LOCUS       NM_030593               1815 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens sirtuin 2 (SIRT2), transcript variant 2, mRNA.
ACCESSION   NM_030593
VERSION     NM_030593.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1815)
  AUTHORS   Yildiz,B., Demirel,R., Staudacher,J.J., Beseren,H., Yildiz,G.,
            Akpinar,A.E., Park,S.H. and Ozden,O.
  TITLE     SIRT2 deacetylates and decreases the expression of FOXM1 in colon
            cancer
  JOURNAL   J Biochem Mol Toxicol 38 (11), e70018 (2024)
   PUBMED   39425454
  REMARK    GeneRIF: SIRT2 deacetylates and decreases the expression of FOXM1
            in colon cancer.
REFERENCE   2  (bases 1 to 1815)
  AUTHORS   Abeywardana,M.Y., Whedon,S.D., Lee,K., Nam,E., Dovarganes,R.,
            DuBois-Coyne,S., Haque,I.A., Wang,Z.A. and Cole,P.A.
  TITLE     Multifaceted regulation of sirtuin 2 (Sirt2) deacetylase activity
  JOURNAL   J Biol Chem 300 (9), 107722 (2024)
   PUBMED   39214297
  REMARK    GeneRIF: Multifaceted regulation of sirtuin 2 (Sirt2) deacetylase
            activity.
REFERENCE   3  (bases 1 to 1815)
  AUTHORS   Geng,A., Sun,J., Tang,H., Yu,Y., Wang,X., Zhang,J., Wang,X.,
            Sun,X., Zhou,X., Gao,N., Tan,R., Xu,Z., Jiang,Y. and Mao,Z.
  TITLE     SIRT2 promotes base excision repair by transcriptionally activating
            OGG1 in an ATM/ATR-dependent manner
  JOURNAL   Nucleic Acids Res 52 (9), 5107-5120 (2024)
   PUBMED   38554113
  REMARK    GeneRIF: SIRT2 promotes base excision repair by transcriptionally
            activating OGG1 in an ATM/ATR-dependent manner.
REFERENCE   4  (bases 1 to 1815)
  AUTHORS   Guo,J., Zhang,H., Hu,H., Zhao,T., Ji,H., Ma,L., Lu,J., Yuan,J. and
            Xu,B.
  TITLE     Silent information regulator 2 deficiency exacerbates chronic cold
            exposure-induced colonic injury and p65 activation in mice
  JOURNAL   Gene 907, 148276 (2024)
   PUBMED   38360128
  REMARK    GeneRIF: Silent information regulator 2 deficiency exacerbates
            chronic cold exposure-induced colonic injury and p65 activation in
            mice.
REFERENCE   5  (bases 1 to 1815)
  AUTHORS   Suzuki,N., Konuma,T., Ikegami,T. and Akashi,S.
  TITLE     Biophysical insights into the dimer formation of human Sirtuin 2
  JOURNAL   Protein Sci 33 (5), e4994 (2024)
   PUBMED   38647411
  REMARK    GeneRIF: Biophysical insights into the dimer formation of human
            Sirtuin 2.
REFERENCE   6  (bases 1 to 1815)
  AUTHORS   Finnin,M.S., Donigian,J.R. and Pavletich,N.P.
  TITLE     Structure of the histone deacetylase SIRT2
  JOURNAL   Nat Struct Biol 8 (7), 621-625 (2001)
   PUBMED   11427894
REFERENCE   7  (bases 1 to 1815)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
REFERENCE   8  (bases 1 to 1815)
  AUTHORS   Frye,R.A.
  TITLE     Phylogenetic classification of prokaryotic and eukaryotic Sir2-like
            proteins
  JOURNAL   Biochem Biophys Res Commun 273 (2), 793-798 (2000)
   PUBMED   10873683
REFERENCE   9  (bases 1 to 1815)
  AUTHORS   Afshar,G. and Murnane,J.P.
  TITLE     Characterization of a human gene with sequence homology to
            Saccharomyces cerevisiae SIR2
  JOURNAL   Gene 234 (1), 161-168 (1999)
   PUBMED   10393250
REFERENCE   10 (bases 1 to 1815)
  AUTHORS   Frye,R.A.
