LOCUS       NM_020808               6914 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens signal induced proliferation associated 1 like 2
            (SIPA1L2), transcript variant 1, mRNA.
ACCESSION   NM_020808 XM_005273211 XM_045839
VERSION     NM_020808.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6914)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 6914)
  AUTHORS   Tao,F., Beecham,G.W., Rebelo,A.P., Svaren,J., Blanton,S.H.,
            Moran,J.J., Lopez-Anido,C., Morrow,J.M., Abreu,L., Rizzo,D.,
            Kirk,C.A., Wu,X., Feely,S., Verhamme,C., Saporta,M.A.,
            Herrmann,D.N., Day,J.W., Sumner,C.J., Lloyd,T.E., Li,J., Yum,S.W.,
            Taroni,F., Baas,F., Choi,B.O., Pareyson,D., Scherer,S.S.,
            Reilly,M.M., Shy,M.E. and Zuchner,S.
  CONSRTM   Inherited Neuropathy Consortium
  TITLE     Variation in SIPA1L2 is correlated with phenotype modification in
            Charcot- Marie- Tooth disease type 1A
  JOURNAL   Ann Neurol 85 (3), 316-330 (2019)
   PUBMED   30706531
  REMARK    GeneRIF: SIPA1L2 is a potential genetic modifier of CMT1A
            phenotypic expressions.
REFERENCE   3  (bases 1 to 6914)
  AUTHORS   Geng,X., Irvin,M.R., Hidalgo,B., Aslibekyan,S.,
            Srinivasasainagendra,V., An,P., Frazier-Wood,A.C., Tiwari,H.K.,
            Dave,T., Ryan,K., Ordovas,J.M., Straka,R.J., Feitosa,M.F.,
            Hopkins,P.N., Borecki,I., Province,M.A., Mitchell,B.D., Arnett,D.K.
            and Zhi,D.
  TITLE     An exome-wide sequencing study of lipid response to high-fat meal
            and fenofibrate in Caucasians from the GOLDN cohort
  JOURNAL   J Lipid Res 59 (4), 722-729 (2018)
   PUBMED   29463568
REFERENCE   4  (bases 1 to 6914)
  AUTHORS   Yang,X., Zheng,J., An,R., Tian,S., Zhao,Q., Chen,Y., Huang,H.,
            Ning,P.P., Song,Y. and Xu,Y.
  TITLE     Polymorphism in MIR4697 but not VPS13C, GCH1, or SIPA1L2 is
            associated with risk of Parkinson's disease in a Han Chinese
            population
  JOURNAL   Neurosci Lett 650, 8-11 (2017)
   PUBMED   28380328
  REMARK    GeneRIF: Our results suggest that rs329648 is associated with risk
            of developing PD in the Han Chinese population. Our findings should
            be verified in further studies, and they highlight the need for
            functional studies of MIR4697.
REFERENCE   5  (bases 1 to 6914)
  AUTHORS   Yachie,N., Petsalaki,E., Mellor,J.C., Weile,J., Jacob,Y., Verby,M.,
            Ozturk,S.B., Li,S., Cote,A.G., Mosca,R., Knapp,J.J., Ko,M., Yu,A.,
            Gebbia,M., Sahni,N., Yi,S., Tyagi,T., Sheykhkarimli,D., Roth,J.F.,
            Wong,C., Musa,L., Snider,J., Liu,Y.C., Yu,H., Braun,P.,
            Stagljar,I., Hao,T., Calderwood,M.A., Pelletier,L., Aloy,P.,
            Hill,D.E., Vidal,M. and Roth,F.P.
  TITLE     Pooled-matrix protein interaction screens using Barcode Fusion
            Genetics
  JOURNAL   Mol Syst Biol 12 (4), 863 (2016)
   PUBMED   27107012
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6914)
  AUTHORS   Ferreira,R.C., Pan-Hammarstrom,Q., Graham,R.R., Gateva,V.,
            Fontan,G., Lee,A.T., Ortmann,W., Urcelay,E., Fernandez-Arquero,M.,
            Nunez,C., Jorgensen,G., Ludviksson,B.R., Koskinen,S., Haimila,K.,
            Clark,H.F., Klareskog,L., Gregersen,P.K., Behrens,T.W. and
            Hammarstrom,L.
