LOCUS       NM_001297595            5038 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens SIN3 transcription regulator family member B (SIN3B),
            transcript variant 2, mRNA.
ACCESSION   NM_001297595 XM_005259832
VERSION     NM_001297595.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5038)
  AUTHORS   Wan,M.S.M., Muhammad,R., Koliopoulos,M.G., Roumeliotis,T.I.,
            Choudhary,J.S. and Alfieri,C.
  TITLE     Mechanism of assembly, activation and lysine selection by the SIN3B
            histone deacetylase complex
  JOURNAL   Nat Commun 14 (1), 2556 (2023)
   PUBMED   37137925
  REMARK    GeneRIF: Mechanism of assembly, activation and lysine selection by
            the SIN3B histone deacetylase complex.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5038)
  AUTHORS   Latypova,X., Vincent,M., Molle,A., Adebambo,O.A., Fourgeux,C.,
            Khan,T.N., Caro,A., Rosello,M., Orellana,C., Niyazov,D.,
            Lederer,D., Deprez,M., Capri,Y., Kannu,P., Tabet,A.C., Levy,J.,
            Aten,E., den Hollander,N., Splitt,M., Walia,J., Immken,L.L.,
            Stankiewicz,P., McWalter,K., Suchy,S., Louie,R.J., Bell,S.,
            Stevenson,R.E., Rousseau,J., Willem,C., Retiere,C., Yang,X.J.,
            Campeau,P.M., Martinez,F., Rosenfeld,J.A., Le Caignec,C., Kury,S.,
            Mercier,S., Moradkhani,K., Conrad,S., Besnard,T., Cogne,B.,
            Katsanis,N., Bezieau,S., Poschmann,J., Davis,E.E. and Isidor,B.
  TITLE     Haploinsufficiency of the Sin3/HDAC corepressor complex member
            SIN3B causes a syndromic intellectual disability/autism spectrum
            disorder
  JOURNAL   Am J Hum Genet 108 (5), 929-941 (2021)
   PUBMED   33811806
  REMARK    GeneRIF: Haploinsufficiency of the Sin3/HDAC corepressor complex
            member SIN3B causes a syndromic intellectual disability/autism
            spectrum disorder.
REFERENCE   3  (bases 1 to 5038)
  AUTHORS   Harada,M., Nagai,J., Kurata,R., Cui,X., Isagawa,T., Semba,H.,
            Yoshida,Y., Takeda,N., Maemura,K. and Yonezawa,T.
  TITLE     Establishment of Novel Protein Interaction Assays between Sin3 and
            REST Using Surface Plasmon Resonance and Time-Resolved Fluorescence
            Energy Transfer
  JOURNAL   Int J Mol Sci 22 (5), 2323 (2021)
   PUBMED   33652591
  REMARK    GeneRIF: Establishment of Novel Protein Interaction Assays between
            Sin3 and REST Using Surface Plasmon Resonance and Time-Resolved
            Fluorescence Energy Transfer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5038)
  AUTHORS   Adams,M.K., Banks,C.A.S., Thornton,J.L., Kempf,C.G., Zhang,Y.,
            Miah,S., Hao,Y., Sardiu,M.E., Killer,M., Hattem,G.L., Murray,A.,
            Katt,M.L., Florens,L. and Washburn,M.P.
  TITLE     Differential Complex Formation via Paralogs in the Human Sin3
            Protein Interaction Network
  JOURNAL   Mol Cell Proteomics 19 (9), 1468-1484 (2020)
   PUBMED   32467258
  REMARK    GeneRIF: Differential Complex Formation via Paralogs in the Human
            Sin3 Protein Interaction Network.
REFERENCE   5  (bases 1 to 5038)
  AUTHORS   Bainor,A.J., Saini,S., Calderon,A., Casado-Polanco,R.,
            Giner-Ramirez,B., Moncada,C., Cantor,D.J., Ernlund,A.,
            Litovchick,L. and David,G.
  TITLE     The HDAC-Associated Sin3B Protein Represses DREAM Complex Targets
            and Cooperates with APC/C to Promote Quiescence
  JOURNAL   Cell Rep 25 (10), 2797-2807 (2018)
   PUBMED   30517867
  REMARK    GeneRIF: These studies identify Sin3B as a transcriptional
            corepressor associated with the DREAM complex in quiescence.
