LOCUS       XM_011542725            5971 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens SIK family kinase 3 (SIK3), transcript
            variant X11, mRNA.
ACCESSION   XM_011542725
VERSION     XM_011542725.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000011.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_011542725.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5971
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
     gene            1..5971
                     /gene="SIK3"
                     /gene_synonym="L19; QSK; SEMDK; SIK-3"
                     /note="SIK family kinase 3; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 3
                     mRNAs, 44 ESTs, 348 long SRA reads, 2 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 43 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:23387"
                     /db_xref="HGNC:HGNC:29165"
                     /db_xref="MIM:614776"
     CDS             98..3730
                     /gene="SIK3"
                     /gene_synonym="L19; QSK; SEMDK; SIK-3"
                     /codon_start=1
                     /product="serine/threonine-protein kinase SIK3 isoform X7"
                     /protein_id="XP_011541027.1"
                     /db_xref="GeneID:23387"
                     /db_xref="HGNC:HGNC:29165"
                     /db_xref="MIM:614776"
                     /translation="MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIK
                     IADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGAL
                     PFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKL
                     GDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSA
                     IYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPEN
                     QIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGV
                     NPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRAS
                     DGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQRYLANRS
                     KRHTLAMTNPTAEIPPDLQRQLGQQPFRSRVWPPHLVPDQHRSTYKDSNTLHLPTERF
                     SPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQ
                     HMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPN
                     HPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVAL
                     TCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLM
                     ATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPS
                     TGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPH
                     ILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQG
                     DAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGY
                     AHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLG
                     TVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPA
                     RPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSL
                     MGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFS
                     MEQAGV"
ORIGIN      
        1 acttgaagaa gattttccgg gaagttcaaa ttatgaagat gctttgccac ccccatatca
       61 tcaggctcta ccagaccacc tggtggccca tggtagaatg gcagaaaagg aggcacgtcg
      121 gaagttcaaa cagatcgtca cagctgtcta tttttgtcac tgtcggaaca ttgttcatcg
      181 tgatttaaaa gctgaaaatt tacttctgga tgccaatctg aatatcaaaa tagcagattt
      241 tggtttcagt aacctcttca ctcctgggca gctgctgaag acctggtgtg gcagccctcc
      301 ctatgctgca cctgaactct ttgaaggaaa agaatatgat gggcccaaag tggacatctg