  TITLE     Association of IFIH1 and other autoimmunity risk alleles with
            selective IgA deficiency
  JOURNAL   Nat Genet 42 (9), 777-780 (2010)
   PUBMED   20694011
REFERENCE   7  (bases 1 to 6914)
  AUTHORS   Docherty,S.J., Kovas,Y., Petrill,S.A. and Plomin,R.
  TITLE     Generalist genes analysis of DNA markers associated with
            mathematical ability and disability reveals shared influence across
            ages and abilities
  JOURNAL   BMC Genet 11, 61 (2010)
   PUBMED   20602751
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 6914)
  AUTHORS   Spilker,C. and Kreutz,M.R.
  TITLE     RapGAPs in brain: multipurpose players in neuronal Rap signalling
  JOURNAL   Eur J Neurosci 32 (1), 1-9 (2010)
   PUBMED   20576033
  REMARK    Review article
REFERENCE   9  (bases 1 to 6914)
  AUTHORS   Spilker,C., Acuna Sanhueza,G.A., Bockers,T.M., Kreutz,M.R. and
            Gundelfinger,E.D.
  TITLE     SPAR2, a novel SPAR-related protein with GAP activity for Rap1 and
            Rap2
  JOURNAL   J Neurochem 104 (1), 187-201 (2008)
   PUBMED   17961154
REFERENCE   10 (bases 1 to 6914)
  AUTHORS   Ficarro,S.B., Salomon,A.R., Brill,L.M., Mason,D.E.,
            Stettler-Gill,M., Brock,A. and Peters,E.C.
  TITLE     Automated immobilized metal affinity chromatography/nano-liquid
            chromatography/electrospray ionization mass spectrometry platform
            for profiling protein phosphorylation sites
  JOURNAL   Rapid Commun Mass Spectrom 19 (1), 57-71 (2005)
   PUBMED   15570572
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL355274.22, AL157409.16 and
            AL356965.14.
            
            On or before Jan 15, 2020 this sequence version replaced
            XM_005273211.2, NM_020808.4.
            
            Summary: This gene encodes a member of the signal-induced
            proliferation-associated 1 like family. Members of this family
            contain a GTPase activating domain, a PDZ domain and a C-terminal
            coiled-coil domain with a leucine zipper. A similar protein in rat
            acts as a GTPases for the small GTPase Rap. [provided by RefSeq,
            Sep 2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AY168879.1, SRR1803611.181496.1
                                    [ECO:0000331]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000674635.1/ ENSP00000502693.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-265               AL355274.22        47788-48052         c
            266-314             AL157409.16        133894-133942       c
            315-2066            AL157409.16        73577-75328         c
            2067-2200           AL157409.16        53247-53380         c
            2201-2389           AL157409.16        50594-50782         c
            2390-2564           AL157409.16        43512-43686         c
            2565-2668           AL157409.16        39347-39450         c
            2669-2826           AL157409.16        31091-31248         c
            2827-3403           AL157409.16        24560-25136         c
            3404-3678           AL157409.16        20607-20881         c
            3679-3936           AL157409.16        5249-5506           c
            3937-4020           AL157409.16        3322-3405           c
            4021-4121           AL356965.14        60907-61007         c
            4122-4225           AL356965.14        60430-60533         c
