LOCUS       NM_006747               3499 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens signal-induced proliferation-associated 1 (SIPA1),
            transcript variant 2, mRNA.
ACCESSION   NM_006747
VERSION     NM_006747.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3499)
  AUTHORS   Guo,L., Zhang,W., Zhang,X., Wang,J., Nie,J., Jin,X., Ma,Y.,
            Wang,S., Zhou,X., Zhang,Y., Xu,Y., Tanaka,Y., Yuan,J., Liao,X.H.,
            Gong,Y. and Su,L.
  TITLE     A novel transcription factor SIPA1: identification and verification
            in triple-negative breast cancer
  JOURNAL   Oncogene 42 (35), 2641-2654 (2023)
   PUBMED   37500797
  REMARK    GeneRIF: A novel transcription factor SIPA1: identification and
            verification in triple-negative breast cancer.
REFERENCE   2  (bases 1 to 3499)
  AUTHORS   Ma,Y., Weng,J., Wang,N., Zhang,Y., Minato,N. and Su,L.
  TITLE     A novel nuclear localization region in SIPA1 determines protein
            nuclear distribution and epirubicin-sensitivity of breast cancer
            cells
  JOURNAL   Int J Biol Macromol 180, 718-728 (2021)
   PUBMED   33753200
  REMARK    GeneRIF: A novel nuclear localization region in SIPA1 determines
            protein nuclear distribution and epirubicin-sensitivity of breast
            cancer cells.
REFERENCE   3  (bases 1 to 3499)
  AUTHORS   Wang,N., Weng,J., Xia,J., Zhu,Y., Chen,Q., Hu,D., Zhang,X., Sun,R.,
            Feng,J., Minato,N., Gong,Y. and Su,L.
  TITLE     SIPA1 enhances SMAD2/3 expression to maintain stem cell features in
            breast cancer cells
  JOURNAL   Stem Cell Res 49, 102099 (2020)
   PUBMED   33296812
  REMARK    GeneRIF: SIPA1 enhances SMAD2/3 expression to maintain stem cell
            features in breast cancer cells.
REFERENCE   4  (bases 1 to 3499)
  AUTHORS   Li,J.Y., Wang,J.B., Liu,C.B., Ma,D.L. and Ma,J.H.
  TITLE     Dynamic relationship between SIPA1 gene and protein expression and
            the development of gastric cancer
  JOURNAL   Genet Mol Res 16 (1) (2017)
   PUBMED   28362978
  REMARK    GeneRIF: Study shows that SIPA1 mRNA and protein expression are
            down-regulated in gastric cancer cells and correlate with tumor
            grading, invasion and lymph node metastasis as well as higher
            expression of VEGFA. Low SIPA1 levels in gastric cancer may then
            accelerate tumor development and progression by promoting VEGFA
            expression to increase vascular density.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3499)
  AUTHORS   Takahara,T., Kasamatsu,A., Yamatoji,M., Iyoda,M., Kasama,H.,
            Saito,T., Takeuchi,S., Endo-Sakamoto,Y., Shiiba,M., Tanzawa,H. and
            Uzawa,K.
  TITLE     SIPA1 promotes invasion and migration in human oral squamous cell
            carcinoma by ITGB1 and MMP7
  JOURNAL   Exp Cell Res 352 (2), 357-363 (2017)
   PUBMED   28237246
  REMARK    GeneRIF: SIPA1 promotes oral squamous cell carcinoma metastasis by
            regulating the ITGB1 and MMP7.
REFERENCE   6  (bases 1 to 3499)
  AUTHORS   Ebrahimi,S., Wang,E., Udar,N., Arnold,E., Burbee,D., Small,K. and
            Sawicki,M.P.
  TITLE     Genomic organization and cloning of the human homologue of murine
            Sipa-1
  JOURNAL   Gene 214 (1-2), 215-221 (1998)
   PUBMED   9651531
REFERENCE   7  (bases 1 to 3499)
  AUTHORS   Kurachi,H., Wada,Y., Tsukamoto,N., Maeda,M., Kubota,H., Hattori,M.,
            Iwai,K. and Minato,N.
  TITLE     Human SPA-1 gene product selectively expressed in lymphoid tissues
            is a specific GTPase-activating protein for Rap1 and Rap2.
            Segregate expression profiles from a rap1GAP gene product
  JOURNAL   J Biol Chem 272 (44), 28081-28088 (1997)
   PUBMED   9346962
REFERENCE   8  (bases 1 to 3499)
  AUTHORS   Wada,Y., Kubota,H., Maeda,M., Taniwaki,M., Hattori,M., Imamura,S.,
            Iwai,K. and Minato,N.