REFERENCE   6  (bases 1 to 5038)
  AUTHORS   Naruse,Y., Aoki,T., Kojima,T. and Mori,N.
  TITLE     Neural restrictive silencer factor recruits mSin3 and histone
            deacetylase complex to repress neuron-specific target genes
  JOURNAL   Proc Natl Acad Sci U S A 96 (24), 13691-13696 (1999)
   PUBMED   10570134
REFERENCE   7  (bases 1 to 5038)
  AUTHORS   Koipally,J., Renold,A., Kim,J. and Georgopoulos,K.
  TITLE     Repression by Ikaros and Aiolos is mediated through histone
            deacetylase complexes
  JOURNAL   EMBO J 18 (11), 3090-3100 (1999)
   PUBMED   10357820
REFERENCE   8  (bases 1 to 5038)
  AUTHORS   Zhang,Y., Sun,Z.W., Iratni,R., Erdjument-Bromage,H., Tempst,P.,
            Hampsey,M. and Reinberg,D.
  TITLE     SAP30, a novel protein conserved between human and yeast, is a
            component of a histone deacetylase complex
  JOURNAL   Mol Cell 1 (7), 1021-1031 (1998)
   PUBMED   9651585
REFERENCE   9  (bases 1 to 5038)
  AUTHORS   David,G., Alland,L., Hong,S.H., Wong,C.W., DePinho,R.A. and
            Dejean,A.
  TITLE     Histone deacetylase associated with mSin3A mediates repression by
            the acute promyelocytic leukemia-associated PLZF protein
  JOURNAL   Oncogene 16 (19), 2549-2556 (1998)
   PUBMED   9627120
REFERENCE   10 (bases 1 to 5038)
  AUTHORS   Ayer,D.E., Lawrence,Q.A. and Eisenman,R.N.
  TITLE     Mad-Max transcriptional repression is mediated by ternary complex
            formation with mammalian homologs of yeast repressor Sin3
  JOURNAL   Cell 80 (5), 767-776 (1995)
   PUBMED   7889570
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY055983.1, AB014600.2 and AY706204.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001297595.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 5' coding region, compared to variant 1. It encodes
            isoform 2, which lacks an internal segment and is shorter, compared
            to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB014600.2, SRR11853563.16662.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000248054.10/ ENSP00000248054.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 HY055983.1         13-14
            3-4286              AB014600.2         1-4284
            4287-5038           AY706204.1         4374-5125
FEATURES             Location/Qualifiers
     source          1..5038
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..5038
                     /gene="SIN3B"
                     /note="SIN3 transcription regulator family member B"
                     /db_xref="GeneID:23309"
                     /db_xref="HGNC:HGNC:19354"
                     /db_xref="MIM:607777"
     exon            1..143
                     /gene="SIN3B"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..3416
                     /gene="SIN3B"
                     /note="isoform 2 is encoded by transcript variant 2;
                     paired amphipathic helix protein Sin3b; transcriptional
                     corepressor Sin3b; histone deacetylase complex subunit
                     Sin3b; SIN3 homolog B, transcriptional regulator; SIN3
                     transcription regulator homolog B"
                     /codon_start=1
                     /product="paired amphipathic helix protein Sin3b isoform
                     2"
                     /protein_id="NP_001284524.1"
                     /db_xref="CCDS:CCDS74308.1"