            4226-4614           AL356965.14        58247-58635         c
            4615-4839           AL356965.14        51386-51610         c
            4840-4993           AL356965.14        47550-47703         c
            4994-5213           AL356965.14        44728-44947         c
            5214-5345           AL356965.14        34633-34764         c
            5346-5399           AL356965.14        23264-23317         c
            5400-5523           AL356965.14        22587-22710         c
            5524-5605           AL356965.14        21531-21612         c
            5606-6914           AL356965.14        17104-18412         c
FEATURES             Location/Qualifiers
     source          1..6914
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.2"
     gene            1..6914
                     /gene="SIPA1L2"
                     /gene_synonym="SPAL2; SPAR2"
                     /note="signal induced proliferation associated 1 like 2"
                     /db_xref="GeneID:57568"
                     /db_xref="HGNC:HGNC:23800"
                     /db_xref="MIM:611609"
     exon            1..265
                     /gene="SIPA1L2"
                     /gene_synonym="SPAL2; SPAR2"
                     /inference="alignment:Splign:2.1.0"
     exon            266..314
                     /gene="SIPA1L2"
                     /gene_synonym="SPAL2; SPAR2"
                     /inference="alignment:Splign:2.1.0"
     exon            315..2066
                     /gene="SIPA1L2"
                     /gene_synonym="SPAL2; SPAR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             584..5752
                     /gene="SIPA1L2"
                     /gene_synonym="SPAL2; SPAR2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     signal-induced proliferation-associated 1-like protein 2;
                     SPA-1-like 2; SIPA1-like protein 2; spine-associated
                     RapGAP 2"
                     /codon_start=1
                     /product="signal-induced proliferation-associated 1-like
                     protein 2 isoform 1"
                     /protein_id="NP_065859.3"
                     /db_xref="CCDS:CCDS41474.1"
                     /db_xref="GeneID:57568"
                     /db_xref="HGNC:HGNC:23800"
                     /db_xref="MIM:611609"
                     /translation="MSDPRQSQEEKHKLGRASSKFKDPPRIMQSDDYFARKFKAINGN
                     MGPTTSLNASNSNETGGGGPANGTPAVPKMGVRARVSEWPPKKDCSKELTCKALWESR
                     SQTSYESITSVLQNGQSDQSEGQQDEQLDLDFVEAKYTIGDIFVHSPQRGLHPIRQRS
                     NSDVTISDIDAEDVLDQNAVNPNTGAALHREYGSTSSIDRQGLSGENFFAMLRGYRVE
                     NYDHKAMVPFGFPEFFRCDPAISPSLHAAAQISRGEFVRISGLDYVDSALLMGRDRDK
                     PFKRRLKSESVETSLFRKLRTVKSEHETFKFTSELEESRLERGIRPWNCQRCFAHYDV
                     QSILFNINEAMATRANVGKRKNITTGASAASQTQMPTGQTGNCESPLGSKEDLNSKEN
                     LDADEGDGKSNDLVLSCPYFRNETGGEGDRRIALSRANSSSFSSGESCSFESSLSSHC
                     TNAGVSVLEVPRENQPIHREKVKRYIIEHIDLGAYYYRKFFYGKEHQNYFGIDENLGP
                     VAVSIRREKVEDAKEKEGSQFNYRVAFRTSELTTLRGAILEDAIPSTARHGTARGLPL
                     KEVLEYVIPELSIQCLRQASNSPKVSEQLLKLDEQGLSFQHKIGILYCKAGQSTEEEM
                     YNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNKTDSTGTHSLYTTYKDYELMFHV
                     STLLPYMPNNRQQLLRKRHIGNDIVTIVFQEPGALPFTPKSIRSHFQHVFVIVKVHNP
                     CTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSAVFRDFLLAKVINAENAAHKSEKFR
