LOCUS       NM_001135812            2941 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens SIN3-HDAC complex associated factor (SINHCAF),
            transcript variant 3, mRNA.
ACCESSION   NM_001135812
VERSION     NM_001135812.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2941)
  AUTHORS   Jhuang,Y.L., Yang,C.W., Tseng,Y.F., Hsu,C.L., Li,H.Y., Yuan,R.H.
            and Jeng,Y.M.
  TITLE     SIN3-HDAC complex-associated factor, a chromatin remodelling gene
            located in the 12p amplicon, is a potential germ cell
            tumour-specific oncogene
  JOURNAL   J Pathol 258 (4), 353-365 (2022)
   PUBMED   36056608
  REMARK    GeneRIF: SIN3-HDAC complex-associated factor, a chromatin
            remodelling gene located in the 12p amplicon, is a potential germ
            cell tumour-specific oncogene.
REFERENCE   2  (bases 1 to 2941)
  AUTHORS   Zhang,Y., Li,J.H., Yuan,Q.G. and Yang,W.B.
  TITLE     Restraint of FAM60A has a cancer-inhibiting role in pancreatic
            carcinoma via the effects on the Akt/GSK-3beta/beta-catenin
            signaling pathway
  JOURNAL   Environ Toxicol 37 (6), 1432-1444 (2022)
   PUBMED   35213078
  REMARK    GeneRIF: Restraint of FAM60A has a cancer-inhibiting role in
            pancreatic carcinoma via the effects on the
            Akt/GSK-3beta/beta-catenin signaling pathway.
REFERENCE   3  (bases 1 to 2941)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 2941)
  AUTHORS   Sun,Y.H., Sun,X.W., Yang,L., Cheng,B. and Chen,Y.L.
  TITLE     [Research Progress of FAM60A in the Regulation of Cellular
            Function]
  JOURNAL   Zhongguo Yi Xue Ke Xue Yuan Xue Bao 43 (3), 469-474 (2021)
   PUBMED   34238425
  REMARK    GeneRIF: [Research Progress of FAM60A in the Regulation of Cellular
            Function].
REFERENCE   5  (bases 1 to 2941)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 2941)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   7  (bases 1 to 2941)
  AUTHORS   Joshi,P., Greco,T.M., Guise,A.J., Luo,Y., Yu,F., Nesvizhskii,A.I.
            and Cristea,I.M.
  TITLE     The functional interactome landscape of the human histone
            deacetylase family
  JOURNAL   Mol Syst Biol 9, 672 (2013)
   PUBMED   23752268
REFERENCE   8  (bases 1 to 2941)
  AUTHORS   Smith,K.T., Sardiu,M.E., Martin-Brown,S.A., Seidel,C.,
            Mushegian,A., Egidy,R., Florens,L., Washburn,M.P. and Workman,J.L.
  TITLE     Human family with sequence similarity 60 member A (FAM60A) protein:
            a new subunit of the Sin3 deacetylase complex
  JOURNAL   Mol Cell Proteomics 11 (12), 1815-1828 (2012)
   PUBMED   22984288
  REMARK    GeneRIF: studies reveal that loss of FAM60A or another component of
            the Sin3 complex, SDS3, leads to a change in cell morphology and an
            increase in cell migration
REFERENCE   9  (bases 1 to 2941)
  AUTHORS   Munoz,I.M., MacArtney,T., Sanchez-Pulido,L., Ponting,C.P., Rocha,S.
            and Rouse,J.
  TITLE     Family with sequence similarity 60A (FAM60A) protein is a cell
            cycle-fluctuating regulator of the SIN3-HDAC1 histone deacetylase
            complex
  JOURNAL   J Biol Chem 287 (39), 32346-32353 (2012)
   PUBMED   22865885
  REMARK    GeneRIF: Family with sequence similarity 60A (FAM60A) protein is a
            cell cycle-fluctuating regulator of the SIN3-HDAC1 histone
            deacetylase complex.
REFERENCE   10 (bases 1 to 2941)
  AUTHORS   Petroziello,J., Yamane,A., Westendorf,L., Thompson,M., McDonagh,C.,
            Cerveny,C., Law,C.L., Wahl,A. and Carter,P.
  TITLE     Suppression subtractive hybridization and expression profiling
            identifies a unique set of genes overexpressed in non-small-cell
            lung cancer
  JOURNAL   Oncogene 23 (46), 7734-7745 (2004)
   PUBMED   15334068
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA741767.1, AK026932.1, DR763430.1 and BC004462.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001135812.1.
