LOCUS       NM_001366686            6364 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens SIK family kinase 3 (SIK3), transcript variant 4,
            mRNA.
ACCESSION   NM_001366686 XM_005271481
VERSION     NM_001366686.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6364)
  AUTHORS   Dai,X., Lin,A., Zhuang,L., Zeng,Q., Cai,L., Wei,Y., Liang,H.,
            Gao,W., Zhang,J. and Chen,X.
  TITLE     Targeting SIK3 to modulate hippocampal synaptic plasticity and
            cognitive function by regulating the transcription of HDAC4 in a
            mouse model of Alzheimer's disease
  JOURNAL   Neuropsychopharmacology 49 (6), 942-952 (2024)
   PUBMED   38057370
  REMARK    GeneRIF: Targeting SIK3 to modulate hippocampal synaptic plasticity
            and cognitive function by regulating the transcription of HDAC4 in
            a mouse model of Alzheimer's disease.
REFERENCE   2  (bases 1 to 6364)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   3  (bases 1 to 6364)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 6364)
  AUTHORS   Jia,X., Li,J., Li,H., Zhu,H., Li,H., Xu,W., Li,N. and Xie,J.
  TITLE     [Analysis of SIK3 gene variation in a boy with autism spectrum
            disorder complicated with epilepsy]
  JOURNAL   Zhonghua Yi Xue Yi Chuan Xue Za Zhi 38 (12), 1228-1232 (2021)
   PUBMED   34839513
  REMARK    GeneRIF: [Analysis of SIK3 gene variation in a boy with autism
            spectrum disorder complicated with epilepsy].
REFERENCE   5  (bases 1 to 6364)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 6364)
  AUTHORS   Kooner,J.S., Chambers,J.C., Aguilar-Salinas,C.A., Hinds,D.A.,
            Hyde,C.L., Warnes,G.R., Gomez Perez,F.J., Frazer,K.A., Elliott,P.,
            Scott,J., Milos,P.M., Cox,D.R. and Thompson,J.F.
  TITLE     Genome-wide scan identifies variation in MLXIPL associated with
            plasma triglycerides
  JOURNAL   Nat Genet 40 (2), 149-151 (2008)
   PUBMED   18193046
REFERENCE   7  (bases 1 to 6364)
  AUTHORS   Al-Hakim,A.K., Goransson,O., Deak,M., Toth,R., Campbell,D.G.,
            Morrice,N.A., Prescott,A.R. and Alessi,D.R.
  TITLE     14-3-3 cooperates with LKB1 to regulate the activity and
            localization of QSK and SIK
  JOURNAL   J Cell Sci 118 (Pt 23), 5661-5673 (2005)
   PUBMED   16306228
REFERENCE   8  (bases 1 to 6364)
  AUTHORS   Petroziello,J., Yamane,A., Westendorf,L., Thompson,M., McDonagh,C.,
            Cerveny,C., Law,C.L., Wahl,A. and Carter,P.
  TITLE     Suppression subtractive hybridization and expression profiling
            identifies a unique set of genes overexpressed in non-small-cell
            lung cancer
  JOURNAL   Oncogene 23 (46), 7734-7745 (2004)
   PUBMED   15334068
REFERENCE   9  (bases 1 to 6364)
  AUTHORS   Katoh,Y., Takemori,H., Horike,N., Doi,J., Muraoka,M., Min,L. and
            Okamoto,M.
  TITLE     Salt-inducible kinase (SIK) isoforms: their involvement in
            steroidogenesis and adipogenesis
  JOURNAL   Mol Cell Endocrinol 217 (1-2), 109-112 (2004)
   PUBMED   15134808
REFERENCE   10 (bases 1 to 6364)
  AUTHORS   Lizcano,J.M., Goransson,O., Toth,R., Deak,M., Morrice,N.A.,
            Boudeau,J., Hawley,S.A., Udd,L., Makela,T.P., Hardie,D.G. and
            Alessi,D.R.
  TITLE     LKB1 is a master kinase that activates 13 kinases of the AMPK
            subfamily, including MARK/PAR-1
  JOURNAL   EMBO J 23 (4), 833-843 (2004)
   PUBMED   14976552
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP000936.7, AP003070.3 and AP006216.1.
