LOCUS       NM_001122962            2679 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens signal regulatory protein beta 2 (SIRPB2), transcript
            variant 1, mRNA.
ACCESSION   NM_001122962 XM_001724775 XM_209363 XM_939897
VERSION     NM_001122962.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2679)
  AUTHORS   Song,Q., Qin,S., Pascal,L.E., Zou,C., Wang,W., Tong,H., Zhang,J.,
            Catalona,W.J., Dhir,R., Morrell,M., Balasubramani,G.K., Lu,Y. and
            Wang,Z.
  TITLE     SIRPB1 promotes prostate cancer cell proliferation via Akt
            activation
  JOURNAL   Prostate 80 (4), 352-364 (2020)
   PUBMED   31905248
  REMARK    GeneRIF: Results suggest that SIRPB1 is a potential oncogene
            capable of activating Akt signaling to stimulate prostate cancer
            proliferation and could be a biomarker for patients at risk of
            developing aggressive prostate cancer.
REFERENCE   2  (bases 1 to 2679)
  AUTHORS   Reiner,A.P., Hartiala,J., Zeller,T., Bis,J.C., Dupuis,J.,
            Fornage,M., Baumert,J., Kleber,M.E., Wild,P.S., Baldus,S.,
            Bielinski,S.J., Fontes,J.D., Illig,T., Keating,B.J., Lange,L.A.,
            Ojeda,F., Muller-Nurasyid,M., Munzel,T.F., Psaty,B.M., Rice,K.,
            Rotter,J.I., Schnabel,R.B., Tang,W.H., Thorand,B., Erdmann,J.,
            Jacobs,D.R. Jr., Wilson,J.G., Koenig,W., Tracy,R.P.,
            Blankenberg,S., Marz,W., Gross,M.D., Benjamin,E.J., Hazen,S.L. and
            Allayee,H.
  CONSRTM   CARDIoGRAM Consortium
  TITLE     Genome-wide and gene-centric analyses of circulating
            myeloperoxidase levels in the charge and care consortia
  JOURNAL   Hum Mol Genet 22 (16), 3381-3393 (2013)
   PUBMED   23620142
REFERENCE   3  (bases 1 to 2679)
  AUTHORS   Nyati,M.K., Feng,F.Y., Maheshwari,D., Varambally,S., Zielske,S.P.,
            Ahsan,A., Chun,P.Y., Arora,V.A., Davis,M.A., Jung,M., Ljungman,M.,
            Canman,C.E., Chinnaiyan,A.M. and Lawrence,T.S.
  TITLE     Ataxia telangiectasia mutated down-regulates phospho-extracellular
            signal-regulated kinase 1/2 via activation of MKP-1 in response to
            radiation
  JOURNAL   Cancer Res 66 (24), 11554-11559 (2006)
   PUBMED   17178844
  REMARK    GeneRIF: Relationship between ATM kinase and extracellular
            signal-regulated kinase 1/2 (ERK1/2), a key mitogenic stimulator.
REFERENCE   4  (bases 1 to 2679)
  AUTHORS   Barclay,A.N. and Brown,M.H.
  TITLE     The SIRP family of receptors and immune regulation
  JOURNAL   Nat Rev Immunol 6 (6), 457-464 (2006)
   PUBMED   16691243
  REMARK    Review article
REFERENCE   5  (bases 1 to 2679)
  AUTHORS   van den Berg,T.K., van Beek,E.M., Buhring,H.J., Colonna,M.,
            Hamaguchi,M., Howard,C.J., Kasuga,M., Liu,Y., Matozaki,T.,
            Neel,B.G., Parkos,C.A., Sano,S., Vignery,A., Vivier,E., Wright,M.,
            Zawatzky,R. and Barclay,A.N.
  TITLE     A nomenclature for signal regulatory protein family members
  JOURNAL   J Immunol 175 (12), 7788-7789 (2005)
   PUBMED   16339511
REFERENCE   6  (bases 1 to 2679)
  AUTHORS   Chen,J., Sun,M., Lee,S., Zhou,G., Rowley,J.D. and Wang,S.M.
  TITLE     Identifying novel transcripts and novel genes in the human genome
            by using novel SAGE tags
  JOURNAL   Proc Natl Acad Sci U S A 99 (19), 12257-12262 (2002)
   PUBMED   12213963
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC313096.1, AK095499.1, AY424277.1, DC358609.1, BM285394.1,
            AL109658.5 and BG539998.1.
