LOCUS       NM_001040023            4580 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens signal regulatory protein alpha (SIRPA), transcript
            variant 2, mRNA.
ACCESSION   NM_001040023
VERSION     NM_001040023.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4580)
  AUTHORS   Koskinen Holm,C., Rosendahl,S., Oldenborg,P.A. and Lundberg,P.
  TITLE     The expression of signal regulatory protein alpha (SIRPalpha) in
            periodontal cells and tissue
  JOURNAL   Acta Odontol Scand 83, 486-492 (2024)
   PUBMED   39258954
  REMARK    GeneRIF: The expression of signal regulatory protein alpha
            (SIRPalpha) in periodontal cells and tissue.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4580)
  AUTHORS   Qian,B., Lu,R., Mao,S., Chen,Y., Yang,M., Zhang,W., Zhang,M.,
            Zhu,D., Liu,Z., Zen,K. and Li,L.
  TITLE     Podocyte SIRPalpha reduction aggravates lupus nephritis via
            promoting T cell inflammatory responses
  JOURNAL   Cell Rep 43 (5), 114249 (2024)
   PUBMED   38758648
  REMARK    GeneRIF: Podocyte SIRPalpha reduction aggravates lupus nephritis
            via promoting T cell inflammatory responses.
REFERENCE   3  (bases 1 to 4580)
  AUTHORS   Hata,K., Tsubouchi,K., Suzuki,K., Eto,D., Ando,H., Yanagihara,T.,
            Kan-O,K. and Okamoto,I.
  TITLE     Surfactant protein D prevents mucin overproduction in airway goblet
            cells via SIRPalpha
  JOURNAL   Sci Rep 14 (1), 1799 (2024)
   PUBMED   38245585
  REMARK    GeneRIF: Surfactant protein D prevents mucin overproduction in
            airway goblet cells via SIRPalpha.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4580)
  AUTHORS   Zhang,Y. and Hao,J.
  TITLE     Anti-tumor effect of PTEN and its effect on inhibition of the bone
            tumor through the CD47-SIRPalpha signaling pathway
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (14), 40-44 (2023)
   PUBMED   38279488
  REMARK    GeneRIF: Anti-tumor effect of PTEN and its effect on inhibition of
            the bone tumor through the CD47-SIRPalpha signaling pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4580)
  AUTHORS   Wang,B., Pan,L., Chen,M., Ma,Y., Gao,J., Tang,D. and Jiang,Z.
  TITLE     SIRP-alpha-IL-6 axis induces immunosuppressive macrophages in
            non-small-cell lung cancer
  JOURNAL   Biochem Biophys Res Commun 682, 386-396 (2023)
   PUBMED   37844448
  REMARK    GeneRIF: SIRP-alpha-IL-6 axis induces immunosuppressive macrophages
            in non-small-cell lung cancer.
REFERENCE   6  (bases 1 to 4580)
  AUTHORS   Kharitonenkov,A., Chen,Z., Sures,I., Wang,H., Schilling,J. and
            Ullrich,A.
  TITLE     A family of proteins that inhibit signalling through tyrosine
            kinase receptors
  JOURNAL   Nature 386 (6621), 181-186 (1997)
   PUBMED   9062191
REFERENCE   7  (bases 1 to 4580)
  AUTHORS   Yamao,T., Matozaki,T., Amano,K., Matsuda,Y., Takahashi,N., Ochi,F.,
            Fujioka,Y. and Kasuga,M.
  TITLE     Mouse and human SHPS-1: molecular cloning of cDNAs and chromosomal
            localization of genes
  JOURNAL   Biochem Biophys Res Commun 231 (1), 61-67 (1997)
   PUBMED   9070220
REFERENCE   8  (bases 1 to 4580)
  AUTHORS   Fujioka,Y., Matozaki,T., Noguchi,T., Iwamatsu,A., Yamao,T.,
            Takahashi,N., Tsuda,M., Takada,T. and Kasuga,M.