                     AMATRTRQEYLKDLAENFVTTATVDTSVKFSFITLGAKKKEKVKPRKDAHLFSIGAIM
                     WHVIARDFGQSADIECLLGISNEFIMLIEKDSKNVVFNCSCRDVIGWTSGLVSIKVFY
                     ERGECVLLSSVDNCAEDIREIVQRLVIVTRGCETVEMTLRRNGLGQLGFHVNFEGIVA
                     DVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSVTVKVVIIQPHDDGSP
                     RRGCSELCRIPMVEYKLDSEGTPCEYKTPFRRNTTWHRVPTPALQPLSRASPIPGTPD
                     RLPCQQLLQQAQAAIPRSTSFDRKLPDGTRSSPSNQSSSSDPGPGGSGPWRPQVGYDG
                     CQSPLLLEHQGSGPLECDGAREREDTMEASRHPETKWHGPPSKVLGSYKERALQKDGS
                     CKDSPNKLSHIGDKSCSSHSSSNTLSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGAS
                     TDSGIDTAPCMPATILGPVHLAGSRSLIHSRAEQWADAADVSGPDDEPAKLYSVHGYA
                     STISAGSAAEGSMGDLSEISSHSSGSHHSGSPSAHCSKSSGSLDSSKVYIVSHSSGQQ
                     VPGSMSKPYHRQGAVNKYVIGWKKSEGSPPPEEPEVTECPGMYSEMDVMSTATQHQTV
                     VGDAVAETQHVLSKEDFLKLMLPDSPLVEEGRRKFSFYGNLSPRRSLYRTLSDESICS
                     NRRGSSFGSSRSSVLDQALPNDILFSTTPPYHSTLPPRAHPAPSMGSLRNEFWFSDGS
                     LSDKSKCADPGLMPLPDTATGLDWTHLVDAARAFEGLDSDEELGLLCHHTSYLDQRVA
                     SFCTLTDMQHGQDLEGAQELPLCVDPGSGKEFMDTTGERSPSPLTGKVNQLELILRQL
                     QTDLRKEKQDKAVLQAEVQHLRQDNMRLQEESQTATAQLRKFTEWFFTTIDKKS"
     exon            2067..2200
                     /gene="SIPA1L2"
                     /gene_synonym="SPAL2; SPAR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..2389
                     /gene="SIPA1L2"
                     /gene_synonym="SPAL2; SPAR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2564
                     /gene="SIPA1L2"
                     /gene_synonym="SPAL2; SPAR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2565..2668
                     /gene="SIPA1L2"
                     /gene_synonym="SPAL2; SPAR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2669..2826
                     /gene="SIPA1L2"
                     /gene_synonym="SPAL2; SPAR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2827..3403
                     /gene="SIPA1L2"
                     /gene_synonym="SPAL2; SPAR2"
                     /inference="alignment:Splign:2.1.0"
     exon            3404..3678
                     /gene="SIPA1L2"
                     /gene_synonym="SPAL2; SPAR2"
                     /inference="alignment:Splign:2.1.0"
     exon            3679..3936
                     /gene="SIPA1L2"
                     /gene_synonym="SPAL2; SPAR2"
                     /inference="alignment:Splign:2.1.0"
     exon            3937..4020
                     /gene="SIPA1L2"
                     /gene_synonym="SPAL2; SPAR2"
                     /inference="alignment:Splign:2.1.0"
     exon            4021..4121
                     /gene="SIPA1L2"
                     /gene_synonym="SPAL2; SPAR2"
                     /inference="alignment:Splign:2.1.0"
     exon            4122..4225
                     /gene="SIPA1L2"
                     /gene_synonym="SPAL2; SPAR2"
                     /inference="alignment:Splign:2.1.0"
     exon            4226..4614
                     /gene="SIPA1L2"
                     /gene_synonym="SPAL2; SPAR2"
                     /inference="alignment:Splign:2.1.0"
     exon            4615..4839
                     /gene="SIPA1L2"
                     /gene_synonym="SPAL2; SPAR2"
