LOCUS       NM_006065               5377 bp    mRNA    linear   PRI 19-MAR-2025
DEFINITION  Homo sapiens signal regulatory protein beta 1 (SIRPB1), transcript
            variant 1, mRNA.
ACCESSION   NM_006065
VERSION     NM_006065.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5377)
  AUTHORS   Geng,R., Zhao,Y., Xu,W., Ma,X., Jiang,Y., Han,X., Zhao,L. and Li,Y.
  TITLE     SIRPB1 regulates inflammatory factor expression in the glioma
            microenvironment via SYK: functional and bioinformatics insights
  JOURNAL   J Transl Med 22 (1), 338 (2024)
   PUBMED   38594692
  REMARK    GeneRIF: SIRPB1 regulates inflammatory factor expression in the
            glioma microenvironment via SYK: functional and bioinformatics
            insights.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5377)
  AUTHORS   Garcia-Alberca,J.M., de Rojas,I., Sanchez-Mejias,E.,
            Garrido-Martin,D., Gonzalez-Palma,L., Jimenez,S., Pino-Angeles,A.,
            Cruz-Gamero,J.M., Mendoza,S., Alarcon-Martin,E., Munoz-Castro,C.,
            Real,L.M., Tena,J.J., Polvillo,R., Govantes,F., Lopez,A.,
            Royo-Aguado,J.L., Navarro,V., Gonzalez,I., Ruiz,M., Reyes-Engel,A.,
            Gris,E., Bravo,M.J., Lopez-Gutierrez,L., Mejias-Ortega,M., De la
            Guia,P., Lopez de la Rica,M., Ocejo,O., Torrecilla,J., Zafra,C.,
            Nieto,M.D., Urbano,C., Jimenez-Sanchez,R., Pareja,N., Luque,M.,
            Garcia-Peralta,M., Carrillejo,R., Furniet,M.D.C., Rueda,L.,
            Sanchez-Fernandez,A., Mancilla,T., Pena,I., Garcia-Casares,N.,
            Moreno-Grau,S., Hernandez,I., Montrreal,L., Quintela,I.,
            Gonzalez-Perez,A., Calero,M., Franco-Macias,E., Macias,J.,
            Menendez-Gonzalez,M., Frank-Garcia,A., Huerto Vilas,R.,
            Diez-Fairen,M., Lage,C., Garcia-Madrona,S., Garcia-Gonzalez,P.,
            Valero,S., Sotolongo-Grau,O., Perez-Cordon,A., Rabano,A., Arias
            Pastor,A., Pastor,A.B., Espinosa,A., Corma-Gomez,A., Martin
            Montes,A., Sanabria,A., Martinez Rodriguez,C., Buiza-Rueda,D.,
            Rodriguez-Rodriguez,E., Ortega,G., Alvarez,I., Rosas Allende,I.,
            Pineda,J.A., Rosende-Roca,M., Bernal Sanchez-Arjona,M.,
            Fernandez-Fuertes,M., Alegret,M., Roberto,N., Del Ser,T.,
            Garcia-Ribas,G., Sanchez-Juan,P., Pastor,P., Pinol-Ripoll,G.,
            Bullido,M.J., Alvarez,V., Mir,P., Medina,M., Marquie,M., Saez,M.E.,
            Carracedo,A., Laplana,M., Tomas-Gallardo,L., Orellana,A.,
            Tarraga,L., Boada,M., Fibla Palazon,J., Vitorica,J., Ruiz,A.,
            Guigo,R., Gutierrez,A. and Royo,J.L.
  CONSRTM   GERALD consortium
  TITLE     An Insertion Within SIRPbeta1 Shows a Dual Effect Over Alzheimer's
            Disease Cognitive Decline Altering the Microglial Response
  JOURNAL   J Alzheimers Dis 98 (2), 601-618 (2024)
   PUBMED   38427484
  REMARK    GeneRIF: An Insertion Within SIRPbeta1 Shows a Dual Effect Over
            Alzheimer's Disease Cognitive Decline Altering the Microglial
            Response.
REFERENCE   3  (bases 1 to 5377)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5377)
  AUTHORS   Ribeiro,G.E., Leon,L.E., Perez,R., Cuiza,A., Vial,P.A., Ferres,M.,
            Mertz,G.J. and Vial,C.
  TITLE     Deletions in Genes Participating in Innate Immune Response Modify
            the Clinical Course of Andes Orthohantavirus Infection
  JOURNAL   Viruses 11 (8), 680 (2019)
   PUBMED   31349540
  REMARK    GeneRIF: Deletions in Genes Participating in Innate Immune Response
            Modify the Clinical Course of Andes Orthohantavirus Infection.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5377)
  AUTHORS   Zhang,H., Li,F., Yang,Y., Chen,J. and Hu,X.