  TITLE     Mitogen-inducible SIPA1 is mapped to the conserved syntenic groups
            of chromosome 19 in mouse and chromosome 11q13.3 centromeric to
            BCL1 in human
  JOURNAL   Genomics 39 (1), 66-73 (1997)
   PUBMED   9027487
REFERENCE   9  (bases 1 to 3499)
  AUTHORS   Minato,N.
  TITLE     [Regulatory mechanisms of lymphocyte proliferation: roles of Spa-1
            gene]
  JOURNAL   Hum Cell 9 (1), 11-16 (1996)
   PUBMED   9183624
  REMARK    Review article
REFERENCE   10 (bases 1 to 3499)
  AUTHORS   Hattori,M., Tsukamoto,N., Nur-e-Kamal,M.S., Rubinfeld,B., Iwai,K.,
            Kubota,H., Maruta,H. and Minato,N.
  TITLE     Molecular cloning of a novel mitogen-inducible nuclear protein with
            a Ran GTPase-activating domain that affects cell cycle progression
  JOURNAL   Mol Cell Biol 15 (1), 552-560 (1995)
   PUBMED   7799964
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001362.5.
            
            On Nov 23, 2018 this sequence version replaced NM_006747.3.
            
            Summary: The product of this gene is a mitogen induced GTPase
            activating protein (GAP). It exhibits a specific GAP activity for
            Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or
            other small GTPases. This protein may also hamper mitogen-induced
            cell cycle progression when abnormally or prematurely expressed. It
            is localized to the perinuclear region. Two alternatively spliced
            variants encoding the same isoform have been characterized to date.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC110353.1, AF029789.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000534313.6/ ENSP00000436269.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                AP001362.5         118712-118793
            83-852              AP001362.5         121442-122211
            853-980             AP001362.5         122861-122988
            981-1157            AP001362.5         123074-123250
            1158-1332           AP001362.5         125566-125740
            1333-1436           AP001362.5         126465-126568
            1437-1594           AP001362.5         126832-126989
            1595-2204           AP001362.5         127067-127676
            2205-2479           AP001362.5         127995-128269
            2480-2698           AP001362.5         129873-130091
            2699-2810           AP001362.5         130172-130283
            2811-2919           AP001362.5         130368-130476
            2920-3021           AP001362.5         130561-130662
            3022-3076           AP001362.5         130749-130803
            3077-3155           AP001362.5         131012-131090
            3156-3499           AP001362.5         131180-131523
FEATURES             Location/Qualifiers
     source          1..3499
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..3499
                     /gene="SIPA1"
                     /gene_synonym="SPA1"
                     /note="signal-induced proliferation-associated 1"
                     /db_xref="GeneID:6494"
                     /db_xref="HGNC:HGNC:10885"
                     /db_xref="MIM:602180"
     exon            1..82
                     /gene="SIPA1"
                     /gene_synonym="SPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            83..852
                     /gene="SIPA1"
                     /gene_synonym="SPA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..3302
                     /gene="SIPA1"
                     /gene_synonym="SPA1"
                     /note="signal-induced proliferation-associated gene 1;
                     GTPase-activating protein Spa-1; p130 SPA-1; sipa-1"
                     /codon_start=1
                     /product="signal-induced proliferation-associated protein
                     1"
                     /protein_id="NP_006738.3"
                     /db_xref="CCDS:CCDS8108.1"
                     /db_xref="GeneID:6494"
                     /db_xref="HGNC:HGNC:10885"