            
            Transcript Variant: This variant (3) lacks a segment in the 5' UTR,
            compared to variant 1. Variants 1, 2, and 3 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK026932.1, AF212220.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000337682.9/ ENSP00000337477.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                DA741767.1         223-236
            15-901              AK026932.1         1-887
            902-1205            DR763430.1         488-791
            1206-2941           BC004462.1         798-2533
FEATURES             Location/Qualifiers
     source          1..2941
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p11.21"
     gene            1..2941
                     /gene="SINHCAF"
                     /gene_synonym="C12orf14; FAM60A; L4; TERA"
                     /note="SIN3-HDAC complex associated factor"
                     /db_xref="GeneID:58516"
                     /db_xref="HGNC:HGNC:30702"
                     /db_xref="MIM:615027"
     exon            1..127
                     /gene="SINHCAF"
                     /gene_synonym="C12orf14; FAM60A; L4; TERA"
                     /inference="alignment:Splign:2.1.0"
     exon            128..275
                     /gene="SINHCAF"
                     /gene_synonym="C12orf14; FAM60A; L4; TERA"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..813
                     /gene="SINHCAF"
                     /gene_synonym="C12orf14; FAM60A; L4; TERA"
                     /note="tera protein homolog; protein FAM60A; family with
                     sequence similarity 60 member A"
                     /codon_start=1
                     /product="SIN3-HDAC complex-associated factor"
                     /protein_id="NP_001129284.1"
                     /db_xref="CCDS:CCDS8723.1"
                     /db_xref="GeneID:58516"
                     /db_xref="HGNC:HGNC:30702"
                     /db_xref="MIM:615027"
                     /translation="MFGFHKPKMYRSIEGCCICRAKSSSSRFTDSKRYEKDFQSCFGL
                     HETRSGDICNACVLLVKRWKKLPAGSKKNWNHVVDARAGPSLKTTLKPKKVKTLSGNR
                     IKSNQISKLQKEFKRHNSDAHSTTSSASPAQSPCYSNQSDDGSDTEMASGSNRTPVFS
                     FLDLTYWKRQKICCGIIYKGRFGEVLIDTHLFKPCCSNKKAAAEKPEEQGPEPLPIST
                     QEW"
     exon            276..375
                     /gene="SINHCAF"
                     /gene_synonym="C12orf14; FAM60A; L4; TERA"
                     /inference="alignment:Splign:2.1.0"
     exon            376..502
                     /gene="SINHCAF"
                     /gene_synonym="C12orf14; FAM60A; L4; TERA"
                     /inference="alignment:Splign:2.1.0"
     exon            503..653
                     /gene="SINHCAF"
                     /gene_synonym="C12orf14; FAM60A; L4; TERA"
                     /inference="alignment:Splign:2.1.0"
     exon            654..2941
                     /gene="SINHCAF"
                     /gene_synonym="C12orf14; FAM60A; L4; TERA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2935..2940
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SINHCAF"
                     /gene_synonym="C12orf14; FAM60A; L4; TERA"
                     /note="hexamer: AATAAA"
     polyA_site      2941
                     /gene="SINHCAF"
                     /gene_synonym="C12orf14; FAM60A; L4; TERA"
                     /note="major polyA site"
ORIGIN      
        1 agaactgcag gagactatct ttctagacaa ggcagttgag gaggagggag cgcttgaggg
       61 ggactggcct ggcgtgcact ccgcacctcg gggacattat tgcgcgtgga acggctgctt