  TITLE     SIRP/CD47 signaling in neurological disorders
  JOURNAL   Brain Res 1623, 74-80 (2015)
   PUBMED   25795378
  REMARK    Review article
REFERENCE   6  (bases 1 to 5377)
  AUTHORS   Chen,J., Sun,M., Lee,S., Zhou,G., Rowley,J.D. and Wang,S.M.
  TITLE     Identifying novel transcripts and novel genes in the human genome
            by using novel SAGE tags
  JOURNAL   Proc Natl Acad Sci U S A 99 (19), 12257-12262 (2002)
   PUBMED   12213963
REFERENCE   7  (bases 1 to 5377)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   8  (bases 1 to 5377)
  AUTHORS   Tomasello,E., Cant,C., Buhring,H.J., Vely,F., Andre,P.,
            Seiffert,M., Ullrich,A. and Vivier,E.
  TITLE     Association of signal-regulatory proteins beta with KARAP/DAP-12
  JOURNAL   Eur J Immunol 30 (8), 2147-2156 (2000)
   PUBMED   10940905
REFERENCE   9  (bases 1 to 5377)
  AUTHORS   Dietrich,J., Cella,M., Seiffert,M., Buhring,H.J. and Colonna,M.
  TITLE     Cutting edge: signal-regulatory protein beta 1 is a
            DAP12-associated activating receptor expressed in myeloid cells
  JOURNAL   J Immunol 164 (1), 9-12 (2000)
   PUBMED   10604985
REFERENCE   10 (bases 1 to 5377)
  AUTHORS   Kharitonenkov,A., Chen,Z., Sures,I., Wang,H., Schilling,J. and
            Ullrich,A.
  TITLE     A family of proteins that inhibit signalling through tyrosine
            kinase receptors
  JOURNAL   Nature 386 (6621), 181-186 (1997)
   PUBMED   9062191
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA761891.1, BM010247.1,
            Y10376.1, BC025286.1, BP295274.1, AL049634.8, DA331023.1 and
            BP268958.1.
            
            On Nov 30, 2019 this sequence version replaced NM_006065.4.
            
            Summary: The protein encoded by this gene is a member of the
            signal-regulatory-protein (SIRP) family, and also belongs to the
            immunoglobulin superfamily. SIRP family members are receptor-type
            transmembrane glycoproteins known to be involved in the negative
            regulation of receptor tyrosine kinase-coupled signaling processes.
            This protein was found to interact with TYROBP/DAP12, a protein
            bearing immunoreceptor tyrosine-based activation motifs. This
            protein was also reported to participate in the recruitment of
            tyrosine kinase SYK. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Feb 2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1). Isoforms 1 and 3
            are the same length but differ in their amino acid sequences.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.2504372.1,
                                           SRR14038197.2476356.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381605.9/ ENSP00000371018.5
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               DA761891.1         88-218
            132-132             BM010247.1         120-120
            133-368             Y10376.1           108-343
            369-369             BC025286.1         356-356
            370-751             Y10376.1           345-726
            752-752             BP295274.1         262-262
            753-1114            Y10376.1           728-1089
            1115-1115           AL049634.8         74705-74705         c
            1116-1151           Y10376.1           1091-1126
            1152-1152           DA331023.1         498-498
            1153-1790           BC025286.1         489-1126
            1791-2209           BP268958.1         94-512
            2210-2379           BC025286.1         1546-1715
            2380-5377           AL049634.8         65251-68248         c
FEATURES             Location/Qualifiers
