LOCUS       NM_025073               5494 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens suppressor of IKBKE 1 (SIKE1), transcript variant 2,
            mRNA.
ACCESSION   NM_025073
VERSION     NM_025073.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5494)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 5494)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5494)
  AUTHORS   Gayed,D.T., Wodeyar,J., Wang,Z.X., Wei,X., Yao,Y.Y., Chen,X.X.,
            Du,Z. and Chen,J.C.
  TITLE     Prognostic values of inhibitory kappaB kinases mRNA expression in
            human gastric cancer
  JOURNAL   Biosci Rep 39 (1) (2019)
   PUBMED   30487159
  REMARK    GeneRIF: mRNA expression of individual inhibitory kappaB kinases
            and SIKE are associated with unique prognostic significance and may
            act as valuable prognostic biomarkers and potential targets for
            future therapeutic interventions in gastric cancer.
            Erratum:[Biosci Rep. 2021 Jul 30;41(7):BSR-2018-0617_COR. doi:
            10.1042/BSR-2018-0617_COR.. PMID: 34196661]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5494)
  AUTHORS   Tang,Y., Chen,M., Zhou,L., Ma,J., Li,Y., Zhang,H., Shi,Z., Xu,Q.,
            Zhang,X., Gao,Z., Zhao,Y., Cheng,Y., Jiao,S. and Zhou,Z.
  TITLE     Architecture, substructures, and dynamic assembly of STRIPAK
            complexes in Hippo signaling
  JOURNAL   Cell Discov 5, 3 (2019)
   PUBMED   30622739
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5494)
  AUTHORS   Deng,K.Q., Wang,A., Ji,Y.X., Zhang,X.J., Fang,J., Zhang,Y.,
            Zhang,P., Jiang,X., Gao,L., Zhu,X.Y., Zhao,Y., Gao,L., Yang,Q.,
            Zhu,X.H., Wei,X., Pu,J. and Li,H.
  TITLE     Suppressor of IKKvarepsilon is an essential negative regulator of
            pathological cardiac hypertrophy
  JOURNAL   Nat Commun 7, 11432 (2016)
   PUBMED   27249321
  REMARK    GeneRIF: SIKE, a negative regulator of the interferon pathway,
            attenuates pathological cardiac hypertrophy.
            Erratum:[Nat Commun. 2023 May 25;14(1):3018. doi:
            10.1038/s41467-023-38331-w.. PMID: 37230962]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5494)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   7  (bases 1 to 5494)
  AUTHORS   Lant,B., Yu,B., Goudreault,M., Holmyard,D., Knight,J.D., Xu,P.,
            Zhao,L., Chin,K., Wallace,E., Zhen,M., Gingras,A.C. and Derry,W.B.
  TITLE     CCM-3/STRIPAK promotes seamless tube extension through endocytic
            recycling
  JOURNAL   Nat Commun 6, 6449 (2015)
   PUBMED   25743393
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 5494)
  AUTHORS   Marion,J.D., Roberts,C.F., Call,R.J., Forbes,J.L., Nelson,K.T.,
            Bell,J.E. and Bell,J.K.
  TITLE     Mechanism of endogenous regulation of the type I interferon
            response by suppressor of IkappaB kinase epsilon (SIKE), a novel
            substrate of TANK-binding kinase 1 (TBK1)
  JOURNAL   J Biol Chem 288 (25), 18612-18623 (2013)
   PUBMED   23649622
  REMARK    GeneRIF: Data indicate that suppressor of IKKepsilon (SIKE)
            inhibits TANK-binding kinase 1 (TBK1)-mediated phosphorylation of
            interferon regulatory factor 3 (IRF3), which is essential to type I
            interferon production.
REFERENCE   9  (bases 1 to 5494)
  AUTHORS   Goudreault,M., D'Ambrosio,L.M., Kean,M.J., Mullin,M.J.,
            Larsen,B.G., Sanchez,A., Chaudhry,S., Chen,G.I., Sicheri,F.,
            Nesvizhskii,A.I., Aebersold,R., Raught,B. and Gingras,A.C.
  TITLE     A PP2A phosphatase high density interaction network identifies a
            novel striatin-interacting phosphatase and kinase complex linked to
            the cerebral cavernous malformation 3 (CCM3) protein
  JOURNAL   Mol Cell Proteomics 8 (1), 157-171 (2009)
   PUBMED   18782753
REFERENCE   10 (bases 1 to 5494)
  AUTHORS   Huang,J., Liu,T., Xu,L.G., Chen,D., Zhai,Z. and Shu,H.B.
