LOCUS       NM_001386936            7952 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens signal induced proliferation associated 1 like 1
            (SIPA1L1), transcript variant 10, mRNA.
ACCESSION   NM_001386936 XM_024449531
VERSION     NM_001386936.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7952)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   2  (bases 1 to 7952)
  AUTHORS   Bentley,S.R., Guella,I., Sherman,H.E., Neuendorf,H.M., Sykes,A.M.,
            Fowdar,J.Y., Silburn,P.A., Wood,S.A., Farrer,M.J. and Mellick,G.D.
  TITLE     Hunting for Familial Parkinson's Disease Mutations in the Post
            Genome Era
  JOURNAL   Genes (Basel) 12 (3), 430 (2021)
   PUBMED   33802862
  REMARK    GeneRIF: Hunting for Familial Parkinson's Disease Mutations in the
            Post Genome Era.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7952)
  AUTHORS   Dolnik,A., Kanwal,N., Mackert,S., Halbedl,S., Proepper,C.,
            Bockmann,J., Schoen,M., Boeckers,T.M., Kuhl,S.J. and
            Schmeisser,M.J.
  TITLE     Sipa1l3/SPAR3 is targeted to postsynaptic specializations and
            interacts with the Fezzin ProSAPiP1/Lzts3
  JOURNAL   J Neurochem 136 (1), 28-35 (2016)
   PUBMED   26364583
  REMARK    GeneRIF: Sipa1L1 is conserved across species, has a distinct
            expression pattern in brain and is localized to excitatory
            postsynapses.
REFERENCE   4  (bases 1 to 7952)
  AUTHORS   Quillen,E.E., Chen,X.D., Almasy,L., Yang,F., He,H., Li,X.,
            Wang,X.Y., Liu,T.Q., Hao,W., Deng,H.W., Kranzler,H.R. and
            Gelernter,J.
  TITLE     ALDH2 is associated to alcohol dependence and is the major genetic
            determinant of 'daily maximum drinks' in a GWAS study of an
            isolated rural Chinese sample
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 165B (2), 103-110 (2014)
   PUBMED   24277619
REFERENCE   5  (bases 1 to 7952)
  AUTHORS   Zhu,J., Shang,Y., Xia,C., Wang,W., Wen,W. and Zhang,M.
  TITLE     Guanylate kinase domains of the MAGUK family scaffold proteins as
            specific phospho-protein-binding modules
  JOURNAL   EMBO J 30 (24), 4986-4997 (2011)
   PUBMED   22117215
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7952)
  AUTHORS   Lee,C., Wooldridge,T.R. and Laimins,L.A.
  TITLE     Analysis of the roles of E6 binding to E6TP1 and nuclear
            localization in the human papillomavirus type 31 life cycle
  JOURNAL   Virology 358 (1), 201-210 (2007)
   PUBMED   16999984
  REMARK    GeneRIF: investigated the consequences of human papillomavirus 31
            E6 binding to E6TP1; observed that binding & degradation of E6TP1
            by HPV type 31 E6 are required to extend life span of keratinocytes
            & the long-term, stable replication of the viral genome
REFERENCE   7  (bases 1 to 7952)
  AUTHORS   Benzinger,A., Muster,N., Koch,H.B., Yates,J.R. 3rd and Hermeking,H.
  TITLE     Targeted proteomic analysis of 14-3-3 sigma, a p53 effector
            commonly silenced in cancer
  JOURNAL   Mol Cell Proteomics 4 (6), 785-795 (2005)
   PUBMED   15778465
REFERENCE   8  (bases 1 to 7952)
  AUTHORS   Chih,D.Y., Park,D.J., Gross,M., Idos,G., Vuong,P.T., Hirama,T.,
            Chumakov,A.M., Said,J. and Koeffler,H.P.