  TITLE     A novel membrane glycoprotein, SHPS-1, that binds the
            SH2-domain-containing protein tyrosine phosphatase SHP-2 in
            response to mitogens and cell adhesion
  JOURNAL   Mol Cell Biol 16 (12), 6887-6899 (1996)
   PUBMED   8943344
REFERENCE   9  (bases 1 to 4580)
  AUTHORS   Ohnishi,H., Kubota,M., Ohtake,A., Sato,K. and Sano,Si.
  TITLE     Activation of protein-tyrosine phosphatase SH-PTP2 by a
            tyrosine-based activation motif of a novel brain molecule
  JOURNAL   J Biol Chem 271 (41), 25569-25574 (1996)
   PUBMED   8810330
REFERENCE   10 (bases 1 to 4580)
  AUTHORS   Margolis,R.L., Breschel,T.S., Li,S.H., Kidwai,A.S.,
            Antonarakis,S.E., McInnis,M.G. and Ross,C.A.
  TITLE     Characterization of cDNA clones containing CCA trinucleotide
            repeats derived from human brain
  JOURNAL   Somat Cell Mol Genet 21 (4), 279-284 (1995)
   PUBMED   8525433
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC038510.2, DN989886.1 and
            AL034562.3.
            
            On Jun 2, 2019 this sequence version replaced NM_001040023.1.
            
            Summary: The protein encoded by this gene is a member of the
            signal-regulatory-protein (SIRP) family, and also belongs to the
            immunoglobulin superfamily. SIRP family members are receptor-type
            transmembrane glycoproteins known to be involved in the negative
            regulation of receptor tyrosine kinase-coupled signaling processes.
            This protein can be phosphorylated by tyrosine kinases. The
            phospho-tyrosine residues of this PTP have been shown to recruit
            SH2 domain containing tyrosine phosphatases (PTP), and serve as
            substrates of PTPs. This protein was found to participate in signal
            transduction mediated by various growth factor receptors. CD47 has
            been demonstrated to be a ligand for this receptor protein. This
            gene and its product share very high similarity with several other
            members of the SIRP family. These related genes are located in
            close proximity to each other on chromosome 20p13. Multiple
            alternatively spliced transcript variants have been determined for
            this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and uses
            an alternate, in-frame, splice donor site in the 3' coding region
            compared to variant 4. This variant encodes a shorter protein
            (isoform 1) compared to isoform 2. Variants 1, 2, and 3 encode the
            same protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC038510.2, SRR3476690.1142435.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358771.5/ ENSP00000351621.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               BC038510.2         228-347
            121-477             DN989886.1         191-547
            478-1307            BC038510.2         702-1531
            1308-3882           AL034562.3         17193-19767
            3883-4580           AL034562.3         19768-20465
FEATURES             Location/Qualifiers
     source          1..4580
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..4580
                     /gene="SIRPA"
                     /gene_synonym="BIT; CD172A; MFR; MYD-1; P84; PTPNS1;
                     SHPS1; SIRP"
