LOCUS       NM_018556               1716 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens signal regulatory protein gamma (SIRPG), transcript
            variant 1, mRNA.
ACCESSION   NM_018556
VERSION     NM_018556.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1716)
  AUTHORS   Smith,M.J., Pastor,L., Newman,J.R.B. and Concannon,P.
  TITLE     Genetic Control of Splicing at SIRPG Modulates Risk of Type 1
            Diabetes
  JOURNAL   Diabetes 71 (2), 350-358 (2022)
   PUBMED   34799406
  REMARK    GeneRIF: Genetic Control of Splicing at SIRPG Modulates Risk of
            Type 1 Diabetes.
REFERENCE   2  (bases 1 to 1716)
  AUTHORS   Sinha,S., Renavikar,P.S., Crawford,M.P., Steward-Tharp,S.M.,
            Brate,A., Tsalikian,E., Tansey,M., Shivapour,E.T., Cho,T.,
            Kamholz,J. and Karandikar,N.J.
  TITLE     Altered expression of SIRPgamma on the T-cells of relapsing
            remitting multiple sclerosis and type 1 diabetes patients could
            potentiate effector responses from T-cells
  JOURNAL   PLoS One 15 (8), e0238070 (2020)
   PUBMED   32853219
  REMARK    GeneRIF: Altered expression of SIRPgamma on the T-cells of
            relapsing remitting multiple sclerosis and type 1 diabetes patients
            could potentiate effector responses from T-cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1716)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1716)
  AUTHORS   Sinha,S., Borcherding,N., Renavikar,P.S., Crawford,M.P.,
            Tsalikian,E., Tansey,M., Shivapour,E.T., Bittner,F., Kamholz,J.,
            Olalde,H., Gibson,E. and Karandikar,N.J.
  TITLE     An autoimmune disease risk SNP, rs2281808, in SIRPG is associated
            with reduced expression of SIRPgamma and heightened effector state
            in human CD8 T-cells
  JOURNAL   Sci Rep 8 (1), 15440 (2018)
   PUBMED   30337675
  REMARK    GeneRIF: The SNP rs2281808 TT variant reduced SIRPgamma expression
            on T-cells. SIRPgamma(low) CD8 T-cells in CT and TT individuals
            were in a heightened effector state with lower activation threshold
            and had greater gene expression of molecules associated with
            migratory and cytotoxic potential.  SIRPgamma(low) CD8 T-cells were
            deficient in transcription factors associated with long-term
            functional memory formation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1716)
  AUTHORS   Lu,C., Xu,M., Wang,R., Qin,Y., Wang,Y., Wu,W., Song,L., Wang,S.,
            Shen,H., Sha,J., Miao,D., Hu,Z., Xia,Y. and Wang,X.
  TITLE     Pathogenic variants screening in five non-obstructive
            azoospermia-associated genes
  JOURNAL   Mol Hum Reprod 20 (2), 178-183 (2014)
   PUBMED   24162948
  REMARK    GeneRIF: The independent non-obstructive azoospermia risk alleles
            are driven by variants in the protein-coding sequence of the two
            genes, SIRPA and SIRPG.
REFERENCE   6  (bases 1 to 1716)
  AUTHORS   van den Berg,T.K., van Beek,E.M., Buhring,H.J., Colonna,M.,
            Hamaguchi,M., Howard,C.J., Kasuga,M., Liu,Y., Matozaki,T.,
            Neel,B.G., Parkos,C.A., Sano,S., Vignery,A., Vivier,E., Wright,M.,
            Zawatzky,R. and Barclay,A.N.
  TITLE     A nomenclature for signal regulatory protein family members
  JOURNAL   J Immunol 175 (12), 7788-7789 (2005)
   PUBMED   16339511
REFERENCE   7  (bases 1 to 1716)
  AUTHORS   Piccio,L., Vermi,W., Boles,K.S., Fuchs,A., Strader,C.A.,
            Facchetti,F., Cella,M. and Colonna,M.
  TITLE     Adhesion of human T cells to antigen-presenting cells through
            SIRPbeta2-CD47 interaction costimulates T-cell proliferation
  JOURNAL   Blood 105 (6), 2421-2427 (2005)
   PUBMED   15383453
REFERENCE   8  (bases 1 to 1716)
  AUTHORS   Brooke,G., Holbrook,J.D., Brown,M.H. and Barclay,A.N.