  TITLE     Protein partners of C/EBPepsilon
  JOURNAL   Exp Hematol 32 (12), 1173-1181 (2004)
   PUBMED   15588942
REFERENCE   9  (bases 1 to 7952)
  AUTHORS   Pak,D.T., Yang,S., Rudolph-Correia,S., Kim,E. and Sheng,M.
  TITLE     Regulation of dendritic spine morphology by SPAR, a
            PSD-95-associated RapGAP
  JOURNAL   Neuron 31 (2), 289-303 (2001)
   PUBMED   11502259
REFERENCE   10 (bases 1 to 7952)
  AUTHORS   Gao,Q., Srinivasan,S., Boyer,S.N., Wazer,D.E. and Band,V.
  TITLE     The E6 oncoproteins of high-risk papillomaviruses bind to a novel
            putative GAP protein, E6TP1, and target it for degradation
  JOURNAL   Mol Cell Biol 19 (1), 733-744 (1999)
   PUBMED   9858596
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005476.4, AC004968.1, AC004974.1 and AC004900.2.
            
            On Sep 16, 2020 this sequence version replaced XM_024449531.1.
            
            Transcript Variant: This variant (10), as well as variant 2,
            encodes isoform 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853563.10286.1,
                                           SRR18074969.845800.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381232.8/ ENSP00000370630.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AC005476.4         25503-25530         c
            29-88               AC005476.4         24825-24884         c
            89-191              AC004968.1         32971-33073         c
            192-250             AC004968.1         16446-16504         c
            251-2050            AC004974.1         69077-70876         c
            2051-2181           AC004974.1         39560-39690         c
            2182-2370           AC004974.1         34211-34399         c
            2371-2545           AC004974.1         7938-8112           c
            2546-2649           AC004974.1         11-114              c
            2650-2807           AC004900.2         110030-110187       c
            2808-3381           AC004900.2         99805-100378        c
            3382-3656           AC004900.2         98875-99149         c
            3657-3926           AC004900.2         85866-86135         c
            3927-4073           AC004900.2         72370-72516         c
            4074-4198           AC004900.2         68992-69116         c
            4199-4317           AC004900.2         66157-66275         c
            4318-4760           AC004900.2         61833-62275         c
            4761-5000           AC004900.2         47611-47850         c
            5001-5166           AC004900.2         46662-46827         c
            5167-5413           AC004900.2         41196-41442         c
            5414-5560           AC004900.2         37685-37831         c
            5561-5675           AC004900.2         36106-36220         c
            5676-5760           AC004900.2         33172-33256         c
            5761-7952           AC004900.2         30288-32479         c
FEATURES             Location/Qualifiers
     source          1..7952
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     gene            1..7952