                     /db_xref="GeneID:23309"
                     /db_xref="HGNC:HGNC:19354"
                     /db_xref="MIM:607777"
                     /translation="MAHAGGGSGGSGAGGPAGRGLSGARWGRSGSAGHEKLPVHVEDA
                     LTYLDQVKIRFGSDPATYNGFLEIMKEFKSQSIDTPGVIRRVSQLFHEHPDLIVGFNA
                     FLPLGYRIDIPKNGKLNIQSPLTSQENSHNHGDGAEDFKQQVPYKEDKPQVPLESDSV
                     EFNNAISYVNKIKTRFLDHPEIYRSFLEILHTYQKEQLNTRGRPFRGMSEEEVFTEVA
                     NLFRGQEDLLSEFGQFLPEAKRSLFTGNGPCEMHSVQKNEHDKTPEHSRKRSRPSLLR
                     PVSAPAKKKMKLRGTKDLSIAAVGKYGTLQEFSFFDKVRRVLKSQEVYENFLRCIALF
                     NQELVSGSELLQLVSPFLGKFPELFAQFKSFLGVKELSFAPPMSDRSGDGISREIDYA
                     SCKRIGSSYRALPKTYQQPKCSGRTAICKEVLNDTWVSFPSWSEDSTFVSSKKTPYEE
                     QLHRCEDERFELDVVLETNLATIRVLESVQKKLSRMAPEDQEKFRLDDSLGGTSEVIQ
                     RRAIYRIYGDKAPEIIESLKKNPVTAVPVVLKRLKAKEEEWREAQQGFNKIWREQYEK
                     AYLKSLDHQAVNFKQNDTKALRSKSLLNEIESVYDEHQEQHSEGRSAPSSEPHLIFVY
                     EDRQILEDAAALISYYVKRQPAIQKEDQGTIHQLLHQFVPSLFFSQQLDLGASEESAD
                     EDRDSPQGQTTDPSERKKPAPGPHSSPPEEKGAFGDAPATEQPPLPPPAPHKPLDDVY
                     SLFFANNNWYFFLRLHQTLCSRLLKIYRQAQKQLLEYRTEKEREKLLCEGRREKGSDP
                     AMELRLKQPSEVELEEYYPAFLDMVRSLLEGSIDPTQYEDTLREMFTIHAYVGFTMDK
                     LVQNIARQLHHLVSDDVCLKVVELYLNEKKRGAAGGNLSSRCVRAARETSYQWKAERC
                     MADENCFKVMFLQRKGQVIMTIELLDTEEAQTEDPVEVQHLARYVEQYVGTEGASSSP
                     TEGFLLKPVFLQRNLKKFRRRWQSEQARALRGEARSSWKRLVGVESACDVDCRFKLST
                     HKMVFIVNSEDYMYRRGTLCRAKQVQPLVLLRHHQHFEEWHSRWLEDNVTVEAASLVQ
                     DWLMGEEDEDMVPCKTLCETVHVHGLPVTRYRVQYSRRPASP"
     exon            144..250
                     /gene="SIN3B"
                     /inference="alignment:Splign:2.1.0"
     exon            251..404
                     /gene="SIN3B"
                     /inference="alignment:Splign:2.1.0"
     exon            405..605
                     /gene="SIN3B"
                     /inference="alignment:Splign:2.1.0"
     exon            606..749
                     /gene="SIN3B"
                     /inference="alignment:Splign:2.1.0"
     exon            750..872
                     /gene="SIN3B"
                     /inference="alignment:Splign:2.1.0"
     exon            873..962
                     /gene="SIN3B"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1081
                     /gene="SIN3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1289
                     /gene="SIN3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1406
                     /gene="SIN3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1645
                     /gene="SIN3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1829
                     /gene="SIN3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..2445
                     /gene="SIN3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..2615
                     /gene="SIN3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2616..2789
                     /gene="SIN3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2790..2882
                     /gene="SIN3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2883..2977
                     /gene="SIN3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2978..3185
                     /gene="SIN3B"