                     /inference="alignment:Splign:2.1.0"
     exon            4840..4993
                     /gene="SIPA1L2"
                     /gene_synonym="SPAL2; SPAR2"
                     /inference="alignment:Splign:2.1.0"
     exon            4994..5213
                     /gene="SIPA1L2"
                     /gene_synonym="SPAL2; SPAR2"
                     /inference="alignment:Splign:2.1.0"
     exon            5214..5345
                     /gene="SIPA1L2"
                     /gene_synonym="SPAL2; SPAR2"
                     /inference="alignment:Splign:2.1.0"
     exon            5346..5399
                     /gene="SIPA1L2"
                     /gene_synonym="SPAL2; SPAR2"
                     /inference="alignment:Splign:2.1.0"
     exon            5400..5523
                     /gene="SIPA1L2"
                     /gene_synonym="SPAL2; SPAR2"
                     /inference="alignment:Splign:2.1.0"
     exon            5524..5605
                     /gene="SIPA1L2"
                     /gene_synonym="SPAL2; SPAR2"
                     /inference="alignment:Splign:2.1.0"
     exon            5606..6914
                     /gene="SIPA1L2"
                     /gene_synonym="SPAL2; SPAR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6883..6888
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIPA1L2"
                     /gene_synonym="SPAL2; SPAR2"
                     /note="hexamer: AATAAA"
     polyA_site      6914
                     /gene="SIPA1L2"
                     /gene_synonym="SPAL2; SPAR2"
                     /note="major polyA site"
ORIGIN      
        1 agactgggag cccgggagga gctggcggag cgagaggagg aggaggacgg aggaggagca
       61 ccgcgccccc gccggccgcc cgagcgcagg ccgagagctc cagccgcagc cagcgggtcc
      121 gggccgcctc cgccggagcc cggcgcgggg agagtccggg ccgatgggca gccccgggca
      181 gcggcgggcg gcgaggcggc agcccgggta cgcgccgccc ggcgcgcaca ggctgtagca
      241 ggttccggcg gacggcgttg cgaaggttct tgccaggctg tgtgagcagg agcccgctgc
      301 tcttccccac tcaggtgaag gaaatactca tgaccagcca gatgtcttaa ggaatgcttt
      361 tgaaaagaac agaggcgtac aacattatta cgacaacaga gaagcaagtt ggctttgaag
      421 aaactgtatt ctgaggatgt tgtttgcttt gggctaagaa aagaaaaaat acaactacag
      481 acaaagcctt tatatctgca agtattatgg cgtggtcggt agcaatgtaa ttagatttac
      541 atcagtcttc ctggtgagac ttggaggctc ttcctcggta gacatgagtg acccaaggca
      601 gtcacaagaa gagaagcaca agctaggcag agcctcttca aagttcaagg atccccctag
      661 aatcatgcag tcagatgatt attttgctcg gaaatttaaa gccattaatg gcaacatggg
      721 acccactact tctttaaatg cctcgaattc caatgagact ggcggtggtg gtccggctaa
      781 tggtacccca gctgtgccca agatgggtgt gagagcaagg gtgtctgaat ggcctcctaa
      841 aaaggactgt tccaaggagc taacatgcaa ggcactgtgg gaaagccggt ctcagaccag
      901 ttatgaaagc atcacttctg tcctgcagaa tgggcagagt gaccagagtg aaggtcagca
      961 agatgaacag ctcgatctgg acttcgtgga ggccaagtac acaatcggag acatctttgt
     1021 ccattccccc caaagaggac ttcaccccat aagacagagg agcaatagtg atgtcactat
     1081 cagtgacatt gatgccgaag atgtcttaga ccaaaatgca gtcaacccca acaccggggc
     1141 tgccctgcac agggagtatg gaagtacttc atccatcgac aggcaaggct tatctggtga
     1201 aaactttttt gctatgctca gagggtaccg agtagaaaat tatgaccaca aagcaatggt
     1261 cccttttggg ttccctgaat ttttccgctg tgaccctgca atctctccga gccttcatgc
     1321 agcagcacag atttctaggg gagaatttgt ccgcatctca ggattagatt atgtggacag
     1381 tgccctcctg atggggagag acagggacaa gcctttcaaa cggaggttga aatcagagtc