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /note="signal induced proliferation associated 1 like 1"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
     exon            1..28
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            29..88
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            89..191
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            192..250
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            251..2050
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             553..5904
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /note="isoform 2 is encoded by transcript variant 10;
                     signal-induced proliferation-associated 1-like protein 1;
                     SIPA1-like protein 1; high-risk human papilloma viruses E6
                     oncoproteins targeted protein 1; spine-associated RapGAP
                     1"
                     /codon_start=1
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform 2"
                     /protein_id="NP_001373865.1"
                     /db_xref="CCDS:CCDS61490.1"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
                     /translation="MTSLKRSQTERPLATDRASVVGTDGTPKVHTDDFYMRRFRSQNG
                     SLGSSVMAPVGPPRSEGSHHITSTPGVPKMGVRARIADWPPRKENIKESSRSSQEIET
                     SSCLDSLSSKSSPVSQGSSVSLNSNDSAMLKSIQNTLKNKTRPSENMDSRFLMPEAYP
                     SSPRKALRRIRQRSNSDITISELDVDSFDECISPTYKTGPSLHREYGSTSSIDKQGTS
                     GESFFDLLKGYKDDKSDRGPTPTKLSDFLITGGGKGSGFSLDVIDGPISQRENLRLFK
                     EREKPLKRRSKSETGDSSIFRKLRNAKGEELGKSSDLEDNRSEDSVRPWTCPKCFAHY
                     DVQSILFDLNEAIMNRHNVIKRRNTTTGASAAAVASLVSGPLSHSASFSSPMGSTEDL
                     NSKGSLSMDQGDDKSNELVMSCPYFRNEIGGEGERKISLSKSNSGSFSGCESASFEST
                     LSSHCTNAGVAVLEVPKENLVLHLDRVKRYIVEHVDLGAYYYRKFFYQKEHWNYFGAD
                     ENLGPVAVSIRREKPDEMKENGSPYNYRIIFRTSELMTLRGSVLEDAIPSTAKHSTAR
                     GLPLKEVLEHVVPELNVQCLRLAFNTPKVTEQLMKLDEQGLNYQQKVGIMYCKAGQST
                     EEEMYNNESAGPAFEEFLQLLGERVRLKGFEKYRAQLDTKTDSTGTHSLYTTYKDYEI
                     MFHVSTMLPYTPNNKQQLLRKRHIGNDIVTIVFQEPGAQPFSPKNIRSHFQHVFVIVR
                     VHNPCSDSVCYSVAVTRSRDVPSFGPPIPKGVTFPKSNVFRDFLLAKVINAENAAHKS
                     EKFRAMATRTRQEYLKDLAEKNVTNTPIDPSGKFPFISLASKKKEKSKPYPGAELSSM
                     GAIVWAVRAEDYNKAMELDCLLGISNEFIVLIEQETKSVVFNCSCRDVIGWTSTDTSL
                     KIFYERGECVSVGSFINIEEIKEIVKRLQFVSKGCESVEMTLRRNGLGQLGFHVNYEG
                     IVADVEPYGYAWQAGLRQGSRLVEICKVAVATLSHEQMIDLLRTSVTVKVVIIPPHDD
                     CTPRRSCSETYRMPVMEYKMNEGVSYEFKFPFRNNNKWQRNASKGPHSPQVPSQVQSP
                     MTSRLNAGKGDGKMPPPERAANIPRSISSDGRPLERRLSPGSDIYVTVSSMALARSQC
                     RNSPSNLSSSSDTGSVGGTYRQKSMPEGFGVSRRSPASIDRQNTQSDIGGSGKSTPSW
                     QRSEDSIADQMEPTCHLPAVSKVLPAFRESPSGRLMRQDPVVHLSPNKQGHSDSHYSS
                     HSSSNTLSSNASSAHSDEKWYDGDRTESELNSYNYLQGTSADSGIDTTSYGPSHGSTA
                     SLGAATSSPRSGPGKEKVAPLWHSSSEVISMADRTLETESHGLDRKTESSLSLDIHSK
