LOCUS       NM_012240               1217 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens sirtuin 4 (SIRT4), transcript variant 1, mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_012240
VERSION     NM_012240.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1217)
  AUTHORS   Lee,H.J., Hah,Y.S., Cheon,S.Y., Won,S.J., Yim,C.D., Ryu,S.,
            Lee,S.J., Seo,J.H. and Park,J.J.
  TITLE     Decreased sirtuin 4 levels promote cellular proliferation and
            invasion in papillary thyroid carcinoma
  JOURNAL   Eur Thyroid J 13 (5), e240079 (2024)
   PUBMED   39121020
  REMARK    GeneRIF: Decreased sirtuin 4 levels promote cellular proliferation
            and invasion in papillary thyroid carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1217)
  AUTHORS   Xing,D., Zhang,W., Cui,W., Yao,X., Xiao,Y., Chen,L., Yuan,S.,
            Duan,Y., Yu,W., Pan,P. and Lu,Y.
  TITLE     SIRT4 promotes neuronal apoptosis in models of Alzheimer's disease
            via the STAT2-SIRT4-mTOR pathway
  JOURNAL   Am J Physiol Cell Physiol 326 (6), C1697-C1709 (2024)
   PUBMED   38586875
  REMARK    GeneRIF: SIRT4 promotes neuronal apoptosis in models of Alzheimer's
            disease via the STAT2-SIRT4-mTOR pathway.
REFERENCE   3  (bases 1 to 1217)
  AUTHORS   Zhang,L., Dai,Z., Shi,S., Yan,Z., Yang,J., Xue,W., He,Y., Mi,S.,
            Cheng,C., Wang,L., Li,N., Tan,W., Jiang,Z., Sun,H. and Li,S.
  TITLE     SIRT3 and SIRT4 double-genes remodeled the mitochondrial network to
            induce hepatocellular carcinoma cell line differentiation and
            suppress malignant phenotypes
  JOURNAL   Biochem Pharmacol 223, 116168 (2024)
   PUBMED   38548246
  REMARK    GeneRIF: SIRT3 and SIRT4 double-genes remodeled the mitochondrial
            network to induce hepatocellular carcinoma cell line
            differentiation and suppress malignant phenotypes.
REFERENCE   4  (bases 1 to 1217)
  AUTHORS   Mehrabipour,M., Nakhaei-Rad,S., Dvorsky,R., Lang,A.,
            Verhulsdonk,P., Ahmadian,M.R. and Piekorz,R.P.
  TITLE     SIRT4 as a novel interactor and candidate suppressor of C-RAF
            kinase in MAPK signaling
  JOURNAL   Life Sci Alliance 7 (6), e202302507 (2024)
   PUBMED   38499327
  REMARK    GeneRIF: SIRT4 as a novel interactor and candidate suppressor of
            C-RAF kinase in MAPK signaling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1217)
  AUTHORS   Noone,J., Rochfort,K.D., O'Sullivan,F. and O'Gorman,D.J.
  TITLE     SIRT4 is a regulator of human skeletal muscle fatty acid metabolism
            influencing inner and outer mitochondrial membrane-mediated fusion
  JOURNAL   Cell Signal 112, 110931 (2023)
   PUBMED   37858614
  REMARK    GeneRIF: SIRT4 is a regulator of human skeletal muscle fatty acid
            metabolism influencing inner and outer mitochondrial
            membrane-mediated fusion.
