LOCUS       NM_012241               4564 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens sirtuin 5 (SIRT5), transcript variant 1, mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_012241
VERSION     NM_012241.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4564)
  AUTHORS   Ren,F., Yang,M., Liu,G., Qi,Y., Li,A., Li,J. and Zheng,L.
  TITLE     SIRT5-mediated PRKAA2 succinylation ameliorates apoptosis of human
            placental trophoblasts in hypertensive disorder complicating
            pregnancy
  JOURNAL   Clin Exp Hypertens 46 (1), 2358030 (2024)
   PUBMED   38785262
  REMARK    GeneRIF: SIRT5-mediated PRKAA2 succinylation ameliorates apoptosis
            of human placental trophoblasts in hypertensive disorder
            complicating pregnancy.
REFERENCE   2  (bases 1 to 4564)
  AUTHORS   Kim,G., Bhattarai,P.Y., Lim,S.C., Lee,K.Y. and Choi,H.S.
  TITLE     Sirtuin 5-mediated deacetylation of TAZ at K54 promotes melanoma
            development
  JOURNAL   Cell Oncol (Dordr) 47 (3), 967-985 (2024)
   PUBMED   38112979
  REMARK    GeneRIF: Sirtuin 5-mediated deacetylation of TAZ at K54 promotes
            melanoma development.
REFERENCE   3  (bases 1 to 4564)
  AUTHORS   Jiang,M., Huang,Z., Chen,L., Deng,T., Liu,J. and Wu,Y.
  TITLE     SIRT5 promote malignant advancement of chordoma by regulating the
            desuccinylation of c-myc
  JOURNAL   BMC Cancer 24 (1), 386 (2024)
   PUBMED   38532359
  REMARK    GeneRIF: SIRT5 promote malignant advancement of chordoma by
            regulating the desuccinylation of c-myc.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4564)
  AUTHORS   Salomone,F., Pipitone,R.M., Longo,M., Malvestiti,F., Amorini,A.M.,
            Distefano,A., Casirati,E., Ciociola,E., Iraci,N., Leggio,L.,
            Zito,R., Vicario,N., Saoca,C., Pennisi,G., Cabibi,D., Lazzarino,G.,
            Fracanzani,A.L., Dongiovanni,P., Valenti,L., Petta,S., Volti,G.L.
            and Grimaudo,S.
  TITLE     SIRT5 rs12216101 T>G variant is associated with liver damage and
            mitochondrial dysfunction in patients with non-alcoholic fatty
            liver disease
  JOURNAL   J Hepatol 80 (1), 10-19 (2024)
   PUBMED   37890719
  REMARK    GeneRIF: SIRT5 rs12216101 T>G variant is associated with liver
            damage and mitochondrial dysfunction in patients with non-alcoholic
            fatty liver disease.
            Erratum:[J Hepatol. 2024 Feb;80(2):378. doi:
            10.1016/j.jhep.2023.12.002.. PMID: 38182533]
REFERENCE   5  (bases 1 to 4564)
  AUTHORS   Fabbrizi,E., Fiorentino,F., Carafa,V., Altucci,L., Mai,A. and
            Rotili,D.
  TITLE     Emerging Roles of SIRT5 in Metabolism, Cancer, and SARS-CoV-2
            Infection
  JOURNAL   Cells 12 (6), 852 (2023)
   PUBMED   36980194
  REMARK    GeneRIF: Emerging Roles of SIRT5 in Metabolism, Cancer, and
            SARS-CoV-2 Infection.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4564)
  AUTHORS   Michishita,E., Park,J.Y., Burneskis,J.M., Barrett,J.C. and
            Horikawa,I.
  TITLE     Evolutionarily conserved and nonconserved cellular localizations
            and functions of human SIRT proteins
  JOURNAL   Mol Biol Cell 16 (10), 4623-4635 (2005)
   PUBMED   16079181
REFERENCE   7  (bases 1 to 4564)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   8  (bases 1 to 4564)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   9  (bases 1 to 4564)
  AUTHORS   Frye,R.A.
  TITLE     Phylogenetic classification of prokaryotic and eukaryotic Sir2-like
            proteins
  JOURNAL   Biochem Biophys Res Commun 273 (2), 793-798 (2000)
   PUBMED   10873683
REFERENCE   10 (bases 1 to 4564)
  AUTHORS   Frye,R.A.