                     SQAGSTPLTRENSTFSINDAASHTSTMSSRHSASPVVFTSARSSPKEELHPAAPSQLA
                     PSFSSSSSSSSGPRSFYPRQGATSKYLIGWKKPEGTINSVGFMDTRKRHQSDGNEIAH
                     TRLRASTRDLRASPKPTSKSTIEEDLKKLIDLESPTPESQKSFKFHALSSPQSPFPST
                     PTSRRALHRTLSDESIYNSQREHFFTSRASLLDQALPNDVLFSSTYPSLPKSLPLRRP
                     SYTLGMKSLHGEFSASDSSLTDIQETRRQPMPDPGLMPLPDTAADLDWSNLVDAAKAY
                     EVQRASFFAASDENHRPLSAASNSDQLEDQALAQMKPYSSSKDSSPTLASKVDQLEGM
                     LKMLREDLKKEKEDKAHLQAEVQHLREDNLRLQEESQNASDKLKKFTEWVFNTIDMS"
     exon            2051..2181
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2182..2370
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2371..2545
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..2649
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2650..2807
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2808..3381
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3382..3656
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3657..3926
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3927..4073
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4074..4198
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4199..4317
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4318..4760
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4761..5000
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            5001..5166
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            5167..5413
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            5414..5560
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            5561..5675
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            5676..5760
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            5761..7952
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6127..6132
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /note="hexamer: AATAAA"
     polyA_site      6148
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /note="major polyA site"
     regulatory      7757..7762
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /note="hexamer: AATAAA"
     polyA_site      7787
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /note="major polyA site"
     regulatory      7930..7935
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /note="hexamer: AATAAA"
     polyA_site      7952
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
ORIGIN      
        1 agtgcgtgcg tgagcgagtg agcgaaaagg agagcgcgcg gcggacgcgc ccgggacgcg
       61 cggcggcacc gggaggccgg gccgagcggc cctccctatc ctgaagacat tagctgagag
      121 tctggcacct tttaaaggtc tgatcatcaa ttgtctctct gggcggccac ctatgagact
      181 tcatctgtgt ggttatacct tattggtgtg gacgttgtct aaatttcggt agccatggca
      241 caagaatata agaaagcatg ggattatggc aaccacagaa tctcagtagt acaagttcca
      301 ttcagttttt tctgaaagaa agccctctgt taaagtgaag caaagaaact gttgtggatt
      361 ataacgttta gaagttccaa tttttcagtg ctttacaaat aaagcatcat ttaacctttt
      421 aaatgaaaaa gattaagatc tcatgcaact gttgtatttt ctggaagcca ttctccaaaa
      481 gggaagtgca catttaaaac acagatatga tggtccttgc tgcagggatt taagtctact