  TITLE     Human lymphocytes interact directly with CD47 through a novel
            member of the signal regulatory protein (SIRP) family
  JOURNAL   J Immunol 173 (4), 2562-2570 (2004)
   PUBMED   15294972
  REMARK    GeneRIF: a novel member of the signal regulatory protein (SIRP)
            family- with unique characteristics from both alpha and beta genes-
            termed SIRPgamma
REFERENCE   9  (bases 1 to 1716)
  AUTHORS   Ichigotani,Y., Matsuda,S., Machida,K., Oshima,K., Iwamoto,T.,
            Yamaki,K., Hayakawa,T. and Hamaguchi,M.
  TITLE     Molecular cloning of a novel human gene (SIRP-B2) which encodes a
            new member of the SIRP/SHPS-1 protein family
  JOURNAL   J Hum Genet 45 (6), 378-382 (2000)
   PUBMED   11185750
REFERENCE   10 (bases 1 to 1716)
  AUTHORS   Kharitonenkov,A., Chen,Z., Sures,I., Wang,H., Schilling,J. and
            Ullrich,A.
  TITLE     A family of proteins that inhibit signalling through tyrosine
            kinase receptors
  JOURNAL   Nature 386 (6621), 181-186 (1997)
   PUBMED   9062191
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA008008.1, BC064532.1,
            AY748247.1, DB046293.1 and AA446468.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018556.3.
            
            Summary: The protein encoded by this gene is a member of the
            signal-regulatory protein (SIRP) family, and also belongs to the
            immunoglobulin superfamily. SIRP family members are receptor-type
            transmembrane glycoproteins known to be involved in the negative
            regulation of receptor tyrosine kinase-coupled signaling processes.
            Alternatively spliced transcript variants encoding different
            isoforms have been described. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292745.1, BC064532.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000303415.7/ ENSP00000305529.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                DA008008.1         4-42
            40-1159             BC064532.1         1-1120
            1160-1229           AY748247.1         762-831
            1230-1423           DB046293.1         263-456
            1424-1716           AA446468.1         5-297               c
FEATURES             Location/Qualifiers
     source          1..1716
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..1716
                     /gene="SIRPG"
                     /gene_synonym="bA77C3.1; CD172g; SIRP-B2; SIRPB2;
                     SIRPgamma"
                     /note="signal regulatory protein gamma"
                     /db_xref="GeneID:55423"
                     /db_xref="HGNC:HGNC:15757"
                     /db_xref="MIM:605466"
     exon            1..138
                     /gene="SIRPG"
                     /gene_synonym="bA77C3.1; CD172g; SIRP-B2; SIRPB2;
                     SIRPgamma"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..1229
                     /gene="SIRPG"
                     /gene_synonym="bA77C3.1; CD172g; SIRP-B2; SIRPB2;
                     SIRPgamma"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; CD172g antigen; SIRP beta 2; SIRP-gamma;
                     signal-regulatory protein beta-2; CD172 antigen-like
                     family member B"
                     /codon_start=1
                     /product="signal-regulatory protein gamma isoform 1
                     precursor"
                     /protein_id="NP_061026.2"
                     /db_xref="CCDS:CCDS13020.2"
                     /db_xref="GeneID:55423"
                     /db_xref="HGNC:HGNC:15757"
                     /db_xref="MIM:605466"
                     /translation="MPVPASWPHPPGPFLLLTLLLGLTEVAGEEELQMIQPEKLLLVT
                     VGKTATLHCTVTSLLPVGPVLWFRGVGPGRELIYNQKEGHFPRVTTVSDLTKRNNMDF
                     SIRISSITPADVGTYYCVKFRKGSPENVEFKSGPGTEMALGAKPSAPVVLGPAARTTP