     source          1..5377
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..5377
                     /gene="SIRPB1"
                     /gene_synonym="CD172b; SIRB1; SIRP-BETA-1"
                     /note="signal regulatory protein beta 1"
                     /db_xref="GeneID:10326"
                     /db_xref="HGNC:HGNC:15928"
                     /db_xref="MIM:603889"
     exon            1..141
                     /gene="SIRPB1"
                     /gene_synonym="CD172b; SIRB1; SIRP-BETA-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..1262
                     /gene="SIRPB1"
                     /gene_synonym="CD172b; SIRB1; SIRP-BETA-1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; CD172 antigen-like family member B"
                     /codon_start=1
                     /product="signal-regulatory protein beta-1 isoform 1
                     precursor"
                     /protein_id="NP_006056.2"
                     /db_xref="CCDS:CCDS13019.1"
                     /db_xref="GeneID:10326"
                     /db_xref="HGNC:HGNC:15928"
                     /db_xref="MIM:603889"
                     /translation="MPVPASWPHLPSPFLLMTLLLGRLTGVAGEDELQVIQPEKSVSV
                     AAGESATLRCAMTSLIPVGPIMWFRGAGAGRELIYNQKEGHFPRVTTVSELTKRNNLD
                     FSISISNITPADAGTYYCVKFRKGSPDDVEFKSGAGTELSVRAKPSAPVVSGPAVRAT
                     PEHTVSFTCESHGFSPRDITLKWFKNGNELSDFQTNVDPAGDSVSYSIHSTARVVLTR
                     GDVHSQVICEIAHITLQGDPLRGTANLSEAIRVPPTLEVTQQPMRAENQANVTCQVSN
                     FYPRGLQLTWLENGNVSRTETASTLIENKDGTYNWMSWLLVNTCAHRDDVVLTCQVEH
                     DGQQAVSKSYALEISAHQKEHGSDITHEAALAPTAPLLVALLLGPKLLLVVGVSAIYI
                     CWKQKA"
     exon            142..498
                     /gene="SIRPB1"
                     /gene_synonym="CD172b; SIRB1; SIRP-BETA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            499..816
                     /gene="SIRPB1"
                     /gene_synonym="CD172b; SIRB1; SIRP-BETA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            817..1149
                     /gene="SIRPB1"
                     /gene_synonym="CD172b; SIRB1; SIRP-BETA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1264
                     /gene="SIRPB1"
                     /gene_synonym="CD172b; SIRB1; SIRP-BETA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..5377
                     /gene="SIRPB1"
                     /gene_synonym="CD172b; SIRB1; SIRP-BETA-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2356..2361
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIRPB1"
                     /gene_synonym="CD172b; SIRB1; SIRP-BETA-1"
                     /note="hexamer: ATTAAA"
     polyA_site      2379
                     /gene="SIRPB1"
                     /gene_synonym="CD172b; SIRB1; SIRP-BETA-1"
                     /note="major polyA site"
     regulatory      3145..3150
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIRPB1"
                     /gene_synonym="CD172b; SIRB1; SIRP-BETA-1"
                     /note="hexamer: ATTAAA"
     polyA_site      3168
                     /gene="SIRPB1"
                     /gene_synonym="CD172b; SIRB1; SIRP-BETA-1"
     regulatory      4153..4158
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIRPB1"
                     /gene_synonym="CD172b; SIRB1; SIRP-BETA-1"
                     /note="hexamer: ATTAAA"
     polyA_site      4176
                     /gene="SIRPB1"
                     /gene_synonym="CD172b; SIRB1; SIRP-BETA-1"
                     /note="major polyA site"
     regulatory      4587..4592
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIRPB1"