  TITLE     SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and
            virus-triggered IRF-3 activation pathways
  JOURNAL   EMBO J 24 (23), 4018-4028 (2005)
   PUBMED   16281057
  REMARK    GeneRIF: Overexpression of SIKE inhibits virus- and Toll-like
            receptor 3-triggered interferon-stimulated response elements (ISRE)
            but not NF-kappa B activation.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA950119.1, BC005934.1, AL096773.6 and AI039175.1.
            
            On Jun 2, 2019 this sequence version replaced NM_025073.2.
            
            Summary: SIKE interacts with IKK-epsilon (IKBKE; MIM 605048) and
            TBK1 (MIM 604834) and acts as a suppressor of TLR3 (MIM 603029) and
            virus-triggered interferon activation pathways (Huang et al., 2005
            [PubMed 16281057]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 1, which
            results in a protein (isoform 2) with a shorter N-terminus,
            compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853566.1625.1,
                                           SRR11853561.1391.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000060969.6/ ENSP00000060969.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                DA950119.1         3-30
            29-1181             BC005934.1         1-1153
            1182-5193           AL096773.6         31318-35329
            5194-5494           AI039175.1         12-312              c
FEATURES             Location/Qualifiers
     source          1..5494
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.2"
     gene            1..5494
                     /gene="SIKE1"
                     /gene_synonym="SIKE"
                     /note="suppressor of IKBKE 1"
                     /db_xref="GeneID:80143"
                     /db_xref="HGNC:HGNC:26119"
                     /db_xref="MIM:611656"
     exon            1..237
                     /gene="SIKE1"
                     /gene_synonym="SIKE"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..702
                     /gene="SIKE1"
                     /gene_synonym="SIKE"
                     /note="isoform 2 is encoded by transcript variant 2;
                     suppressor of IKK epsilon"
                     /codon_start=1
                     /product="suppressor of IKBKE 1 isoform 2"
                     /protein_id="NP_079349.2"
                     /db_xref="CCDS:CCDS878.1"
                     /db_xref="GeneID:80143"
                     /db_xref="HGNC:HGNC:26119"
                     /db_xref="MIM:611656"
                     /translation="MSCTIEKILTDAKTLLERLREHDAAAESLVDQSAALHRRVAAMR
                     EAGTALPDQYQEDASDMKDMSKYKPHILLSQENTQIRDLQQENRELWISLEEHQDALE
                     LIMSKYRKQMLQLMVAKKAVDAEPVLKAHQSHSAEIESQIDRICEMGEVMRKAVQVDD
                     DQFCKIQEKLAQLELENKELRELLSISSESLQARKENSMDTASQAIK"
     exon            238..343
                     /gene="SIKE1"
                     /gene_synonym="SIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            344..486
                     /gene="SIKE1"
                     /gene_synonym="SIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            487..600
                     /gene="SIKE1"
                     /gene_synonym="SIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            601..5494
                     /gene="SIKE1"
                     /gene_synonym="SIKE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      811..816
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIKE1"
                     /gene_synonym="SIKE"
                     /note="hexamer: ATTAAA"
     polyA_site      848