            
            On May 17, 2019 this sequence version replaced NM_001122962.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The extent of this transcript
            is supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.132123.1,
                                           DRR138524.794375.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA2147920
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359801.8/ ENSP00000352849.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                DC313096.1         66-89
            25-118              AK095499.1         1-94
            119-218             AY424277.1         58-157
            219-380             AK095499.1         195-356
            381-571             DC358609.1         411-601
            572-704             AK095499.1         548-680
            705-712             BM285394.1         873-880
            713-1612            AK095499.1         689-1588
            1613-1613           AL109658.5         98646-98646         c
            1614-1649           AK095499.1         1590-1625
            1650-1650           AL109658.5         98609-98609         c
            1651-2164           AK095499.1         1627-2140
            2165-2182           BG539998.1         493-510
            2183-2317           AK095499.1         2155-2289
            2318-2380           BG539998.1         645-707
            2381-2666           AK095499.1         2353-2638
            2667-2679           AL109658.5         97580-97592         c
FEATURES             Location/Qualifiers
     source          1..2679
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..2679
                     /gene="SIRPB2"
                     /gene_synonym="dJ776F14.2; PTPN1L; PTPNS1L3"
                     /note="signal regulatory protein beta 2"
                     /db_xref="GeneID:284759"
                     /db_xref="HGNC:HGNC:16247"
     exon            1..146
                     /gene="SIRPB2"
                     /gene_synonym="dJ776F14.2; PTPN1L; PTPNS1L3"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..1090
                     /gene="SIRPB2"
                     /gene_synonym="dJ776F14.2; PTPN1L; PTPNS1L3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protein tyrosine phosphatase, non-receptor type
                     substrate 1-like 3; SIRP-beta-2; protein tyrosine
                     phosphatase non-receptor type substrate protein"
                     /codon_start=1
                     /product="signal-regulatory protein beta-2 isoform 1
                     precursor"
                     /protein_id="NP_001116434.1"
                     /db_xref="CCDS:CCDS42849.1"
                     /db_xref="GeneID:284759"
                     /db_xref="HGNC:HGNC:16247"
                     /translation="MCSTMSAPTCLAHLPPCFLLLALVLVPSDASGQSSRNDWQVLQP
                     EGPMLVAEGETLLLRCMVVGSCTDGMIKWVKVSTQDQQEIYNFKRGSFPGVMPMIQRT
                     SEPLNCDYSIYIHNVTREHTGTYHCVRFDGLSEHSEMKSDEGTSVLVKGAGDPEPDLW
                     IIQPQELVLGTTGDTVFLNCTVLGDGPPGPIRWFQGAGLSREAIYNFGGISHPKETAV
                     QASNNDFSILLQNVSSEDAGTYYCVKFQRKPNRQYLSGQGTSLKVKAKSTSSKEAEFT
                     SEPATEMSPTGLLVVFAPVVLGLKAITLAALLLALATSRRSPGQEDVKTTGPAGAMNT
                     LAWSKGQE"
     exon            147..512
                     /gene="SIRPB2"
                     /gene_synonym="dJ776F14.2; PTPN1L; PTPNS1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            513..854
                     /gene="SIRPB2"
                     /gene_synonym="dJ776F14.2; PTPN1L; PTPNS1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            855..920
                     /gene="SIRPB2"
