LOCUS       NM_001040022            4201 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens signal regulatory protein alpha (SIRPA), transcript
            variant 1, mRNA.
ACCESSION   NM_001040022
VERSION     NM_001040022.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4201)
  AUTHORS   Koskinen Holm,C., Rosendahl,S., Oldenborg,P.A. and Lundberg,P.
  TITLE     The expression of signal regulatory protein alpha (SIRPalpha) in
            periodontal cells and tissue
  JOURNAL   Acta Odontol Scand 83, 486-492 (2024)
   PUBMED   39258954
  REMARK    GeneRIF: The expression of signal regulatory protein alpha
            (SIRPalpha) in periodontal cells and tissue.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4201)
  AUTHORS   Qian,B., Lu,R., Mao,S., Chen,Y., Yang,M., Zhang,W., Zhang,M.,
            Zhu,D., Liu,Z., Zen,K. and Li,L.
  TITLE     Podocyte SIRPalpha reduction aggravates lupus nephritis via
            promoting T cell inflammatory responses
  JOURNAL   Cell Rep 43 (5), 114249 (2024)
   PUBMED   38758648
  REMARK    GeneRIF: Podocyte SIRPalpha reduction aggravates lupus nephritis
            via promoting T cell inflammatory responses.
REFERENCE   3  (bases 1 to 4201)
  AUTHORS   Hata,K., Tsubouchi,K., Suzuki,K., Eto,D., Ando,H., Yanagihara,T.,
            Kan-O,K. and Okamoto,I.
  TITLE     Surfactant protein D prevents mucin overproduction in airway goblet
            cells via SIRPalpha
  JOURNAL   Sci Rep 14 (1), 1799 (2024)
   PUBMED   38245585
  REMARK    GeneRIF: Surfactant protein D prevents mucin overproduction in
            airway goblet cells via SIRPalpha.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4201)
  AUTHORS   Zhang,Y. and Hao,J.
  TITLE     Anti-tumor effect of PTEN and its effect on inhibition of the bone
            tumor through the CD47-SIRPalpha signaling pathway
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (14), 40-44 (2023)
   PUBMED   38279488
  REMARK    GeneRIF: Anti-tumor effect of PTEN and its effect on inhibition of
            the bone tumor through the CD47-SIRPalpha signaling pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4201)
  AUTHORS   Wang,B., Pan,L., Chen,M., Ma,Y., Gao,J., Tang,D. and Jiang,Z.
  TITLE     SIRP-alpha-IL-6 axis induces immunosuppressive macrophages in
            non-small-cell lung cancer
  JOURNAL   Biochem Biophys Res Commun 682, 386-396 (2023)
   PUBMED   37844448
  REMARK    GeneRIF: SIRP-alpha-IL-6 axis induces immunosuppressive macrophages
            in non-small-cell lung cancer.
REFERENCE   6  (bases 1 to 4201)
  AUTHORS   Kharitonenkov,A., Chen,Z., Sures,I., Wang,H., Schilling,J. and
            Ullrich,A.
  TITLE     A family of proteins that inhibit signalling through tyrosine
            kinase receptors
  JOURNAL   Nature 386 (6621), 181-186 (1997)
   PUBMED   9062191
REFERENCE   7  (bases 1 to 4201)
  AUTHORS   Yamao,T., Matozaki,T., Amano,K., Matsuda,Y., Takahashi,N., Ochi,F.,
            Fujioka,Y. and Kasuga,M.
  TITLE     Mouse and human SHPS-1: molecular cloning of cDNAs and chromosomal
            localization of genes
  JOURNAL   Biochem Biophys Res Commun 231 (1), 61-67 (1997)
   PUBMED   9070220
REFERENCE   8  (bases 1 to 4201)
  AUTHORS   Fujioka,Y., Matozaki,T., Noguchi,T., Iwamatsu,A., Yamao,T.,
            Takahashi,N., Tsuda,M., Takada,T. and Kasuga,M.