            
            On Sep 30, 2020 this sequence version replaced NM_001366686.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK008396.1, SRR11853559.6902.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000445177.6/ ENSP00000391295.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-286               AP000936.7         177509-177794       c
            287-403             AP000936.7         36314-36430         c
            404-467             AP000936.7         33410-33473         c
            468-629             AP000936.7         6585-6746           c
            630-754             AP003070.3         68444-68568         c
            755-878             AP003070.3         67504-67627         c
            879-997             AP006216.1         165972-166090       c
            998-1108            AP006216.1         165301-165411       c
            1109-1252           AP006216.1         164914-165057       c
            1253-1330           AP006216.1         164422-164499       c
            1331-1440           AP006216.1         164206-164315       c
            1441-1594           AP006216.1         162951-163104       c
            1595-1750           AP006216.1         162529-162684       c
            1751-1821           AP006216.1         159379-159449       c
            1822-1965           AP006216.1         156994-157137       c
            1966-2116           AP006216.1         152716-152866       c
            2117-2242           AP006216.1         151250-151375       c
            2243-2328           AP006216.1         150889-150974       c
            2329-2438           AP006216.1         150322-150431       c
            2439-2778           AP006216.1         148313-148652       c
            2779-3668           AP006216.1         146858-147747       c
            3669-3832           AP006216.1         138168-138331       c
            3833-3965           AP006216.1         136524-136656       c
            3966-4136           AP006216.1         135431-135601       c
            4137-6364           AP006216.1         132450-134677       c
FEATURES             Location/Qualifiers
     source          1..6364
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.3"
     gene            1..6364
                     /gene="SIK3"
                     /gene_synonym="L19; QSK; SEMDK; SIK-3"
                     /note="SIK family kinase 3"
                     /db_xref="GeneID:23387"
                     /db_xref="HGNC:HGNC:29165"
                     /db_xref="MIM:614776"
     exon            1..286
                     /gene="SIK3"
                     /gene_synonym="L19; QSK; SEMDK; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..4123
                     /gene="SIK3"
                     /gene_synonym="L19; QSK; SEMDK; SIK-3"
                     /EC_number="2.7.11.1"
                     /note="isoform 4 is encoded by transcript variant 4;
                     serine/threonine-protein kinase QSK; salt-inducible kinase
                     3; serine/threonine-protein kinase SIK3"
                     /codon_start=1
                     /product="serine/threonine-protein kinase SIK3 isoform 4"
                     /protein_id="NP_001353615.1"
                     /db_xref="CCDS:CCDS91600.1"
                     /db_xref="GeneID:23387"
                     /db_xref="HGNC:HGNC:29165"
                     /db_xref="MIM:614776"
                     /translation="MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPA
                     AGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQL
                     DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRM
                     AEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQL
                     LKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVL
                     SGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQ
                     QLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTL
                     RLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDE
                     GEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNF
                     MHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLK
                     RPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQRYLANRSKRHTLAMTNPTAEIP
                     PDLQRQLGQQPFRSRVWPPHLVPDQHRSTYKDSNTLHLPTERFSPVRRFSDGAASIQA
