LOCUS       NM_001308195            3305 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens SUMO interacting motifs containing 1 (SIMC1),
            transcript variant 1, mRNA.
ACCESSION   NM_001308195 XM_005265909
VERSION     NM_001308195.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3305)
  AUTHORS   Oravcova,M., Nie,M., Zilio,N., Maeda,S., Jami-Alahmadi,Y.,
            Lazzerini-Denchi,E., Wohlschlegel,J.A., Ulrich,H.D., Otomo,T. and
            Boddy,M.N.
  TITLE     The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral
            replication centers
  JOURNAL   Elife 11, e79676 (2022)
   PUBMED   36373674
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3305)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3305)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 3305)
  AUTHORS   Ono,Y., Iemura,S., Novak,S.M., Doi,N., Kitamura,F., Natsume,T.,
            Gregorio,C.C. and Sorimachi,H.
  TITLE     PLEIAD/SIMC1/C5orf25, a novel autolysis regulator for a
            skeletal-muscle-specific calpain, CAPN3, scaffolds a CAPN3
            substrate, CTBP1
  JOURNAL   J Mol Biol 425 (16), 2955-2972 (2013)
   PUBMED   23707407
  REMARK    GeneRIF: Authors found that PLEIAD also interacts with CTBP1
            (C-terminal binding protein 1), a transcriptional co-regulator, and
            CTBP1 is proteolyzed in COS7 cells expressing CAPN3.
REFERENCE   5  (bases 1 to 3305)
  AUTHORS   Sun,H. and Hunter,T.
  TITLE     Poly-small ubiquitin-like modifier (PolySUMO)-binding proteins
            identified through a string search
  JOURNAL   J Biol Chem 287 (50), 42071-42083 (2012)
   PUBMED   23086935
REFERENCE   6  (bases 1 to 3305)
  AUTHORS   Vinayagam,A., Stelzl,U., Foulle,R., Plassmann,S., Zenkner,M.,
            Timm,J., Assmus,H.E., Andrade-Navarro,M.A. and Wanker,E.E.
  TITLE     A directed protein interaction network for investigating
            intracellular signal transduction
  JOURNAL   Sci Signal 4 (189), rs8 (2011)
   PUBMED   21900206
REFERENCE   7  (bases 1 to 3305)
  AUTHORS   Brill,L.M., Salomon,A.R., Ficarro,S.B., Mukherji,M.,
            Stettler-Gill,M. and Peters,E.C.
  TITLE     Robust phosphoproteomic profiling of tyrosine phosphorylation sites
            from human T cells using immobilized metal affinity chromatography
            and tandem mass spectrometry
  JOURNAL   Anal Chem 76 (10), 2763-2772 (2004)
   PUBMED   15144186
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY028607.1, AK299336.1, KF151170.1 and BC032390.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001308195.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.88300.1,
                                           SRR1803616.122789.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000429602.7/ ENSP00000410552.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 HY028607.1         67-71
            6-1530              AK299336.1         31-1555
            1531-2456           KF151170.1         1464-2389
            2457-3305           BC032390.1         946-1794
FEATURES             Location/Qualifiers
     source          1..3305
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.2"
     gene            1..3305
                     /gene="SIMC1"
                     /gene_synonym="C5orf25; OOMA1; PLEIAD"
                     /note="SUMO interacting motifs containing 1"
                     /db_xref="GeneID:375484"
                     /db_xref="HGNC:HGNC:24779"
                     /db_xref="MIM:618102"
     exon            1..214
                     /gene="SIMC1"
                     /gene_synonym="C5orf25; OOMA1; PLEIAD"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..2761
                     /gene="SIMC1"
                     /gene_synonym="C5orf25; OOMA1; PLEIAD"
                     /note="isoform a is encoded by transcript variant 1;
                     oocyte maturation associated 1; SUMO-interacting