     1441 ggtggaaaca tctctcttcc gaaagcttcg aactgttaaa agtgagcacg aaactttcaa
     1501 gttcacgtct gagctggagg agagccgact ggagaggggc attcgccctt ggaattgtca
     1561 gcgatgtttt gcacattatg atgtccagag cattttgttt aatatcaacg aagccatggc
     1621 tacgagggct aatgtgggga aaaggaaaaa cataaccact ggggcatctg cagcatccca
     1681 gactcagatg cctacgggcc agacaggcaa ctgtgagtcc cctttaggga gcaaggagga
     1741 cctcaactcc aaagagaacc tggatgccga tgagggtgat gggaaaagta acgacctcgt
     1801 ccttagttgt ccttacttta gaaatgagac tggaggggaa ggcgacaggc ggattgcgct
     1861 ctctcgagcc aactcatcct ctttcagttc tggggaaagc tgctctttcg aatcgtcact
     1921 cagctctcac tgcacaaatg caggtgtctc cgtcttggaa gtgcccagag aaaaccagcc
     1981 tattcacagg gagaaagtga agcgctacat catagaacac attgaccttg gggcctatta
     2041 ttaccgcaaa ttcttctatg ggaaagagca ccaaaactac tttggaatag atgaaaacct
     2101 tggtccagta gcagtcagca tccggagaga gaaggtggaa gatgccaagg agaaagaagg
     2161 atcccagttc aactacaggg tggctttcag gacaagtgag cttacaacac tgagaggagc
     2221 aattttagaa gatgctatac cctctactgc taggcatggt accgcacgag gactacctct
     2281 caaagaagtt ttggaatacg tcattccaga gctgagcatt cagtgtttgc gacaggcttc
     2341 caactcaccc aaggtctcag agcagctgct caagcttgat gaacaagggc tgagctttca
     2401 gcacaagatc gggatccttt attgcaaagc aggccagagc acagaggaag agatgtataa
     2461 caatgagacg gcgggaccag cttttgaaga attccttgat cttctgggcc agagagtccg
     2521 actgaaagga tttagtaaat atcgagctca gctagacaat aagactgatt ccacgggcac
     2581 gcactctctc tataccacat acaaagacta cgaactcatg ttccacgtgt caaccctgct
     2641 tccctacatg cccaacaaca gacaacagct actgaggaaa aggcacatag gaaatgacat
     2701 cgtcaccatc gtcttccagg agcctggggc acttcctttt actccaaaaa gcatccggtc
     2761 tcactttcag catgtctttg tcatagtcaa agtgcataat ccatgtaccg aaaatgtgtg
     2821 ttatagtgtt ggagtttcca gatcaaaaga tgtgccacca tttggcccac cgattcccaa
     2881 aggtgtaact tttccaaagt cagccgtgtt ccgggacttc cttttagcca aagtaatcaa
     2941 tgcagaaaat gcagcccata aatcagaaaa gtttcgagca atggccactc gaacgaggca
     3001 ggagtacttg aaagatctgg cggagaactt tgtcacaacc gccaccgtgg atacctctgt
     3061 gaagttcagc ttcattacgc tgggtgcgaa gaaaaaggag aaggtaaagc caaggaagga
     3121 tgcccacttg tttagcattg gggccatcat gtggcacgtg atagcccggg acttcggcca
     3181 gtctgctgac attgaatgtc ttctcgggat ctccaatgag ttcatcatgt tgattgaaaa
     3241 ggattccaag aatgttgtat tcaactgttc ctgcagggat gtgattgggt ggacatctgg
     3301 attagtgagt atcaaagtgt tttacgaaag aggagaatgt gtcctcctgt cctcggtaga
     3361 caactgtgct gaagacatca gggaaattgt tcagcgatta gtaatagtga cgagaggctg
     3421 cgagactgtg gaaatgaccc tgaggaggaa cgggctgggc cagcttggct tccatgtgaa
     3481 ttttgaagga attgtcgcag atgtggaacc ttttggcttt gcctggaagg ctggccttcg
     3541 ccaagggagc cgcctcgtgg agatctgcaa agtagccgtg gccactctga cccacgagca
     3601 gatgatcgac ctgctccgta cttctgtgac tgtgaaggtg gtcatcatcc agccccatga
     3661 tgacggctcg ccccgaagag ggtgttcaga gctctgccgg atccctatgg tggaatataa
     3721 actcgacagc gagggcaccc cctgcgagta taaaaccccc ttcaggagga acaccacgtg
     3781 gcaccgggtg cccactcctg ccctgcagcc cctctctaga gcttccccca tccccggcac
     3841 gcccgaccgg ctgccgtgcc aacagctgct ccagcaggcc caggctgcca ttcctcgaag
     3901 cacctccttc gaccggaagc tgcccgatgg cacgagaagc tcacccagca accagtcatc
     3961 ctccagcgac cctggacccg gcgggagcgg accctggaga ccacaagtgg gctacgacgg
     4021 gtgccagtcc cctctactgc tcgaacacca gggctcaggc cctttggaat gtgacggagc
     4081 cagggagagg gaagacacca tggaagcaag caggcacccg gaaaccaaat ggcatggccc
     4141 accttccaaa gtcctgggtt cctataaaga aagagctctg cagaaagatg gaagttgcaa