                     /gene="SIKE1"
                     /gene_synonym="SIKE"
                     /note="major polyA site"
     regulatory      5474..5479
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIKE1"
                     /gene_synonym="SIKE"
                     /note="hexamer: ATTATA"
     polyA_site      5494
                     /gene="SIKE1"
                     /gene_synonym="SIKE"
                     /note="major polyA site"
ORIGIN      
        1 aatgctgaga cagactccca gaagatctga gcgagtcgcg tagctgagcc cggcaggggc
       61 tggggtggtg ctgctgctat gagctgcacc atcgagaaga tcctgacaga cgccaagacg
      121 ctgctggaga ggctacggga gcacgatgcg gccgccgagt cgctggtgga tcagtcggcg
      181 gcgctgcacc ggcgggtagc agctatgcgg gaggcgggga cagcgcttcc ggaccagtat
      241 caagaggatg catccgatat gaaggacatg tccaaataca aacctcacat tctgctgtcc
      301 caagagaaca cacagattag agacttgcaa caggaaaaca gagagctatg gatttccttg
      361 gaggaacacc aggatgcttt ggaacttatc atgagcaaat atcggaaaca gatgttacag
      421 ttaatggttg ctaaaaaagc ggtggatgct gaaccagtcc tgaaagctca ccagtctcac
      481 tctgcagaaa ttgagagtca gattgacaga atctgtgaaa tgggagaagt gatgaggaaa
      541 gcagttcagg tggatgatga ccagttttgt aagattcagg aaaaattagc ccaattagag
      601 cttgaaaata aggaacttcg agaattattg tccatcagca gtgagtctct tcaagccaga
      661 aaggaaaact caatggacac tgcttcccaa gccatcaaat aactgaactc tgaatgatgg
      721 ctggagattg tctatcaagg aaggaagtta ctgtcttccc attcaagtac tgtccattaa
      781 gtgtcttgcc tcagatttga tttaatctta attaaaggta tcaggtggca atttagaatt
      841 ccagtcaata ttggctgtcc acagttctca gatgtgttaa tgtgaatact acatgctgaa
      901 tttcaccatt cctttctcaa agagactact tttaattttc atttctggga ccttgattta
      961 tataaactat gttttcagtt ctttgttatt tttcacatct ctgaaacttt gagcattttt
     1021 tataagccag caatttattt tacatagcat tgtaaaatac acttctagga aattttagga
     1081 aagatttaac tgtttaaatc tatttggcat aaaccttgat tttttttttc catttgacaa
     1141 aaataataca attccacaga actagatcag cagattctct gatttgtaat gtcattcacc
     1201 tgtgacattt taagtctctc tggtgctaag aattggcact ttatagcctg gtgcctttac
     1261 ttttaatttg agagaaccta ctgctagtcc caggaaacac acttggaaat aagtcagcta
     1321 ttttttttgc ccagtgatgc tatagttgtc atattgtcca aagttcatat tgttcaaagc
     1381 tgaggagctt gtcctgtgta tgtgaatgca cacatgtgca cttagttcaa atactaaaag
     1441 tagcttttat taaatataat cagccaaaaa cacacacaaa ataaaaaaaa caaatataag
     1501 tagtcagttt ttcaatgtta tcctactagt tctacattct attttaattt ttatacaatt
     1561 tccattttat agttaagaac catcacttac ttggattgga tgtctttcat tcctagcact
     1621 aatagttggc tttctttttt tttgtttaca tagaagcagg gttttttttt atcttttttc
     1681 tttttttttg tttaagctat ataaaaaggt gaggaagcag ttttgttacc taatgaaaat
     1741 tattacactc ataatgctgt gtaggcaaca ttgagattca aatgcccagt ggtcaactgg
     1801 gttcactcat caactcattc ccgtcccagt ttactcacat ttcaaattta taaatttctt
     1861 catgttatac tattctattt agatttgccc agaattagtt gaaataatgc taaacctgtc
     1921 aatattttcc agtaacatta agcaccatac tgcatgggag agacacagta ctaaaaagag
     1981 ttgttagtgc tttatgtgag tgatatttct ttcgtaatgc tataaagaac tacagttaaa
     2041 ataacaaaat attttaaaga tgtcctaaaa gcatctgatc ccagtaataa ctaatggatg
     2101 tcatctagag cagtgggtgt taatgaatag gtatatgtca tttaagaatt tttcaaattt
     2161 ctgtttgata tcctgcatag aatttgacaa aaaaaacact tccaagtgtg agcatttttt
     2221 atttcatttc ccaagagtaa gtaagtaact attagcccag ccatctgcct cgaagtatac
     2281 cttaagtgac cccataaatc cattcaagag gcaggtactc tataccattt ggcagccacg
     2341 gccaaaccta ccatggccag atttcagtga aaatgatgaa gtaatcaaat caaggtataa
     2401 tatggtgtcc ctttatgtgc tttatgttcc tttagagctg tttataaagt tctttatatc
     2461 tcaagtgtta ggataaatcg acatactaac ttttccccct gcaaaattaa aagcctgagg
     2521 tacaagtcta agaagctttt agtgctctac ataatataaa ttctggctgg tgttaatgct