  TITLE     Characterization of five human cDNAs with homology to the yeast
            SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may
            have protein ADP-ribosyltransferase activity
  JOURNAL   Biochem Biophys Res Commun 260 (1), 273-279 (1999)
   PUBMED   10381378
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC003012.1.
            
            On May 31, 2019 this sequence version replaced NM_030593.2.
            
            Summary: This gene encodes a member of the sirtuin family of
            proteins, homologs to the yeast Sir2 protein. Members of the
            sirtuin family are characterized by a sirtuin core domain and
            grouped into four classes. The functions of human sirtuins have not
            yet been determined; however, yeast sirtuin proteins are known to
            regulate epigenetic gene silencing and suppress recombination of
            rDNA. Studies suggest that the human sirtuins may function as
            intracellular regulatory proteins with mono-ADP-ribosyltransferase
            activity. The protein encoded by this gene is included in class I
            of the sirtuin family. Several transcript variants are resulted
            from alternative splicing of this gene. [provided by RefSeq, Jul
            2010].
            
            Transcript Variant: This variant (2) lacks an exon in the 5'
            region, resulting in a downstream in-frame AUG start codon, as
            compared to variant 1. The resulting isoform (2) has a shorter
            N-terminus, as compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003547.1, AK025876.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1815              BC003012.1         96-1910
FEATURES             Location/Qualifiers
     source          1..1815
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..1815
                     /gene="SIRT2"
                     /gene_synonym="SIR2; SIR2L; SIR2L2"
                     /note="sirtuin 2"
                     /db_xref="GeneID:22933"
                     /db_xref="HGNC:HGNC:10886"
                     /db_xref="MIM:604480"
     exon            1..113
                     /gene="SIRT2"
                     /gene_synonym="SIR2; SIR2L; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            114..162
                     /gene="SIRT2"
                     /gene_synonym="SIR2; SIR2L; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..1220
                     /gene="SIRT2"
                     /gene_synonym="SIR2; SIR2L; SIR2L2"
                     /EC_number="2.3.1.286"
                     /note="isoform 2 is encoded by transcript variant 2;
                     sir2-related protein type 2; sirtuin type 2; NAD-dependent
                     deacetylase sirtuin-2; silent information regulator 2;
                     SIR2-like protein 2; regulatory protein SIR2 homolog 2;
                     NAD-dependent protein deacetylase sirtuin-2; NAD-dependent
                     protein defatty-acylase sirtuin-2"
                     /codon_start=1
                     /product="NAD-dependent protein deacetylase sirtuin-2
                     isoform 2"
                     /protein_id="NP_085096.1"
                     /db_xref="CCDS:CCDS46069.1"
                     /db_xref="GeneID:22933"
                     /db_xref="HGNC:HGNC:10886"
                     /db_xref="MIM:604480"
                     /translation="MDFLRNLFSQTLSLGSQKERLLDELTLEGVARYMQSERCRRVIC
                     LVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELY
                     PGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVS
                     ASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVD
                     LLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKK
                     AYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGVPNPSTSASPKK
                     SPPPAKDEARTTEREKPQ"
     exon            163..276
                     /gene="SIRT2"
                     /gene_synonym="SIR2; SIR2L; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            277..318
                     /gene="SIRT2"
                     /gene_synonym="SIR2; SIR2L; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            319..425
                     /gene="SIRT2"