      361 gagccttgga gttgtcctct acgtgcttgt gtgcggtgcc ctgccatttg atggaagcac
      421 actgcagaat ctgcgggccc gcgtgctgag tggaaagttc cgcatcccat tttttatgtc
      481 cacagaatgt gagcatttga tccgccatat gttggtgtta gatcccaata agcgcctctc
      541 catggagcag atctgcaagc acaagtggat gaagctaggg gacgccgatc ccaactttga
      601 caggttaata gctgaatgcc aacaactaaa ggaagaaaga caggtggacc ccctgaatga
      661 ggatgtcctc ttggccatgg aggacatggg actggacaaa gaacagacac tgcagtcatt
      721 aagatcagat gcctatgatc actatagtgc aatctacagc ctgctgtgtg atcgacataa
      781 gagacataaa accctgcgtc tcggagcact tcctagcatg ccccgagccc tggcctttca
      841 agcaccagtc aatatccagg cggagcaggc aggtactgct atgaacatca gcgttcccca
      901 ggtgcagctg atcaacccag agaaccaaat tgtggagccg gatgggacac tgaatttgga
      961 cagtgatgag ggtgaagagc cttcccctga agcattggtg cgctatttgt caatgaggag
     1021 gcacacagtg ggtgtggctg acccacgcac ggaagttatg gaagatctgc agaagctcct
     1081 acctggcttt cctggagtca acccccaggc tccattcctg caggtggccc ctaatgtgaa
     1141 cttcatgcac aacctgttgc ctatgcaaaa cttgcaacca accgggcaac ttgagtacaa
     1201 ggagcagtct ctcctacagc cgcccacgct acagctgttg aatggaatgg gcccccttgg
     1261 ccggagggca tcagatggag gagccaacat ccaactgcat gcccagcagc tgctgaagcg
     1321 cccacgggga ccctctccgc ttgtcaccat gacaccagca gtgccagcag ttacccctgt
     1381 ggacgaggag agctcagacg gggagccaga ccaggaagct gtgcagaggt acttggcaaa
     1441 taggtccaaa agacatacac tggccatgac caaccctaca gctgagatcc caccggacct
     1501 acaacggcag ctaggacagc agcctttccg ttcccgggtc tggcctcctc acctggtacc
     1561 tgatcagcat cgctctacct acaaggactc caacactctg cacctcccta cggagcgttt
     1621 ctcccctgtg cgccggttct cagatggggc tgcgagcatc caggccttca aagctcacct
     1681 ggaaaaaatg ggcaacaaca gcagcatcaa acagctgcag caggagtgtg agcagctgca
     1741 gaagatgtac ggggggcaga ttgatgaaag aaccctggag aagacccagc agcagcatat
     1801 gttataccag caggagcagc accatcaaat tctccagcaa caaattcaag actctatctg
     1861 tcctcctcag ccatctccac ctcttcaggc tgcatgtgaa aatcagccag ccctccttac
     1921 ccatcagctc cagaggttaa ggattcagcc ttcaagccca ccccccaacc accccaacaa
     1981 ccatctcttc aggcagccca gtaatagtcc tccccccatg agcagtgcca tgatccagcc
     2041 tcacggggct gcatcttctt cccagtttca aggcttacct tcccgcagtg caatctttca
     2101 gcagcaacct gagaactgtt cctctcctcc caacgtggca ctaacctgct tgggtatgca
     2161 gcagcctgct cagtcacagc aggtcaccat ccaagtccaa gagcctgttg acatgctcag
     2221 caacatgcca ggcacagctg caggctccag tgggcgcggc atctccatca gccccagtgc
     2281 tggtcagatg cagatgcagc accgtaccaa cctgatggcc accctcagct atgggcaccg
     2341 tcccttgtcc aagcagctga gtgctgacag tgcagaggct cacagcttga acgtgaatcg
     2401 gttctcccct gctaactacg accaggcgca tttacacccc catctgtttt cggaccagtc
     2461 ccggggttcc cccagcagct acagcccttc aacaggagtg gggttctctc caacccaagc
     2521 cctgaaagtc cctccacttg accaattccc caccttccct cccagtgcac atcagcagcc
     2581 gccacactat accacgtcgg cactacagca ggccctgctg tctcccacgc cgccagacta
     2641 tacaagacac cagcaggtac cccacatcct tcaaggactg ctttctcccc ggcattcgct
     2701 caccggccac tcggacatcc ggctgccccc aacagagttt gcacagctca ttaaaaggca
     2761 gcagcaacaa cggcagcagc agcagcaaca gcagcaacag caagaatacc aggaactgtt
     2821 caggcacatg aaccaagggg atgcggggag tctggctccc agccttgggg gacagagcat
     2881 gacagagcgc caggctttat cttatcaaaa tgctgactct tatcaccatc acaccagccc
     2941 ccagcatctg ctacaaatca gggcacaaga atgtgtctca caggcttcct cacccacccc
     3001 gccccacggg tatgctcacc agccggcact gatgcattca gagagcatgg aggaggactg
     3061 ctcgtgtgag ggggccaagg atggcttcca agacagtaag agttcaagta cattgaccaa
     3121 aggttgccat gacagccctc tgctcttgag taccggtgga cctggggacc ctgaatcttt
