LOCUS       NM_012238               4107 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens sirtuin 1 (SIRT1), transcript variant 1, mRNA.
ACCESSION   NM_012238
VERSION     NM_012238.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4107)
  AUTHORS   Zhao,Y., Wang,Y., Zheng,H., Xu,Q., Zhou,K., Liu,H., Xia,Y.,
            Wei,D.H., Jiang,M., Tang,Z.H., Liu,L.S., Zheng,H. and Jiang,Z.
  TITLE     Hydrogen sulfide upregulates SIRT1 to inhibit ox-HDL-induced
            endothelial cell damage and mitochondrial dysfunction
  JOURNAL   Nitric Oxide 152, 78-89 (2024)
   PUBMED   39305980
  REMARK    GeneRIF: Hydrogen sulfide upregulates SIRT1 to inhibit
            ox-HDL-induced endothelial cell damage and mitochondrial
            dysfunction.
REFERENCE   2  (bases 1 to 4107)
  AUTHORS   Nevoral,J., Drutovic,D., Vaskovicova,M., Benc,M., Liska,F.,
            Valentova,I., Stachovicova,S., Kubovciak,J., Havrankova,J.,
            Shavit,M., Monsef,L., Iniesta-Cuerda,M., Zalmanova,T., Hosek,P.,
            Strejcek,F., Kralickova,M. and Petr,J.
  TITLE     Dynamics and necessity of SIRT1 for maternal-zygotic transition
  JOURNAL   Sci Rep 14 (1), 21598 (2024)
   PUBMED   39285243
  REMARK    GeneRIF: Dynamics and necessity of SIRT1 for maternal-zygotic
            transition.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4107)
  AUTHORS   Chen,J., Chen,K., Zhang,S. and Huang,X.
  TITLE     SIRT1 silencing ameliorates malignancy of non-small cell lung
            cancer via activating FOXO1
  JOURNAL   Sci Rep 14 (1), 19948 (2024)
   PUBMED   39198693
  REMARK    GeneRIF: SIRT1 silencing ameliorates malignancy of non-small cell
            lung cancer via activating FOXO1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4107)
  AUTHORS   Yang,K., Wu,Y., Zhang,R., Lei,X.P., Kang,L. and Dong,W.B.
  TITLE     [Role of reactive oxygen species/silent information regulator 1 in
            hyperoxia-induced bronchial epithelial cell injury]
  JOURNAL   Zhongguo Dang Dai Er Ke Za Zhi 26 (8), 852-860 (2024)
   PUBMED   39148391
  REMARK    GeneRIF: [Role of reactive oxygen species/silent information
            regulator 1 in hyperoxia-induced bronchial epithelial cell injury].
REFERENCE   5  (bases 1 to 4107)
  AUTHORS   Zhang,X., Wang,Y., Xu,F., Zhao,B., Liang,X. and Shu,J.
  TITLE     Downregulation of miR-138-5p alleviates propofol-induced
            neurotoxicity and autophagy by regulating SIRT1
  JOURNAL   Hum Exp Toxicol 43, 9603271241269021 (2024)
   PUBMED   39441175
  REMARK    GeneRIF: Downregulation of miR-138-5p alleviates propofol-induced
            neurotoxicity and autophagy by regulating SIRT1.
REFERENCE   6  (bases 1 to 4107)
  AUTHORS   Giblin,W., Skinner,M.E. and Lombard,D.B.
  TITLE     Sirtuins: guardians of mammalian healthspan
  JOURNAL   Trends Genet 30 (7), 271-286 (2014)
   PUBMED   24877878
  REMARK    Review article
REFERENCE   7  (bases 1 to 4107)
  AUTHORS   Vaziri,H., Dessain,S.K., Ng Eaton,E., Imai,S.I., Frye,R.A.,
            Pandita,T.K., Guarente,L. and Weinberg,R.A.
  TITLE     hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase
  JOURNAL   Cell 107 (2), 149-159 (2001)
   PUBMED   11672523
REFERENCE   8  (bases 1 to 4107)
  AUTHORS   Luo,J., Nikolaev,A.Y., Imai,S., Chen,D., Su,F., Shiloh,A.,
            Guarente,L. and Gu,W.
  TITLE     Negative control of p53 by Sir2alpha promotes cell survival under
            stress
  JOURNAL   Cell 107 (2), 137-148 (2001)
   PUBMED   11672522
  REMARK    GeneRIF: SIRT1(Sir2alpha) deacetylates p53 and promotes survival
REFERENCE   9  (bases 1 to 4107)
  AUTHORS   Frye,R.A.