                     /gene_synonym="CD172b; SIRB1; SIRP-BETA-1"
                     /note="hexamer: AAGAAA"
     polyA_site      4610
                     /gene="SIRPB1"
                     /gene_synonym="CD172b; SIRB1; SIRP-BETA-1"
     regulatory      5352..5357
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIRPB1"
                     /gene_synonym="CD172b; SIRB1; SIRP-BETA-1"
                     /note="hexamer: AATAAA"
     polyA_site      5377
                     /gene="SIRPB1"
                     /gene_synonym="CD172b; SIRB1; SIRP-BETA-1"
ORIGIN      
        1 agagcagagt ctgcgatctt cccagcacag acgtttggac agagcaggct cctaaggtct
       61 ccagaatgcc cgtgccagcc tcctggcccc accttcctag tcctttcctg ctgatgacgc
      121 tactgctggg gagactcaca ggagtggcag gtgaggacga gctacaggtg attcagcctg
      181 aaaagtccgt atcagttgca gctggagagt cggccactct gcgctgtgct atgacgtccc
      241 tgatccctgt ggggcccatc atgtggttta gaggagctgg agcaggccgg gaattaatct
      301 acaatcagaa agaaggccac ttcccacggg taacaactgt ttcagaactc acaaagagaa
      361 acaacctgga cttttccatc agcatcagta acatcacccc agcagacgcc ggcacctact
      421 actgtgtgaa gttccggaaa gggagccctg acgacgtgga gtttaagtct ggagcaggca
      481 ctgagctgtc tgtgcgcgcc aaaccctctg cccccgtggt atcgggccct gcggtgaggg
      541 ccacacctga gcacacagtg agcttcacct gcgagtccca tggcttctct cccagagaca
      601 tcaccctgaa atggttcaaa aatgggaatg agctctcaga cttccagacc aacgtggacc
      661 ccgcaggaga cagtgtgtcc tacagcatcc acagcacagc cagggtggtg ctgacccgtg
      721 gggacgttca ctctcaagtc atctgcgaga tagcccacat caccttgcag ggggaccctc
      781 ttcgtgggac tgccaacttg tctgaggcca tccgagttcc acccaccttg gaggttactc
      841 aacagcccat gagggcagag aaccaggcaa acgtcacctg ccaggtgagc aatttctacc
      901 cccggggact acagctgacc tggttggaga atggaaatgt gtcccggaca gaaacagctt
      961 cgaccctcat agagaacaag gatggcacct acaactggat gagctggctc ctggtgaaca
     1021 cctgtgccca cagggacgat gtggtgctca cctgtcaggt ggagcatgat gggcagcaag
     1081 cagtcagcaa aagctatgcc ctggagatct cagcgcacca gaaggagcac ggctcagata
     1141 tcacccatga agcagcgctg gctcctactg ctccactcct cgtagctctc ctcctgggcc
     1201 ccaagctgct actggtggtt ggtgtctctg ccatctacat ctgctggaaa cagaaggcct
     1261 gactgaccct cagtctctgc tgcctcctcc tttcttgaga agctcagcct gagagaagga
     1321 gctggcgaga accttcccca cactcagctc caaacgcctc ctctcccagg tcatctgcct
     1381 gcccacacgc tcctgttcca ccttcacaag accatgatgc cccaaagcag tgtctctatt
     1441 cacggtcctg agcaggggcc atgggattgg gctctgggca ctgactcatg gcacctccct
     1501 agaaggtgag aaacactcca aatctaaaca caccaggact tctcccatcc gtcgccttgg
     1561 gactggccat aaaccacaga ctctctccag gctctcaaga gttatcctgt cttctggatt
     1621 cctgcctacc ccaactcccc cagccttgtt gaggttctct actgcctcct gaatacacat
     1681 gaacccctat accaatttta agaaaaaaat gattctcttt cctctttgtc caagcatcct
     1741 atccctcaaa cccaaaaaga aagaagctct cccttctctc tctgtgatgg agacagtatt
     1801 tcttctagta tcctgcagcc ttcccagtcc tgctgcttgt ggtagaaatg ctgccacagc
     1861 ccaacattga ggagccctcg atgactgccc tttacaactc atattcagtt ctgcctccaa
     1921 aatgcatgtg tccacttaca tgagatggta aatgtttaac aatggacttt ctgaaaggga
     1981 aaaaccaaaa gctgttttgc agtgcttgcc aatttctcta gtgtaataac tcccaacctg
     2041 accaatttca cactgccaac agttaaacaa ccagattgca agattcctga aatttaacaa
     2101 ttggttttca gggcccagtc caagcctgct gctggaaacc tcagagttaa atccctattc
     2161 tccacacctc tcacctccac cacccctccc tgtcccagcc agcatcatct ctttggggac
     2221 cactcctctg gctttcattt ttcagccaca gtgattcttt ggaaaagtca aatcatatca
     2281 cttctctgct tcttccccaa cacagctgca tggctcccgc tctccctcct tcaagtctct
     2341 gctcaatgtc acttcattaa aggcaccttc tataaactac cttgtataaa atattattta
     2401 ttttctctat cccggcattc taatttctct tatcctaatt aatttttctt tagcccttat