REFERENCE   6  (bases 1 to 1217)
  AUTHORS   Scherer,S.E., Muzny,D.M., Buhay,C.J., Chen,R., Cree,A., Ding,Y.,
            Dugan-Rocha,S., Gill,R., Gunaratne,P., Harris,R.A., Hawes,A.C.,
            Hernandez,J., Hodgson,A.V., Hume,J., Jackson,A., Khan,Z.M.,
            Kovar-Smith,C., Lewis,L.R., Lozado,R.J., Metzker,M.L.,
            Milosavljevic,A., Miner,G.R., Montgomery,K.T., Morgan,M.B.,
            Nazareth,L.V., Scott,G., Sodergren,E., Song,X.Z., Steffen,D.,
            Lovering,R.C., Wheeler,D.A., Worley,K.C., Yuan,Y., Zhang,Z.,
            Adams,C.Q., Ansari-Lari,M.A., Ayele,M., Brown,M.J., Chen,G.,
            Chen,Z., Clerc-Blankenburg,K.P., Davis,C., Delgado,O., Dinh,H.H.,
            Draper,H., Gonzalez-Garay,M.L., Havlak,P., Jackson,L.R.,
            Jacob,L.S., Kelly,S.H., Li,L., Li,Z., Liu,J., Liu,W., Lu,J.,
            Maheshwari,M., Nguyen,B.V., Okwuonu,G.O., Pasternak,S., Perez,L.M.,
            Plopper,F.J., Santibanez,J., Shen,H., Tabor,P.E., Verduzco,D.,
            Waldron,L., Wang,Q., Williams,G.A., Zhang,J., Zhou,J., Allen,C.C.,
            Amin,A.G., Anyalebechi,V., Bailey,M., Barbaria,J.A., Bimage,K.E.,
            Bryant,N.P., Burch,P.E., Burkett,C.E., Burrell,K.L., Calderon,E.,
            Cardenas,V., Carter,K., Casias,K., Cavazos,I., Cavazos,S.R.,
            Ceasar,H., Chacko,J., Chan,S.N., Chavez,D., Christopoulos,C.,
            Chu,J., Cockrell,R., Cox,C.D., Dang,M., Dathorne,S.R., David,R.,
            Davis,C.M., Davy-Carroll,L., Deshazo,D.R., Donlin,J.E., D'Souza,L.,
            Eaves,K.A., Simons,R., Emery-Cohen,A.J., Escotto,M., Flagg,N.,
            Forbes,L.D., Gabisi,A.M., Garza,M., Hamilton,C., Henderson,N.,
            Hernandez,O., Hines,S., Hogues,M.E., Huang,M., Idlebird,D.G.,
            Johnson,R., Jolivet,A., Jones,S., Kagan,R., King,L.M., Leal,B.,
            Lebow,H., Lee,S., LeVan,J.M., Lewis,L.C., London,P.,
            Lorensuhewa,L.M., Loulseged,H., Lovett,D.A., Lucier,A.,
            Lucier,R.L., Ma,J., Madu,R.C., Mapua,P., Martindale,A.D.,
            Martinez,E., Massey,E., Mawhiney,S., Meador,M.G., Mendez,S.,
            Mercado,C., Mercado,I.C., Merritt,C.E., Miner,Z.L., Minja,E.,
            Mitchell,T., Mohabbat,F., Mohabbat,K., Montgomery,B., Moore,N.,
            Morris,S., Munidasa,M., Ngo,R.N., Nguyen,N.B., Nickerson,E.,
            Nwaokelemeh,O.O., Nwokenkwo,S., Obregon,M., Oguh,M., Oragunye,N.,
            Oviedo,R.J., Parish,B.J., Parker,D.N., Parrish,J., Parks,K.L.,
            Paul,H.A., Payton,B.A., Perez,A., Perrin,W., Pickens,A.,
            Primus,E.L., Pu,L.L., Puazo,M., Quiles,M.M., Quiroz,J.B.,
            Rabata,D., Reeves,K., Ruiz,S.J., Shao,H., Sisson,I., Sonaike,T.,
            Sorelle,R.P., Sutton,A.E., Svatek,A.F., Svetz,L.A., Tamerisa,K.S.,
            Taylor,T.R., Teague,B., Thomas,N., Thorn,R.D., Trejos,Z.Y.,
            Trevino,B.K., Ukegbu,O.N., Urban,J.B., Vasquez,L.I., Vera,V.A.,
            Villasana,D.M., Wang,L., Ward-Moore,S., Warren,J.T., Wei,X.,
            White,F., Williamson,A.L., Wleczyk,R., Wooden,H.S., Wooden,S.H.,
            Yen,J., Yoon,L., Yoon,V., Zorrilla,S.E., Nelson,D.,
            Kucherlapati,R., Weinstock,G. and Gibbs,R.A.
