LOCUS       NM_012237               1862 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens sirtuin 2 (SIRT2), transcript variant 1, mRNA.
ACCESSION   NM_012237
VERSION     NM_012237.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1862)
  AUTHORS   Yildiz,B., Demirel,R., Staudacher,J.J., Beseren,H., Yildiz,G.,
            Akpinar,A.E., Park,S.H. and Ozden,O.
  TITLE     SIRT2 deacetylates and decreases the expression of FOXM1 in colon
            cancer
  JOURNAL   J Biochem Mol Toxicol 38 (11), e70018 (2024)
   PUBMED   39425454
  REMARK    GeneRIF: SIRT2 deacetylates and decreases the expression of FOXM1
            in colon cancer.
REFERENCE   2  (bases 1 to 1862)
  AUTHORS   Abeywardana,M.Y., Whedon,S.D., Lee,K., Nam,E., Dovarganes,R.,
            DuBois-Coyne,S., Haque,I.A., Wang,Z.A. and Cole,P.A.
  TITLE     Multifaceted regulation of sirtuin 2 (Sirt2) deacetylase activity
  JOURNAL   J Biol Chem 300 (9), 107722 (2024)
   PUBMED   39214297
  REMARK    GeneRIF: Multifaceted regulation of sirtuin 2 (Sirt2) deacetylase
            activity.
REFERENCE   3  (bases 1 to 1862)
  AUTHORS   Geng,A., Sun,J., Tang,H., Yu,Y., Wang,X., Zhang,J., Wang,X.,
            Sun,X., Zhou,X., Gao,N., Tan,R., Xu,Z., Jiang,Y. and Mao,Z.
  TITLE     SIRT2 promotes base excision repair by transcriptionally activating
            OGG1 in an ATM/ATR-dependent manner
  JOURNAL   Nucleic Acids Res 52 (9), 5107-5120 (2024)
   PUBMED   38554113
  REMARK    GeneRIF: SIRT2 promotes base excision repair by transcriptionally
            activating OGG1 in an ATM/ATR-dependent manner.
REFERENCE   4  (bases 1 to 1862)
  AUTHORS   Guo,J., Zhang,H., Hu,H., Zhao,T., Ji,H., Ma,L., Lu,J., Yuan,J. and
            Xu,B.
  TITLE     Silent information regulator 2 deficiency exacerbates chronic cold
            exposure-induced colonic injury and p65 activation in mice
  JOURNAL   Gene 907, 148276 (2024)
   PUBMED   38360128
  REMARK    GeneRIF: Silent information regulator 2 deficiency exacerbates
            chronic cold exposure-induced colonic injury and p65 activation in
            mice.
REFERENCE   5  (bases 1 to 1862)
  AUTHORS   Suzuki,N., Konuma,T., Ikegami,T. and Akashi,S.
  TITLE     Biophysical insights into the dimer formation of human Sirtuin 2
  JOURNAL   Protein Sci 33 (5), e4994 (2024)
   PUBMED   38647411
  REMARK    GeneRIF: Biophysical insights into the dimer formation of human
            Sirtuin 2.
REFERENCE   6  (bases 1 to 1862)
  AUTHORS   Finnin,M.S., Donigian,J.R. and Pavletich,N.P.
  TITLE     Structure of the histone deacetylase SIRT2
  JOURNAL   Nat Struct Biol 8 (7), 621-625 (2001)
   PUBMED   11427894
REFERENCE   7  (bases 1 to 1862)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
REFERENCE   8  (bases 1 to 1862)
  AUTHORS   Frye,R.A.
  TITLE     Phylogenetic classification of prokaryotic and eukaryotic Sir2-like
            proteins
  JOURNAL   Biochem Biophys Res Commun 273 (2), 793-798 (2000)
   PUBMED   10873683
REFERENCE   9  (bases 1 to 1862)
  AUTHORS   Afshar,G. and Murnane,J.P.
  TITLE     Characterization of a human gene with sequence homology to
            Saccharomyces cerevisiae SIR2
  JOURNAL   Gene 234 (1), 161-168 (1999)
   PUBMED   10393250
REFERENCE   10 (bases 1 to 1862)
  AUTHORS   Frye,R.A.