      541 tgcttttaca tcatgaccag cttgaaacgg tcacagacag aaaggcctct tgccactgac
      601 agggcctctg ttgttggcac agacggcacc cccaaagtcc acactgatga tttctacatg
      661 cggcgcttcc ggtcccaaaa tggcagctta ggatcatcag ttatggctcc tgtaggaccc
      721 ccccgaagtg aaggttctca ccatataacc tcaacccccg gagtcccaaa aatgggggta
      781 agggcaagga ttgcagattg gcccccaaga aaggaaaaca taaaagaatc tagccgttca
      841 agccaggaaa tagaaacctc aagttgcctt gatagcctgt cctccaaaag cagtcctgtg
      901 agtcagggaa gttctgttag cctcaattcc aatgactcag ccatgctgaa aagcatacag
      961 aacacgctga aaaacaagac aagaccgtcg gagaacatgg actccagatt tctcatgcct
     1021 gaagcctacc ccagctcccc cagaaaagct cttcgcagaa tacgccagcg aagcaacagt
     1081 gatatcacca taagtgaact tgatgtggat agctttgatg aatgtatctc acctacatac
     1141 aagactggac catcactgca cagggaatat ggtagcacat cttcaattga taaacaggga
     1201 acatctggag aaagcttttt tgatttgtta aagggctaca aagatgacaa atctgatcga
     1261 ggtccaactc caaccaagct cagtgacttt ctcattactg gtggtggcaa gggttctggt
     1321 ttctctttgg atgtaataga cgggcctatc tcacagagag agaacctcag gctttttaag
     1381 gaaagggaaa aaccactcaa gcgacgttca aaatctgaaa ctggagactc atctattttt
     1441 cgtaaattgc gcaatgccaa aggtgaagaa cttgggaagt catcagatct tgaagataac
     1501 cgatcagaag actctgtcag gccctggaca tgtccaaagt gctttgccca ctatgatgtc
     1561 cagagtatat tatttgattt gaatgaggca attatgaaca ggcacaatgt tattaagagg
     1621 agaaacacca ccactggagc ttccgcagct gccgtggcat ccttggtctc tggacctctg
     1681 tctcattcag ccagttttag ctccccaatg ggcagcacag aggacctgaa ttccaaagga
     1741 agcctcagca tggaccaggg agatgataaa agcaatgagc ttgtaatgag ctgtccatat
     1801 tttcggaatg agataggtgg agaaggggag aggaaaatca gcctttcaaa atcaaattct
     1861 ggctccttta gtggatgtga aagtgcctcc tttgagtcta cccttagttc ccattgcaca
     1921 aatgcaggag tggcagtact tgaagtgccc aaggagaact tggtgttgca cctagataga
     1981 gtgaaaagat acatcgtgga acacgtagat ctgggtgcat actattatag aaaatttttc
     2041 taccagaagg aacactggaa ctattttggg gctgatgaga atcttggtcc agtggctgtg
     2101 agcattcgaa gggaaaaacc agatgaaatg aaagaaaatg gatctccgta caactaccga
     2161 ataattttta gaactagtga gctcatgaca ctgagaggtt cggtcctgga ggacgccatt
     2221 ccgtcgacag ccaagcactc gacagccaga ggcctgcctc tcaaagaagt gctggagcac
     2281 gtggttcctg agctcaatgt ccagtgcctg cggttggcct tcaacacacc caaggtcaca
     2341 gagcagctca tgaaactgga tgaacaaggg ctgaactacc agcagaaagt aggcatcatg
     2401 tactgcaaag ctggacagag cactgaagaa gagatgtaca acaatgagtc agctggccca
     2461 gcctttgaag aatttcttca actattggga gagcgagttc ggctcaaagg atttgagaag
     2521 tatcgagcac agcttgatac caaaactgac tccactggaa cccattctct gtacacaaca
     2581 tacaaagatt atgaaattat gttccatgtt tctaccatgc tgccatacac acccaacaac
     2641 aaacaacagc tcctgaggaa gcggcacatt ggaaatgata tcgtaacaat tgttttccaa
     2701 gagcctggag cacagccatt cagcccaaaa aacatccgat cccacttcca gcacgttttc
     2761 gtcatcgtca gggtgcacaa tccgtgctct gacagtgtct gttatagtgt ggctgttacc
     2821 aggtccagag atgtgccttc ctttgggcct cccattccta aaggggtcac tttccctaag
     2881 tcaaatgtgt tcagggactt ccttttggcg aaagtgatta atgcagaaaa tgctgctcat
     2941 aaatcggaga agtttcgggc catggcaact cggacccgcc aggaatacct gaaagatctg