                     FKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQ
                     QIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPP
                     PMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVT
                     IQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLS
                     ADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPP
                     LDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGH
                     SDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMT
                     ERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEED
                     CSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGH
                     QPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQR
                     HHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECG
                     ASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV"
     exon            287..403
                     /gene="SIK3"
                     /gene_synonym="L19; QSK; SEMDK; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            404..467
                     /gene="SIK3"
                     /gene_synonym="L19; QSK; SEMDK; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            468..629
                     /gene="SIK3"
                     /gene_synonym="L19; QSK; SEMDK; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            630..754
                     /gene="SIK3"
                     /gene_synonym="L19; QSK; SEMDK; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            755..878
                     /gene="SIK3"
                     /gene_synonym="L19; QSK; SEMDK; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            879..997
                     /gene="SIK3"
                     /gene_synonym="L19; QSK; SEMDK; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1108
                     /gene="SIK3"
                     /gene_synonym="L19; QSK; SEMDK; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1252
                     /gene="SIK3"
                     /gene_synonym="L19; QSK; SEMDK; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1330
                     /gene="SIK3"
                     /gene_synonym="L19; QSK; SEMDK; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1440
                     /gene="SIK3"
                     /gene_synonym="L19; QSK; SEMDK; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1594
                     /gene="SIK3"
                     /gene_synonym="L19; QSK; SEMDK; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1750
                     /gene="SIK3"
                     /gene_synonym="L19; QSK; SEMDK; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1821
                     /gene="SIK3"
                     /gene_synonym="L19; QSK; SEMDK; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1822..1965
                     /gene="SIK3"
                     /gene_synonym="L19; QSK; SEMDK; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..2116
                     /gene="SIK3"
                     /gene_synonym="L19; QSK; SEMDK; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2242
                     /gene="SIK3"
                     /gene_synonym="L19; QSK; SEMDK; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2243..2328
                     /gene="SIK3"
                     /gene_synonym="L19; QSK; SEMDK; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2438
                     /gene="SIK3"
                     /gene_synonym="L19; QSK; SEMDK; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..2778
                     /gene="SIK3"
                     /gene_synonym="L19; QSK; SEMDK; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2779..3668
                     /gene="SIK3"
                     /gene_synonym="L19; QSK; SEMDK; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3669..3832
                     /gene="SIK3"
                     /gene_synonym="L19; QSK; SEMDK; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3833..3965
                     /gene="SIK3"
                     /gene_synonym="L19; QSK; SEMDK; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3966..4136
                     /gene="SIK3"
                     /gene_synonym="L19; QSK; SEMDK; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            4137..6364
                     /gene="SIK3"