  TITLE     Characterization of five human cDNAs with homology to the yeast
            SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may
            have protein ADP-ribosyltransferase activity
  JOURNAL   Biochem Biophys Res Commun 260 (1), 273-279 (1999)
   PUBMED   10381378
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF083107.2 and BF529906.1.
            
            On Nov 23, 2018 this sequence version replaced NM_012237.3.
            
            Summary: This gene encodes a member of the sirtuin family of
            proteins, homologs to the yeast Sir2 protein. Members of the
            sirtuin family are characterized by a sirtuin core domain and
            grouped into four classes. The functions of human sirtuins have not
            yet been determined; however, yeast sirtuin proteins are known to
            regulate epigenetic gene silencing and suppress recombination of
            rDNA. Studies suggest that the human sirtuins may function as
            intracellular regulatory proteins with mono-ADP-ribosyltransferase
            activity. The protein encoded by this gene is included in class I
            of the sirtuin family. Several transcript variants are resulted
            from alternative splicing of this gene. [provided by RefSeq, Jul
            2010].
            
            Transcript Variant: This variant (1) is the longest transcript and
            encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF083107.2, SRR11853563.16947.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000249396.12/ ENSP00000249396.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1860              AF083107.2         104-1963
            1861-1862           BF529906.1         139-140
FEATURES             Location/Qualifiers
     source          1..1862
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..1862
                     /gene="SIRT2"
                     /gene_synonym="SIR2; SIR2L; SIR2L2"
                     /note="sirtuin 2"
                     /db_xref="GeneID:22933"
                     /db_xref="HGNC:HGNC:10886"
                     /db_xref="MIM:604480"
     exon            1..113
                     /gene="SIRT2"
                     /gene_synonym="SIR2; SIR2L; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1267
                     /gene="SIRT2"
                     /gene_synonym="SIR2; SIR2L; SIR2L2"
                     /EC_number="2.3.1.286"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sir2-related protein type 2; sirtuin type 2; NAD-dependent
                     deacetylase sirtuin-2; silent information regulator 2;
                     SIR2-like protein 2; regulatory protein SIR2 homolog 2;
                     NAD-dependent protein deacetylase sirtuin-2; NAD-dependent
                     protein defatty-acylase sirtuin-2"
                     /codon_start=1
                     /product="NAD-dependent protein deacetylase sirtuin-2
                     isoform 1"
                     /protein_id="NP_036369.2"
                     /db_xref="CCDS:CCDS12523.1"
                     /db_xref="GeneID:22933"
                     /db_xref="HGNC:HGNC:10886"
                     /db_xref="MIM:604480"
                     /translation="MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNL
                     FSQTLSLGSQKERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTG
                     LYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGL
                     LLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVT
                     PKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKA
                     PLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAEL
                     LGWKKELEDLVRREHASIDAQSGAGVPNPSTSASPKKSPPPAKDEARTTEREKPQ"
     exon            114..160
                     /gene="SIRT2"
                     /gene_synonym="SIR2; SIR2L; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            161..209
                     /gene="SIRT2"
                     /gene_synonym="SIR2; SIR2L; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            210..323
                     /gene="SIRT2"
                     /gene_synonym="SIR2; SIR2L; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            324..365
                     /gene="SIRT2"
                     /gene_synonym="SIR2; SIR2L; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            366..472