     3001 gcagaaaaga atgtcaccaa cacccctatc gacccttctg gcaagtttcc gttcatctct
     3061 ctggcttcca agaagaagga aaagtctaag ccatatccag gagccgagct cagcagcatg
     3121 ggggccattg tatgggcagt ccgggctgaa gactacaaca aggccatgga actagactgc
     3181 cttttaggga tctccaatga gttcattgtg ctcattgaac aggaaacaaa gagcgtggtc
     3241 ttcaattgtt cctgtagaga tgtgataggg tggacttcaa ctgacaccag cctcaaaatc
     3301 ttctatgaac gaggagaatg tgtttcagtg ggtagtttta ttaacattga ggagatcaaa
     3361 gagattgtca aaaggttgca gtttgtttca aaaggctgtg aatcggtgga gatgactctg
     3421 cgaagaaatg ggctaggaca gcttggcttc catgtcaact atgagggcat tgtggcggat
     3481 gtggagccct acggttatgc ctggcaggca gggctgaggc agggcagtcg cctggtggag
     3541 atctgcaagg tggcggtagc cactctgagc catgagcaga tgatcgacct cctgagaaca
     3601 tctgtcacgg tgaaggttgt catcattccc ccgcatgatg actgcacccc gcggaggagt
     3661 tgctctgaaa cctaccgcat gccagtgatg gagtacaaaa tgaatgaagg tgtttcatac
     3721 gaattcaagt ttcccttccg aaataataac aagtggcaga ggaacgccag caaggggcct
     3781 cattcacctc aagtcccgtc ccaggtgcag agtcccatga cctcgcggct gaatgctgga
     3841 aaaggagatg ggaagatgcc tcctccagaa agagccgcca acatccctcg aagcatctcc
     3901 agtgacgggc gcccactaga gaggcggctg tctcctggtt cggacatcta tgtgacggtc
     3961 tcatccatgg ctttagcaag atcccagtgt cggaactctc ctagcaactt gtcttcatcc
     4021 agtgatactg gttctgtggg gggcacttac aggcagaagt ccatgcccga agggtttgga
     4081 gtgagccgta gatccccagc ctccattgac aggcagaaca cccagtcaga tattggtggc
     4141 agcggaaaat ccacgcctag ctggcaaaga agtgaggata gcattgctga ccagatggag
     4201 ccaacatgcc atctcccagc agtatcaaag gtactgccag ctttccgaga gagccccagt
     4261 gggagattaa tgcggcagga tccagtggtt catttgtctc caaacaaaca agggcattct
     4321 gatagccact actcgagcca ctccagtagc aatactctct ccagcaatgc gtcaagtgcc
     4381 catagtgatg agaagtggta cgatggggac cgcacagaat ccgaactcaa cagctataac
     4441 tatctgcaag gcacctctgc tgacagtggc attgacacca cctcttatgg ccccagccac
     4501 ggcagcacag cctcgctggg ggctgccaca tcgtcacctc gctcagggcc aggcaaggag
     4561 aaagtggcac ccctatggca cagctccagt gaagtaatct ccatggcaga tcggactttg
     4621 gagacagaga gccacggcct ggaccggaaa acagagtctt ccctgagctt agacatacac
     4681 agcaagagcc aagccggctc gacccctctg acaagggaga acagcacctt cagtataaac
     4741 gatgctgctt cccacacaag taccatgagc tcccgacact ctgccagccc agtggttttc
     4801 accagtgccc ggagttcacc taaagaagag cttcatccag ctgccccctc acagctcgca
     4861 ccatccttct cctcctcttc ctcctcctcc tctggtccta ggagttttta ccctcgccag
     4921 ggcgctacta gcaagtacct gattggatgg aaaaaacccg aaggaaccat aaactccgtg
     4981 ggatttatgg acacgagaaa gcgtcatcag agcgatggca atgaaatagc ccacaccagg
     5041 ctgcgtgcct caaccagaga cctccgggca tctcctaagc caacctccaa gtccaccatt
     5101 gaagaagatc taaagaaact aattgatctt gaaagcccaa ctcctgaatc acagaagagt
     5161 tttaagttcc acgcactctc ctctcctcag tctcctttcc ccagcacccc cacctcacgg
     5221 cgggccttgc acagaacact gtcggacgag agcatttaca atagccagag ggagcacttt
     5281 ttcacctcca gggcgtcact tctggaccaa gccctgccca acgacgtcct cttcagtagc
     5341 acgtaccctt ctctccccaa gtcgctcccg ttgaggaggc cttcttacac cttaggaatg
     5401 aaatcgctgc atggagagtt ctcagcctcg gacagctccc tcactgacat ccaggagacc