  TITLE     Phylogenetic classification of prokaryotic and eukaryotic Sir2-like
            proteins
  JOURNAL   Biochem Biophys Res Commun 273 (2), 793-798 (2000)
   PUBMED   10873683
REFERENCE   10 (bases 1 to 4107)
  AUTHORS   Frye,R.A.
  TITLE     Characterization of five human cDNAs with homology to the yeast
            SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may
            have protein ADP-ribosyltransferase activity
  JOURNAL   Biochem Biophys Res Commun 260 (1), 273-279 (1999)
   PUBMED   10381378
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL133551.13.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_012238.4.
            
            Summary: This gene encodes a member of the sirtuin family of
            proteins, homologs to the yeast Sir2 protein. Members of the
            sirtuin family are characterized by a sirtuin core domain and
            grouped into four classes. The functions of human sirtuins have not
            yet been determined; however, yeast sirtuin proteins are known to
            regulate epigenetic gene silencing and suppress recombination of
            rDNA. Studies suggest that the human sirtuins may function as
            intracellular regulatory proteins with mono-ADP-ribosyltransferase
            activity. The protein encoded by this gene is included in class I
            of the sirtuin family. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Dec 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012499.1, AF083106.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000212015.11/ ENSP00000212015.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-496               AL133551.13        132508-133003
            497-613             AL133551.13        135269-135385
            614-855             AL133551.13        136734-136975
            856-1008            AL133551.13        139254-139406
            1009-1156           AL133551.13        154641-154788
            1157-1236           AL133551.13        155897-155976
            1237-1423           AL133551.13        157107-157293
            1424-1981           AL133551.13        160325-160882
            1982-4107           AL133551.13        164116-166241
FEATURES             Location/Qualifiers
     source          1..4107
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q21.3"
     gene            1..4107
                     /gene="SIRT1"
                     /gene_synonym="SIR2; SIR2alpha; SIR2L1"
                     /note="sirtuin 1"
                     /db_xref="GeneID:23411"
                     /db_xref="HGNC:HGNC:14929"
                     /db_xref="MIM:604479"
     exon            1..496
                     /gene="SIRT1"
                     /gene_synonym="SIR2; SIR2alpha; SIR2L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..2310
                     /gene="SIRT1"
                     /gene_synonym="SIR2; SIR2alpha; SIR2L1"
                     /EC_number="2.3.1.286"
                     /note="isoform a is encoded by transcript variant 1;
                     sirtuin type 1; SIR2-like protein 1; regulatory protein
                     SIR2 homolog 1; NAD-dependent protein deacetylase
                     sirtuin-1; NAD-dependent protein deacylase sirtuin-1"
                     /codon_start=1
                     /product="NAD-dependent protein deacetylase sirtuin-1
                     isoform a"
                     /protein_id="NP_036370.2"
                     /db_xref="CCDS:CCDS7273.1"
                     /db_xref="GeneID:23411"
                     /db_xref="HGNC:HGNC:14929"
                     /db_xref="MIM:604479"
                     /translation="MADEAALALQPGGSPSAAGADREAASSPAGEPLRKRPRRDGPGL
                     ERSPGEPGGAAPEREVPAAARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGD
                     NGPGLQGPSREPPLADNLYDEDDDDEGEEEEEAAAAAIGYRDNLLFGDEIITNGFHSC
                     ESDEEDRASHASSSDWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDM
                     TLWQIVINILSEPPKRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSR
                     DGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSD
                     KEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVV
                     PRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVAL
                     IPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLCCNPVKLS
                     EITEKPPRTQKELAYLSELPPTPLHVSEDSSSPERTSPPDSSVIVTLLDQAAKSNDDL
                     DVSESKGCMEEKPQEVQTSRNVESIAEQMENPDLKNVGSSTGEKNERTSVAGTVRKCW
                     PNRVAKEQISRRLDGNQYLFLPPNRYIFHGAEVYSDSEDDVLSSSSCGSNSDSGTCQS
                     PSLEEPMEDESEIEEFYNGLEDEPDVPERAGGAGFGTDGDDQEAINEAISVKQEVTDM
                     NYPSNKS"
     exon            497..613
                     /gene="SIRT1"
                     /gene_synonym="SIR2; SIR2alpha; SIR2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            614..855
                     /gene="SIRT1"
                     /gene_synonym="SIR2; SIR2alpha; SIR2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            856..1008
                     /gene="SIRT1"
                     /gene_synonym="SIR2; SIR2alpha; SIR2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1156
                     /gene="SIRT1"
                     /gene_synonym="SIR2; SIR2alpha; SIR2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1236
                     /gene="SIRT1"
                     /gene_synonym="SIR2; SIR2alpha; SIR2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1423
                     /gene="SIRT1"
                     /gene_synonym="SIR2; SIR2alpha; SIR2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1981
                     /gene="SIRT1"
                     /gene_synonym="SIR2; SIR2alpha; SIR2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1982..4107
                     /gene="SIRT1"
                     /gene_synonym="SIR2; SIR2alpha; SIR2L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4072..4077
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIRT1"
                     /gene_synonym="SIR2; SIR2alpha; SIR2L1"
                     /note="hexamer: ATTAAA"
     polyA_site      4107
                     /gene="SIRT1"
                     /gene_synonym="SIR2; SIR2alpha; SIR2L1"
                     /note="major polyA site"
ORIGIN      
        1 gccagtgccg cgcgtcgagc gggagcagag gaggcgaggg aggagggcca gagaggcagt
       61 tggaagatgg cggacgaggc ggccctcgcc cttcagcccg gcggctcccc ctcggcggcg
      121 ggggccgaca gggaggccgc gtcgtccccc gccggggagc cgctccgcaa gaggccgcgg
      181 agagatggtc ccggcctcga gcggagcccg ggcgagcccg gtggggcggc cccagagcgt
      241 gaggtgccgg cggcggccag gggctgcccg ggtgcggcgg cggcggcgct gtggcgggag
      301 gcggaggcag aggcggcggc ggcaggcggg gagcaagagg cccaggcgac tgcggcggct
      361 ggggaaggag acaatgggcc gggcctgcag ggcccatctc gggagccacc gctggccgac
      421 aacttgtacg acgaagacga cgacgacgag ggcgaggagg aggaagaggc ggcggcggcg
      481 gcgattgggt accgagataa ccttctgttc ggtgatgaaa ttatcactaa tggttttcat
      541 tcctgtgaaa gtgatgagga ggatagagcc tcacatgcaa gctctagtga ctggactcca
      601 aggccacgga taggtccata tacttttgtt cagcaacatc ttatgattgg cacagatcct
      661 cgaacaattc ttaaagattt attgccggaa acaatacctc cacctgagtt ggatgatatg
      721 acactgtggc agattgttat taatatcctt tcagaaccac caaaaaggaa aaaaagaaaa
      781 gatattaata caattgaaga tgctgtgaaa ttactgcaag agtgcaaaaa aattatagtt
      841 ctaactggag ctggggtgtc tgtttcatgt ggaatacctg acttcaggtc aagggatggt
      901 atttatgctc gccttgctgt agacttccca gatcttccag atcctcaagc gatgtttgat
      961 attgaatatt tcagaaaaga tccaagacca ttcttcaagt ttgcaaagga aatatatcct
     1021 ggacaattcc agccatctct ctgtcacaaa ttcatagcct tgtcagataa ggaaggaaaa