                     /gene="SIRT2"
                     /gene_synonym="SIR2; SIR2L; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            473..529
                     /gene="SIRT2"
                     /gene_synonym="SIR2; SIR2L; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            530..598
                     /gene="SIRT2"
                     /gene_synonym="SIR2; SIR2L; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            599..728
                     /gene="SIRT2"
                     /gene_synonym="SIR2; SIR2L; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            729..788
                     /gene="SIRT2"
                     /gene_synonym="SIR2; SIR2L; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            789..844
                     /gene="SIRT2"
                     /gene_synonym="SIR2; SIR2L; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            845..921
                     /gene="SIRT2"
                     /gene_synonym="SIR2; SIR2L; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            922..973
                     /gene="SIRT2"
                     /gene_synonym="SIR2; SIR2L; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1044
                     /gene="SIRT2"
                     /gene_synonym="SIR2; SIR2L; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1111
                     /gene="SIRT2"
                     /gene_synonym="SIR2; SIR2L; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1862
                     /gene="SIRT2"
                     /gene_synonym="SIR2; SIR2L; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1845..1850
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIRT2"
                     /gene_synonym="SIR2; SIR2L; SIR2L2"
                     /note="hexamer: AACAAA"
     polyA_site      1862
                     /gene="SIRT2"
                     /gene_synonym="SIR2; SIR2L; SIR2L2"
                     /note="major polyA site"
ORIGIN      
        1 agtcggtgac aggacagagc agtcggtgac gggacacagt ggttggtgac gggacagagc
       61 ggtcggtgac agcctcaagg gcttcagcac cgcgcccatg gcagagccag acccctctca
      121 ccctctggag acccaggcag ggaaggtgca ggaggctcag gactcagatt cagactctga
      181 gggaggagcc gctggtggag aagcagacat ggacttcctg cggaacttat tctcccagac
      241 gctcagcctg ggcagccaga aggagcgtct gctggacgag ctgaccttgg aaggggtggc
      301 ccggtacatg cagagcgaac gctgtcgcag agtcatctgt ttggtgggag ctggaatctc
      361 cacatccgca ggcatccccg actttcgctc tccatccacc ggcctctatg acaacctaga
      421 gaagtaccat cttccctacc cagaggccat ctttgagatc agctatttca agaaacatcc
      481 ggaacccttc ttcgccctcg ccaaggaact ctatcctggg cagttcaagc caaccatctg
      541 tcactacttc atgcgcctgc tgaaggacaa ggggctactc ctgcgctgct acacgcagaa
      601 catagatacc ctggagcgaa tagccgggct ggaacaggag gacttggtgg aggcgcacgg
      661 caccttctac acatcacact gcgtcagcgc cagctgccgg cacgaatacc cgctaagctg
      721 gatgaaagag aagatcttct ctgaggtgac gcccaagtgt gaagactgtc agagcctggt
      781 gaagcctgat atcgtctttt ttggtgagag cctcccagcg cgtttcttct cctgtatgca
      841 gtcagacttc ctgaaggtgg acctcctcct ggtcatgggt acctccttgc aggtgcagcc
      901 ctttgcctcc ctcatcagca aggcacccct ctccacccct cgcctgctca tcaacaagga
      961 gaaagctggc cagtcggacc ctttcctggg gatgattatg ggcctcggag gaggcatgga
     1021 ctttgactcc aagaaggcct acagggacgt ggcctggctg ggtgaatgcg accagggctg
     1081 cctggccctt gctgagctcc ttggatggaa gaaggagctg gaggaccttg tccggaggga
     1141 gcacgccagc atagatgccc agtcgggggc gggggtcccc aaccccagca cttcagcttc
     1201 ccccaagaag tccccgccac ctgccaagga cgaggccagg acaacagaga gggagaaacc
     1261 ccagtgacag ctgcatctcc caggcgggat gccgagctcc tcagggacag ctgagcccca
     1321 accgggcctg gccccctctt aaccagcagt tcttgtctgg ggagctcaga acatccccca
     1381 atctcttaca gctccctccc caaaactggg gtcccagcaa ccctggcccc caaccccagc
     1441 aaatctctaa cacctcctag aggccaaggc ttaaacaggc atctctacca gccccactgt
     1501 ctctaaccac tcctgggcta aggagtaacc tccctcatct ctaactgccc ccacggggcc
     1561 agggctaccc cagaactttt aactcttcca ggacagggag cttcgggccc ccactctgtc
     1621 tcctgccccc gggggcctgt ggctaagtaa accataccta acctacccca gtgtgggtgt
     1681 gggcctctga atataaccca cacccagcgt agggggagtc tgagccggga gggctcccga
     1741 gtctctgcct tcagctccca aagtgggtgg tgggccccct tcacgtggga cccacttccc
     1801 atgctggatg ggcagaagac attgcttatt ggagacaaat taaaaacaaa aacaactaac
     1861 aa
//