  TITLE     Characterization of five human cDNAs with homology to the yeast
            SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may
            have protein ADP-ribosyltransferase activity
  JOURNAL   Biochem Biophys Res Commun 260 (1), 273-279 (1999)
   PUBMED   10381378
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL441883.11, DC314190.1,
            BC000126.1 and AF083110.1.
            
            On May 17, 2019 this sequence version replaced NM_012241.4.
            
            Summary: This gene encodes a member of the sirtuin family of
            proteins, homologs to the yeast Sir2 protein. Members of the
            sirtuin family are characterized by a sirtuin core domain and
            grouped into four classes. The functions of human sirtuins have not
            yet been determined; however, yeast sirtuin proteins are known to
            regulate epigenetic gene silencing and suppress recombination of
            rDNA. Studies suggest that the human sirtuins may function as
            intracellular regulatory proteins with mono-ADP-ribosyltransferase
            activity. The protein encoded by this gene is included in class III
            of the sirtuin family. Alternative splicing of this gene results in
            multiple transcript variants. [provided by RefSeq, Jul 2010].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1). Variants 1 and 5-14 all encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.272142.1,
                                           SRR1660803.132182.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000606117.2/
                                                  ENSP00000476228.1
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AL441883.11        5732-5757
            27-42               DC314190.1         1-16
            43-994              BC000126.1         1-952
            995-1698            AF083110.1         930-1633
            1699-4564           AL441883.11        43424-46289
FEATURES             Location/Qualifiers
     source          1..4564
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p23"
     gene            1..4564
                     /gene="SIRT5"
                     /gene_synonym="SIR2L5"
                     /note="sirtuin 5"
                     /db_xref="GeneID:23408"
                     /db_xref="HGNC:HGNC:14933"
                     /db_xref="MIM:604483"
     exon            1..144
                     /gene="SIRT5"
                     /gene_synonym="SIR2L5"
                     /inference="alignment:Splign:2.1.0"
     exon            145..303
                     /gene="SIRT5"
                     /gene_synonym="SIR2L5"
                     /inference="alignment:Splign:2.1.0"
     exon            304..453
                     /gene="SIRT5"
                     /gene_synonym="SIR2L5"
                     /inference="alignment:Splign:2.1.0"
     CDS             339..1271
                     /gene="SIRT5"
                     /gene_synonym="SIR2L5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sir2-like 5; silent mating type information regulation 2,
                     S.cerevisiae, homolog 5; sirtuin type 5; NAD-dependent
                     deacetylase sirtuin-5; NAD-dependent lysine demalonylase
                     and desuccinylase sirtuin-5, mitochondrial"
                     /codon_start=1
                     /product="NAD-dependent protein deacylase sirtuin-5,
                     mitochondrial isoform 1"
                     /protein_id="NP_036373.1"
                     /db_xref="CCDS:CCDS4526.1"
                     /db_xref="GeneID:23408"
                     /db_xref="HGNC:HGNC:14933"
                     /db_xref="MIM:604483"
                     /translation="MRPLQIVPSRLISQLYCGLKPPASTRNQICLKMARPSSSMADFR