                     /note="signal regulatory protein alpha"
                     /db_xref="GeneID:140885"
                     /db_xref="HGNC:HGNC:9662"
                     /db_xref="MIM:602461"
     exon            1..120
                     /gene="SIRPA"
                     /gene_synonym="BIT; CD172A; MFR; MYD-1; P84; PTPNS1;
                     SHPS1; SIRP"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1556
                     /gene="SIRPA"
                     /gene_synonym="BIT; CD172A; MFR; MYD-1; P84; PTPNS1;
                     SHPS1; SIRP"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 2; myd-1 antigen; brain-immunoglobulin-like
                     molecule with tyrosine-based activation motifs; tyrosine
                     phosphatase SHP substrate 1; macrophage fusion receptor;
                     tyrosine-protein phosphatase non-receptor type substrate
                     1; inhibitory receptor SHPS-1; CD172 antigen-like family
                     member A"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type
                     substrate 1 isoform 1 precursor"
                     /protein_id="NP_001035112.1"
                     /db_xref="CCDS:CCDS13022.1"
                     /db_xref="GeneID:140885"
                     /db_xref="HGNC:HGNC:9662"
                     /db_xref="MIM:602461"
                     /translation="MEPAGPAPGRLGPLLCLLLAASCAWSGVAGEEELQVIQPDKSVL
                     VAAGETATLRCTATSLIPVGPIQWFRGAGPGRELIYNQKEGHFPRVTTVSDLTKRNNM
                     DFSIRIGNITPADAGTYYCVKFRKGSPDDVEFKSGAGTELSVRAKPSAPVVSGPAARA
                     TPQHTVSFTCESHGFSPRDITLKWFKNGNELSDFQTNVDPVGESVSYSIHSTAKVVLT
                     REDVHSQVICEVAHVTLQGDPLRGTANLSETIRVPPTLEVTQQPVRAENQVNVTCQVR
                     KFYPQRLQLTWLENGNVSRTETASTVTENKDGTYNWMSWLLVNVSAHRDDVKLTCQVE
                     HDGQPAVSKSHDLKVSAHPKEQGSNTAAENTGSNERNIYIVVGVVCTLLVALLMAALY
                     LVRIRQKKAQGSTSSTRLHEPEKNAREITQDTNDITYADLNLPKGKKPAPQAAEPNNH
                     TEYASIQTSPQPASEDTLTYADLDMVHLNRTPKQPAPKPEPSFSEYASVQVPRK"
     exon            121..477
                     /gene="SIRPA"
                     /gene_synonym="BIT; CD172A; MFR; MYD-1; P84; PTPNS1;
                     SHPS1; SIRP"
                     /inference="alignment:Splign:2.1.0"
     exon            478..795
                     /gene="SIRPA"
                     /gene_synonym="BIT; CD172A; MFR; MYD-1; P84; PTPNS1;
                     SHPS1; SIRP"
                     /inference="alignment:Splign:2.1.0"
     exon            796..1128
                     /gene="SIRPA"
                     /gene_synonym="BIT; CD172A; MFR; MYD-1; P84; PTPNS1;
                     SHPS1; SIRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1242
                     /gene="SIRPA"
                     /gene_synonym="BIT; CD172A; MFR; MYD-1; P84; PTPNS1;
                     SHPS1; SIRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1267
                     /gene="SIRPA"
                     /gene_synonym="BIT; CD172A; MFR; MYD-1; P84; PTPNS1;
                     SHPS1; SIRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1307
                     /gene="SIRPA"
                     /gene_synonym="BIT; CD172A; MFR; MYD-1; P84; PTPNS1;
                     SHPS1; SIRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..4580
                     /gene="SIRPA"
