6"
                     /gene_synonym="hSIRT6; SIR2L6"
                     /note="major polyA site"
ORIGIN      
        1 attgttcccg tggggcagtc gaggatgtcg gtgaattacg cggcggggct gtcgccgtac
       61 gcggacaagg gcaagtgcgg cctcccggag atcttcgacc ccccggagga gctggagcgg
      121 aaggtgtggg aactggcgag gctggtctgg cagtcttcca gtgtggtgtt ccacacgggt
      181 gccggcatca gcactgcctc tggcatcccc gacttcaggg gtccccacgg agtctggacc
      241 atggaggagc gaggtctggc ccccaagttc gacaccacct ttgagagcgc gcggcccacg
      301 cagacccaca tggcgctggt gcagctggag cgcgtgggcc tcctccgctt cctggtcagc
      361 cagaacgtgg acgggctcca tgtgcgctca ggcttcccca gggacaaact ggcagagctc
      421 cacgggaaca tgtttgtgga agaatgtgcc aagtgtaaga cgcagtacgt ccgagacaca
      481 gtcgtgggca ccatgggcct gaaggccacg ggccggctct gcaccgtggc taaggcaagg
      541 gggctgcgag cctgcagggg agagctgagg gacaccatcc tagactggga ggactccctg
      601 cccgaccggg acctggcact cgccgatgag gccagcagga acgccgacct gtccatcacg
      661 ctgggtacat cgctgcagat ccggcccagc gggaacctgc cgctggctac caagcgccgg
      721 ggaggccgcc tggtcatcgt caacctgcag cccaccaagc acgaccgcca tgctgacctc
      781 cgcatccatg gctacgttga cgaggtcatg acccggctca tgaagcacct ggggctggag
      841 atccccgcct gggacggccc ccgtgtgctg gagagggcgc tgccacccct gccccgcccg
      901 cccaccccca agctggagcc caaggaggaa tctcccaccc ggatcaacgg ctctatcccc
      961 gccggcccca agcaggagcc ctgcgcccag cacaacggct cagagcccgc cagccccaaa
     1021 cgggagcggc ccaccagccc tgccccccac agacccccca aaagggtgaa ggccaaggcg
     1081 gtccccagct gaccagggtg cttggggagg gtggggcttt ttgtagaaac tgtggattct
     1141 ttttctctcg tggtctcact ttgttacttg tttctgtccc cgggagcctc agggctctga
     1201 gagctgtgct ccaggccagg ggttacacct gccctccgtg gtccctccct gggctccagg
     1261 ggcctctggt gcggttccgg gaagaagcca caccccagag gtgacaggtg agcccctgcc
     1321 acaccccagc ctctgacttg ctgtgttgtc cagaggtgag gctgggccct ccctggtctc
     1381 cagcttaaac aggagtgaac tccctctgtc cccagggcct cccttctggg ccccctacag
     1441 cccaccctac ccctcctcca tgggccctgc aggaggggag acccaccttg aagtggggga
     1501 tcagtagagg cttgcactgc ctttggggct ggagggagac gtgggtccac caggcttctg
     1561 gaaaagtcct caatgcaata aaaacaattt ctttcttgca
//