                     motif-containing protein 1; platform element for
                     inhibition of autolytic degradation"
                     /codon_start=1
                     /product="SUMO-interacting motif-containing protein 1
                     isoform a"
                     /protein_id="NP_001295124.1"
                     /db_xref="CCDS:CCDS78088.1"
                     /db_xref="GeneID:375484"
                     /db_xref="HGNC:HGNC:24779"
                     /db_xref="MIM:618102"
                     /translation="MEDFIVISDDSGSESSGGARPGRSRRPRRALSRTSGALPRRTVD
                     FIDLTRETRPRTKDRSGLYVIDLTRAEGENRPIATLDLTLEPVTPSQKEPTSLQTCAS
                     LSGKAVMEGHVDRSSQPTARRIINSDPVDLDLVEENTFVGPPPATSISGGSVYPTEPN
                     CSSATFTGNLSFLASLQLSSDVSSLSPTSNNSRSSSSSSNQKAPLPCPQQDVSRPPQA
                     LPCPLRPLPCPPRASPCPPRASSCPPRALSCPSQTMQCQLPALTHPPQEVPCPRQNIP
                     GPPQDSLGLPQDVPGLPQSILHPQDVAYLQDMPRSPGDVPQSPSDVSPSPDAPQSPGG
                     MPHLPGDVLHSPGDMPHSSGDVTHSPRDIPHLPGDRPDFTQNDVQNRDMPMDISALSS
                     PSCSPSPQSETPLEKVPWLSVMETPARKEISLSEPAKPGSAHVQSRTPQGGLYNRPCL
                     HRLKYFLRPPVHHLFFQTLIPDKDTRENKGQKLEPIPHRRLRMVTNTIEENFPLGTVQ
                     FLMDFVSPQHYPPREIVAHIIQKILLSGSETVDVLKEAYMLLMKIQQLHPANAKTVEW
                     DWKLLTYVMEEEGQTLPGRVLFLRYVVQTLEDDFQQTLRRQRQHLQQSIANMVLSCDK
                     QPHNVRDVIKWLVKAVTEDGLTQPPNGNQTSSGTGILKASSSHPSSQPNLTKNTNQLI
                     VCQLQRMLSIAVEVDRTPTCSSNKIAEMMFGFVLDIPERSQREMFFTTMESHLLRCKV
                     LEIIFLHSCETPTRLPLSLAQALYFLNNSTSLLKCQSDKSQWQTWDELVEHLQFLLSS
                     YQHVLREHLRSSVIDRKDLIIKRIKPKPQQGDDITVVDVEKQIEAFRSRLIQMLGEPL
                     VPQLQDKVHLLKLLLFYAADLNPDAEPFQKGWSGS"
     exon            215..1516
                     /gene="SIMC1"
                     /gene_synonym="C5orf25; OOMA1; PLEIAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1749
                     /gene="SIMC1"
                     /gene_synonym="C5orf25; OOMA1; PLEIAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1819
                     /gene="SIMC1"
                     /gene_synonym="C5orf25; OOMA1; PLEIAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1974
                     /gene="SIMC1"
                     /gene_synonym="C5orf25; OOMA1; PLEIAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2127
                     /gene="SIMC1"
                     /gene_synonym="C5orf25; OOMA1; PLEIAD"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..2256
                     /gene="SIMC1"
                     /gene_synonym="C5orf25; OOMA1; PLEIAD"
                     /inference="alignment:Splign:2.1.0"
     exon            2257..2413
                     /gene="SIMC1"
                     /gene_synonym="C5orf25; OOMA1; PLEIAD"
                     /inference="alignment:Splign:2.1.0"
     exon            2414..2498
                     /gene="SIMC1"
                     /gene_synonym="C5orf25; OOMA1; PLEIAD"
                     /inference="alignment:Splign:2.1.0"
     exon            2499..3305
                     /gene="SIMC1"
                     /gene_synonym="C5orf25; OOMA1; PLEIAD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3280..3285
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIMC1"
                     /gene_synonym="C5orf25; OOMA1; PLEIAD"
                     /note="hexamer: AATAAA"
     polyA_site      3305
                     /gene="SIMC1"
                     /gene_synonym="C5orf25; OOMA1; PLEIAD"
                     /note="major polyA site"
ORIGIN      
        1 gccccgccgc cgccacctca gaagcaggaa ccgaagtcgt cgccgccgcc gccactgcct
       61 gggtcttcgg tcggggcccg cagccatgga ggatttcatc gtgatctcgg acgacagcgg
      121 ctctgagagc tccgggggcg cccgcccggg ccggtcgcgg aggccgcgcc gggccctgtc
      181 gcgaacctcc ggcgcgctgc cccgccggac cgtggacttc attgacttaa ctagagagac