                     /gene_synonym="L19; QSK; SEMDK; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4335..4340
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIK3"
                     /gene_synonym="L19; QSK; SEMDK; SIK-3"
                     /note="hexamer: AATAAA"
     polyA_site      4355
                     /gene="SIK3"
                     /gene_synonym="L19; QSK; SEMDK; SIK-3"
                     /note="major polyA site"
     regulatory      6331..6336
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIK3"
                     /gene_synonym="L19; QSK; SEMDK; SIK-3"
                     /note="hexamer: ATTAAA"
     polyA_site      6356
                     /gene="SIK3"
                     /gene_synonym="L19; QSK; SEMDK; SIK-3"
ORIGIN      
        1 actgcacaac aagatggcgg cggcggcggc gagcggagct ggcggggctg ccggggccgg
       61 gactggggga gccgggcccg cgggccgcct gctgcctccg cccgcgccgg ggtccccagc
      121 cgcccccgct gccgtgtccc ctgcggccgg ccagccgcgt cccccagccc cggcctcccg
      181 cggacccatg cccgcccgta tcggctacta cgagatcgac cgcaccatcg gcaagggcaa
      241 cttcgcggtg gtcaagcggg ccacgcacct cgtcaccaag gccaaggttg ctatcaagat
      301 catagataag acccagctgg atgaagaaaa cttgaagaag attttccggg aagttcaaat
      361 tatgaagatg ctttgccacc cccatatcat caggctctac caggttatgg agacagaacg
      421 gatgatttat ctggtgacag aatatgctag tggaggggaa atatttgacc acctggtggc
      481 ccatggtaga atggcagaaa aggaggcacg tcggaagttc aaacagatcg tcacagctgt
      541 ctatttttgt cactgtcgga acattgttca tcgtgattta aaagctgaaa atttacttct
      601 ggatgccaat ctgaatatca aaatagcaga ttttggtttc agtaacctct tcactcctgg
      661 gcagctgctg aagacctggt gtggcagccc tccctatgct gcacctgaac tctttgaagg
      721 aaaagaatat gatgggccca aagtggacat ctggagcctt ggagttgtcc tctacgtgct
      781 tgtgtgcggt gccctgccat ttgatggaag cacactgcag aatctgcggg cccgcgtgct
      841 gagtggaaag ttccgcatcc cattttttat gtccacagaa tgtgagcatt tgatccgcca
      901 tatgttggtg ttagatccca ataagcgcct ctccatggag cagatctgca agcacaagtg
      961 gatgaagcta ggggacgccg atcccaactt tgacaggtta atagctgaat gccaacaact
     1021 aaaggaagaa agacaggtgg accccctgaa tgaggatgtc ctcttggcca tggaggacat
     1081 gggactggac aaagaacaga cactgcagtc attaagatca gatgcctatg atcactatag
     1141 tgcaatctac agcctgctgt gtgatcgaca taagagacat aaaaccctgc gtctcggagc
     1201 acttcctagc atgccccgag ccctggcctt tcaagcacca gtcaatatcc aggcggagca
     1261 ggcaggtact gctatgaaca tcagcgttcc ccaggtgcag ctgatcaacc cagagaacca
     1321 aattgtggag ccggatggga cactgaattt ggacagtgat gagggtgaag agccttcccc
     1381 tgaagcattg gtgcgctatt tgtcaatgag gaggcacaca gtgggtgtgg ctgacccacg
     1441 cacggaagtt atggaagatc tgcagaagct cctacctggc tttcctggag tcaaccccca
     1501 ggctccattc ctgcaggtgg cccctaatgt gaacttcatg cacaacctgt tgcctatgca
     1561 aaacttgcaa ccaaccgggc aacttgagta caaggagcag tctctcctac agccgcccac
     1621 gctacagctg ttgaatggaa tgggccccct tggccggagg gcatcagatg gaggagccaa
     1681 catccaactg catgcccagc agctgctgaa gcgcccacgg ggaccctctc cgcttgtcac
     1741 catgacacca gcagtgccag cagttacccc tgtggacgag gagagctcag acggggagcc
     1801 agaccaggaa gctgtgcaga ggtacttggc aaataggtcc aaaagacata cactggccat
     1861 gaccaaccct acagctgaga tcccaccgga cctacaacgg cagctaggac agcagccttt
     1921 ccgttcccgg gtctggcctc ctcacctggt acctgatcag catcgctcta cctacaagga
     1981 ctccaacact ctgcacctcc ctacggagcg tttctcccct gtgcgccggt tctcagatgg
     2041 ggctgcgagc atccaggcct tcaaagctca cctggaaaaa atgggcaaca acagcagcat
     2101 caaacagctg cagcaggagt gtgagcagct gcagaagatg tacggggggc agattgatga
     2161 aagaaccctg gagaagaccc agcagcagca tatgttatac cagcaggagc agcaccatca
     2221 aattctccag caacaaattc aagactctat ctgtcctcct cagccatctc cacctcttca
     2281 ggctgcatgt gaaaatcagc cagccctcct tacccatcag ctccagaggt taaggattca
     2341 gccttcaagc ccacccccca accaccccaa caaccatctc ttcaggcagc ccagtaatag
     2401 tcctcccccc atgagcagtg ccatgatcca gcctcacggg gctgcatctt cttcccagtt
     2461 tcaaggctta ccttcccgca gtgcaatctt tcagcagcaa cctgagaact gttcctctcc
     2521 tcccaacgtg gcactaacct gcttgggtat gcagcagcct gctcagtcac agcaggtcac
     2581 catccaagtc caagagcctg ttgacatgct cagcaacatg ccaggcacag ctgcaggctc
     2641 cagtgggcgc ggcatctcca tcagccccag tgctggtcag atgcagatgc agcaccgtac
     2701 caacctgatg gccaccctca gctatgggca ccgtcccttg tccaagcagc tgagtgctga
     2761 cagtgcagag gctcacagct tgaacgtgaa tcggttctcc cctgctaact acgaccaggc
     2821 gcatttacac ccccatctgt tttcggacca gtcccggggt tcccccagca gctacagccc