                     /gene_synonym="dJ776F14.2; PTPN1L; PTPNS1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            921..2679
                     /gene="SIRPB2"
                     /gene_synonym="dJ776F14.2; PTPN1L; PTPNS1L3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agactccaac actcacaaga gagcagagga gccccaagtc ttggggacca cagaagatgc
       61 catgtgctcc acgatgtcgg cccccacctg cctggcccac ttgcctccct gcttcctgct
      121 gctggcactg gtccttgtcc cctcagatgc ctctgggcag agcagcagga atgactggca
      181 ggtgctacag cccgagggcc ccatgctggt ggcagaaggt gagacacttc tactgaggtg
      241 tatggtggtc ggctcctgca ctgatggtat gataaaatgg gtgaaggtga gcactcagga
      301 ccaacaggaa atttataact ttaaacgtgg ctccttccct ggggtaatgc ccatgatcca
      361 acggacatca gaaccactga attgtgatta ttccatctat atccacaatg tcaccaggga
      421 gcacactgga acctaccact gtgtgaggtt tgatggtttg agtgaacact cagaaatgaa
      481 atcggatgaa ggcacctcag tgcttgtgaa gggagctggg gaccctgaac cagacctgtg
      541 gatcatccag ccccaggaat tggtgttggg gaccactgga gacactgtct ttctgaactg
      601 cacagtgctt ggagacggtc cccctggacc catcaggtgg ttccagggag ctggtctgag
      661 ccgggaggcc atttacaact ttggaggcat ctcccacccc aaggagacag cggtgcaggc
      721 ctccaacaat gacttcagca ttcttctgca aaacgtctcc agtgaggatg caggcaccta
      781 ttactgtgta aagtttcaga ggaaacccaa caggcaatac ctgtctggac agggcaccag
      841 cctgaaagtg aaagcaaaat ctacctcttc caaagaggca gaattcacca gtgaacctgc
      901 aactgagatg tctccaacag gcctcctggt tgtgttcgca cctgtggtcc tggggctgaa
      961 ggcaattacc ttggctgcac tcctactggc cctggctacc tctcggagga gccctgggca
     1021 agaagatgtc aagaccacag gcccagcagg agccatgaac accttagcat ggagcaaggg
     1081 tcaagagtga ggggtcagcc ccagagtgag gaccctctga gttggagagg agccagggct
     1141 cctcaaccat ttccctacct ccagtcccag cctctaggtg cccccaggcc tcatgacaaa
     1201 ctcctagatc cctacatctg gttttggtcc acctagtgaa attcccttct ttgcaccggg
     1261 cttccctcta aaatgtctcc ctttctcttt ttggcctgtt caagacctcc ttgcttttca
     1321 gtccctggct cagtctctcc tcaacaccct tgcccctgct gcagcccttt ctggtgcgcc
     1381 ctgccccttt ccccacctcg ctacatcctt cttggcctcc aacatccaac tcagagtctt
     1441 cttcccagga gatgtctgta agaatctctg aactcaacca gccagaccat ctgtgcccct
     1501 ccatctacac ctttctcccc actccttcct gccttccttc catccccctc atggctggct
     1561 tgggcaggta taatattaga atgcaggttc agcaactata acaaagctct taaataacag
     1621 tggcttaaac cagtggaaat caaccagaaa gttgaccatc agcaggccaa gcaatacaga
     1681 gactccctgg tattgagacc caggattcac tgatctcatt gctaccaggt ccaccttcta
     1741 ggcagccaga ctggaaaaga gggcaggaaa ggggagcagg accctcccct ttaagtgcac
     1801 agtcaggaac ttggccacct cacttatctc tacttggctg gaatgtggtc acatggtcac
     1861 acctagctgc aagaaacact gggagatgta gtctttattt ctggcagcaa tgcgcccagc
     1921 tgcaagtttt cactagagaa accagatggc agatatcagg ggataaccag ttatctccac
     1981 cacagcagca tacagacagc ctctcacctg ccctgtggga cacctgagtt caatgcccag
     2041 ctagctagcc agcacttctt cccactatca cctcccctgg ggcagcatga tgtggggcag
     2101 tagttcccaa gatgagtgat tttgccccca ctggactttt ggcaatgtct agagatgttt
     2161 ttggttggca caacctgggg gggtgctacc accatctagt ggactgagaa gccctgacat
     2221 ggggaagagt gtgcatgccc aggagtcaga cacacctgcc tttaaccctg aggcctctgc
     2281 ctcctccctg tgcaccctca gtgactaatc agagtccctt cccatcacgg aacatccagg
     2341 atactaatgt ggacttctct gcattgtgta agaaccaatt caagaccagg cacggtggct
     2401 tatgcatgta atcccagcac tttgggaggc cgaggtgggt ggatcacctg agttcaggag
     2461 tttgagacca gcctggctaa catggtgaaa cctcgtctct actaaaaata caaaaaatta
     2521 gccaggcgtg gtggtgtgca cctgtaatcc cagctacttg ggaggatggg gcaggagaac
     2581 cgcttgaact gggaggcaga ggctgcagtg agctgagatc gcgccattgc actccagcct
     2641 gggcaacaag agcaaaactc cgtctcaaaa aaaaaaaaa
//