                     /gene_synonym="BIT; CD172A; MFR; MYD-1; P84; PTPNS1;
                     SHPS1; SIRP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3858..3863
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIRPA"
                     /gene_synonym="BIT; CD172A; MFR; MYD-1; P84; PTPNS1;
                     SHPS1; SIRP"
                     /note="hexamer: AATAAA"
     polyA_site      3882
                     /gene="SIRPA"
                     /gene_synonym="BIT; CD172A; MFR; MYD-1; P84; PTPNS1;
                     SHPS1; SIRP"
                     /note="major polyA site"
     regulatory      4554..4559
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIRPA"
                     /gene_synonym="BIT; CD172A; MFR; MYD-1; P84; PTPNS1;
                     SHPS1; SIRP"
                     /note="hexamer: AATAAA"
     polyA_site      4580
                     /gene="SIRPA"
                     /gene_synonym="BIT; CD172A; MFR; MYD-1; P84; PTPNS1;
                     SHPS1; SIRP"
ORIGIN      
        1 actcacggcc gctctccctc ctcgctccgc agccgcggcc catggagccc gccggcccgg
       61 cccccggccg cctcgggccg ctgctctgcc tgctgctcgc cgcgtcctgc gcctggtcag
      121 gagtggcggg tgaggaggag ctgcaggtga ttcagcctga caagtccgtg ttggttgcag
      181 ctggagagac agccactctg cgctgcactg cgacctctct gatccctgtg gggcccatcc
      241 agtggttcag aggagctgga ccaggccggg aattaatcta caatcaaaaa gaaggccact
      301 tcccccgggt aacaactgtt tcagacctca caaagagaaa caacatggac ttttccatcc
      361 gcatcggtaa catcacccca gcagatgccg gcacctacta ctgtgtgaag ttccggaaag
      421 ggagccccga tgacgtggag tttaagtctg gagcaggcac tgagctgtct gtgcgcgcca
      481 aaccctctgc ccccgtggta tcgggccctg cggcgagggc cacacctcag cacacagtga
      541 gcttcacctg cgagtcccac ggcttctcac ccagagacat caccctgaaa tggttcaaaa
      601 atgggaatga gctctcagac ttccagacca acgtggaccc cgtaggagag agcgtgtcct
      661 acagcatcca cagcacagcc aaggtggtgc tgacccgcga ggacgttcac tctcaagtca
      721 tctgcgaggt ggcccacgtc accttgcagg gggaccctct tcgtgggact gccaacttgt
      781 ctgagaccat ccgagttcca cccaccttgg aggttactca acagcccgtg agggcagaga
      841 accaggtgaa tgtcacctgc caggtgagga agttctaccc ccagagacta cagctgacct
      901 ggttggagaa tggaaacgtg tcccggacag aaacggcctc aaccgttaca gagaacaagg
      961 atggtaccta caactggatg agctggctcc tggtgaatgt atctgcccac agggatgatg
     1021 tgaagctcac ctgccaggtg gagcatgacg ggcagccagc ggtcagcaaa agccatgacc
     1081 tgaaggtctc agcccacccg aaggagcagg gctcaaatac cgccgctgag aacactggat
     1141 ctaatgaacg gaacatctat attgtggtgg gtgtggtgtg caccttgctg gtggccctac
     1201 tgatggcggc cctctacctc gtccgaatca gacagaagaa agcccagggc tccacttctt
     1261 ctacaaggtt gcatgagccc gagaagaatg ccagagaaat aacacaggac acaaatgata
     1321 tcacatatgc agacctgaac ctgcccaagg ggaagaagcc tgctccccag gctgcggagc
     1381 ccaacaacca cacggagtat gccagcattc agaccagccc gcagcccgcg tcggaggaca
     1441 ccctcaccta tgctgacctg gacatggtcc acctcaaccg gacccccaag cagccggccc
     1501 ccaagcctga gccgtccttc tcagagtacg ccagcgtcca ggtcccgagg aagtgaatgg
     1561 gaccgtggtt tgctctagca cccatctcta cgcgctttct tgtcccacag ggagccgccg
     1621 tgatgagcac agccaaccca gttcccggag ggctggggcg gtgcaggctc tgggacccag
     1681 gggccagggt ggctcttctc tccccacccc tccttggctc tccagcactt cctgggcagc
     1741 cacggccccc tccccccaca ttgccacata cctggaggct gacgttgcca aaccagccag
     1801 ggaaccaacc tgggaagtgg ccagaactgc ctggggtcca agaactcttg tgcctccgtc
     1861 catcaccatg tgggttttga agaccctcga ctgcctcccc gatgctccga agcctgatct