                     EHTVSFTCESHGFSPRDITLKWFKNGNELSDFQTNVDPTGQSVAYSIRSTARVVLDPW
                     DVRSQVICEVAHVTLQGDPLRGTANLSEAIRVPPTLEVTQQPMRVGNQVNVTCQVRKF
                     YPQSLQLTWSENGNVCQRETASTLTENKDGTYNWTSWFLVNISDQRDDVVLTCQVKHD
                     GQLAVSKRLALEVTVHQKDQSSDATPGPASSLTALLLIAVLLGPIYVPWKQKT"
     exon            139..495
                     /gene="SIRPG"
                     /gene_synonym="bA77C3.1; CD172g; SIRP-B2; SIRPB2;
                     SIRPgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            496..813
                     /gene="SIRPG"
                     /gene_synonym="bA77C3.1; CD172g; SIRP-B2; SIRPB2;
                     SIRPgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            814..1146
                     /gene="SIRPG"
                     /gene_synonym="bA77C3.1; CD172g; SIRP-B2; SIRPB2;
                     SIRPgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1231
                     /gene="SIRPG"
                     /gene_synonym="bA77C3.1; CD172g; SIRP-B2; SIRPB2;
                     SIRPgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1716
                     /gene="SIRPG"
                     /gene_synonym="bA77C3.1; CD172g; SIRP-B2; SIRPB2;
                     SIRPgamma"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1697..1702
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIRPG"
                     /gene_synonym="bA77C3.1; CD172g; SIRP-B2; SIRPB2;
                     SIRPgamma"
                     /note="hexamer: AATAAA"
     polyA_site      1716
                     /gene="SIRPG"
                     /gene_synonym="bA77C3.1; CD172g; SIRP-B2; SIRPB2;
                     SIRPgamma"
                     /note="major polyA site"
ORIGIN      
        1 agagcagggc ctgacatctc cccagaacag acgtttgaac agagcaggct tctgaggtct
       61 ccaaaatgcc tgtcccagcc tcctggcccc atcctcctgg tcctttcctg cttctgactc
      121 tactgctggg acttacagaa gtggcaggtg aggaggagct acagatgatt cagcctgaga
      181 agctcctgtt ggtcacagtt ggaaagacag ccactctgca ctgcactgtg acctccctgc
      241 ttcccgtggg acccgtcctg tggttcagag gagttggacc aggccgggaa ttaatctaca
      301 atcaaaaaga aggccacttc cccagggtaa caacagtttc agacctcaca aagagaaaca
      361 acatggactt ttccatccgc atcagtagca tcaccccagc agatgtcggc acatactact
      421 gtgtgaagtt tcgaaaaggg agccctgaga acgtggagtt taagtctgga ccaggcactg
      481 agatggcttt gggtgccaaa ccctctgccc ccgtggtatt gggccctgcg gcgaggacca
      541 cacctgagca tacagtgagt ttcacctgtg agtcccatgg cttctctccc agagacatca
      601 ccctgaaatg gttcaaaaat gggaatgagc tctcagactt ccagaccaac gtggacccca
      661 caggacagag tgtggcctac agcatccgca gcacagccag ggtggtactg gacccctggg
      721 acgttcgctc tcaggtcatc tgcgaggtgg cccatgtcac cttgcagggg gaccctcttc
      781 gtgggactgc caacttgtct gaggccatcc gagttccacc caccttggag gttactcaac
      841 agcccatgag ggtggggaac caggtaaacg tcacctgcca ggtgaggaag ttctaccccc
      901 agagcctaca gctgacctgg tcggagaatg gaaacgtgtg ccagagagaa acagcctcga
      961 cccttacaga gaacaaggat ggtacctaca actggacaag ctggttcctg gtgaacatat
     1021 ctgaccaaag ggatgatgtg gtcctcacct gccaggtgaa gcatgatggg cagctggcgg
     1081 tcagcaaacg ccttgcccta gaggtcacag tccaccagaa ggaccagagc tcagatgcta
     1141 cccctggccc ggcatcatcc cttactgcgc tgctcctcat agctgtcctc ctgggcccca
     1201 tctacgtccc ctggaagcag aagacctgac tctccttcct tcctcccctg ccacgtggga
     1261 ccctcatctc tgctgcctcc ttcctttcct gagaggctca gcttgagaga atgagccagt
     1321 gagaagcttc tctagacttg gctccaaaca tctcccctcc caagacatct gcctgcccac
     1381 aggctcctgt tgctccttca cacagacctg gatgccccag agcaaggtct tcattcatgg
     1441 tcctgagcag gtgccatggg attgggctct gggcactgac ttaacggcac ctccctagaa
     1501 ggcgagaaac atgccaaatc taaacacacc aggactccca tccatcgcct tgagactgac
     1561 cgtaaaccac agacgctctc caggttctca agagttatcc tgccttccag attcctgcct
     1621 atcccaactc cccagccttg ttgaggttct ctattgcctc ttgaatacaa atgcactccc
     1681 aaagtggttt taagaaaata aaaagattat ccttcc
//