      241 cagaccaagg acaaaagatc gcagtggact gtatgtgatt gacctgacaa gagctgaggg
      301 agaaaataga cctattgcca ctcttgactt aactttagaa cctgtcactc cttcccagaa
      361 ggagccaacc agtcttcaga catgtgccag cctctctggc aaagcggtga tggaagggca
      421 cgtggacaga agctctcagc ctacagcacg gagaatcatt aacagtgatc ctgtagattt
      481 ggacctagtg gaagaaaaca cctttgtagg tcccccaccc gctacatcca tcagtggagg
      541 ctctgtttat ccaacagagc ctaattgtag ctcagccaca ttcacaggta acctcagctt
      601 cttggcaagt ctacagctgt cttcagatgt tagctccctc tccccaacaa gcaataatag
      661 taggagcagc agcagcagca gcaatcaaaa agcacccttg ccatgcccac agcaagatgt
      721 atctcgccca ccacaggcct tgccgtgccc cctgcgacct ttgccatgcc caccgagagc
      781 ctcaccatgt ccaccacgag cctcctcatg cccaccacga gccttgtcat gcccatcaca
      841 aaccatgcag tgccaactac cagctctaac tcacccacct caagaagtgc catgccctcg
      901 gcagaatatc ccaggcccac ctcaagactc tctgggccta cctcaagatg tgccagggct
      961 gcctcaaagc atattacatc cacaagatgt ggcatacctg caagacatgc cacggtcacc
     1021 aggagatgtg ccacagtcac caagtgatgt ttcaccgtca ccagatgcac cacagtcacc
     1081 agggggcatg ccacacttac cgggagatgt gttacattca cctggagaca tgccacactc
     1141 atcaggggac gtgacacact cacctagaga catccctcac ttaccaggag acaggcctga
     1201 ctttacccag aatgatgtac agaaccgtga catgcctatg gatatctcag ctctgtcctc
     1261 tccaagctgc tctcccagcc cacagtctga aactccctta gagaaagttc cttggctctc
     1321 tgtcatggaa accccagcca gaaaagaaat atcactgtca gagcctgcca aacctgggtc
     1381 tgcccacgta caatcacgaa caccacaagg tgggttgtac aacagaccat gcctgcatag
     1441 actgaagtac ttcttacgtc ctccggttca tcacctcttc tttcagacgc taataccgga
     1501 taaagacaca agagagaaca agggtcaaaa attagaaccc atccctcatc gaagactaag
     1561 aatggtaaca aataccattg aagagaattt tcctctgggg actgtgcagt ttttgatgga
     1621 ctttgtgtca ccccagcatt acccaccaag agaaatcgtg gctcacatca tccagaaaat
     1681 cttgctcagt ggctctgaga ctgtggatgt cctaaaggag gcctacatgc ttctcatgaa
     1741 aattcaacag ctacatccag ccaatgccaa gacagtggag tgggactgga aactgctcac
     1801 ctatgtcatg gaggaagagg gacaaactct gcctgggcga gtccttttcc tgcgttatgt
     1861 cgttcagacc ctagaagatg actttcagca gaccctgagg aggcaacggc agcacctgca
     1921 gcaatccatt gcaaacatgg tgctttcctg tgacaagcag ccccacaatg tcagggatgt
     1981 tatcaagtgg ctggtcaaag cagtaactga agatggattg actcagcccc caaatggaaa
     2041 tcaaacgtct tcaggaacag gaatcttgaa agccagcagt agccaccctt cttcccagcc
     2101 caacctgaca aagaacacca atcagctgat tgtgtgccag cttcagagga tgctctccat
     2161 agccgtagag gtggacagga cccccacctg cagctccaat aaaattgccg agatgatgtt
     2221 tgggtttgtg ctggacattc ctgagaggag ccagagagaa atgttcttta ctaccatgga
     2281 aagccacctt ctgcgctgca aagtgttaga aatcatattc ctccacagct gtgagacacc
     2341 cacccgcctg cctctgtctc tggcccaggc cctctacttt ctgaataatt ctacgtcact
     2401 gctcaagtgt cagtcagata aaagccagtg gcagacttgg gacgaattgg ttgagcatct
     2461 gcagtttctg ctgtccagtt atcaacatgt tttaagagaa cacttaagga gttccgtgat
     2521 cgaccgaaag gacttaataa tcaaaaggat taagcccaaa ccccagcaag gagatgacat
     2581 cacagtggta gacgtagaga agcagattga ggccttccgc agccgcctga tccagatgct
     2641 gggggagcct cttgtccccc aactccaaga caaagtgcac ttgttgaagc tcctgctctt
     2701 ctatgctgcg gacttgaacc ctgatgcaga gccctttcaa aagggctgga gcggctcctg
     2761 agggcctgcc aagcactgaa tgccaagaat acctcctgaa ctctctctcc aactgctcag
     2821 aagctctaaa agcatgaaaa gtggttaaaa tcttacagga ccaaacctgc attatttaat
     2881 cagtaggttg taatttctaa ctctagtaaa tatctttttt taaataatcc tatcctagcc
     2941 tgttctcaaa tatggcttaa atatacaagg tatatatatt ttttaataaa ttatttatct
     3001 atactttttt gaaacaggtt aatactctgt gcatcacatg tttaacattt tcattcaaga
     3061 tgtggaaaaa atccctctgc tgaacctagt ctatacacca atattatgtc attcaaggta
     3121 ccgacaacct gtttcaggag agagacgttc atttttccct aatgaaatgc aagcattctg
     3181 ttagacctat tatattgcct gttaatttga ctgtaatgaa tagggggtag aaacaaaagg
     3241 atcaagtgtg ttataaaaca tttgatgtta aaaggagaca ataaaaaggc aatggttttt
     3301 caaaa
//