  TITLE     A novel membrane glycoprotein, SHPS-1, that binds the
            SH2-domain-containing protein tyrosine phosphatase SHP-2 in
            response to mitogens and cell adhesion
  JOURNAL   Mol Cell Biol 16 (12), 6887-6899 (1996)
   PUBMED   8943344
REFERENCE   9  (bases 1 to 4201)
  AUTHORS   Ohnishi,H., Kubota,M., Ohtake,A., Sato,K. and Sano,Si.
  TITLE     Activation of protein-tyrosine phosphatase SH-PTP2 by a
            tyrosine-based activation motif of a novel brain molecule
  JOURNAL   J Biol Chem 271 (41), 25569-25574 (1996)
   PUBMED   8810330
REFERENCE   10 (bases 1 to 4201)
  AUTHORS   Margolis,R.L., Breschel,T.S., Li,S.H., Kidwai,A.S.,
            Antonarakis,S.E., McInnis,M.G. and Ross,C.A.
  TITLE     Characterization of cDNA clones containing CCA trinucleotide
            repeats derived from human brain
  JOURNAL   Somat Cell Mol Genet 21 (4), 279-284 (1995)
   PUBMED   8525433
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA471662.1, BC075849.1,
            DN989886.1 and AL034562.3.
            
            Summary: The protein encoded by this gene is a member of the
            signal-regulatory-protein (SIRP) family, and also belongs to the
            immunoglobulin superfamily. SIRP family members are receptor-type
            transmembrane glycoproteins known to be involved in the negative
            regulation of receptor tyrosine kinase-coupled signaling processes.
            This protein can be phosphorylated by tyrosine kinases. The
            phospho-tyrosine residues of this PTP have been shown to recruit
            SH2 domain containing tyrosine phosphatases (PTP), and serve as
            substrates of PTPs. This protein was found to participate in signal
            transduction mediated by various growth factor receptors. CD47 has
            been demonstrated to be a ligand for this receptor protein. This
            gene and its product share very high similarity with several other
            members of the SIRP family. These related genes are located in
            close proximity to each other on chromosome 20p13. Multiple
            alternatively spliced transcript variants have been determined for
            this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) uses an alternate, in-frame,
            splice donor site in the 3' coding region compared to variant 4.
            This variant encodes a shorter protein (isoform 1) compared to
            isoform 2. Variants 1, 2, and 3 encode the same protein (isoform
            1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC075849.1, AK290776.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               DA471662.1         42-192
            152-439             BC075849.1         1-288
            440-796             DN989886.1         191-547
            797-2147            BC075849.1         643-1993
            2148-4201           AL034562.3         17714-19767
FEATURES             Location/Qualifiers
     source          1..4201
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..4201
                     /gene="SIRPA"
                     /gene_synonym="BIT; CD172A; MFR; MYD-1; P84; PTPNS1;