      121 ttggaagact attgcccaga agaaaagatg tttggttttc acaagccaaa gatgtaccga
      181 agtatagagg gctgctgtat ttgcagagct aagtcctcca gttctcgatt cactgacagt
      241 aaacgctatg aaaaggactt ccagagctgt tttggattgc atgagactcg ttcaggagac
      301 atctgcaatg cctgtgtcct gcttgtgaaa agatggaaga agttgccagc aggatcaaaa
      361 aaaaactgga atcatgtggt agatgcaagg gctggaccca gtctaaagac tacattgaaa
      421 ccaaagaaag tgaaaactct atctgggaac aggataaaaa gcaaccagat cagtaaactg
      481 cagaaggaat ttaaacgtca taattctgat gctcacagta ccacctcaag tgcctcccca
      541 gctcaatctc cttgttacag taaccagtca gatgacggct cagatacaga gatggcttct
      601 ggttctaaca gaacaccagt tttttccttt ttagatctca cttactggaa aagacagaag
      661 atatgttgtg ggatcatcta taaaggccgt tttggggaag tcctcattga cacacatctc
      721 ttcaagcctt gctgcagcaa taagaaagca gctgctgaga agccagagga gcaggggcca
      781 gagcctctgc ccatctccac tcaggagtgg tgactgaggt ttttatgtag aaggggaaca
      841 aaaaaaaaaa tatctgaatt ttgaaaaacc acaaagctac aaactgaccc tctttttttt
      901 ttgagacgga gttttgctct tgttacccag gctggagtgc agtggcgtga tcttggctca
      961 ctgcaacttc cgtctcccgg gttcaagtga ttctcctgcc tcagcctccc aagtagctgg
     1021 gtttataggt gcccgccacc agacccggct aattttttag ttttagtaga gacggggttt
     1081 caccacgttg gccaggctgg tcttaaatga ccctcttatt tttaacttgg atacctgcta
     1141 ttctgccaaa agacaatttc tagagtagtt ttgaatgggt tgatttcccc cactcccaca
     1201 aactctgaag ccagtgtcta gcttactaaa aaaagagttg tatataatat ttaagatgct
     1261 gagtatttca taggaaagct gaatgctgct gtaaagtgct ctttaagtct tttttttttt
     1321 taatcccctt ctaatgaatg aaactagggg aatttcaggg gacagagatg ggatttgttg
     1381 tatgataaac tgtatgtagt ttttagtctt tctgttttga gaagcagtgg ttggggcatt
     1441 tttaagatgg ctggctactc ttgttttccc tcatgataat aaatttgtca taactcagta
     1501 acatgaactt gcccctagag gtagttgtta ataattttga aatattaagg tcttgccaag
     1561 cttctgatga ttcacacctg tactactgat tattaagcag gacagactga gctttctgtt
     1621 gcaaatacct tggaggagaa agtaatttct aaatatacag agaggtaact tgactatata
     1681 tgttgcatcc tgtgcctccc ttcatattaa tatttgataa agattttaat ttatgtaaaa
     1741 cttctaaagc agaatcaaag ctcctcttgg ggaaatggca agtctttagg ataggcaaga
     1801 ccctgtatga atagtaccaa agcattaccg catggtagag aacacactcg attaaaaatg
     1861 ttaagctatc tgaaaaataa aatgtgcaag tcttcaggat ggcacaaaac aaaggttaat
     1921 gcttcttggg gcacatttct tagagggctt gctgagtgtg taaatataat cgacttttgt
     1981 ttgtgttaca tgacttctgt gacttcattg aaaatctgca caattcagtt tcagctctgg
     2041 attacttcag ttgacctttg tgaaggtttt tatctgtgta gaatgggtgt ttgacttgtt
     2101 ttagcctatt aaatttttat tttctttcac tctgtattaa aagtaaaact tactaaaaga
     2161 aaagaggttt gtgttcacat taaatggttt tggtttggct tcttttagtc aggctttctg
     2221 aacattgaga tatcctgaac ttagagctct tcaatcctaa gattttcatg aaaagcctct
     2281 cacttgaacc caaaccagag tactcttact gcctcttttc taaatgttca ggaaaagcat
     2341 tgccagttca gtcttttcaa aatgagggag aaacatttgc ctgccttgta ataacaagac
     2401 tcagtgctta ttttttaaac tgcattttaa aaattggata gtataataac aataaggagt
     2461 aagccacctt ttataggcac cctgtagttt tatagttctt aatctaaaca ttttatattt
     2521 ccttcttttg gaaaaaacct acatgctaca agccaccata tgcacagact atacagtgag
     2581 ttgagttggc tctcccacag tctttgaggt gaattacaaa agtccagcca ttatcatcct
     2641 cctgagttat ttgaaatgat tttttttgta cattttggct gcagtattgg tggtagaata
     2701 tactataata tggatcatct ctacttctgt atttatttat ttattactag acctcaacca
     2761 cagtcttctt tttccccttc cacctctctt tgcctgtagg atgtactgta tgtagtcatg
     2821 cactttgtat taatatatta gaaatctaca gatctgtttt gtacttttta tactgttgga
     2881 tacttataat caaaactttt actagggtat tgaataaatc tagtcttact agaaaataaa
     2941 a
//