                     /db_xref="MIM:602180"
                     /translation="MPMWAGGVGSPRRGMAPASTDDLFARKLRQPARPPLTPHTFEPR
                     PVRGPLLRSGSDAGEARPPTPASPRARAHSHEEASRPAATSTRLFTDPLALLGLPAEE
                     PEPAFPPVLEPRWFAHYDVQSLLFDWAPRSQGMGSHSEASSGTLASAEDQAASSDLLH
                     GAPGFVCELGGEGELGLGGPASPPVPPALPNAAVSILEEPQNRTSAYSLEHADLGAGY
                     YRKYFYGKEHQNFFGMDESLGPVAVSLRREEKEGSGGGTLHSYRVIVRTTQLRTLRGT
                     ISEDALPPGPPRGLSPRKLLEHVAPQLSPSCLRLGSASPKVPRTLLTLDEQVLSFQRK
                     VGILYCRAGQGSEEEMYNNQEAGPAFMQFLTLLGDVVRLKGFESYRAQLDTKTDSTGT
                     HSLYTTYQDHEIMFHVSTMLPYTPNNQQQLLRKRHIGNDIVTIVFQEPGSKPFCPTTI
                     RSHFQHVFLVVRAHTPCTPHTTYRVAVSRTQDTPAFGPALPAGGGPFAANADFRAFLL
                     AKALNGEQAAGHARQFHAMATRTRQQYLQDLATNEVTTTSLDSASRFGLPSLGGRRRA
                     APRGPGAELQAAGSLVWGVRAAPGARVAAGAQASGPEGIEVPCLLGISAEALVLVAPR
                     DGRVVFNCACRDVLAWTFSEQQLDLYHGRGEAITLRFDGSPGQAVGEVVARLQLVSRG
                     CETRELALPRDGQGRLGFEVDAEGFVTHVERFTFAETAGLRPGARLLRVCGQTLPSLR
                     PEAAAQLLRSAPKVCVTVLPPDESGRPRRSFSELYTLSLQEPSRRGAPDPVQDEVQGV
                     TLLPTTKQLLHLCLQDGGSPPGPGDLAEERTEFLHSQNSLSPRSSLSDEAPVLPNTTP
                     DLLLATTAKPSVPSADSETPLTQDRPGSPSGSEDKGNPAPELRASFLPRTLSLRNSIS
                     RIMSEAGSGTLEDEWQAISEIASTCNTILESLSREGQPIPESGDPKGTPKSDAEPEPG
                     NLSEKVSHLESMLRKLQEDLQKEKADRAALEEEVRSLRHNNRRLQAESESAATRLLLA
                     SKQLGSPTADLA"
     exon            853..980
                     /gene="SIPA1"
                     /gene_synonym="SPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1157
                     /gene="SIPA1"
                     /gene_synonym="SPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1332
                     /gene="SIPA1"
                     /gene_synonym="SPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1436
                     /gene="SIPA1"
                     /gene_synonym="SPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1594
                     /gene="SIPA1"
                     /gene_synonym="SPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..2204
                     /gene="SIPA1"
                     /gene_synonym="SPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2479
                     /gene="SIPA1"
                     /gene_synonym="SPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2480..2698
                     /gene="SIPA1"
                     /gene_synonym="SPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2699..2810
                     /gene="SIPA1"
                     /gene_synonym="SPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2811..2919
                     /gene="SIPA1"
                     /gene_synonym="SPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2920..3021
                     /gene="SIPA1"
                     /gene_synonym="SPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3022..3076
                     /gene="SIPA1"
                     /gene_synonym="SPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3077..3155
                     /gene="SIPA1"
                     /gene_synonym="SPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3156..3499
                     /gene="SIPA1"
                     /gene_synonym="SPA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3487..3492
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIPA1"
                     /gene_synonym="SPA1"
                     /note="hexamer: AGTAAA"
     polyA_site      3499
                     /gene="SIPA1"
                     /gene_synonym="SPA1"
                     /note="major polyA site"
ORIGIN      
        1 ggagccggcg ccgggagcgg tagcgggaga gcggcagcgg gaccccagcg cgggcggcgg
       61 cggctgggcg ggagccccag agggcaggaa ctgctgccac aacctcaggc tgggcaccaa
      121 acacccgtgc ccgccaatgc ggcccagccc ccggagagtc aggcccacag agcatgccca
      181 tgtgggccgg cggtgtgggg agccctcggc ggggcatggc ccctgcgtcc acagatgacc
      241 tctttgcccg caagctgcgc cagccagcaa ggcccccgct gacaccgcac accttcgagc