                     /inference="alignment:Splign:2.1.0"
     exon            3186..5038
                     /gene="SIN3B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5014..5019
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIN3B"
                     /note="hexamer: ATTAAA"
     polyA_site      5038
                     /gene="SIN3B"
                     /note="major polyA site"
ORIGIN      
        1 ggggcgcagc tccgacttcg gacatggcgc acgctggcgg tggcagcggt ggcagcggtg
       61 ccggcggccc cgcgggccgg gggctgagcg gcgcccgctg gggtcgctcg ggctccgcag
      121 gccacgagaa gctgccggtg cacgtagaag acgccctcac ctatctggac caggtgaaga
      181 tccgctttgg cagcgaccct gccacctaca acggcttcct ggagatcatg aaggagttca
      241 aaagccagag catcgatact cctggagtca tcagacgtgt ctcgcagctc ttccacgagc
      301 accctgacct cattgttgga ttcaacgctt ttcttcccct cggatataga atagacattc
      361 ccaagaatgg caagttaaac atacagtcgc ctctgacaag ccaggagaat tcgcacaacc
      421 acggggacgg tgcagaggac ttcaagcagc aggtgccgta taaagaggac aaaccccagg
      481 tgcccctgga gtccgattcc gtggaattca acaacgccat cagctatgtg aataagatta
      541 aaacccgctt cctagaccac ccagaaatct acaggtcatt cctggagatc ctgcacacgt
      601 accagaagga gcagctgaac acgaggggcc ggccattccg aggcatgtct gaagaggagg
      661 tgttcaccga ggtggccaac ctcttccggg gccaggagga cctgctctca gagtttggac
      721 agttcctgcc cgaagccaag cggtctctgt tcacaggaaa cgggccgtgc gagatgcaca
      781 gcgtgcagaa gaacgagcac gacaagaccc cggagcacag caggaagcgc tcccggccct
      841 cgctcctccg ccccgtgtct gcacccgcca agaaaaaaat gaaacttcgt ggtaccaaag
      901 acctgtccat cgctgcagtg gggaagtacg ggactctgca ggaattttct ttctttgaca
      961 aggtccgccg ggtgctgaag agccaggagg tgtatgaaaa cttcctccgc tgcatcgcac
     1021 tcttcaacca ggagctggtg tctggctctg agctcctgca gctcgtcagc ccatttctgg
     1081 ggaaatttcc agaactcttt gcacagttca agtccttcct gggggtaaaa gagctgtcct
     1141 tcgcgccacc catgagcgac agatccgggg acgggataag ccgggaaatt gattatgcat
     1201 cctgcaagcg cataggatcc agctaccggg cactccccaa aacctaccag cagcccaagt
     1261 gcagtgggag gacagccatc tgcaaggagg tactgaacga cacctgggtc tccttccctt
     1321 cctggtctga ggactccacg ttcgtcagct ccaagaagac accgtacgag gagcagcttc
     1381 accgctgtga ggacgagcgc ttcgagttag acgttgtcct ggagacgaac ctggccacaa
     1441 tccgtgtgtt ggaaagtgtg cagaagaagc tgtctcggat ggcgccggaa gaccaggaga
     1501 agttccggct ggacgactcc ctgggaggca cgtcggaggt gatccagcgc cgtgccattt
     1561 atcgcatcta tggcgacaag gccccggaga tcatcgagag cctcaagaag aaccctgtca
     1621 ccgctgtccc cgttgtcctg aaaagactga aggccaagga agaggagtgg cgggaggccc
     1681 agcagggctt caacaagatc tggcgggagc agtatgagaa ggcgtacctc aagtcccttg
     1741 accaccaggc tgtgaacttc aagcagaacg acaccaaggc cctgcgctcc aagagcttgc
     1801 tcaacgagat cgagagcgtc tacgacgagc accaggagca gcactcggag ggccgcagtg
     1861 ccccctctag cgagccgcac ctcatctttg tgtacgagga ccggcagatc ctggaggacg
     1921 cagcagcgct catcagctac tacgtgaagc ggcagccggc catccagaag gaggaccagg
     1981 gcaccatcca ccagctgctg caccagttcg tgcccagcct cttcttctct cagcagctgg
     2041 acctgggcgc ctccgaggag tcagctgatg aggaccggga cagcccccag gggcagacca
     2101 cagaccccag tgagcggaag aagccggcgc caggacccca cagtagcccc ccagaggaga
     2161 agggggcctt cggggatgcc ccggccactg agcagccacc cctgccgccc ccagccccgc
     2221 acaagcccct ggacgatgtc tacagcctat tttttgccaa caacaactgg tacttcttcc
     2281 tgcgcctgca ccagaccctg tgctccaggc tgctgaagat ctaccgccag gcgcagaagc