     2461 tttgatgagt attatgccga atacaggcag ccctcacttt tcatggcagt gcaagattgc
     2521 aaaaatgact gtgcaacctg aaacccagga aagcagtctc catagtcaat cagaaaaaca
     2581 atgatcattc tgtgaccttt accatttttt gtcaaaatat tagaaactct cacactctca
     2641 gttacaaatg tagaggacaa tgaaaatata atgaaataaa tatttatttg tgcactacaa
     2701 ttcaaagcat tagaaacatt gagagttcaa gtgctgtttc tttgtaaaaa tgtatccaga
     2761 gtagttggaa gagtgcttgc ctttttttgt atatttctaa tatggagtga tatagtttgg
     2821 ctctgtgtct ccatccaaat ctcatcttaa attgtaatct gcatgtgttg tgggatgggc
     2881 ctggtaggag gtgactgaat catgggggcg gacttccccc ttgctgttct tgtgatagtg
     2941 agttctcata agatctcagt gagttctcat gagatctggt tttttgaaag tgtgtggcaa
     3001 gtcccccttc gctctctctc tctctctccc tcctgccacc atgtgaagaa ggtgcctgct
     3061 tccttttctc cttccaccat ggttgtaagt ttcctgaggc ctcccagtca tgcttcctgt
     3121 taagcctgtg gaactgtgag tccaattaaa cctcttttat tcataaaata tccagtttct
     3181 ggtagttctt tatagcagtg tgagaatggg ctaatacacg gagcaagcat tgtttctttt
     3241 catttgttta ttttattttt atttttttga gatggagttt cacccttatt gcccaggctg
     3301 gagtgcaatg tcgtgatctt ggctcactgc aacccccgcc tccagggttc aagtgattct
     3361 cctgcctcag cctcctgagt agctgggatt acaggcatgt accaccacac ccagctaatt
     3421 ttgtattttt agtagagatg gggtttctcc atgttgatca gactagtctt gaactcccga
     3481 cctcaggtga tccacctgtc ttggcctccc aaagtgctgg gattacaggc atgagccacc
     3541 atgcctagcc agcaagcatc atttctatta taccttggtg ttttgccatc tttctaagtt
     3601 tggactagct tccaacatct tatcccttga attttcaata ttgtggaatc actccagaag
     3661 atcctttcat gtgaagtttt ttgctggcat ttcaaccttt gggacatctt cagccctttt
     3721 attaccactc ctctcccatt tgtggcagtt tgcgtttact acctccctct ggctgcctat
     3781 ctgaagttcc tgcatcaggg tctacattgc cacagtcaac tatttgtact tctagaattc
     3841 cactcacatt caatttgaac ctcacttgca gcattttcac ttctcatttc ttcactgcac
     3901 tttcatcttg gttgcaaaat tcctctttca attattcatt tctgtaaaat gtcatatggg
     3961 ctcatcactg ggaggcaagg aggcaaccca actataggat ttgctgtttg agtaggagag
     4021 ccatagggac caatcaccaa cagactttga aagacacaac atgactggtt actgatcatg
     4081 acgagctttt attaccatgg tgatttgtgg actgaagagc tagcccagaa gtttgtactc
     4141 tatgcaaatt acattaaatt tactatggca cctaaatttt gagacttgtg ttgtgggact
     4201 gatgttactt aactaaacta tggtaagaga aatgcatgca tgtcatcacc aaagtgagaa
     4261 ctgcctgtat ttatctatgt tacgcaaatg gaatgtcagt tatatcgtgg ggggttgggg
     4321 gtgggggagg attatctgta tcctcagttg ccagaactgt gtctgccata taataggctg
     4381 tcaatttttt taaatgagtg aatacatcat tgaggtcatt ggtttctact aggtgttgga
     4441 tttcaaaaga aaacttctct tcatttgatc acttggcttg tgtgctgtat tctcaagctc
     4501 tttctttaaa gactactctc tcttctttct gtttaaaaca ttccatcaaa aattcaacat
     4561 cctctagaaa gtaagaaagt gctaacaaga aaaaaaagtc aaccccaaaa ccaaaaccca
     4621 cagtgactgg agtacatcaa agaggcgcag gaaccaactg aaagagctcc caaaggccaa
     4681 agctggaaca ctttcagcaa aaaaataagt aaagtagtaa tgagttatag tccaaagtat
     4741 aaaataaata tctgagtcca tactgatata aataaatgat tgaataaatt aatgggaaag
     4801 aagagaagaa tctccagtgc agaagagtcc cagataattt atttatacac tccactctaa
     4861 aggaggtgga acataacttc cactcctgaa gtgtgggctg tgcactgcga cttctttgca
     4921 aagagtacag catggaaaaa aggagaaaaa ataactttac agtggaaaaa tctgacaaat
     4981 acagcttcag ccaggtgatc aagagttcat caacagttat aaatcaacat caagaatcat
     5041 aaatcatgtc actaatatgt acctttaata tgatgtgatg aagatgacac ttttcctcta
     5101 ttaccttccc cccaaaactc acaaccccaa tctaatcatg aggaaaacat cagacaaatt
     5161 tcaataagga ggcattctgc aacatcgggc ccagaactcc tcaaaactgt caaggtcatc
     5221 aaaatcaagg aaagtctaaa aaactgtcat agccaagaga agcttgagga gatatgacaa
     5281 gtaaatgtaa caggtatcct ggatgggatg ctggaagaga aaaacgacat taggtaaaaa
     5341 gaaaagatct aaataaacta tgaactttga ttaatca
//