     4201 agattccccc aataagcttt ctcacattgg ggataaaagt tgctccagtc actccagcag
     4261 caacacgctc tccagcaaca cctccagcaa cagtgacgac aagcactttg ggtctggcga
     4321 cctgatggac cccgaattac tggggctgac ctacatcaaa ggggcctcca ccgacagtgg
     4381 catcgacacg gccccctgca tgcctgccac catcctcggc cctgtgcacc tggcaggcag
     4441 caggtccctg atccacagcc gggccgagca gtgggctgat gctgccgacg tctctgggcc
     4501 tgacgacgag ccagccaagt tatattctgt gcatggctac gcgtccacca tctccgccgg
     4561 cagtgctgcg gaaggcagca tgggcgatct cagtgagata tcctctcatt ccagtggttc
     4621 tcaccattca ggaagccctt cagctcactg ttcaaaaagt agtgggtctc tggattcatc
     4681 caaagtctac atcgtgtctc acagcagcgg acaacaggtt cccgggtcca tgtccaagcc
     4741 ctaccacaga caaggggcag tgaacaaata tgtcatcggc tggaagaaat cggagggcag
     4801 cccaccgccc gaggagcctg aagtgactga atgtcccggg atgtatagtg agatggatgt
     4861 catgtccaca gcaactcagc atcagacagt ggtgggagat gctgttgcag agactcaaca
     4921 tgttctgtct aaagaagatt ttctgaaatt gatgcttcct gacagcccct tagtggagga
     4981 ggggcgaaga aagttttcgt tctatgggaa cctgtctcca aggaggtcgc tttaccgcac
     5041 gctgtctgac gagagcatct gcagcaacag gagggggtcc tcctttggca gttcccggag
     5101 ttccgtgctt gaccaggccc tgcccaacga cattctgttc agcaccaccc caccctacca
     5161 cagcacgctg cctccgcggg cccaccccgc acccagcatg gggagcctga gaaatgagtt
     5221 ctggttctcc gatgggtcct tatcagataa gtccaagtgc gcagatcctg gcctgatgcc
     5281 cctcccggac acagccacag ggttagattg gacccacctc gtggatgctg cacgggcatt
     5341 tgaaggtctt gactcagatg aagaactggg gctgctctgt caccacacgt cctatctaga
     5401 ccagagggtg gcatccttct gcaccctgac agatatgcag catgggcagg acctggaagg
     5461 ggcccaagag ctgcccttat gtgtagatcc aggcagtggc aaagagttca tggacacaac
     5521 tggggagcgt tctccatcac cactgaccgg gaaagtcaat cagctggaat taattcttcg
     5581 acaactccag accgaccttc ggaaggaaaa acaagacaag gccgttctcc aagcagaagt
     5641 gcagcacctg agacaggaca acatgagact gcaggaggag tcccagaccg cgacagctca
     5701 gctgcggaaa ttcacagaat ggtttttcac caccatcgac aaaaaatctt agccaatccg
     5761 cacctcatca agggaccact gggaaatgcc ccttgtccct ttgaagtcac aaacatgtgg
     5821 tttttctgtg tgctttcaac caatcgtaga tgtttttgct gttccattct gtgtagcacc
     5881 attcaccaca gcaggatagg gagcctcgac tctttctcgg taaccacggc agagagcagc
     5941 gccgatgtga agatgaatga atgtaactcc tggtgtgaag atgaatgtaa accctggcga
     6001 cagttgagac ctttttcttt tagactctgc taaaacagtg ctctggcttg ggcttacctc
     6061 aagagggaag atagttgagt tttatttcct gtatatcagg tgacctggta gagatgtaaa
     6121 gcaatttacc atagtttggg ctttagtatt gtaaaataaa catgagaaca aataatcaga
     6181 catatacttt aatgttaaag gtgctctatt tttttggatg tacagtagtt ttatttccac
     6241 agccacatta ccatagcaat aagaaaggag gcatagtaca tagttggaaa agctttgtgg
     6301 ggggattaaa aaaaaaaaaa agcactgttg tgtttaacac tagttcagat gcagttacct
     6361 tagagactta tttatttgca ggaacaaatg gtgcctgaat attaacagtg ttctgattaa
     6421 aaacaaaaaa aagatacata tgccttgtaa atggctcacc gagtggtcag tagtcacttc
     6481 aactcttagt tcacttttgt atagttgctc tgctggaaag aaatgagagt gaatctgctt
     6541 actcactaga acttccctgt gtgctgtgag ccagcggaac cacttgtaca atgccagatt
     6601 tgtttatctt tgtacagaag ctttgatgaa gtgtcttgta tttaacaccc ttatttaagc
     6661 ttatttaacc ttaaattgtt aattttataa aatttggttt ggcctgcact acgatgaggg
     6721 atggaggtag ctgcaggctc agaagagact gagcttgcac agatcagacc gagaagcagg
     6781 gtgagagatt ctaacgactg gatgctgcta gtaacacatt gtttgtattg ctttaccatt
     6841 tttaactgtt agatttgaga tgaacataca ttttgctttt ttaataaatg tttaaaagaa
     6901 gtccacataa gaaa
//