     5461 cgcaggcagc ctatgcccga ccctggcctg atgcccctgc ctgacactgc tgcagacttg
     5521 gattggtcca acctggtaga tgctgccaaa gcctatgagg tccagagagc ctcatttttt
     5581 gctgctagtg atgaaaacca tcgccccttg agtgctgcat ccaacagtga tcagctggag
     5641 gaccaggctc tggcccagat gaagccttac agcagcagta aagactcctc tcccactctg
     5701 gcttctaaag tggaccagct ggaaggtatg ctgaagatgc ttcgggaaga tttgaagaag
     5761 gaaaaagaag acaaagctca ccttcaggcg gaggtgcagc acctgcgaga ggacaacctg
     5821 aggctacagg aggagtccca gaacgcctcg gacaagctga agaagttcac agaatgggtc
     5881 ttcaacacca tagacatgag ctagggaagg ctgaggagga caggagaagg gcccagacac
     5941 tccctccagt gagtgtcctg cagcccttat tccctccata gaaagcatcc tcagagcacc
     6001 ttccctggct tcctactctg ccccctttcg gggagtgcac aacacaatag ttgcagatca
     6061 acaatcatca cctgcctttt gtagaaaaga aaaacaaaaa aagtaaataa aaattttaaa
     6121 cagtaaaata aaagtttaac tgctaaaatg tgaatgtctt tatttttttg cacaatatct
     6181 ttatctgtta tgtatttaag aagaaactgg gccttggacc agggcgcccc ctggcccatc
     6241 cgcctctatt cccatcagct ttcttatcaa cttcaggtaa cccaagcttt cccttgttat
     6301 tctaacaaat atcattattc ctagaaaaag aatgttttta taacttgttt ggggagtaga
     6361 gagggatatt tccttacctt cttccctaaa atgcctggag agggagttgc tttgagaaaa
     6421 tgcctacctc ccttgaatga ctcgtgcatg agctagtgct gtctgtacct gtcctccaga
     6481 gatcagcagg accggagtta aatatttaac agcaagtctg taaaccagag cagctctgac
     6541 agtgcctgca ggccacaccc cttctcagtc ctgcattgtg aggtcatttc ctgcttctcc
     6601 ctttccccag gaagatggtc ccacttgtgc tgcaagactc ttttttgttt ggcttaattg
     6661 agccccacta aattggaatc aatctctctt acagcttcct ggctccaaac attaattgat
     6721 ttcagaattc ccccaaacta aaaccttatc tgtctgcatt ttgaatgcat tttggtcaaa
     6781 agtatacgtt ttaaagattt ttaaagataa aaatgtggca caactggttt ttttagcttg
     6841 ctgaaaatga ccatatctct aaattaatct ttctctccag agcaagactt caccagtatt
     6901 tgtaactagg agaagctaac agtgaatgtt taattgtgaa ttttaatcat tgcttgttag
     6961 gaataatgac tgtgatacta gaatgggctt ttgaaacctg catgtcccag tgtgaaattt
     7021 cagcacggca ttttctgcat cctttcatgg ccatccaaag gattccgctg cagaaattat
     7081 tgatgtgcta tttttgctgt cttgtgatgc aggctgcttt gggcccctgg gtcactcttc
     7141 caaggctgct gtagagcaca gagacatggg gctggccagt gttgactgac ctgaggagac
     7201 ccctttgttt gttgccttca taactgtcac taaaccgacc cctctgccct ttcagtggca
     7261 actctggtct aagggaacat tcagcactct agcggcatct gattggaagt tccctcaccc
     7321 aagtaatctc aattccttcc tctctccatc cctgaaagaa acaggatgga ttttcctctc
     7381 ttctccctgc tacattcact accagatttt tatgctacag tttcattctt gattgtgatt
     7441 tctccatgga attttttttt tctggtgaca tttctatcat ggaaatagga agatttcgga
     7501 gtgctttgtg aagatttcaa ttgtctgtct ctttctctct ttgacttgta tgaaggagat
     7561 tgtacattgc ctgatatctc tttgtaaatg agaaatattg ctaacatcca agcattctga
     7621 agtcttgctt atccttctga gtttagttct cattttgttt tacattttgt ttggggactt
     7681 ggggcaagct atttattaga gttttgcaac agagttcttg tttgaagcct ctaaagacta
     7741 cctgtaaaat tcaaagaata aaattcattt taaacgctct tttaaaacac tttggtatta
     7801 ttgcttgagg tttgcttatt tgaaagacca cccaataact cattgaccct ccttgcatcc
     7861 gaattttttc atcaagcttt gttaacacta atgatgattc ttgaaaattt ctgtccttct
     7921 cagaatgtta ataaactttt ttactctgtc ca
//