                     SHPS1; SIRP"
                     /note="signal regulatory protein alpha"
                     /db_xref="GeneID:140885"
                     /db_xref="HGNC:HGNC:9662"
                     /db_xref="MIM:602461"
     exon            1..351
                     /gene="SIRPA"
                     /gene_synonym="BIT; CD172A; MFR; MYD-1; P84; PTPNS1;
                     SHPS1; SIRP"
                     /inference="alignment:Splign:2.1.0"
     exon            352..439
                     /gene="SIRPA"
                     /gene_synonym="BIT; CD172A; MFR; MYD-1; P84; PTPNS1;
                     SHPS1; SIRP"
                     /inference="alignment:Splign:2.1.0"
     CDS             361..1875
                     /gene="SIRPA"
                     /gene_synonym="BIT; CD172A; MFR; MYD-1; P84; PTPNS1;
                     SHPS1; SIRP"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; myd-1 antigen; brain-immunoglobulin-like
                     molecule with tyrosine-based activation motifs; tyrosine
                     phosphatase SHP substrate 1; macrophage fusion receptor;
                     tyrosine-protein phosphatase non-receptor type substrate
                     1; inhibitory receptor SHPS-1; CD172 antigen-like family
                     member A"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type
                     substrate 1 isoform 1 precursor"
                     /protein_id="NP_001035111.1"
                     /db_xref="CCDS:CCDS13022.1"
                     /db_xref="GeneID:140885"
                     /db_xref="HGNC:HGNC:9662"
                     /db_xref="MIM:602461"
                     /translation="MEPAGPAPGRLGPLLCLLLAASCAWSGVAGEEELQVIQPDKSVL
                     VAAGETATLRCTATSLIPVGPIQWFRGAGPGRELIYNQKEGHFPRVTTVSDLTKRNNM
                     DFSIRIGNITPADAGTYYCVKFRKGSPDDVEFKSGAGTELSVRAKPSAPVVSGPAARA
                     TPQHTVSFTCESHGFSPRDITLKWFKNGNELSDFQTNVDPVGESVSYSIHSTAKVVLT
                     REDVHSQVICEVAHVTLQGDPLRGTANLSETIRVPPTLEVTQQPVRAENQVNVTCQVR
                     KFYPQRLQLTWLENGNVSRTETASTVTENKDGTYNWMSWLLVNVSAHRDDVKLTCQVE
                     HDGQPAVSKSHDLKVSAHPKEQGSNTAAENTGSNERNIYIVVGVVCTLLVALLMAALY
                     LVRIRQKKAQGSTSSTRLHEPEKNAREITQDTNDITYADLNLPKGKKPAPQAAEPNNH
                     TEYASIQTSPQPASEDTLTYADLDMVHLNRTPKQPAPKPEPSFSEYASVQVPRK"
     exon            440..796
                     /gene="SIRPA"
                     /gene_synonym="BIT; CD172A; MFR; MYD-1; P84; PTPNS1;
                     SHPS1; SIRP"
                     /inference="alignment:Splign:2.1.0"
     exon            797..1114
                     /gene="SIRPA"
                     /gene_synonym="BIT; CD172A; MFR; MYD-1; P84; PTPNS1;
                     SHPS1; SIRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1447
                     /gene="SIRPA"
                     /gene_synonym="BIT; CD172A; MFR; MYD-1; P84; PTPNS1;
                     SHPS1; SIRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1561
                     /gene="SIRPA"
                     /gene_synonym="BIT; CD172A; MFR; MYD-1; P84; PTPNS1;
                     SHPS1; SIRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1586