     2881 ttcaacagga gtggggttct ctccaaccca agccctgaaa gtccctccac ttgaccaatt
     2941 ccccaccttc cctcccagtg cacatcagca gccgccacac tataccacgt cggcactaca
     3001 gcaggccctg ctgtctccca cgccgccaga ctatacaaga caccagcagg taccccacat
     3061 ccttcaagga ctgctttctc cccggcattc gctcaccggc cactcggaca tccggctgcc
     3121 cccaacagag tttgcacagc tcattaaaag gcagcagcaa caacggcagc agcagcagca
     3181 acagcagcaa cagcaagaat accaggaact gttcaggcac atgaaccaag gggatgcggg
     3241 gagtctggct cccagccttg ggggacagag catgacagag cgccaggctt tatcttatca
     3301 aaatgctgac tcttatcacc atcacaccag cccccagcat ctgctacaaa tcagggcaca
     3361 agaatgtgtc tcacaggctt cctcacccac cccgccccac gggtatgctc accagccggc
     3421 actgatgcat tcagagagca tggaggagga ctgctcgtgt gagggggcca aggatggctt
     3481 ccaagacagt aagagttcaa gtacattgac caaaggttgc catgacagcc ctctgctctt
     3541 gagtaccggt ggacctgggg accctgaatc tttgctagga actgtgagtc atgcccaaga
     3601 attggggata catccctatg gtcatcagcc aactgctgca ttcagtaaaa ataaggtgcc
     3661 cagcagagag cctgtcatag ggaactgcat ggatagaagt tctccaggac aagcagtgga
     3721 gctgccggat cacaatgggc tcgggtaccc agcacgcccc tccgtccatg agcaccacag
     3781 gccccgggcc ctccagagac accacacgat ccagaacagc gacgatgctt atgtacagct
     3841 ggataacttg ccaggaatga gtctcgtggc tgggaaagca cttagctctg cccggatgtc
     3901 ggatgcagtt ctcagtcagt cttcgctcat gggcagccag cagtttcagg atggggaaaa
     3961 tgaggaatgt ggggcaagcc tgggaggtca tgagcaccca gacctgagtg atggcagcca
     4021 gcatttaaac tcctcttgct atccatctac gtgtattaca gacattctgc tcagctacaa
     4081 gcaccccgaa gtctccttca gcatggagca ggcaggcgtg taacaagaaa cagagagttt
     4141 tgtgtacagc ttgggaatga aaaggttgat tgtaaaccca cagtatctag cagcgttgtg
     4201 ccaaattgcc cttgtgtttc tctccaccca aaatatcaca gctgctttcc tcacatttgg
     4261 ttcatccgtg tgctgttctt ttgggttctg agagggtttt gccatgtttg cttgtatgac
     4321 caagtcacca aggaaataaa caggaaggaa atccatgttc tccatctttt gtgaaagtat
     4381 atttgagttg gtggtttttt gttttgtttg ggggtttgtg ttttgttttg tttttggtat
     4441 gttttcttcc agaggtgata tactttcttt tttttcttcc tttctttttt ttctttcgtt
     4501 ccttttttga aacaggagag caaagcagtt agagttcaga ggccagcggc ctcagggcca
     4561 ctccctccct agccttcatc agcagagcac cctccatccc cctgcattgc tcttctgtga
     4621 aagcaaatac taaaggatgc catcctctgg aatcctaatg gcaggcaaag ggagagagga
     4681 agggtgacgg cttctggcac ttagaaaaca aaaagaacaa aaaaagagaa acccccaagc
     4741 ctggaacgca gagaggtctt tactgctggg atccacggaa aacatgtctg tcctagccaa
     4801 gatcatatga agagtttggc acggaggctg agaatgacct ggcatagatg gtttgccagt
     4861 taggatgtct caatttgagc ctttgctttt ggtggataac tcagctcccc tcttgtaacc
     4921 tggaaagttg gttgccttta tcatcctgct ggttttatcc atggactgaa cacccaacag
     4981 cagtgcacta tgctttctat ggcatctttc attctcattt tatattgtgc tataaaaagg
     5041 attgtttctc catatatata ttatatatgt gtgtatatat ataatataat atatgtgtat
     5101 atatatatta tatatataat atataatata atatattata tatatattat atatataata
     5161 tatatataaa atatatatat atatgctctc ctctttcagc ctctttgtca cagggaagaa
     5221 gtgtaggagg ttgccttggg ccctgcctct ctcctaacct cctcttcccc actgggtacc
     5281 ctcagcccct atattttaat tcttgatcat gtagaaattg tttttggtaa atgttgatat
     5341 tattgttatt atcattatta ataaataaag agaaaaggaa tttttgttta aatgagaaat
     5401 gtttaaccag attctgttct atttgaattg tgacttgcac cttttgttca aagtatttcc
     5461 tttaggcatt gtaattgtga acagctctta cttgtgccag tgacagatgc agtggtctcc
     5521 tttccccagt tgaagcagtg catacgcagt agctattatt tgtgttatct ttatttctct
     5581 tcattgttag aaaccaaagt cttctctgct ggctggggct gagagagggt ctgggttatc
     5641 tccttctgat cttcaaaaca agagagagac cttgaataca ctgactcttc cacccttttt
     5701 ttttctggga aaggagagca agaggtcccg agtcccctcc tagtctttca tcctgaattt
     5761 gcacagagga aagcgggtgc ccggcatggc catcctgatg ttgctggcgg gatccccatg
     5821 caccttgtcc ttctccactg atactggcag ctcggctcct ggacccaaga tcccttgagt
     5881 ggaattctgc agtgcaagag cccttcgtgg gagctgtccc atgtttccat ggtccccagt
     5941 ctcccctcca cttggtgggg tcaccaacta ctcaccagaa gggggcttac caagaaagcc
     6001 ctaaaaagct gttgacttat ctgcgcttgt tccaactctt atgcccccaa cctgccctac
     6061 caccaccacg cgctcagcct gatgtgttta catggtactg tatgtatggg agagcagact
     6121 gcaccctcca gcaacaacag atgaaagcca gtgagcctac taaccgtgcc atcttgcaaa
     6181 ctacacttta aaaaaaactc attgctttgt attgtagtaa ccaatatgtg cagtatacgt
     6241 tgaatgtata tgaacatact ttcctatttc tgttctttga aaatgtcaga aatatttttt
     6301 tctttctcat tttatgttga actaaaaagg attaaaaaaa aaatctccag actcaagttg
     6361 ctaa
//