     1081 ctacttcgca actataccca gaacatagac acgctggaac aggttgcggg aatccaaagg
     1141 ataattcagt gtcatggttc ctttgcaaca gcatcttgcc tgatttgtaa atacaaagtt
     1201 gactgtgaag ctgtacgagg agatattttt aatcaggtag ttcctcgatg tcctaggtgc
     1261 ccagctgatg aaccgcttgc tatcatgaaa ccagagattg tgttttttgg tgaaaattta
     1321 ccagaacagt ttcatagagc catgaagtat gacaaagatg aagttgacct cctcattgtt
     1381 attgggtctt ccctcaaagt aagaccagta gcactaattc caagttccat accccatgaa
     1441 gtgcctcaga tattaattaa tagagaacct ttgcctcatc tgcattttga tgtagagctt
     1501 cttggagact gtgatgtcat aattaatgaa ttgtgtcata ggttaggtgg tgaatatgcc
     1561 aaactttgct gtaaccctgt aaagctttca gaaattactg aaaaacctcc acgaacacaa
     1621 aaagaattgg cttatttgtc agagttgcca cccacacctc ttcatgtttc agaagactca
     1681 agttcaccag aaagaacttc accaccagat tcttcagtga ttgtcacact tttagaccaa
     1741 gcagctaaga gtaatgatga tttagatgtg tctgaatcaa aaggttgtat ggaagaaaaa
     1801 ccacaggaag tacaaacttc taggaatgtt gaaagtattg ctgaacagat ggaaaatccg
     1861 gatttgaaga atgttggttc tagtactggg gagaaaaatg aaagaacttc agtggctgga
     1921 acagtgagaa aatgctggcc taatagagtg gcaaaggagc agattagtag gcggcttgat
     1981 ggtaatcagt atctgttttt gccaccaaat cgttacattt tccatggcgc tgaggtatat
     2041 tcagactctg aagatgacgt cttatcctct agttcttgtg gcagtaacag tgatagtggg
     2101 acatgccaga gtccaagttt agaagaaccc atggaggatg aaagtgaaat tgaagaattc
     2161 tacaatggct tagaagatga gcctgatgtt ccagagagag ctggaggagc tggatttggg
     2221 actgatggag atgatcaaga ggcaattaat gaagctatat ctgtgaaaca ggaagtaaca
     2281 gacatgaact atccatcaaa caaatcatag tgtaataatt gtgcaggtac aggaattgtt
     2341 ccaccagcat taggaacttt agcatgtcaa aatgaatgtt tacttgtgaa ctcgatagag
     2401 caaggaaacc agaaaggtgt aatatttata ggttggtaaa atagattgtt tttcatggat
     2461 aatttttaac ttcattattt ctgtacttgt acaaactcaa cactaacttt ttttttttta
     2521 aaaaaaaaaa ggtactaagt atcttcaatc agctgttggt caagactaac tttcttttaa
     2581 aggttcattt gtatgataaa ttcatatgtg tatatataat tttttttgtt ttgtctagtg
     2641 agtttcaaca tttttaaagt tttcaaaaag ccatcggaat gttaaattaa tgtaaaggga
     2701 acagctaatc tagaccaaag aatggtattt tcacttttct ttgtaacatt gaatggtttg
     2761 aagtactcaa aatctgttac gctaaacttt tgattcttta acacaattat ttttaaacac
     2821 tggcattttc caaaactgtg gcagctaact ttttaaaatc tcaaatgaca tgcagtgtga
     2881 gtagaaggaa gtcaacaata tgtggggaga gcactcggtt gtctttactt ttaaaagtaa
     2941 tacttggtgc taagaatttc aggattattg tatttacgtt caaatgaaga tggcttttgt
     3001 acttcctgtg gacatgtagc aatgtctata ttggctcata aaactaacct gaaaaacaaa
     3061 taaatgcttt ggaaatgttt cagttgcttt agaaacatta gtgcctgcct ggatcccctt
     3121 agttttgaaa tatttgccat tgttgtttaa atacctatca ctgtggtaga gcttgcattg
     3181 atcttttcca caagtattaa actgccaaaa tgtgaatatg caaagccttt ctgaatctat
     3241 aataatggta cttctactgg ggagagtgta atattttgga ctgctgtttt ccattaatga
     3301 ggagagcaac aggcccctga ttatacagtt ccaaagtaat aagatgttaa ttgtaattca
     3361 gccagaaagt acatgtctcc cattgggagg atttggtgtt aaataccaaa ctgctagccc
     3421 tagtattatg gagatgaaca tgatgatgta acttgtaata gcagaatagt taatgaatga
     3481 aactagttct tataatttat ctttatttaa aagcttagcc tgccttaaaa ctagagatca
     3541 actttctcag ctgcaaaagc ttctagtctt tcaagaagtt catactttat gaaattgcac
     3601 agtaagcatt tatttttcag accatttttg aacatcactc ctaaattaat aaagtattcc
     3661 tctgttgctt tagtatttat tacaataaaa agggtttgaa atatagctgt tctttatgca
     3721 taaaacaccc agctaggacc attactgcca gagaaaaaaa tcgtattgaa tggccatttc
     3781 cctacttata agatgtctca atctgaattt atttggctac actaaagaat gcagtatatt
     3841 tagttttcca tttgcatgat gtttgtgtgc tatagatgat attttaaatt gaaaagtttg
     3901 ttttaaatta tttttacagt gaagactgtt ttcagctctt tttatattgt acatagtctt
     3961 ttatgtaatt tactggcata tgttttgtag actgtttaat gactggatat cttccttcaa
     4021 cttttgaaat acaaaaccag tgttttttac ttgtacactg ttttaaagtc tattaaaatt
     4081 gtcatttgac ttttttctgt taactta
//