                     /gene="SIRPA"
                     /gene_synonym="BIT; CD172A; MFR; MYD-1; P84; PTPNS1;
                     SHPS1; SIRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1626
                     /gene="SIRPA"
                     /gene_synonym="BIT; CD172A; MFR; MYD-1; P84; PTPNS1;
                     SHPS1; SIRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..4201
                     /gene="SIRPA"
                     /gene_synonym="BIT; CD172A; MFR; MYD-1; P84; PTPNS1;
                     SHPS1; SIRP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4177..4182
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIRPA"
                     /gene_synonym="BIT; CD172A; MFR; MYD-1; P84; PTPNS1;
                     SHPS1; SIRP"
                     /note="hexamer: AATAAA"
     polyA_site      4201
                     /gene="SIRPA"
                     /gene_synonym="BIT; CD172A; MFR; MYD-1; P84; PTPNS1;
                     SHPS1; SIRP"
                     /note="major polyA site"
ORIGIN      
        1 tccggcccgc acccaccccc aagaggggcc ttcagctttg gggctcagag gcacgacctc
       61 ctggggaggg ttaaaaggca gacgcccccc cgccccccgc gcccccgcgc cccgactcct
      121 tcgccgcctc cagcctctcg ccagtgggaa gcggggagca gccgcgcggc cggagtccgg
      181 aggcgagggg aggtcggccg caacttcccc ggtccacctt aagaggacga tgtagccagc
      241 tcgcagcgct gaccttagaa aaacaagttt gcgcaaagtg gagcggggac ccggcctctg
      301 ggcagccccg gcggcgcttc cagtgccttc cagccctcgc gggcggcgca gccgcggccc
      361 atggagcccg ccggcccggc ccccggccgc ctcgggccgc tgctctgcct gctgctcgcc
      421 gcgtcctgcg cctggtcagg agtggcgggt gaggaggagc tgcaggtgat tcagcctgac
      481 aagtccgtgt tggttgcagc tggagagaca gccactctgc gctgcactgc gacctctctg
      541 atccctgtgg ggcccatcca gtggttcaga ggagctggac caggccggga attaatctac
      601 aatcaaaaag aaggccactt cccccgggta acaactgttt cagacctcac aaagagaaac
      661 aacatggact tttccatccg catcggtaac atcaccccag cagatgccgg cacctactac
      721 tgtgtgaagt tccggaaagg gagccccgat gacgtggagt ttaagtctgg agcaggcact
      781 gagctgtctg tgcgcgccaa accctctgcc cccgtggtat cgggccctgc ggcgagggcc
      841 acacctcagc acacagtgag cttcacctgc gagtcccacg gcttctcacc cagagacatc
      901 accctgaaat ggttcaaaaa tgggaatgag ctctcagact tccagaccaa cgtggacccc
      961 gtaggagaga gcgtgtccta cagcatccac agcacagcca aggtggtgct gacccgcgag
     1021 gacgttcact ctcaagtcat ctgcgaggtg gcccacgtca ccttgcaggg ggaccctctt
     1081 cgtgggactg ccaacttgtc tgagaccatc cgagttccac ccaccttgga ggttactcaa
     1141 cagcccgtga gggcagagaa ccaggtgaat gtcacctgcc aggtgaggaa gttctacccc
     1201 cagagactac agctgacctg gttggagaat ggaaacgtgt cccggacaga aacggcctca
     1261 accgttacag agaacaagga tggtacctac aactggatga gctggctcct ggtgaatgta
     1321 tctgcccaca gggatgatgt gaagctcacc tgccaggtgg agcatgacgg gcagccagcg
     1381 gtcagcaaaa gccatgacct gaaggtctca gcccacccga aggagcaggg ctcaaatacc
     1441 gccgctgaga acactggatc taatgaacgg aacatctata ttgtggtggg tgtggtgtgc
     1501 accttgctgg tggccctact gatggcggcc ctctacctcg tccgaatcag acagaagaaa
     1561 gcccagggct ccacttcttc tacaaggttg catgagcccg agaagaatgc cagagaaata
     1621 acacaggaca caaatgatat cacatatgca gacctgaacc tgcccaaggg gaagaagcct