                     KFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFY
                     HYRREVMGSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGS
                     LFKTRCTSCGVVAENYKSPICPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRP
                     HVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNT
                     ETTPATNRFRFHFQGPCGTTLPEALACHENETVS"
     exon            454..587
                     /gene="SIRT5"
                     /gene_synonym="SIR2L5"
                     /inference="alignment:Splign:2.1.0"
     exon            588..813
                     /gene="SIRT5"
                     /gene_synonym="SIR2L5"
                     /inference="alignment:Splign:2.1.0"
     exon            814..901
                     /gene="SIRT5"
                     /gene_synonym="SIR2L5"
                     /inference="alignment:Splign:2.1.0"
     exon            902..955
                     /gene="SIRT5"
                     /gene_synonym="SIR2L5"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1079
                     /gene="SIRT5"
                     /gene_synonym="SIR2L5"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1195
                     /gene="SIRT5"
                     /gene_synonym="SIR2L5"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..4564
                     /gene="SIRT5"
                     /gene_synonym="SIR2L5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3947..3952
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIRT5"
                     /gene_synonym="SIR2L5"
                     /note="hexamer: AATATA"
     polyA_site      3964
                     /gene="SIRT5"
                     /gene_synonym="SIR2L5"
                     /note="major polyA site"
ORIGIN      
        1 attcgggggc gcgagctgcc ccaggtgagc cgtggctcag gtccggagcg cggtcgggac
       61 acagcgcctc taggagaaag cctggaaggc gctccggggg tacccagagc tcttagcggg
      121 ccggcagcat gtgcggggcc caagtaaatg gaaatgtttt ctaacatata aaaacctaca
      181 gaagaagaaa ataattttct ggatcaaatt agaagtctgt attatattga tgtctccaga
      241 ttcaaatata ttagaaagca gccgtggaga caaccatctt cattttggga gaaataacta
      301 aagcccgcct caagcattag aactacagac aaaccctgat gcgacctctc cagattgtcc
      361 caagtcgatt gatttcccag ctatattgtg gcctgaagcc tccagcgtcc acacgaaacc
      421 agatttgcct gaaaatggct cggccaagtt caagtatggc agattttcga aagttttttg
      481 caaaagcaaa gcacatagtc atcatctcag gagctggtgt tagtgcagaa agtggtgttc
      541 cgaccttcag aggagctgga ggttattgga gaaaatggca agcccaggac ctggcgactc
      601 ccctggcctt tgcccacaac ccgtcccggg tgtgggagtt ctaccactac cggcgggagg
      661 tcatggggag caaggagccc aacgccgggc accgcgccat agccgagtgt gagacccggc
      721 tgggcaagca gggccggcga gtcgtggtca tcacccagaa catcgatgag ctgcaccgca
      781 aggctggcac caagaacctt ctggagatcc atggtagctt atttaaaact cgatgtacct
      841 cttgtggagt tgtggctgag aattacaaga gtccaatttg tccagcttta tcaggaaaag
      901 gtgctccaga acctggaact caagatgcca gcatcccagt tgagaaactt ccccggtgtg
      961 aagaggcagg ctgcgggggc ttgctgcgac ctcacgtcgt gtggtttgga gaaaacctgg
     1021 atcctgccat tctggaggag gttgacagag agctcgccca ctgtgattta tgtctagtgg
     1081 tgggcacttc ctctgtggtg tacccagcag ccatgtttgc cccccaggtg gctgccaggg
     1141 gcgtgccagt ggctgaattt aacacggaga ccaccccagc tacgaacaga ttcaggtttc
     1201 atttccaggg accctgtgga acgactcttc ctgaagccct tgcctgtcat gaaaatgaaa
     1261 ctgtttctta agtgtcctgg ggaagaaaga aattacagta tatctaagaa ctaggccaca
     1321 cgcagaggag aaatggtctt atgggtggtg agctgagtac tgaacaatct aaaaatagcc
     1381 tctgattccc tcgctggaat ccaacctgtt gataagtgat gggggtttag aagtagcaaa
     1441 gagcacccac attcaaaagt cacagaactg gaaagttaat tcatattatt tggtttgaac
     1501 tgaaacgtga ggtatctttg atgtgtatgg ttggttattg ggagggaaaa attttgtaaa