  CONSRTM   Baylor College of Medicine Human Genome Sequencing Center Sequence
            Production Team
  TITLE     The finished DNA sequence of human chromosome 12
  JOURNAL   Nature 440 (7082), 346-351 (2006)
   PUBMED   16541075
REFERENCE   7  (bases 1 to 1217)
  AUTHORS   Michishita,E., Park,J.Y., Burneskis,J.M., Barrett,J.C. and
            Horikawa,I.
  TITLE     Evolutionarily conserved and nonconserved cellular localizations
            and functions of human SIRT proteins
  JOURNAL   Mol Biol Cell 16 (10), 4623-4635 (2005)
   PUBMED   16079181
REFERENCE   8  (bases 1 to 1217)
  AUTHORS   Irobi,J., Van Impe,K., Seeman,P., Jordanova,A., Dierick,I.,
            Verpoorten,N., Michalik,A., De Vriendt,E., Jacobs,A., Van
            Gerwen,V., Vennekens,K., Mazanec,R., Tournev,I., Hilton-Jones,D.,
            Talbot,K., Kremensky,I., Van Den Bosch,L., Robberecht,W., Van
            Vandekerckhove,J., Van Broeckhoven,C., Gettemans,J., De Jonghe,P.
            and Timmerman,V.
  TITLE     Hot-spot residue in small heat-shock protein 22 causes distal motor
            neuropathy
  JOURNAL   Nat Genet 36 (6), 597-601 (2004)
   PUBMED   15122253
REFERENCE   9  (bases 1 to 1217)
  AUTHORS   Frye,R.A.
  TITLE     Phylogenetic classification of prokaryotic and eukaryotic Sir2-like
            proteins
  JOURNAL   Biochem Biophys Res Commun 273 (2), 793-798 (2000)
   PUBMED   10873683
REFERENCE   10 (bases 1 to 1217)
  AUTHORS   Frye,R.A.
  TITLE     Characterization of five human cDNAs with homology to the yeast
            SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may
            have protein ADP-ribosyltransferase activity
  JOURNAL   Biochem Biophys Res Commun 260 (1), 273-279 (1999)
   PUBMED   10381378
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC003982.1.
            
            On Jul 27, 2020 this sequence version replaced NM_012240.2.
            
            Summary: This gene encodes a member of the sirtuin family of
            proteins, homologs to the yeast Sir2 protein. Members of the
            sirtuin family are characterized by a sirtuin core domain and
            grouped into four classes. The functions of human sirtuins have not
            yet been determined; however, yeast sirtuin proteins are known to
            regulate epigenetic gene silencing and suppress recombination of
            rDNA. Studies suggest that the human sirtuins may function as
            intracellular regulatory proteins with mono-ADP-ribosyltransferase
            activity. The protein encoded by this gene is included in class IV
            of the sirtuin family. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF083109.1, BC034736.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000202967.4/ ENSP00000202967.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                AC003982.1         3319-3376
            59-556              AC003982.1         4559-5056
            557-851             AC003982.1         13454-13748
            852-1217            AC003982.1         13882-14247
FEATURES             Location/Qualifiers
     source          1..1217
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.23-q24.31"
     gene            1..1217
                     /gene="SIRT4"
                     /gene_synonym="SIR2L4"
                     /note="sirtuin 4"
                     /db_xref="GeneID:23409"
                     /db_xref="HGNC:HGNC:14932"
                     /db_xref="MIM:604482"
     exon            1..58
                     /gene="SIRT4"
                     /gene_synonym="SIR2L4"
                     /inference="alignment:Splign:2.1.0"
     exon            59..556
                     /gene="SIRT4"
                     /gene_synonym="SIR2L4"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1004
                     /gene="SIRT4"