     1681 gctccccagg ctgcggagcc caacaaccac acggagtatg ccagcattca gaccagcccg
     1741 cagcccgcgt cggaggacac cctcacctat gctgacctgg acatggtcca cctcaaccgg
     1801 acccccaagc agccggcccc caagcctgag ccgtccttct cagagtacgc cagcgtccag
     1861 gtcccgagga agtgaatggg accgtggttt gctctagcac ccatctctac gcgctttctt
     1921 gtcccacagg gagccgccgt gatgagcaca gccaacccag ttcccggagg gctggggcgg
     1981 tgcaggctct gggacccagg ggccagggtg gctcttctct ccccacccct ccttggctct
     2041 ccagcacttc ctgggcagcc acggccccct ccccccacat tgccacatac ctggaggctg
     2101 acgttgccaa accagccagg gaaccaacct gggaagtggc cagaactgcc tggggtccaa
     2161 gaactcttgt gcctccgtcc atcaccatgt gggttttgaa gaccctcgac tgcctccccg
     2221 atgctccgaa gcctgatctt ccagggtggg gaggagaaaa tcccacctcc cctgacctcc
     2281 accacctcca ccaccaccac caccaccacc accaccacta ccaccaccac ccaactgggg
     2341 ctagagtggg gaagatttcc cctttagatc aaactgcccc ttccatggaa aagctggaaa
     2401 aaaactctgg aacccatatc caggcttggt gaggttgctg ccaacagtcc tggcctcccc
     2461 catccctagg ctaaagagcc atgagtcctg gaggaggaga ggacccctcc caaaggactg
     2521 gagacaaaac cctctgcttc cttgggtccc tccaagactc cctggggccc aactgtgttg
     2581 ctccacccgg acccatctct cccttctaga cctgagcttg cccctccagc tagcactaag
     2641 caacatctcg ctgtggacgc ctgtaaatta ctgagaaatg tgaaacgtgc aatcttgaaa
     2701 ctgaggtgtt agaaaacttg atctgtggtg ttttgttttg ttttttttct taaaacaaca
     2761 gcaacgtgat cttggctgtc tgtcatgtgt tgaagtccat ggttgggtct tgtgaagtct
     2821 gaggtttaac agtttgttgt cctggaggga ttttcttaca gcgaagactt gagttcctcc
     2881 aagtcccaga accccaagaa tgggcaagaa ggatcaggtc agccactccc tggagacaca
     2941 gccttctggc tgggactgac ttggccatgt tctcagctga gccacgcggc tggtagtgca
     3001 gccttctgtg accccgctgt ggtaagtcca gcctgcccag ggctgctgag ggctgcctct
     3061 tgacagtgca gtcttatcga gacccaatgc ctcagtctgc tcatccgtaa agtggggata
     3121 gtgaagatga cacccctccc caccacctct cataagcact ttaggaacac acagagggta
     3181 gggatagtgg ccctggccgt ctatcctacc cctttagtga ccgcccccat cccggctttc
     3241 tgagctgatc cttgaagaag aaatcttcca tttctgctct caaaccctac tgggatcaaa
     3301 ctggaataaa ttgaagacag ccagggggat ggtgcagctg tgaagctcgg gctgattccc
     3361 cctctgtccc agaaggttgg ccagagggtg tgacccagtt accctttaac ccccaccctt
     3421 ccagtcgggt gtgagggcct gaccgggccc agggcaagca gatgtcgcaa gccctattta
     3481 ttcagtcttc actataactc ttagagttga gacgctaatg ttcatgactc ctggccttgg
     3541 gatgcccaag ggatttctgg ctcaggctgt aaaagtagct gagccatcct gcccattcct
     3601 ggaggtccta caggtgaaac tgcaggagct cagcatagac ccagctctct gggggatggt
     3661 cacctggtga tttcaatgat ggcatccagg aattagctga gccaacagac catgtggaca
     3721 gctttggcca gagctcccgt gtggcatctg ggagccacag tgacccagcc acctggctca
     3781 ggctagttcc aaattccaaa agattggctt gtaaaccttc gtctccctct cttttaccca
     3841 gagacagcac atacgtgtgc acacgcatgc acacacacat tcagtatttt aaaagaatgt
     3901 tttcttggtg ccattttcat tttattttat tttttaattc ttggaggggg aaataaggga
     3961 ataaggccaa ggaagatgta tagctttagc tttagcctgg caacctggag aatccacata
     4021 ccttgtgtat tgaaccccag gaaaaggaag aggtcgaacc aaccctgcgg aaggagcatg
     4081 gtttcaggag tttattttaa gactgctggg aaggaaacag gccccatttt gtatatagtt
     4141 gcaacttaaa ctttttggct tgcaaaatat ttttgtaata aagatttctg ggtaataatg
     4201 a
//