     3181 gctaggaact gtgagtcatg cccaagaatt ggggatacat ccctatggtc atcagccaac
     3241 tgctgcattc agtaaaaata aggtgcccag cagagagcct gtcataggga actgcatgga
     3301 tagaagttct ccaggacaag cagtggagct gccggatcac aatgggctcg ggtacccagc
     3361 acgcccctcc gtccatgagc accacaggcc ccgggccctc cagagacacc acacgatcca
     3421 gaacagcgac gatgcttatg tacagctgga taacttgcca ggaatgagtc tcgtggctgg
     3481 gaaagcactt agctctgccc ggatgtcgga tgcagttctc agtcagtctt cgctcatggg
     3541 cagccagcag tttcaggatg gggaaaatga ggaatgtggg gcaagcctgg gaggtcatga
     3601 gcacccagac ctgagtgatg gcagccagca tttaaactcc tcttgctatc catctacgtg
     3661 tattacagac attctgctca gctacaagca ccccgaagtc tccttcagca tggagcaggc
     3721 aggcgtgtaa caagaaacag agagttttgt gtacagcttg ggaatgaaaa ggttgattgt
     3781 aaacccacag tatctagcag cgttgtgcca aattgccctt gtgtttctct ccacccaaaa
     3841 tatcacagct gctttcctca catttggttc atccgtgtgc tgttcttttg ggttctgaga
     3901 gggttttgcc atgtttgctt gtatgaccaa gtcaccaagg aaataaacag gaaggaaatc
     3961 catgttctcc atcttttgtg aaagtatatt tgagttggtg gttttttgtt ttgtttgggg
     4021 gtttgtgttt tgttttgttt ttggtatgtt ttcttccaga ggtgatatac tttctttttt
     4081 ttcttccttt cttttttttc tttcgttcct tttttgaaac aggagagcaa agcagttaga
     4141 gttcagaggc cagcggcctc agggccactc cctccctagc cttcatcagc agagcaccct
     4201 ccatccccct gcattgctct tctgtgaaag caaatactaa aggatgccat cctctggaat
     4261 cctaatggca ggcaaaggga gagaggaagg gtgacggctt ctggcactta gaaaacaaaa
     4321 agaacaaaaa aagagaaacc cccaagcctg gaacgcagag aggtctttac tgctgggatc
     4381 cacggaaaac atgtctgtcc tagccaagat catatgaaga gtttggcacg gaggctgaga
     4441 atgacctggc atagatggtt tgccagttag gatgtctcaa tttgagcctt tgcttttggt
     4501 ggataactca gctcccctct tgtaacctgg aaagttggtt gcctttatca tcctgctggt
     4561 tttatccatg gactgaacac ccaacagcag tgcactatgc tttctatggc atctttcatt
     4621 ctcattttat attgtgctat aaaaaggatt gtttctccat atatatatta tatatgtgtg
     4681 tatatatata atataatata tgtgtatata tatattatat atataatata taatataata
     4741 tattatatat atattatata tataatatat atataaaata tatatatata tgctctcctc
     4801 tttcagcctc tttgtcacag ggaagaagtg taggaggttg ccttgggccc tgcctctctc
     4861 ctaacctcct cttccccact gggtaccctc agcccctata ttttaattct tgatcatgta
     4921 gaaattgttt ttggtaaatg ttgatattat tgttattatc attattaata aataaagaga
     4981 aaaggaattt ttgtttaaat gagaaatgtt taaccagatt ctgttctatt tgaattgtga
     5041 cttgcacctt ttgttcaaag tatttccttt aggcattgta attgtgaaca gctcttactt
     5101 gtgccagtga cagatgcagt ggtctccttt ccccagttga agcagtgcat acgcagtagc
     5161 tattatttgt gttatcttta tttctcttca ttgttagaaa ccaaagtctt ctctgctggc
     5221 tggggctgag agagggtctg ggttatctcc ttctgatctt caaaacaaga gagagacctt
     5281 gaatacactg actcttccac cctttttttt tctgggaaag gagagcaaga ggtcccgagt
     5341 cccctcctag tctttcatcc tgaatttgca cagaggaaag cgggtgcccg gcatggccat
     5401 cctgatgttg ctggcgggat ccccatgcac cttgtccttc tccactgata ctggcagctc
     5461 ggctcctgga cccaagatcc cttgagtgga attctgcagt gcaagagccc ttcgtgggag
     5521 ctgtcccatg tttccatggt ccccagtctc ccctccactt ggtggggtca ccaactactc
     5581 accagaaggg ggcttaccaa gaaagcccta aaaagctgtt gacttatctg cgcttgttcc
     5641 aactcttatg cccccaacct gccctaccac caccacgcgc tcagcctgat gtgtttacat
     5701 ggtactgtat gtatgggaga gcagactgca ccctccagca acaacagatg aaagccagtg
     5761 agcctactaa ccgtgccatc ttgcaaacta cactttaaaa aaaactcatt gctttgtatt
     5821 gtagtaacca atatgtgcag tatacgttga atgtatatga acatactttc ctatttctgt
     5881 tctttgaaaa tgtcagaaat atttttttct ttctcatttt atgttgaact aaaaaggatt
     5941 aaaaaaaaaa tctccagact caagttgcta a
//