     2341 agcttctgga gtatcggacc gagaaggagc gggagaagct gctgtgtgag ggccgcaggg
     2401 agaagggcag cgaccccgcc atggagctgc ggctgaagca gcccagtgaa gtggagctgg
     2461 aggagtacta cccggccttc ctggacatgg tgcggagcct gctggagggc agcatcgacc
     2521 ccacgcagta cgaggacacc ctacgcgaga tgttcaccat ccatgcctac gtgggcttca
     2581 ccatggacaa gctggtgcag aacattgcgc ggcagctgca ccacctcgtg agcgatgacg
     2641 tctgcctgaa ggtggtggag ctctacctga acgagaagaa gcggggtgcc gctggtggga
     2701 acctgtcctc ccgctgcgtc cgcgctgcta gggagaccag ctaccagtgg aaggctgagc
     2761 gctgcatggc cgacgagaac tgcttcaagg tgatgttcct gcagcgcaaa gggcaggtga
     2821 tcatgaccat cgagctcctg gacaccgagg aggcccagac ggaggaccct gtggaggtcc
     2881 agcacctggc tcggtacgtg gagcagtatg tggggaccga gggcgcgtcc agctcgccca
     2941 ctgagggctt cctcctgaaa cctgtgttcc tgcagaggaa cctcaagaag ttccgccgcc
     3001 ggtggcagag cgagcaggcg cgggccctgc gcggtgaggc caggagctcc tggaagcggc
     3061 tggtgggcgt ggagagcgcc tgcgacgtgg actgccgctt caagctcagc actcacaaga
     3121 tggtgttcat cgtgaactcc gaggactaca tgtaccgtcg cgggaccctc tgccgggcca
     3181 agcaggtgca gcccctggtc ctgctccgcc accaccagca ctttgaggag tggcacagcc
     3241 gctggctgga ggacaatgtg acggtggagg cggctagcct ggtgcaggac tggctgatgg
     3301 gtgaggagga cgaggacatg gtaccctgca agacgctgtg tgagacagtg cacgtgcacg
     3361 gcctgcccgt gacccgctac cgcgtgcagt acagccgccg cccggcctcg ccctgacccg
     3421 ccctcatggg caccgggcag gcgcctcaca gagcacagac gtgccctcgg ccttggtcgt
     3481 gtcggggccg ttttcttgaa cgacgtgaga ggcatctccc agcccctctg ctgccggaca
     3541 gcgcactcca gggcaggacg ccgcccccgt ggctcccggt ctcctgtggg cctgctgtgt
     3601 gccaaacctg agctacctgc acccgagccc tggggctcag ccccaccaca ggggcgggtg
     3661 gacgtgctgg ccgaggaaca agcaatcatg tttgcgtccc cgtccgtcac atgtgccaaa
     3721 tccctggcag gcagatggct cctgccccat attcttgccg tgtcttggaa aagtcacagg
     3781 tgacagccct cctgaggccc acactttgga gggggtccat gtccaagaga ccctgacaag
     3841 gaaggagttg agccctgggt aggcttgctt gaaaagtgag tccttccaga atattctcag
     3901 agctgccaga aacatcatct gagggtttgg gcatcagctc tgcctggctg gtgttcaggc
     3961 cctcagtcac tttggaagtg agaagaaccc ttcagccaaa cctttgggat cccattttga
     4021 agtccagagc tggagcaggc gggcagtgcc ctgggagacc ccgctctgga taagacaccc
     4081 aaccccaact ccagcagctg gactctgggc ccacaagggg agggacccca gccagtattc
     4141 cctcagagcc ggcacgaccc tgctgtgggg cggcgggccc agtcgtgttc ctgcagtggg
     4201 caccctaggc gtatgtgtat acacgcacag atatttattc ctttcgcttt tagtggttgt
     4261 tatttctgta gcagccaagt cctgcggctc cctggggctg agatctccct ttgtggaact
     4321 ccgagagccg ccctgacagt cccagccgcc acccaaggag ccccatccgc ccacccaccc
     4381 tgggacccac gcggccactc cagggatcat tgttgtcctt ttgtgagggg ctgaggcgac
     4441 tgtcccatgg aggcatccaa ggctttctgt gccaagaatc ccaagtgact ggggctgggg
     4501 accacttctc caggcctctc tccccgacca tgagagcccc tggccctggc ccctgcacac
     4561 cagtaggccc agaataaccg ccacccttgc catcctgcaa cagctggact caagtttcca
     4621 ggaagtggag atgtgtttct agaagtttcc tgtggaacct ggaggctcct gatgcctttg
     4681 actccaggct gggcgattcc gatgctgacc cgtcctcctg ggctccccac ccccgctccc
     4741 caagtgtcac acaggcactt tgtacacatc ctggttttct aagaagggaa cttgccatca
     4801 agattcctgt accaggccca cggccgtctc gggcagagcc acctgggccc cgggtgcagc
     4861 cggagacccc gccgagcccc tcctcccagt attcccatcc ccgcatgctt ctagggagcg
     4921 cctcttttcc gttcttgagg aatttctgtt ctggggcttg tccttccttt gcagctgttt
     4981 tgaatgtagt tttccttttc tatttatttg cacattaaag ttaataattg aatattga
//