     2581 atgaagataa tatgtagtta gaaaattgag tcggggagga atgctcttca ttttaagtgg
     2641 attttaaagt ttctccttga gtggatgaag aacttgcctg gtttgcaaaa atcttagttc
     2701 aaaattatat tttctaacaa aaactgcatt ttgagaagat aagctaattt tactcagtag
     2761 taagtcaaat gaggaagtgc agagggtttt tttacatata tatagcaacc ttgtcaagtg
     2821 gtcctcacaa gagtcataaa tactttgtaa ttagcacagt atattcagca gtgtataact
     2881 ctacaaatag taccttatat tagtgtagta ttatatcaat atcttatgta taattcttat
     2941 attaatacct tatgcataat tggattcaaa cattgaaggt ctattttagt gttcttcaaa
     3001 atgtgcttcc ctgacctact gaaatagaaa cttggtgatg aagttcaaga atttgtattc
     3061 taatcatctc aaacaattcc taaagacact gattttaaaa tatctagtct aggccccatt
     3121 gtgtaatagt tagcactcta aaagatgaaa aagaaaatag tctatgtgcc aaccacttca
     3181 ttagtactta tgaatttaaa aatgaaaaag tctggtacag gagacaagta tatatataaa
     3241 attataatgc agtgtgataa atccattata gtatgtataa gatacagaag agggacttta
     3301 aacttgagaa ttcaatagag ataataaatg ggtaggaggg aaatagaaaa ctttggtgcc
     3361 acaaaagcaa agtatgtatg gtattgccaa taatagctac catctattga gtgctttact
     3421 acctgtcagg tactgtatta tataaactcc attttaactg tacctcattt tgcagatact
     3481 caggcacaag gaggtggtta tttgtccaaa ctggaaccaa gattcaaacc cagacagagt
     3541 cttaagcaca tttttaatca ctaactaact tgagatgcct aaatgccaaa tactgttggg
     3601 agttcaagtg gttcttgatt agcaaaatct atttttatta gtgcaaaaga aacaccacag
     3661 cttataaagt attatgaatt caataaatgg agtcttaact aatgagatat tattttctag
     3721 aatggtgtag ctgagagtat gtgtgattca actgaaagga ataatgttta atcagtgact
     3781 cttactatat acaggaaaag gtgcagttct gtctttcaaa tctgcctcct taccatattg
     3841 gcttacatcc ctcatgctgt tttcttgtgt ttgctagaaa gttgttgcca agccaaatgt
     3901 catggccatg ttgaaggcaa ggaagaaaaa atggaaatgg cctgtgccag ctatatatat
     3961 cgccttttat gagggaaagc aaagctttct cagaaatccc aaatggattt tcccttgact
     4021 taattgcctg accagttaaa tggccactgg tacctgcaaa gaaagcaggg tacatagctg
     4081 tcccaaataa aatcagtatt agcaagaaga aagaatattg agaaagcaat taacagtgtc
     4141 tgtgactgtg acatgtctgt gactttatat tgtcaagtcc tttccccttg aatatagttt
     4201 tggaagaatt agctgaagga gtgtgttgac attgaatggc caagagaatg ggctgtagca
     4261 gacatctgtc atttctcttt tggctgccca gtatcctaac tcctgtgttt aaggaatccc
     4321 tcacctaatg aggcagagca tttcttcctc ctaaagaatt tgaaagtacc aggtaatgtt
     4381 ttctcagcct ccttttgcag ctaaggaaga aacatctgcc ttcaatttta aaattagtga
     4441 tacaaagaag gagggaacca tgcagattcc tttgaagatg gtgattaaca acactactgc
     4501 attcatctcc acagaggtac agcaaaagtg atttagttag cgataacctc taattctatt
     4561 tttttatttt tattttttga gacagtcttg ctctgtcaac caggctggag tgcagtagca
     4621 ctgtcttaac tcactgcaac ctccacctcc tgggttcaag cgattctcct gcctcagcct
     4681 cccaagtcgc tgggattaca agtgcccacc accatgcaca gctaattttt gtgtttttag
     4741 tagatggggt ttctccatgt tggccaggct ggtctcgaac ttatgacttc aggtgatccg
     4801 cccgccttgg cctcccaaag tgctgggatt ataggcgtga gccactgtgc ctggcctgta
     4861 acctctaatt cttgtttgct ggctgtccta gagatcctga gaattacttt taataaaatc
     4921 atttttttgc tgttattaaa actaacctga attgcctaaa accaagaact ctgcttgata
     4981 aaataagcat agttttagga acagccatgc agatataaat tttatcaaca ctttatacat
     5041 aatttgggac ttatatttaa atgtaatatt tgatgcttat aaaagggtaa atggggaatg
     5101 caaataaatt atcaagcata ataactcatc acctaactta agaataacat tatgagtgct
     5161 tgtattttat ctatttgagc tcttctccta tctttgccga cccccccgct ctctttttaa
     5221 tagatttgtt cgaatgtaga aagacctaaa atacatatgt atccctaaag tgacttattt
     5281 tatagttttc tttctttttg aacttcaaaa aaattgtatc atactctatg tagtctaagg
     5341 atttggtttt tttcactcaa catgtctcta gaattcacaa gttttattgt tttatagctg
     5401 tcattttcat tgatgtatat ttcattgttg ggttatacaa catattgtta aggaatacat
     5461 acatatataa taaattatac attttttaaa aaaa
//