     1561 ttagattgtc taaaaaaaat agttattctg attatatttt tgttatctgg gcaaagtaga
     1621 agtcaagggg taaaaaccct actattctga tttttgcaca agttttagtg gaaaataaaa
     1681 tcacactcta cagtaggtaa tttattgtat aaagacatta ccccacgata tggctttatt
     1741 agggactttt tttttttttt tttgagacag agtttcactc ttgttgccca ggctggagtg
     1801 cagtggtgcg atctcagctc acagcaacct ccgcctcccg ggttcaagag attctcctgc
     1861 ctcagcctca tgagtagctg ggattacagg tatgtaccac cacacccagc taattttgta
     1921 tttttagtag agacggggtt tctccatgtt ggtcaggctg gtcttaaact ctcgacctca
     1981 ggtgatctgc ccgcctcggc ctcccaaagt gctgagatta cgggcatgag ccaccgcacc
     2041 cggcttactg ggggcttttt aaccttgttt ggctacatta cctcagtgaa caaggggaag
     2101 ctcacaacag gaactcacac aaagaaggaa gagaacagta ccaacaaggt agaacatcac
     2161 gatgagaaga aagaatgatg caaatatgtg gacccccagg ataaacacag ctgcccaaaa
     2221 tttagctctg gcccccttag atgggggaag tcaacagtga agtgtttctc agcatcataa
     2281 aggcagaagc tgtggttcct gtggggcctg ccaaccgttc ccagatgctg aactctgctg
     2341 ggagtttttt ccatgggact ttaaaaaatg atgcccttag gttgggccag acctctgtta
     2401 acttcagtag ggatggcacc aggttcaaga ggccaaagaa gagacctgga gctagtgaag
     2461 gaaacatagg gtttatttgg ggaaccttac agggtggtcc agtggccgcg ggctggacag
     2521 aactgcaacc acttataaaa agcatgcagt ttacatagca ctttcactca gcaccctccc
     2581 ctcagcagcc tccacgtggc aaccctcact tcttaagtta ttgctgtcag atgcatctgc
     2641 catacagggt cattctcagg ggatgcttaa gttatttctg tcaggtacat cttccataca
     2701 ctttactacc ttggagtaaa gtagtaagaa tacagctttt tccttaacct ttaccagcta
     2761 actcagtgct taggggcctt ggaatgcctg ctgtccagca ggtgtcacag gcctgactgg
     2821 gaggcatggc cattatcaac agtgtatgaa ggtcacatat ggctccctga agtgattaca
     2881 tacttggacc acatcacctc agccccttgc aaaattgcat ttaatgttac acccttggct
     2941 tttgtagaaa caggcaacaa gacactatca tataaaactt tgtactgcat tgcaaggcat
     3001 aacctttaat aaatcccagt ggtcctttgt gtagggaacg gggatgctca tagcctatgg
     3061 ggcggctgga gaaccagtca gggaccctga gggctcgatg tacactttac atgggtgggc
     3121 caaggagttt acactgaggg cactggtaat acctgtaata gtcttatagt acttataaag
     3181 cagttttgca cataaaatac catcatgcac ttataagttt gttcttgggc tgctccaagt
     3241 taactttatt cattttccta gtgttagtgt ctcagggagt ctgattatat ttttgatttg
     3301 taatttctat ctgactaagg cctagagatt tcaaaactgt tctttgcaat tcctctcata
     3361 ctgaacctct ggttcagcag ctttttttgt tgttgttgtt ttcaagtttt atcatttttg
     3421 ttcctatttg gttttgtcgt ttttaaattg agaattgctt ctaaaacaga agacatgaaa
     3481 agagaattaa aaatacaata tatgtgtaag atagaattat tcaacttagc atttattaaa
     3541 catctaccag atgatagaca ttagaaataa aatgactagc aagacctggc ccttcccctc
     3601 aggggttcac agaatggctg gagcaactgt catataagct gttatgaagt gcagaaacta
     3661 cacagacatt tgtgcgggtt cagaccagcg caattagaga tgggcagagt gggatggggt
     3721 aggggtaagg tgcttgaaat ttgcctgggt gggaattttt gaagtataaa aaggacttct
     3781 acctgggggg ctgcggcagt agagggaaga gcacggtcgg tacaaatgca tggcaggtgt
     3841 gaaacagttt gatttgttca aagaatgatg aatcacttag tgttgtataa tggatgggag
     3901 gagagaaaca cagcgatcac aaagggccat gtttgccaag aaataaaata tacttggaaa
     3961 aaaagtacgt atgtgtatat accacaaaac tcgggtgcat tctctaggga ccggcgaagc
     4021 cattctttca ggagatatgc tcagcatttg ccacgggcca gctgctgttc caggtcgtgg
     4081 gttagggccc ggcaccagga agggcgcccc tcccacaggg ccgacatcct aaccggcgtc
     4141 gctgcggccg cggagctggg aaggccgagg gcgccgggca cgtctgtgca gatttcttta
     4201 gagtccaggt ctgtcgcccg cgtcttcgtc ggtggcagca gggctgactg gccacggcgg
     4261 ccatctgcta gagcgcattt cttcccatga aacgccacct cctccgaagt gcggagcgaa
     4321 cgcagccaaa tctacacaaa gactgacaag ctggatccac tcgacggaac ccagggccaa
     4381 aaaacggcgg cgagcagcgc ctcgggcccg cgattaccgg ttttctgagc accggacagc
     4441 gtgagccgtg ccagccctgt ctcgccatcc cagccgagga gggcagcgcg atggctcttc
     4501 cctgccttga aatcaacccc attgccagcc gctttcgccg gcagagcatt ttccgtgggg
     4561 tcca
//