                     /gene_synonym="SIR2L4"
                     /EC_number="2.3.1.286"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sir2-like 4; sirtuin type 4; NAD-dependent
                     ADP-ribosyltransferase sirtuin-4; NAD-dependent protein
                     biotinylase sirtuin-4; SIR2-like protein 4; regulatory
                     protein SIR2 homolog 4; NAD-dependent protein deacetylase
                     sirtuin-4; NAD-dependent protein lipoamidase sirtuin-4,
                     mitochondrial"
                     /codon_start=1
                     /product="NAD-dependent protein lipoamidase sirtuin-4,
                     mitochondrial isoform 1"
                     /protein_id="NP_036372.1"
                     /db_xref="CCDS:CCDS9194.1"
                     /db_xref="GeneID:23409"
                     /db_xref="HGNC:HGNC:14932"
                     /db_xref="MIM:604482"
                     /translation="MKMSFALTFRSAKGRWIANPSQPCSKASIGLFVPASPPLDPEKV
                     KELQRFITLSKRLLVMTGAGISTESGIPDYRSEKVGLYARTDRRPIQHGDFVRSAPIR
                     QRYWARNFVGWPQFSSHQPNPAHWALSTWEKLGKLYWLVTQNVDALHTKAGSRRLTEL
                     HGCMDRVLCLDCGEQTPRGVLQERFQVLNPTWSAEAHGLAPDGDVFLSEEQVRSFQVP
                     TCVQCGGHLKPDVVFFGDTVNPDKVDFVHKRVKEADSLLVVGSSLQVYSGYRFILTAW
                     EKKLPIAILNIGPTRSDDLACLKLNSRCGELLPLIDPC"
     exon            557..851
                     /gene="SIRT4"
                     /gene_synonym="SIR2L4"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1217
                     /gene="SIRT4"
                     /gene_synonym="SIR2L4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1169..1174
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIRT4"
                     /gene_synonym="SIR2L4"
                     /note="hexamer: ATTAAA"
     regulatory      1189..1194
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIRT4"
                     /gene_synonym="SIR2L4"
                     /note="hexamer: AATAAA"
     polyA_site      1197
                     /gene="SIRT4"
                     /gene_synonym="SIR2L4"
                     /note="major polyA site"
     polyA_site      1217
                     /gene="SIRT4"
                     /gene_synonym="SIR2L4"
                     /note="major polyA site"
ORIGIN      
        1 gcaaatgcaa tcagacggtc ccactgtggg gtgtgaagtg tccgtagagc tgtgagagaa
       61 tgaagatgag ctttgcgttg actttcaggt cagcaaaagg ccgttggatc gcaaacccca
      121 gccagccgtg ctcgaaagcc tccattgggt tatttgtgcc agcaagtcct cctctggacc
      181 ctgagaaggt caaagagtta cagcgcttca tcaccctttc caagagactc cttgtgatga
      241 ctggggcagg aatctccacc gaatcgggga taccagacta caggtcagaa aaagtggggc
      301 tttatgcccg cactgaccgc aggcccatcc agcatggtga ttttgtccgg agtgccccaa
      361 tccgccagcg gtactgggcg agaaacttcg taggctggcc tcaattctcc tcccaccagc
      421 ctaaccctgc acactgggct ttgagcacct gggagaaact cggaaagctg tactggttgg
      481 tgacccaaaa tgtggatgct ttgcacacca aggcggggag tcggcgcctg acagagctcc
      541 acggatgcat ggacagggtc ctgtgcttgg attgtgggga acagactccc cggggggtgc
      601 tgcaagagcg tttccaagtc ctgaacccca cctggagtgc tgaggcccat ggcctggctc
      661 ctgatggtga cgtctttctc tcagaggagc aagtccggag ctttcaggtc ccaacctgcg
      721 ttcaatgtgg aggccatctg aaaccagatg tcgttttctt cggggacaca gtgaaccctg
      781 acaaggttga ttttgtgcac aagcgtgtaa aagaagccga ctccctcttg gtggtgggat
      841 catccttgca ggtatactct ggttacaggt ttatcctcac tgcctgggag aagaagctcc
      901 cgattgcaat actgaacatt gggcccacac ggtcggatga cttggcgtgt ctgaaactga
      961 attctcgttg tggagagttg ctgcctttga tagacccatg ctgaccacag cctgatattc
     1021 cagaacctgg aacagggact ttcacttgaa tcttgctgct aaatgtaaat gccttctcaa
     1081 atgacagatt ccagttccca ttcaacagag tagggtgcac tgacaaagta tagaaggttc
     1141 taggtatctt aatgtgtgga tattcttaat taaaactcat tttttttaaa taaaaaattg
     1201 ttcagcttta tatgaaa
//