                     /gene_synonym="SIR2; SIR2L; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            426..482
                     /gene="SIRT2"
                     /gene_synonym="SIR2; SIR2L; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            483..551
                     /gene="SIRT2"
                     /gene_synonym="SIR2; SIR2L; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            552..681
                     /gene="SIRT2"
                     /gene_synonym="SIR2; SIR2L; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            682..741
                     /gene="SIRT2"
                     /gene_synonym="SIR2; SIR2L; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            742..797
                     /gene="SIRT2"
                     /gene_synonym="SIR2; SIR2L; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            798..874
                     /gene="SIRT2"
                     /gene_synonym="SIR2; SIR2L; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            875..926
                     /gene="SIRT2"
                     /gene_synonym="SIR2; SIR2L; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            927..997
                     /gene="SIRT2"
                     /gene_synonym="SIR2; SIR2L; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1064
                     /gene="SIRT2"
                     /gene_synonym="SIR2; SIR2L; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1815
                     /gene="SIRT2"
                     /gene_synonym="SIR2; SIR2L; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1798..1803
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIRT2"
                     /gene_synonym="SIR2; SIR2L; SIR2L2"
                     /note="hexamer: AACAAA"
     polyA_site      1815
                     /gene="SIRT2"
                     /gene_synonym="SIR2; SIR2L; SIR2L2"
                     /note="major polyA site"
ORIGIN      
        1 agtcggtgac aggacagagc agtcggtgac gggacacagt ggttggtgac gggacagagc
       61 ggtcggtgac agcctcaagg gcttcagcac cgcgcccatg gcagagccag accgactcag
      121 attcagactc tgagggagga gccgctggtg gagaagcaga catggacttc ctgcggaact
      181 tattctccca gacgctcagc ctgggcagcc agaaggagcg tctgctggac gagctgacct
      241 tggaaggggt ggcccggtac atgcagagcg aacgctgtcg cagagtcatc tgtttggtgg
      301 gagctggaat ctccacatcc gcaggcatcc ccgactttcg ctctccatcc accggcctct
      361 atgacaacct agagaagtac catcttccct acccagaggc catctttgag atcagctatt
      421 tcaagaaaca tccggaaccc ttcttcgccc tcgccaagga actctatcct gggcagttca
      481 agccaaccat ctgtcactac ttcatgcgcc tgctgaagga caaggggcta ctcctgcgct
      541 gctacacgca gaacatagat accctggagc gaatagccgg gctggaacag gaggacttgg
      601 tggaggcgca cggcaccttc tacacatcac actgcgtcag cgccagctgc cggcacgaat
      661 acccgctaag ctggatgaaa gagaagatct tctctgaggt gacgcccaag tgtgaagact
      721 gtcagagcct ggtgaagcct gatatcgtct tttttggtga gagcctccca gcgcgtttct
      781 tctcctgtat gcagtcagac ttcctgaagg tggacctcct cctggtcatg ggtacctcct
      841 tgcaggtgca gccctttgcc tccctcatca gcaaggcacc cctctccacc cctcgcctgc
      901 tcatcaacaa ggagaaagct ggccagtcgg accctttcct ggggatgatt atgggcctcg
      961 gaggaggcat ggactttgac tccaagaagg cctacaggga cgtggcctgg ctgggtgaat
     1021 gcgaccaggg ctgcctggcc cttgctgagc tccttggatg gaagaaggag ctggaggacc
     1081 ttgtccggag ggagcacgcc agcatagatg cccagtcggg ggcgggggtc cccaacccca
     1141 gcacttcagc ttcccccaag aagtccccgc cacctgccaa ggacgaggcc aggacaacag
     1201 agagggagaa accccagtga cagctgcatc tcccaggcgg gatgccgagc tcctcaggga
     1261 cagctgagcc ccaaccgggc ctggccccct cttaaccagc agttcttgtc tggggagctc
     1321 agaacatccc ccaatctctt acagctccct ccccaaaact ggggtcccag caaccctggc
     1381 ccccaacccc agcaaatctc taacacctcc tagaggccaa ggcttaaaca ggcatctcta
     1441 ccagccccac tgtctctaac cactcctggg ctaaggagta acctccctca tctctaactg
     1501 cccccacggg gccagggcta ccccagaact tttaactctt ccaggacagg gagcttcggg
     1561 cccccactct gtctcctgcc cccgggggcc tgtggctaag taaaccatac ctaacctacc
     1621 ccagtgtggg tgtgggcctc tgaatataac ccacacccag cgtaggggga gtctgagccg
     1681 ggagggctcc cgagtctctg ccttcagctc ccaaagtggg tggtgggccc ccttcacgtg
     1741 ggacccactt cccatgctgg atgggcagaa gacattgctt attggagaca aattaaaaac
     1801 aaaaacaact aacaa
//