     1921 tccagggtgg ggaggagaaa atcccacctc ccctgacctc caccacctcc accaccacca
     1981 ccaccaccac caccaccact accaccacca cccaactggg gctagagtgg ggaagatttc
     2041 ccctttagat caaactgccc cttccatgga aaagctggaa aaaaactctg gaacccatat
     2101 ccaggcttgg tgaggttgct gccaacagtc ctggcctccc ccatccctag gctaaagagc
     2161 catgagtcct ggaggaggag aggacccctc ccaaaggact ggagacaaaa ccctctgctt
     2221 ccttgggtcc ctccaagact ccctggggcc caactgtgtt gctccacccg gacccatctc
     2281 tcccttctag acctgagctt gcccctccag ctagcactaa gcaacatctc gctgtggacg
     2341 cctgtaaatt actgagaaat gtgaaacgtg caatcttgaa actgaggtgt tagaaaactt
     2401 gatctgtggt gttttgtttt gttttttttc ttaaaacaac agcaacgtga tcttggctgt
     2461 ctgtcatgtg ttgaagtcca tggttgggtc ttgtgaagtc tgaggtttaa cagtttgttg
     2521 tcctggaggg attttcttac agcgaagact tgagttcctc caagtcccag aaccccaaga
     2581 atgggcaaga aggatcaggt cagccactcc ctggagacac agccttctgg ctgggactga
     2641 cttggccatg ttctcagctg agccacgcgg ctggtagtgc agccttctgt gaccccgctg
     2701 tggtaagtcc agcctgccca gggctgctga gggctgcctc ttgacagtgc agtcttatcg
     2761 agacccaatg cctcagtctg ctcatccgta aagtggggat agtgaagatg acacccctcc
     2821 ccaccacctc tcataagcac tttaggaaca cacagagggt agggatagtg gccctggccg
     2881 tctatcctac ccctttagtg accgccccca tcccggcttt ctgagctgat ccttgaagaa
     2941 gaaatcttcc atttctgctc tcaaacccta ctgggatcaa actggaataa attgaagaca
     3001 gccaggggga tggtgcagct gtgaagctcg ggctgattcc ccctctgtcc cagaaggttg
     3061 gccagagggt gtgacccagt taccctttaa cccccaccct tccagtcggg tgtgagggcc
     3121 tgaccgggcc cagggcaagc agatgtcgca agccctattt attcagtctt cactataact
     3181 cttagagttg agacgctaat gttcatgact cctggccttg ggatgcccaa gggatttctg
     3241 gctcaggctg taaaagtagc tgagccatcc tgcccattcc tggaggtcct acaggtgaaa
     3301 ctgcaggagc tcagcataga cccagctctc tgggggatgg tcacctggtg atttcaatga
     3361 tggcatccag gaattagctg agccaacaga ccatgtggac agctttggcc agagctcccg
     3421 tgtggcatct gggagccaca gtgacccagc cacctggctc aggctagttc caaattccaa
     3481 aagattggct tgtaaacctt cgtctccctc tcttttaccc agagacagca catacgtgtg
     3541 cacacgcatg cacacacaca ttcagtattt taaaagaatg ttttcttggt gccattttca
     3601 ttttatttta ttttttaatt cttggagggg gaaataaggg aataaggcca aggaagatgt
     3661 atagctttag ctttagcctg gcaacctgga gaatccacat accttgtgta ttgaacccca
     3721 ggaaaaggaa gaggtcgaac caaccctgcg gaaggagcat ggtttcagga gtttatttta
     3781 agactgctgg gaaggaaaca ggccccattt tgtatatagt tgcaacttaa actttttggc
     3841 ttgcaaaata tttttgtaat aaagatttct gggtaataat gagtccttcc ggtgttcagt
     3901 attcttgtct ttgtgagtgc gtcccggggc cgcctcgggg cctgcctgcc ctcctgccaa
     3961 agcctggaag aggattgaat ggaccccagg gtttggaaac aacctacagc atttgagccc
     4021 ctcacgtagg ttttagagac gtacaatttt tgtttgccct ggctcagaag gagccggtgt
     4081 aaggttgaga taaaattcca tatagacaac tgagtttgga tctcggctct gctgctttgt
     4141 agctgtggga gttcaaacag cacctctttg agacttgggc cccgcgtcgg cacaatgggg
     4201 caggaatagt ccctgccagg gtgactgtgt ggattcaagg aggttggaag cactgagccc
     4261 acgcttggca ctgggtaggc catcactgag gcttgtgtct ttccttcctg ccctgaccct
     4321 gcatagctga gtctcgtggc ctctcaccac tgatgggatc tcggacaccc ggctcaccct
     4381 cctcctgggg cctcactttc cttccccacc aaatgcagac atctaatgct tgtcctgtaa
     4441 tatccttgcc agatgactga tgtcaagtgc tggtttatag tgggtgctca ataaatgtta
     4501 gtttcctttc tatccctcca ttagatcatt aatgatatta gtgctaatta tgtaataaag
     4561 ttaaggcata aatatgttaa
//