      301 cgaggccagt ccggggccca ctcctgcgca gcggcagcga tgcaggcgag gccaggcccc
      361 ccacgccagc cagcccccgt gcccgtgccc acagccacga agaggccagc cgacctgcag
      421 ccacttccac ccggctcttc actgacccgc tggcactgct ggggctgcca gcagaggaac
      481 cagagcctgc cttcccacca gtgcttgagc ctcgatggtt tgcccactat gacgtgcaaa
      541 gcctgctctt tgattgggct ccgaggtctc aggggatggg gagccactca gaggccagct
      601 ctgggaccct ggcttcagcc gaggaccagg ctgccagctc ggacctgctg catggggcac
      661 ctggctttgt gtgtgagctc gggggtgagg gtgagctagg cctgggtgga ccagcatccc
      721 cacctgtgcc ccctgcactg cccaacgcgg ccgtgtccat cctggaggag ccacagaacc
      781 gaacctcggc ctacagcctg gagcacgcag acctgggtgc tggctactac cgcaaatact
      841 tctatggcaa agaacatcag aacttcttcg ggatggacga gtcgctgggc ccggtggcag
      901 tgagcctgcg gcgggaggag aaggagggca gcggaggggg caccctgcac agctaccgcg
      961 tcatcgtgcg gaccacgcag ctccggacac tccgtggcac catctcggag gacgcgctgc
     1021 cgccggggcc cccacggggt ctgtccccaa ggaaacttct ggagcacgtg gcgccgcagc
     1081 tgagccccag ctgcctgcgc ctgggctcag cttcacccaa ggtaccacgg acgctgctca
     1141 cactggatga gcaagtgctg agcttccaac gcaaggtggg catcctgtac tgccgggcgg
     1201 gccagggctc ggaggaggag atgtacaaca accaggaggc gggaccggcc ttcatgcagt
     1261 ttctcacctt gctgggcgat gtggtgcggc tcaaaggctt tgagagttac cgggcccagc
     1321 tagacaccaa aacggattcc acaggcacgc actccctcta caccacatac caggaccacg
     1381 agatcatgtt ccacgtgtcc acgatgctgc cttacacccc taataaccag cagcagctcc
     1441 tccggaagcg ccacattggc aacgacattg tgaccatcgt gttccaggag cctggcagca
     1501 agcccttctg ccccaccacc atccgctcgc acttccagca cgtgttccta gtggtgcggg
     1561 cacacacacc ctgcacgcca cacaccacct acagggtggc cgtgagccgc acccaggaca
     1621 cccctgcctt cgggccagct ctgcctgctg gcggaggccc cttcgcagcc aacgccgact
     1681 tccgggcctt cctgctggcc aaagcgctga atggtgagca ggcggccggc cacgcgcgcc
     1741 agttccacgc catggccacg cgcacccgcc agcagtacct gcaagacctg gccaccaacg
     1801 aggtgaccac tacgtcgctg gactcggctt cacgcttcgg cctgccctcc ctgggtggga
     1861 ggcgccgggc ggcccctcgg ggcccaggcg ccgagctgca ggcagcgggc tcactggtgt
     1921 ggggagtgcg cgcggcgccc ggggcgcggg tcgccgccgg ggctcaggcg agcggccccg
     1981 aaggcatcga ggtgccctgc ctgctgggca tctcggccga ggctctggtg ctggtggcgc
     2041 cgcgcgacgg ccgcgtagtg ttcaattgcg cctgtcgcga cgtgctggcc tggaccttct
     2101 ccgagcagca gctggacctg taccacggcc gcggggaggc gatcacgctg cgcttcgacg
     2161 ggtcccccgg ccaagccgtg ggcgaggtgg tggcgcgcct gcagctggtg agccgtggct
     2221 gcgagacccg cgagctggcg ctgccccgcg acggtcaagg ccgcctgggc ttcgaggtgg
     2281 acgccgaggg attcgtcacg cacgtggagc gcttcacatt cgccgagacg gcggggctgc
     2341 ggcccggggc gcgcctcctg cgcgtgtgcg gccagactct gcccagcctc cggcccgagg
     2401 ccgctgccca gctcctgcgc tcggcgccca aggtctgcgt caccgtcctg ccccccgacg
     2461 agagcggccg gccccgcagg agtttttcgg agctgtacac gctgtcgctg caggagccta
     2521 gccggcgggg ggccccagat cctgtgcagg atgaggtcca gggggtgacc ctgctgccca
     2581 ccacaaagca gctgctgcac ctgtgcctgc aagatggtgg cagtcctcca gggcctgggg
     2641 atctggccga ggagaggact gagttcctgc acagccagaa ctcgctgtca ccacgcagct
     2701 ctctgtcgga tgaggcccca gtcctgccca acaccacccc ggacctcctc ctggccacca
     2761 cagccaagcc atcagtaccc agtgctgaca gtgagacacc cctgacccag gacaggccag
     2821 gcagtcccag tggctctgag gacaagggca acccggcgcc ggagctgagg gcctcctttc
     2881 tgccacgtac cttgtctctg cggaactcca tcagcaggat catgtcggag gcgggcagtg
     2941 ggaccctgga ggacgagtgg caggccatct cggagattgc ctctacttgc aacaccattc
     3001 tggagtcgct gtcccgagag ggacagccca tcccagagag tggagaccct aagggaactc
     3061 caaaatctga tgctgagcca gagcctggga acctctcaga gaaggtctct cacttggagt
     3121 ccatgctcag gaagctgcag gaggacctgc agaaggagaa ggcggacagg gcggccctgg
     3181 aggaggaggt gcggagcctg agacacaaca accggcggct gcaggcggag tctgagagtg
     3241 cagccacacg cctcctcctg gcctccaagc agctgggctc acccaccgcc gacctggcct
     3301 gagccgtctg gaaccacctg ggcccctgag ggcactgtgg tcacactggg ccctcctcag
     3361 gaactctccc tgcgcagagg cgtgtcttag cactgccccc ctccctagcc ccttatttgg
     3421 tggcggaagt ggcctccacc ccttccctgt ttgtaaatat tctgtggaga aaagaggact
     3481 tcagggagta aaaaagcca
//
